Fc glycan sialylation of biotherapeutic monoclonal antibodies has limited impact on antibody‐dependent cellular cytotoxicity by Elaine Branstetter, Robert J. Duff, Scott Kuhns, Rupa Padaki

“…Different glycosylation patterns can affect Fc‐dependent activities, such as the ability of mAbs to bind Fcγ receptors on the effector cell surface, which is critical to immune effector functions, such as antibody‐dependent cellular cytotoxicity (ADCC). …”
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The effects of interleukin-21 in the biology of transplant rejection by Xiandong Zeng, Xiandong Zeng, Yixiao Pan, Yixiao Pan, Qiang Xia, Qiang Xia, Kang He, Kang He

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CIRCULATION OF ANTIPHOSPHOLIPID ANTIBODIES AND IVF FAILURES by N. S. Stuleva, D. K. Khizroeva, T. Y. Mashkova, G. R. Abramyan

“…The antiphospholipid antibodies (APA) exert multiple effects on the hemostasis system causing damage to all of its protective components including the endothelial barrier, natural anticoagulant function and endogenous fibrinolysis and activating the platelet of hemostasis, which is associated with numerous obstetrical complications and infertility. …”
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Natural antibodies – facts known and unknown by Joanna Palma, Beata Tokarz-Deptuła, Jakub Deptuła, Wiesław Deptuła

“…In contrast to adaptive antibodies, natural antibodies are present in a non-immunised organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural antibodies, which are developed as a result of the effect of the -Gal epitope and physiological flora. …”
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Regulatory effects of Ishige okamurae extract and Diphlorethohydroxycarmalol on skin barrier function by Seon Gyeong Bak, Hyung Jin Lim, Yeong-Seon Won, Sang-Ik Park, Sun Hee Cheong, Seung Jae Lee

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Biparatopic antibodies: therapeutic applications and prospects by David L. Niquille, Kyle M. Fitzgerald, Nimish Gera

“…This unique binding mode enables new mechanisms of action beyond monospecific and bispecific antibodies (bsAbs) that can make bpAbs effective therapeutics for various indications, including oncology and infectious diseases. …”
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MORPHOLOGICAL STRUCTURE OF LATE RENAL GRAFT DYSFUNCTION AND ITS EFFECT FOR LONG-TERM RESULTS by E. S. Stolyarevich, T. R. Zhilinskaya, L. Yu. Artyukhina, I. G. Kim, V. A. Zaydenov, N. A. Tomilina

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Effectiveness of preeclampsia prognosis in pregnancy by Loskutova T.O.

“…With the purpose to develop and assess the effectiveness of prediction method of pre-eclampsia (PE) 177 women in III trimester of pregnancy were examined. …”
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Increasing donor kidney age significantly aggravates the negative effect of pretransplant donor-specific anti-HLA antibodies on kidney graft survival by Michiel G. H. Betjes, Judith A. Kal-van Gestel, Dave Roelen, Marcia M. L. Kho, Sebastian Heidt, Annelies E. de Weerd, Jacqueline van de Wetering

“…The preDSA-associated increase in graft failure was caused primarily by an increase in the incidence of antibody-mediated rejection (ABMR), intragraft thrombosis, and primary non-function. …”
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Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function by Luke Yi Hao, Shalom Lerrer, Matthieu Paiola, Emily K. Moore, Yevgeniya Gartshteyn, Ruijiang Song, Michael Goeckeritz, Matilda J. Black, Shoiab Bukhari, Xizi Hu, Adam Mor

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Pad Printing of Carbon Electrodes with Argon Plasma Activation as a Simple and Low Temperature Manufacturing Process for Antibody‐Type Biosensors by Enrico Condemi, Joanna Kunikowski, Spyridon Schoinas, Philippe Passeraub

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Effects of Anti-GPIbαantibody on the expression of platelet GPIbα,CD62P and CD63 in maintenance hemodialysis patients by LUO Min-hong, YANG Tie-cheng, ZHU Lang-jing, CHEN Zhen-wei, ZENG Hai-ou, MO Cai-ju, WU Qiang, XIAO Jie

