Exploration of novel bioactive compounds from the microbiome of fish and shellfish as an alternative to replace antibiotic drugs in aquaculture farming by Arvind Diwan, Sanjay Harke, Archana N. Panche

“…However, their overuse has resulted in the contamination of closed aquatic ecosystems, reduced antibiotic resistance in organisms that fight infectious diseases, and compromised the effectiveness of various antibiotic medications in controlling diseases. …”
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Thymic Microenvironment Remodeling in Cancer Cachexia as a Determinant of Checkpoint Inhibitor Efficacy and Toxicity by Run‐Kai Huang, Yan‐Fang Xing, Xiang‐Yuan Wu, Zhao‐Hui Shi, Li Wei, Xiao‐Tong Lv, Lin‐Jiao Peng, Xiu‐Qing Pang, Qin‐Tai Yang, Xing Li

“…This study aimed to investigate this effect and its association with immune checkpoint inhibitor (ICI) treatment. …”
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A double-edged sword role of IFN-γ-producing iNKT cells in sepsis: Persistent suppression of Treg cell formation in an Nr4a1-dependent manner by Yingyu Qin, Yilin Qian, Shengqiu Liu, Rong Chen

“…Summary: Sepsis, a leading cause of mortality in intensive care units worldwide, lacks effective treatments for advanced-stage sepsis. Therefore, understanding the underlying mechanisms of this disease is crucial. …”
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Probing Bacterial Interactions with the <i>Schistosoma mansoni</i>-Killing Toxin Biomphalysin via Atomic Force Microscopy and Single Molecule Force Spectroscopy by Jihen Zouaoui, Pierre Poteaux, Audrey Beaussart, Nicolas Lesniewska, David Duval, Jérôme F. L. Duval

“…Exposure of <i>M. luteus</i> to BM compromised cell surface integrity and induced cell aggregation. These effects correlated with a patch-like distribution of BM on <i>M. luteus</i> reminiscent of pore-forming toxins, as revealed by the anti-BM antibody-functionalized AFM tip. …”
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Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice. by Ali A Almishaal, Pranav D Mathur, Elaine Hillas, Liting Chen, Anne Zhang, Jun Yang, Yong Wang, Wayne M Yokoyama, Matthew A Firpo, Albert H Park

“…BALB/c mice, which lack functional Ly49H, inoculated with mCMV at post-natal day 3 developed profound hearing loss and significant outer hair cell loss by 28 days of life. …”
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Rapid and Sensitive Detection of Thrombospondin-2 Using Nanoparticle Sensors for Cancer Screening and Prognosis by Maziyar Kalateh Mohammadi, Seyedsina Mirjalili, Md Ashif Ikbal, Hao Xie, Chao Wang

“…Here, we propose and demonstrate a modular, in-solution assay design concept, Nanoparticle-Supported Rapid Electronic Detection (NasRED), as a versatile cancer screening and diagnostic platform. NasRED utilizes antibody-functionalized gold nanoparticles (AuNPs) to capture target proteins from a minute amount of sample (<10 µL) and achieve optimal performance with a short assay time by introducing active fluidic forces that act to promote biochemical reaction and accelerate signal transduction. …”
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Novel immunotargets in multiple myeloma: biological relevance and therapeutic potential by Jana Kotulová, Klára Baďurová, Zuzana Chyra, Sabina Ševčíková, Nikola Garbová, Tomáš Jelínek, Roman Hájek, Matouš Hrdinka

“…These immunotargets demonstrate significant potential for next-generation immunotherapies, including antibody–drug conjugates, bispecific antibodies, and chimeric antigen receptor (CAR) T-cell therapies. …”
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Molecularly imprinted biomimetic plasmonic sensor decorated with gold nanoparticles for selective and sensitive detection of bisphenol A by Ilgım Göktürk, Süleyman Aşır, Deniz Türkmen, Adil Denizli, Fatma Yılmaz

“…Molecularly imprinted polymers inspired by antigen-antibody interactions have received substantial interest as a biomimetic artificial receptor system in environmental applications. …”
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Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure. by Tommi A White, Alberto Bartesaghi, Mario J Borgnia, Joel R Meyerson, M Jason V de la Cruz, Julian W Bess, Rachna Nandwani, James A Hoxie, Jeffrey D Lifson, Jacqueline L S Milne, Sriram Subramaniam

