Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation by Pazhanichamy Kalailingam, Khalilatul‐Hanisah Mohd‐Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O'Leary, Kah Leong Lim, I Hsin Su, Yong‐Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy, Siu Kwan Sze

“…Mechanistically, isoDGR‐mAb mediated immune clearance of damaged isoDGR‐proteins via antibody‐dependent cellular phagocytosis (ADCP). These results indicate that immunotherapy targeting age‐linked protein damage may represent an effective intervention strategy in a range of human degenerative disorders.…”
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Age-associated defect in ADCC response to COVID-19 vaccine by Benjamin L. Sievers, Mazharul Altaf, Mark T. K. Cheng, Kimia Kamelian, Claire Cormie, The CITIID-NIHR BioResource COVID-19 Collaboration, Rainer Doffinger, Ravindra K. Gupta

“…While neutralization titers remained comparable across age groups, Fc-mediated effector functions declined with age. Individuals >80 demonstrated reduced antibody-dependent cellular cytotoxicity (ADCC), via a surrogate ADCC-signaling assay, correlating with diminished IgG1 binding. …”
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Early and Sustained Response to Benralizumab in Severe, Eosinophilic Asthma: A Real-World Observational Study by Stolz D, Schuoler C, Charbonnier F, Bridevaux PO, Jandus P, Leuppi JD, Pavlov N, Piecyk A, Rothe T

“…Daiana Stolz,1,2 Claudio Schuoler,3 Florian Charbonnier,4 Pierre-Olivier Bridevaux,4,5 Peter Jandus,6 Jörg D Leuppi,7 Nikolay Pavlov,8 Andreas Piecyk,9 Thomas Rothe10 1Pulmonology Clinic, University Hospital Basel, Basel, Switzerland; 2Clinic of Respiratory Medicine and Faculty of Medicine, University of Freiburg, Freiburg, Germany; 3Medical Department, AstraZeneca AG, Baar, Switzerland; 4Pulmonology Division, University Hospital Geneva, Geneva, Switzerland; 5Service de Pneumologie, Centre Hospitalier du Valais Romand, Sion, Switzerland; 6Immunology and Allergology Division, University Hospital Geneva, Geneva, Switzerland; 7University Centre of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland; 8Department for Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; 9Pulmonary Center Hirslanden, Zurich, Switzerland; 10Pulmonology Clinic, Cantonal Hospital Graubünden, Chur, SwitzerlandCorrespondence: Claudio Schuoler, AstraZeneca AG, Medical Department, Baar, Switzerland, Email claudio.schuoler@astrazeneca.comPurpose: Although studies have evaluated benralizumab, a monoclonal IL-5 receptor α antibody in severe eosinophilic asthma (SEA), in real-world settings, additional evidence is needed to further characterize its effectiveness in specific patient populations. …”
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Diagnostic significance of TGF-β1 in kidney recipients with graft dysfunction by О. P. Shevchenko, S. О. Sharapchenko, D. A. Velikiy, О. Е. Gichkun, E. S. Stolyarevich, N. P. Mozheiko, D. A. Saydulaev, R. М. Kurabekova, E. A. Vakurova, A. A. Mamedova, M. A. Osoblivaya

“…Transforming growth factor beta 1 (TGF-β1), which has multiple effects in the body, among the potential indicators of complications.Objective: to assess the diagnostic significance of serum TGF-β1 in kidney recipients with graft dysfunction.Materials and methods. …”
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Extracellular Vesicles as Precision Delivery Systems for Biopharmaceuticals: Innovations, Challenges, and Therapeutic Potential by Sidhesh Mohak, Zsolt Fabian

“…Recent innovations in surface modification technologies, including ligand and antibody attachment, have further enhanced EVs’ targeting capabilities, making them particularly effective in personalized medicine. …”
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Phylogenetic analysis of migration, differentiation, and class switching in B cells. by Kenneth B Hoehn, Oliver G Pybus, Steven H Kleinstein

