Comparative efficacy of chronic lymphocytic leukemia treatment with or without rituximab by E. A. Zenkova, Б. Е. Kugushev, E. R. Vasilieva

“…The addition of rituximab (RFC therapy) to cyclophosphamide + fludarabine (FC therapy) provides a more rapid therapy response without adverse toxic effects such as impact on bone marrow functional activity and tumor lysis syndrome.…”
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Enhancement of Dopaminergic Differentiation in Proliferating Midbrain Neuroblasts by Sonic Hedgehog and Ascorbic Acid by Floriana Volpicelli, Claudia Consales, Massimiliano Caiazzo, Luca Colucci-D'Amato, Carla Perrone-Capano, Umberto di Porzio

“…Recombinant Sonic hedgehog (SHH) protein increases up to three fold the number of tyrosine hydroxylase (TH)-positive cells and their differentiation, an effect abolished by anti-SHH antibodies. The expanded cultures are rich in nestin-positive neurons, glial cells are rare, all TH+ neurons are DA, and all DA and GABAergic markers analyzed are expressed. …”
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Comparative efficacy and safety of Faricimab with other intravitreal anti-vascular endothelial growth factor in the treatment of Neovascular age related macular degeneration- A Sys... by Renuga Devi Kaliaperumal, Nandhini P, Reena Mohan, Nallamuthu P, Jenifer Florence Mary J

“…The fixed-effect model was used to assess and compare the effectiveness of Faricimab with other intravitreal anti-VEGF therapy. …”
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CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors by Yi Sun, Eduardo Davila, YuJie Guo, Richard D Schulick, Elliott Yee, Yuki Fujiwara, Kaitlyn Dickinson, Zhiwei Sun, Junyi Hu, Yuwen Zhu

“…The objective of this study is to evaluate whether CD93 blockade improves ACT in solid cancers.Methods Monoclonal antibodies (mAbs) against CD93 or IGFBP7 were administered in implanted mouse melanoma models to assess the effect of CD93 blockade on ACT. …”
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Bacteroides fragilis and propionate synergize with low-dose methimazole to treat Graves’ disease by Xinjie Zhang, Qingxin Pan, Guixiang Yao, Danxia Kong, Haiyan Chen, Qunye Zhang, Zhe Wang

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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart by Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad

“…Diabetic and vehicle control animals were randomly divided into groups with/without AKG treatment. Cardiac function was monitored by performing cardiac catheterization. …”
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Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin. by Fu-Shi Quan, Yeu-Chun Kim, Dae-Goon Yoo, Richard W Compans, Mark R Prausnitz, Sang-Moo Kang

“…<h4>Background</h4>Simple and effective vaccine administration is particularly important for annually recommended influenza vaccination. …”
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Targeting Th17 Cells with Small Molecules and Small Interference RNA by Hui Lin, Pingfang Song, Yi Zhao, Li-Jia Xue, Yi Liu, Cong-Qiu Chu

“…Anti-IL-17 monoclonal antibodies show potent efficacy in psoriasis but poor effect in rheumatoid arthritis (RA) and Crohn’s disease. …”
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Preclinical Evaluation of a New Anti-COVID-19 Intravenous Immunoglobulin by A. M. Nikolaeva, A. V. Ivanov, T. I. Smolyanova, M. V. Razumikhin, O. V. Belyakova, E. G. Shilova, N. R. Selezneva, T. V. Vyaznikova, A. I. Semicheva, E. I. Sakanyan

“…Using of immunoglobulins containing SARS-CoV-2 neutralizing antibodies may be an effective and safe tool for COVID-19 treatment. …”
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The GPI sidechain of Toxoplasma gondii inhibits parasite pathogenesis by Julia A. Alvarez, Elisabet Gas-Pascual, Sahil Malhi, Juan C. Sánchez-Arcila, Ferdinand Ngale Njume, Hanke van der Wel, Yanlin Zhao, Laura García-López, Gabriella Ceron, Jasmine Posada, Scott P. Souza, George S. Yap, Christopher M. West, Kirk D. C. Jensen

“…Cytokine responses, antibody recognition of GPI-anchored SAGs, and complement binding to PIGJ mutants are intact. …”
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Nanoparticle-mediated delivery of oncolytic viral genomes: an innovative strategy for tumor-targeted immunotherapy by Junhan Yang, Binlei Liu

“…By encapsulating vGenomes within functionalized NPs, this platform achieves tumor-targeted delivery via enhanced permeability and retention (EPR) effects or ligand-mediated active targeting. …”
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TIGIT+ CD4+ regulatory T cells enhance PD-1 expression on CD8+ T cells and promote tumor growth in a murine ovarian cancer model by Fengzhen Chen, Yanying Xu, Xiangyu Liu, Na Dong, Lei Tian