“…Strikingly, in SIV CP-MAC, a CD4-independent strain, trimeric Env is in a constitutively "open" conformation with gp120 trimers splayed out in a conformation similar to that seen for HIV-1 BaL Env when it is complexed with sCD4 and the CD4i antibody 17b. Our findings suggest a structural explanation for the molecular mechanism of CD4-independent viral entry and further establish that cryo-electron tomography can be used to discover distinct, functionally relevant quaternary structures of Env displayed on intact viruses.…”
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Ankylosing Spondylitis by Nazanin Ebrahimiadib, Sahar Berijani, Mohammadreza Ghahari, Fatemeh Golsoorat Pahlaviani

“…NSAIDs, disease-modifying anti-rheumatic drugs (DMARDs), methotrexate, azathioprine, anti-IL-17A monoclonal antibodies, and TNF-α antagonists are effective treatments for ocular and systemic manifestations of AS. …”
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From Conjugation to Detection: Development of Lateral Flow Assay for Zearalenone by Vinayak Sharma, Bilal Javed, Hugh J. Byrne, Furong Tian

“…Beginning with the synthesis and functionalization of gold nanoparticles, it proceeds to compare the immobilization of antibodies using chemical conjugation and physical adsorption binding strategies, upon optimizing parameters including the pH, antibody concentration and blocking conditions to enhance the stability of the prepared bioconjugates. …”
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A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer by Lijuan Chen, Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang

“…These results demonstrate that VVL-12 has strong potential as a safe and effective antitumor therapeutic for lung cancer. Importantly, VVL-12 can sensitize lung cancers to α-PD1 antibody therapy, and the combined regime creates a highly effective treatment option for patients.…”
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Differential regulation of C-C chemokines during fibroblast-monocyte interactions: adhesion vs. inflammatory cytokine pathways by C. Zickus, S. L. Kunkel, K. Simpson, H. Evanoff, M. Glass, R. M. Strieter, N. W. Lukacs

“…The cell-to-ce ll interactions during chronic inflammatory diseases likely contribute to leukocyte accumulation leading to increased pathology and organ dys -function. In particular, there is a paucity of information relating to the maintenance of chronic fibrotic diseases . …”
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Luciferase mRNA Transfection of Antigen Presenting Cells Permits Sensitive Nonradioactive Measurement of Cellular and Humoral Cytotoxicity by Tana A. Omokoko, Uli Luxemburger, Shaheer Bardissi, Petra Simon, Magdalena Utsch, Andrea Breitkreuz, Özlem Türeci, Ugur Sahin

“…Immunotherapy is rapidly evolving as an effective treatment option for many cancers. With the emerging fields of cancer vaccines and adoptive cell transfer therapies, there is an increasing demand for high-throughput in vitro cytotoxicity assays that efficiently analyze immune effector functions. …”
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SPAG5 is a potential therapeutic target affecting proliferation, apoptosis, and invasion of esophageal cancer cells by Xiaohui Zhang, Lingmin Zhang, Manli Cui, Shiyu Ji, Yanan Zhang, Qian Li, Mingxin Zhang

“…Increasing evidence suggests that SPAG5 is overexpressed in various malignancies, functioning as an oncogene. However, research specifically examining SPAG5 in esophageal cancer remains limited. …”
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Perforation of small intestinal metastasis of lung adenocarcinoma treated with pembrolizumab: a case report by Shoki Sato, Naoto Senmaru, Keita Ishido, Takahiro Saito, Saseem Poudel, Jun Muto, Yasuhito Syouji, Ryunosuke Hase, Satoshi Hirano

“…Because pembrolizumab causes some side effects, particularly autoimmune side effects, careful attention during treatment is warranted.…”
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Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies by Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian

“…However, these therapies have some limitations, such as unusual toxic side effects, drug resistance, limited indications, and high costs. …”
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Trem2 regulates microglial migratory responses via type I interferon signaling during photoreceptor degeneration by Jincan He, Wenchuan Zhou, Jing Li

“…Abstract Background Various functions of activated microglia play crucial roles in the progression of retinitis pigmentosa (RP). …”
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B-CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS by A. I. Budkova, S. V. Lapin, M. K. Serebriakova, I. V. Kudryavtsev, I. N. Trishina, A. L. Maslyansky, A. A. Totolian

“…Thus, therapy targeted against certain B cell subsets, could be able to provide a more effective treatment for the patients with systemic rheumatic diseases.…”
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Physicochemical properties and IgE binding ability changes of turbot allergen during oxidation by LU Zongchao, LI Zhenxing, ZHANG Limin, LIN Hong

“…Therefore, the objective of this study was to explore modification of fish muscle proteins by oxidizing radicals, including functional properties such as the allergenicity and functionality groups. …”
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