Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors by Zhenzhen Fan, Yahui Tian, Zhipeng Chen, Lu Liu, Qian Zhou, Jingjing He, James Coleman, Changjiang Dong, Nan Li, Junqi Huang, Chenqi Xu, Zhimin Zhang, Song Gao, Penghui Zhou, Ke Ding, Liang Chen

“…Abstract Small molecular PD‐1 inhibitors are lacking in current immuno‐oncology clinic. PD‐1/PD‐L1 antibody inhibitors currently approved for clinical usage block interaction between PD‐L1 and PD‐1 to enhance cytotoxicity of CD8+ cytotoxic T lymphocyte (CTL). …”
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Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis by Shuaiwei Wang, Hao Fu, Hao Fu, Xiaoqing Li, Xiaoqing Li, Hongrui Xu, Yu Bai, Wenjun Jiang, Xiaozhe Cheng, Na Chen, Na Chen, Yijie Zhang, Yijie Zhang, Wei Li

“…Intravenous administrations of recombinant pIgR (r_pIgR) increased the mortality in mouse models of Klebsiella pneumoniae (KP)-induced pneumosepsis (KPS) and polymicrobial sepsis. r_pIgR also increased the injury score, caspase-11 and GSDMD-NT in the lungs of KPS mice. pIgR-neutralizing antibody (pIgR_Ab) exhibited opposite effects on animal survival in both sepsis models and on the injury score, caspase-11 and GSDMD-NT. …”
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MODERN OPPORTUNITIES IN UVEITIS TREATMENT by D. A. Krakhmaleva, E. A. Pivin, S. V. Trufanov, S. A. Malozhen

“…So the  search continues to develop new therapies for use  in uveitis that  aim  to  suppress inflammatory  activit y,  prevent  accumulation of damage, and  preserve  visual function  for  patients with the minimum possible  side effects.…”
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Prognostic significance and immune infiltration analysis of HMGA2 in endometrial cancer by Peng Jiang, Jiaxin Yu, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Chunxia Gong, Hangkun Yu, Yi Luo, Zhuoying Hu

“…The combination of HMGA2 inhibitors and targeted macrophage immunotherapy (CD47 monoclonal antibody) had the better tumor suppression effect. …”
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Current advances in the role of classical non‐homologous end joining in hematologic malignancies by Pengcheng Liu, Zizhen Xu

“…Such DSBs, which require NHEJ for resolution, can arise from intrinsic and extrinsic DNA‐damaging factors or emerge naturally during essential biological processes like V(D)J recombination and antibody class switch recombination. Main Body Failure to properly repair DSBs may lead to genomic instability, disruption of cellular functions, and immunodeficiency, thereby promoting the development of hematologic malignancies. …”
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Pervasiveness of urinary tract infection in diabetic patients and their causative organisms with antibiotic sensitivity pattern by Zeel Paresh Bhagat, Mahesh Chandra Sahu

“…DM also hampers immunologic functions such as phagocytosis, decrease in antibody production, failure of T cells and B cells to fight against pathogens which ameliorate bacterial growth. …”
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Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer. by Minsung Kim, Suhkneung Pyo, Chung Hyo Kang, Chong Ock Lee, Heung Kyoung Lee, Sang Un Choi, Chi Hoon Park

“…T cells expressing CAR have specific activation and cytotoxic effects against cancer cells containing the target antigen. …”
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CXCL13 suppresses liver regeneration through the negative regulation of HGF signaling by Qun Zhao, Jingyi Wu, Mengyuan Feng, Anjie Zhang, Liwei Fu, Jinglin Chen, Lian Li, Fangzhou Li, Tingting Li, Shu Jin, Shengbao Li, Xianjun Yu

“…Importantly, treatment with CXCL13-neutralizing antibody effectively improved liver regeneration in mice PHx model. …”
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Sunitinib-Induced Acute Interstitial Nephritis in a Thrombocytopenic Renal Cell Cancer Patient by Ibrahim Azar, Saghi Esfandiarifard, Pedram Sinai, Ali Wazir, Llewellyn Foulke, Syed Mehdi

“…Four other cases of AIN reported along with inhibition of the vascular endothelial growth factor (VEGF) by either TKI (sunitinib and sorafenib) or antibodies (bevacizumab) suggest a possible class effect. …”
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Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques by Lis de Weerd, Selina Hummel, Stephan A. Müller, Iñaki Paris, Thomas Sandmann, Marie Eichholtz, Robin Gröger, Amelie L. Englert, Stephan Wagner, Connie Ha, Sonnet S. Davis, Valerie Warkins, Dan Xia, Brigitte Nuscher, Anna Berghofer, Marvin Reich, Astrid F. Feiten, Kai Schlepckow, Michael Willem, Stefan F. Lichtenthaler, Joseph W. Lewcock, Kathryn M. Monroe, Matthias Brendel, Christian Haass

“…To improve the safety profile of these molecules, it is imperative to understand the consequences of anti-Aβ antibody treatment on immune cell function. Here, we investigated the effects of long-term chronic anti-Aβ treatment on amyloid plaque pathology and microglial response in the APP-SAA triple knock-in mouse model with an intervention paradigm early during amyloidogenesis. …”
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Enhancement of Human Immunodeficiency Virus-Specific CD8⁺ T Cell Responses with TIGIT Blockade Involves Trogocytosis by Nazanin Ghasemi, Kayla A. Holder, Danielle P. Ings, Michael D. Grant