“…B cells undergo rapid mutation and selection for antibody binding affinity when producing antibodies capable of neutralizing pathogens. …”
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B cells are not drivers of stromal cell activation during acute CNS infection by Brendan T. Boylan, Mihyun Hwang, Elyse Brozost, Hyunsuk Oh, Alexei V. Tumanov, Antoine Louveau, Cornelia C. Bergmann

“…B cell depletion by anti-CD20 antibody also had no adverse effects. Surprisingly, LTβR agonism reduced viral control and parenchymal T cell localization despite increasing stromal cell lymphoid chemokines and PDPN. …”
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Growing attention of immunogenicity among patients with autoimmune diseases post-SARS-CoV-2 vaccination: meta-analysis and systematic reviews of the current studies by Chao Zhang, Yu-Qiang Zhang, Run-Ben Liu, Yu-Tong Ma, Lin-Kang Zhao, Fu-Qiang Yin, Jing Tu, Yang-Yang Yao

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A SpA+LukAB vaccine targeting Staphylococcus aureus evasion factors restricts infection in two minipig infection models by Jan T. Poolman, Victor J. Torres, Dominique Missiakas, Suzanne P. M. Welten, Jeffrey Fernandez, Ashley L. DuMont, Anna O’Keeffe, Sergey R. Konstantinov, Brian Morrow, Peter Burghout, Jan Grijpstra, Miranda M. C. van Beers, Chakkumkal Anish, Michel Beurret, Jeroen Geurtsen, Pauline M. L. Rood, Oliver Koeberling, Miaomiao Shi, Germie P. J. M. van den Dobbelsteen

“…Increasing antimicrobial resistance highlights the urgent need for effective preventative strategies. Antibody-mediated opsonophagocytosis, the key mechanism for protection against S. aureus, is disabled by critical virulence factors such as Staphylococcal protein A (SpA) and leukocidin AB (LukAB). …”
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The influence of natural immunostimulant on some indicators of specific immunity of carp by O. V. Krushelnytska

“…This was reflected in an increase in the level of total T-lymphocytes, active T-lymphocytes, B-lymphocytes and immunoglobulins. An effective immunostimulating effect was achieved at a dose of 10 mg/kg of fish weight with a duration of use of the preparation  for 15–20 days. …”
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Neuropathological correlations of 18F-florzolotau PET in a case with Pick’s disease by Hisaomi Suzuki, Manabu Kubota, Shin Kurose, Kenji Tagai, Hironobu Endo, Mitsumoto Onaya, Yasuharu Yamamoto, Naruhiko Sahara, Masahiro Ohgidani, Chie Haga, Hiroya Hara, Haruhiko Akiyama, Keisuke Takahata, Makoto Higuchi

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An FPGA-Based SiNW-FET Biosensing System for Real-Time Viral Detection: Hardware Amplification and 1D CNN for Adaptive Noise Reduction by Ahmed Hadded, Mossaad Ben Ayed, Shaya A. Alshaya

“…The SiNW-FET biosensor, functionalized with antibodies specific to viral antigens, detects impedance shifts caused by antibody–antigen interactions, providing a highly sensitive platform for viral detection. …”
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Overcoming challenges of developing a live-attenuated dengue vaccine and the path forward by Dr Walid Kandeil, Dr Mayuri Sharma

“…Additional immunogenicity analysis across phase I/II/III trials revealed engagement of long-lasting tetravalent, functional antibody, and cell-mediated immune responses directed against the structural and nonstructural components of the vaccine, irrespective of baseline serostatus. …”
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MANAGEMENT OF BLEEDING IN A PATIENT WITH ACQUIRED HAEMOPHILIA A: A CASE REPORT by Mihriban Yıldırım, Muzaffer Keklik, Şerife Emre Ünsal, Nesibe Taşer Kanat, Hacı Ahmet Aslaner, Gülşah Akyol, Neslihan Mandacı Şanlı, Ali Ünal