“…Furthermore, using Foxp3-diphtheria toxin receptor (DTR) mice, we substantiated that the combined TIGIT antibody treatment, based on targeting regulatory T cells, effectively slowed down the progression of ovarian cancer. …”
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Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma by Yan Liao, Hao Yao, Weidong Chen, Yutong Zou, Ji Fang, Jiongfeng Zhang, Zehao Guo, Jian Tu, Junkai Chen, Zijun Huo, Lili Wen, Xianbiao Xie

“…Combining the MIF inhibitor 4-IPP with a programmed cell death 1 (PD-1) monoclonal antibody treatment demonstrated a significant antitumor effect.Conclusion MIF acts as a novel therapeutic target by regulating macrophage polarization and chemotaxis. …”
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Utilization of universal-targeting mSA2 CAR-T cells for the treatment of glioblastoma by Alexandros Kourtesakis, Eileen Bailey, Hiu Nam Hannah Chow, Hannah Rohdjeß, Normann Mussnig, Dennis Alexander Agardy, Dirk Carsten Frieder Hoffmann, Yu-Chan Chih, Rainer Will, Leon Kaulen, Melissa Hahn, Robin Wagener, Denise Reibold, Sonja Pusch, Felix Sahm, Tim Sauer, Michael Schmitt, Lukas Bunse, Michael Platten, Wolfgang Wick, Tobias Kessler

“…CAR-T cells utilizing monomeric streptavidin-2 (mSA2) instead of a traditional target binding domain, bind biotinylated antibodies and can be directed to variable targets to mediate anti-tumor effects. …”
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Pneumococcal vaccine hyporesponsiveness in people living with HIV: A narrative review of immunological mechanisms and insights from minimally invasive lymph node sampling by Giovanni E. Loe-Sack-Sioe, Danny W. de Vos, Leo G. Visser, Simon P. Jochems, Anna H. E. Roukens

“…Germinal centers (GCs), located within lymph nodes, are essential for generating high-affinity antibodies, but are structurally and functionally disrupted in PLWH. …”
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T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Rα targeting by Jelena Pesic, Juan José Nieto-Fontarigo, Juan José Nieto-Fontarigo, Katerina Pardali, Stephen Delaney, Henric Olsson, Lena Uller

“…Biologic therapies targeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies (mAbs), have shown improvements in lung function and reductions in exacerbation rates for severe asthma. …”
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Engineered oncolytic virus OH2-FLT3L enhances antitumor immunity via dendritic cell activation by Duo Wan, Qi Zhang, Zhenrong Yang, Xiaoli Zhang, Peipei Xie, Shujun Cheng, Libin Xu, Binlei Liu, Kaitai Zhang, Wen Zhang

“…We found that OH2-FLT3L specifically infects tumor cells, induces immunogenic cell death (ICD), and releases a large number of tumor-specific antigens, which bound to danger signals and facilitated antigenic cross-presentation by DCs, significantly enhancing T cell activation and function. Experimental results showed that OH2-FLT3L significantly increased the proportion of activated DCs, enhanced the antitumor immune response, and effectively converted “cold” tumors into “hot” tumors. …”
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P24 | DEVELOPMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT-DERIVED XENOGRAFTS (PDXS) AND ORGANOIDS (PDXOS) FOR MORPHOLOGICAL ANALYSIS AND DRUG SCREENING

“…The anti-EGFR monoclonal antibody cetuximab (CTX) was approved as a radiation sensitiser for recurrent or metastatic HNSCCs, but patients often develop resistance1. …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Yan Yi Chan, Pui Yan Ho, Carla Dib, Leah Swartzrock, Maire Rayburn, Hana Willner, Ethan Ko, Katie Ho, Julian D. Down, Adam C. Wilkinson, Hiro Nakauchi, Morgane Denis, Taylor Cool, Agnieszka Czechowicz

“…We previously demonstrated that targeted monoclonal antibody (mAb)-based HSC depletion with anti(α)-CD117 mAbs could be an effective alternative conditioning approach for HSCT without toxicity in severe combined immunodeficiency (SCID) mouse models, which has prompted parallel clinical αCD117 mAbs to be developed and tested as conditioning agents in clinical trials starting with treatment of patients with SCID. …”
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Exploring the associations between gut microbiota composition and SARS-CoV-2 inactivated vaccine response in mice with type 2 diabetes mellitus by Long Liu, Xianzhen He, Jiaqi Wang, Moran Li, Xiuli Wei, Jing Yang, Gong Cheng, Weixing Du, Zhixin Liu, Xiao Xiao

“…T2DM was associated with a diminished initial IgG antibody response against the spike protein, which subsequently normalized after 28 days. …”
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