“…Reduced CD8⁺ T cell TIGIT expression with TIGIT blockade involved trogocytosis by circulating monocytes, suggesting that an effector monocyte population and intact fragment crystallizable (Fc) functions are required for mAb-based TIGIT blockade to effectively enhance HIV-specific CD8⁺ T cell responses.…”
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Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitors by Anna Hernández‐Prat, Alejo Rodriguez‐Vida, Laura Cardona, Mengjuan Qin, Oriol Arpí‐Llucià, Luis Soria‐Jiménez, Sílvia Menendez, Fabricio Gerel Quimis, Miguel Galindo, Edurne Arriola, Marta Salido, Nuria Juanpere‐Rodero, Federico Rojo, Aura Muntasell, Joan Albanell, Ana Rovira, Joaquim Bellmunt

“…The correlation between PD‐L1 expression and ICI effectiveness is uncertain, leaving the role of PD‐L1 as a predictive marker for ICI efficacy unclear. …”
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Association of rituximab use with adverse events in adults with lymphoma or autoimmune disease: a single center experience by Mengsi Hu, Mengsi Hu, Tingwei Zhang, Tingwei Zhang, Bing Liu, Qi Guo, Bing Zhao, Jiangong Lin, Zhimei Lv, Zhimei Lv, Rong Wang, Rong Wang

“…ObjectiveRituximab (RTX) is a chimeric human/murine CD20 monoclonal antibody, which has been administered in treating hematological malignancies and various autoimmune disorders. …”
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Case Report: long-term misdiagnosis and follow-up of a patient with HNF4A-MODY carrying a new de novo mutation by Jing Luo, Jing Luo, Ai Li, Ai Li, Xiaoli Wang

“…At a routine follow-up at age 21, another physician observed that his pancreatic islet function remained preserved, with negative results for diabetes-related antibodies. …”
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Immunobiological status of the organism of young pigs during their triphasic period cultivation and actions of corrective factors by N. Yu. Krempa, O. V. Kozenko, B. V. Gutyj, I. V. Dvylyuk, N. V. Magrelo, H. V. Sus, U. M. Vus, T. V. Martyshuk, V. V. Voroniak, A. O. Vysotskyi, O. O. Dashkovskyi

“…Research data prove that the specificity of the action of Ig Y has a positive effect on the preservation of the integrity of the villi of the intestinal mucosa, which is reflected by the strengthening of its protective and barrier function, which in general contributes to the increase in the percentage of animal survival: using Globigen®Pig Doser 80.0 % and 86.7 % using Globigen®Jump Start. …”
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The combination of dietary active dry yeast and Bacillus subtilis improves productive performance, egg quality, and immunity of aged breeder hens by Yuchen Liu, Xintong Wang, Xiaoyu Zhao, Ying Ma, Lujiang Qu, Zhong Wang, Zhonghua Ning

“…This study aimed to investigate the effects of dietary supplementation with active dry yeast (ADY) alone or in combination with Bacillus subtilis (BS) on physiological parameters (laying performance, egg quality, blood indexes), reproductive traits, ileum microbiome, metabolome, and uterine gene expression in aged breeder hens. …”
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Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signalling and drug detoxification and are essential for parasite survival. by Bemnet A Tedla, Javier Sotillo, Darren Pickering, Ramon M Eichenberger, Stephanie Ryan, Luke Becker, Alex Loukas, Mark S Pearson

“…Antibodies to recombinant forms of each SmChE localized the proteins to the tegument of adults and schistosomula and developmental expression profiling differed among the three molecules, suggestive of functions extending beyond traditional cholinergic signaling. …”
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Contraception for antiphospholipid syndrome and systemic lupus erythematosus (according to the recommendations of the European Alliance of Associations for Rheumatology/American Co... by T. M. Reshetnyak, S. B. Kertchelaeva, N. M. Kosheleva

“…Maintaining and strengthening the health of the population is one of the primary functions of society. Inadequate understanding of the importance of contraception by the medical community and its application by society can lead to the population’s reproductive health becoming compromised. …”
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Thyroid dysfunction as a long-term post-COVID-19 complication in mild-to-moderate COVID-19 by Vesselina Yanachkova, Teodora Stankova, Radiana Staynova

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), may lead to thyroid disorders, including both thyrotoxicosis and suppression of thyroid function. The aim of the present study was to assess the post-COVID-19 effects on thyroid function in patients without history of thyroid disease after complete recovery from mild-to-moderate COVID-19. …”
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NEW POSSIBILITIES OF PHARMACOTHERAPY FOR IMMUNOINFLAMMATORY RHEUMATIC DISEASES: A FOCUS ON INHIBITORS OF INTERLEUKIN-17 by E. L. Nasonov

“…Special attention is paid to the clinical efficacy and safety of anti-IL-17A monoclonal antibody secukinumab used to treat psoriasis, PsA, AS, and RA.…”
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