“…Objective: Acquired haemophilia A (AHA) is a blood clotting disorder caused by the presence of autoantibodies that interfere with the function of factor VIII, often called factor VIII inhibitor (1). …”
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Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition by Hayley M. Sabol, Aric Anloague, Japneet Kaur, Cecile Bustamante-Gomez, Sharmin Khan, Bethany C. Paxton, Mattie R. Nester, Jillian Hackney, Marta Diaz-delCastillo, Daniel Mann, Jeffrey B. Stambough, C. Lowry Barnes, Elena Ambrogini, Alison Frontier, Frank H. Ebetino, Syed Naqvi, Frits van Rhee, Christopher P. Wardell, Matthew T. Drake, Intawat Nookaew, Carolina Schinke, Maurizio Zangari, Jesus Delgado-Calle

“…Sclerostin, an antagonist of Wnt signaling, is elevated in MM patients, and its inhibition with a neutralizing antibody (Scl-ab) has been shown to restore osteoblast function in mouse models of MM. …”
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Current approaches to therapy for complications of bone metastases from breast cancer by L. G. Zhukova

“…Denosumab, a fully human monoclonal antibody to RANKL, suppresses the forma- tion and functional activity of osteoclasts, thus inhibiting bone resorption.The results of a registration study have indicated that denosumab is not only as effective as zoledronic acid, but also can reduce the risk of BMRCs and significantly delay time to the first and further skeletal complications, including the need for radiotherapy, the development of hypercalcemia and pathological fractures. …”
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Immune-checkpoint-inhibitor therapy directed against PD-L1 is tolerated in the heart without manifestation of cardiac inflammation in a preclinical reversible melanoma mouse model by Caroline Schoenherr, Caroline Schoenherr, Stefan Pietzsch, Stefan Pietzsch, Cristina Barca, Franziska E. Müller, Frauke S. Bahr, Martina Kasten, Andre Zeug, Sergej Erschow, Christine S. Falk, Evgeni Ponimaskin, James T. Thackeray, Denise Hilfiker-Kleiner, Denise Hilfiker-Kleiner, Melanie Ricke-Hoch

“…Thus, enabling the study of anti-cancer-therapy effects. Here, we analyzed potential cardiac side effects of antibody-mediated PD-L1 inhibition in the preclinical B16F10-GCV mouse model after tumor elimination and 2 weeks recovery (50 days after tumor inoculation). …”
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CLINICAL EFFICACY AND SAFETY OF ADEMETIONINE IN PATIENTS WITH DIABETES-ASSOCIATED OSTEOARTHRITIS: A CROSS-OVER PILOT STUDY by I. V. Shirinsky, O. V. Sazonova, N. Yu. Kalinovskaya, V. S. Shirinsky

“…It has been demonstrated that ademetionine showed a statistically significant analgetic effect (decrease in VAS pain), improved knee function and reduced symptoms in knee joints (as measured by KOOS subscales), and did not influence the levels of systemic inflammation or cartilage destruction biomarkers. …”
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Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1 by Giuseppe Curigliano, Sebastian Kobold, Maria Rescigno, Juliette Mouriès, Giuseppe Penna, Alessia Melacarne, Abbass Darwich, Alessandra Silvestri, Mohamed-Reda Benmebarek, Bruno Cadilha, Lapo Morelli, Domenico Supino, Alexandre Taleb, Hannah Obeck, Claudio Sustmann, Agnese Losurdo, Giovanna Masci

“…Background Natural killer (NK) cells require a functional lytic granule machinery to mediate effective antitumor responses. …”
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Dynamical Analysis of Secondary Dengue Viral Infection with Multiple Target Cells and Diffusion by Mathematical Model by Aeshah A. Raezah

“…Understanding disease mechanisms through mathematical modeling is one of the most effective tools for this purpose. The aim of this manuscript is to develop and analyze a dynamical system of PDEs that describes the secondary infection caused by DENV, considering (i) the diffusion due to spatial mobility of cells and DENV particles, (ii) the interactions between multiple target cells, DENV, and antibodies of two types (heterologous and homologous). …”
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