Bimekizumab: The First FDA-Approved Dual IL-17A/IL-17F Inhibitor for Plaque Psoriasis – A Comprehensive Literature Review by Al Alshaikh SA, Almarhoon ZM, Momattin H, Aleid M, Almousa ZH, Alqaisum AK, Mobarki FI, Almakki SA, Alturfi H, Almajed KJ

“…Bimekizumab is a humanized IgG1 monoclonal antibody that selectively binds and diminishes the biological functions of both IL-17A and − 17F. …”
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A case report: interstitial pneumonia following treatment of gastric cancer with sintilimab in combination with S-1 by Pei Zhu, Qingming Sun, Sheng Xu, Wanhui Dong

“…This disease can extend to the surrounding blood vessels and pulmonary interstitium, sometimes affecting the entire lung, resulting in functional limitations, including restrictive ventilatory defect, impaired gas exchange, and hypoxemia. …”
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Synthesis and Biological Evaluation of Herceptin-Conjugated Liposomes Loaded with Lipocalin-2 siRNA for the Treatment of Inflammatory Breast Cancer by Marienid Flores-Colón, Mariela Rivera-Serrano, Esther A. Peterson-Peguero, Pablo E. Vivas-Rivera, Fatima Valiyeva, Pablo E. Vivas-Mejía

“…Approximately 50% of IBC cases are HER2+ and can be treated with the monoclonal antibody-based therapy Herceptin (trastuzumab). However, resistance to Herceptin develops within a year, and effective second-line targeted therapies are currently unavailable for IBC patients. …”
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Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1. by Sumi Biswas, Matthew D J Dicks, Carole A Long, Edmond J Remarque, Loredana Siani, Stefano Colloca, Matthew G Cottingham, Anthony A Holder, Sarah C Gilbert, Adrian V S Hill, Simon J Draper

“…Adenovirus-MVA immunization leads to the induction of T cell responses common to both alleles, as well as functional antibody responses that are effective against both of the encoded strains of P. falciparum in vitro. …”
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Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade by Torstein Baade Rø, Rui Yang, Zachary Cooper, Richard Woessner, Samah Elsaadi, Kristine Misund, Pegah Abdollahi, Esten Nymoen Vandsemb, Siv Helen Moen, Anna Kusnierczyk, Geir Slupphaug, Therese Standal, Anders Waage, Tobias S Slørdahl, Even Rustad, Anders Sundan, Carl Hay, Alwin G Schuller, Alexandra Borodovsky, Eline Menu, Magne Børset, Anne Marit Sponaas

“…Transplantable 5T33MM myeloma cells were used to determine the effect of inhibiting CD39, CD73 and A2AR in mice in vivo.Results Elevated level of adenosine was found in BM plasma of MM patients. …”
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Multi-omics unveils BCAA metabolism markers L-leucine and HMGCS1 as prognostic marker for immunotherapy efficacy in non-small cell lung cancer by Liyuan Dai, Xinzheng Wang, Ning Lou, Lin Li, Liling Huang, Le Tang, Jiarui Yao, Yuankai Shi, Xiaohong Han

“…And our cell and animal function experiments found HMGCS1 overexpression promotes metabolic pathways and accelerates tumor growth, whereas HMGCS1 knockdown suppresses tumor progression in a mouse model treated with PD-1 monoclonal antibody (P < 0.05). …”
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Peritoneal cavity-derived small extracellular vesicles from aged tumor-naïve hosts promote ovarian cancer adhesion and invasion by Reihaneh Safavi-Sohi, Jeff Johnson, Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Christopher Barile, Josh Mijares, Ceming Wang, Hsueh-Chia Chang, Rebecca J. Whelan, M. Sharon Stack

“…This was confirmed using meso-mimetic adhesion assays with function blocking antibodies or small molecule inhibitors, supporting a potential role for several proteins in promoting intra-peritoneal dissemination in the aged host. …”
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The human STING agonist E7766 induces immunogenic tumor clearance, independent of tumor-intrinsic STING expression in the KRASG12D/+ Trp53−/− murine model of sarcoma by Karys M. Hildebrand, Kurt N. Hildebrand, Carolina Salazar Arcila, Kayla Marritt, Jahanara Rajwani, Golpira Elmi Assadzadeh, Antoine Dufour, Frank R. Jirik, Michael J. Monument

“…Activation of the Stimulator of INterferon Genes (STING) pathway has shown promising anti-tumor effects in preclinical models of carcinoma, but evaluations in sarcoma are lacking. …”
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Metabolic profiling of glioblastoma and identification of G0S2 as a metabolic target by Jianlei Kang, Yujie Xu, Qitai Zhao, Ying Wang, Zhenyan He, Xin Xu

“…Additionally, in vivo experiments were conducted to explore the antitumor effects of G0S2 knockout in combination with PD-1 monoclonal antibody.ResultsSignificant metabolic differences were identified between low-grade gliomas (LGG) and glioblastomas (GBM), with consistent findings across both databases. …”
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IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology by Michela Croce, Valentina Rigo, Silvano Ferrini

“…Indeed, it costimulates T and natural killer (NK) cell proliferation and function and regulates B cell survival and differentiation and the function of dendritic cells. …”
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Adoptively transferred macrophages for cancer immunotherapy by Jennifer L Guerriero, Kyung Soo Park, Alexander P Gottlieb, Morgan E Janes, Supriya Prakash, Neha Kapate, Vineeth Chandran Suja, Lily Li-Wen Wang, Samir Mitragotri

“…Background Macrophages have been classically associated with their innate immune functions of responding to acute injury or pathogenic insult, but they have been largely overlooked as primary initiators of adaptive immune responses. …”
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Advances in the study of artemisinin and its derivatives for the treatment of rheumatic skeletal disorders, autoimmune inflammatory diseases, and autoimmune disorders: a comprehens... by Zhiyong Long, Wang Xiang, Wei Xiao, Yu Min, Fei Qu, Bolin Zhang, Liuting Zeng

“…Ongoing multicenter randomized clinical trials are investigating the effects of these compounds on rheumatic, inflammatory, and autoimmune diseases, with the aim of translating promising preclinical data into clinical applications.…”
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Targeting Streptococcus pyogenes atpF protein for multi-epitope vaccine development: a genomics-driven immunoinformatics strategy by Manisha Agarwal, Sanjeeb Handique, Sanchaita Rajkhowa, Abhichandan Das, Debashis Panda, Sami A. Al-Hussain, Magdi E.A. Zaki

“…Molecular modeling identified SM1 as the most promising candidate, demonstrating superior immune receptor binding affinity and flexible epitope interactions, facilitating effective antibody recognition. In silico immune simulations further demonstrated SM1′s potential to elicit strong humoral and cellular immune responses, while codon optimization confirmed efficient expression in E. coli. …”
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In-silico molecular analysis and blocking of the viral G protein of Nipah virus interacting with ephrin B2 and B3 receptor by using peptide mass fingerprinting by Ayesha Sajjad, Ihteshamul Haq, Rabia Syed, Faheem Anwar, Muhammad Hamza, Muhammad Hamza, Muhammad Musharaf, Tehmina Kiani, Faisal Nouroz

“…The lack of a vaccine and limited understanding of NiV pathogenesis underscore the urgent need for effective therapeutics. This study focuses on identifying viral peptides of the Nipah virus using the peptide mass fingerprinting technique. …”
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Spermatogenesis after extreme hyperthermal, hypothermal and traumatic infl uences and the possibility of its drug correction in the experiment by N. V. Avramenko, O. A. Nikiforov, О. О. Lomeyko

“…Research objective To analyze the status of spermatogenesis after extreme hyperthermal, hypothermal and traumatic effects and the possibility of drug correction in the experiment. …”
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The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis by Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li

“…Polymorphonuclear MDSCs (PMN‐MDSCs) expressing elevated PD‐L1 after sepsis demonstrated more substantial suppressive effects on T‐cell proliferation than controls. Treatment with anti‐PD‐1 monoclonal antibodies successfully restored T‐cell function, reduced mortality, and decreased metastasis in CLP mice. …”
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Plasmonic optical fiber biosensors for ultra-low detection of respiratory syncytial virus via point-of-care tests by Federica Passeggio, Luigi Zeni, Massimiliano Galdiero, Francesco Arcadio, Carla Zannella, Anna De Filippis, Chiara Marzano, Ines Tavoletta, Fabiana Napolitano, Rosalba Pitruzzella, Giuseppe Portella, Nunzio Cennamo

“…In this frame, for the first time, a plasmonic RSV biosensor based on modified plastic optical fibers (POFs) has been developed and tested by functionalizing the plasmonic platform with a specific antibody targeting the RSV fusion (F) protein. …”
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Aducanumab binds high molecular weight soluble Aβ oligomers and restores intracellular calcium levels by Lu Yu, Xueying Wang, Tri H. Doan, Yutian Fan, Thierry Bussiere, Brian J. Bacskai, Ksenia V. Kastanenka

“…However, its specificity toward different AβO species and its functional impact on calcium homeostasis remain unclear. …”
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Immunological testing for female infertility: a modern view on the problem by A. V. Konkina, L. A. Blikyan, D. E. Aleynikova, I. R. Abubakarov, A. S.-M. Dzhumanyazova, A. V. Abramian, L. G. Gafurova, D. A. Lobko, A. A. Pozoyan, K. M. Thagapsova, M. S. Golubeva, E. E. Shvanova, E. O. Ryzhov

“…It has been suggested that antinuclear antibodies (ANA) may affect reproductive function by disrupting trophoblast cell development and interfering with RNA transcription, which may lead to lowered reproductive success. …”
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Efficacy and safety of once-daily single-inhaler triple therapy for mild-to-moderate chronic obstructive pulmonary disease: a study protocol for a randomised and interventional stu... by Hiromasa Inoue, Ayako Takamori, Atsushi Kawaguchi, Takashi Kinoshita, Kazuhiro Yatera, Koichiro Takahashi, Tomotaka Kawayama, Hiroki Tashiro, Koichi Takagi, Kei Yamasaki, Kentaro Machida

“…The efficacy of triple therapy (inhaled corticosteroids/LAMA/LABA) has also been reported. However, the effect of triple therapy on patients with mild-to-moderate COPD has not yet been clarified. …”
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