“…Objective To explore the effects of anti-platelet membrane glycoprotein Ib alpha(GPIbα)antibody on the expression of peripheral GPIbα,alpha particle membrane glycoprotein(CD62 P)and lysosomal membrane protein(CD63)in maintenance hemodialysis(MHD)patients.Methods Thirty-seven patients with chronic renal failure undergoing MHD from March 2016 to March 2018 in the Department of Nephrology in Eighth Affiliated Hospital of Sun Yat-sen University and 31 healthy people in the Physical Examination Center were enrolled in this study.Using flow cytomery,the expression of platelet member GPIbα,CD62 P and CD63 was detected before and after addition of anti-GPIbαantibody in MHD patients.Results The expression of platelet membrane GPIbαin no antibody treatment group(29.9±4.9)% was significantly lower than in control group(63.8±9.0)%and antibody treatment group(42.3±6.5)%(both P<0.01).The expression of CD62 P and CD63 in no antibody treatment group(50.9±7.5)% and(54.1±5.5)% was significantly higher than that in the control group(23.3±8.7% and 30.9±6.2%)and antibody treatment group(36.5±2.0)% and(47.2±2.2)%(P<0.01,P<0.05).Conclusions Anti-GPIbαantibody can regulate platelet function and activity by up-regulating the expression of platelet membrane GPIbα,and down-regulating the expression of CD62 P and CD63 in MHD patients,as a result to suppress adhesion and aggregation of platelets and thrombosis,and reduce the possibility of thromboembolism events in MHD patients.…”
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Efficacy and safety of obinutuzumab in primary membranous nephropathy: a real-world retrospective study by Xi Cheng, Zhen-feng Zheng, Yan Qi, Xin Cao, Xi-qian Gao, Ying-xin Fang, Li Wei, Wen-ya Shang, Tie-kun Yan, Jun-ya Jia, Peng-cheng Xu, Qiu-hua Gu

“…Furthermore, obinutuzumab also had a comparable efficiency in patients without response to previous rituximab treatment and patients with negative anti-PLA2R antibody. More patients in the initial therapy group had infusion-related reactions (33.3 vs. 15.0%, P=0.149), while severe infections were all occurred in the alternative therapy group, particularly those with a history of long-term immunosuppressive therapy.ConclusionsObinutuzumab, used as both initial and alternative therapy, can induce significant clinical response in patients with pMN, implying its potentially promising therapeutic effect on pMN.…”
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LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy by Jiqi Shan, Wei Jing, Yu Ping, Chunyi Shen, Dong Han, Fengsen Liu, Yaqing Liu, Congcong Li, Yi Zhang

“…The combination of IL-2 and anti-PD-1 antibody effectively enhanced LFA-1 expression and the antitumor function of intratumoral CD8+ T cells. …”
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Effects of metabolic and organ function factors on the efficacy of radioactive iodine therapy for hyperthyroidism by Yue Hu, Shan Liu, Xiaoliang Xiong, Lixing Wang, Yinlong Zhao

“…IntroductionRecent studies suggest that metabolic and organ function indicators could influence radioactive iodine treatment (RAIT) efficacy in hyperthyroid patients, but their relationships with thyroid function remain unclear.ObjectiveThis study aims to explore the impact of these markers on RAIT efficacy and thyroid function.MethodA total of 135 hyperthyroid patients undergoing RAIT were enrolled, with biomarkers collected at baseline and 1, 3, and 6 months posttreatment. …”
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Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations by Bingjun Qian, Shanqi Shen, Jianhua Zhang, Pu Jing

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Effects of anti-CD4 antibody treatment on calcium ions influx in peanut-sensitized C3H/HeJ mice by Junjuan Wang, Cui Zhou, Shiwen Han, Zainabu Majid, Na Sun, Huilian Che

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Effect of tocilizumab on pulmonary gas exchange function in patients with severe COVID-19 by D. A. Lebedev, Yu. Kh. Dolya, G. E. Savkov, M. A. Godkov, E. V. Klychnikova, А. P. Shakotko, D. A. Kosolapov, S. N. Kuznetsov, A. M. Kvasnikov, Yu. N. Vrabiy, K. V. Kiselev, V. B. Poluektova, S. S. Petrikov, K. A. Popugaev

“…Early use of monoclonal antibodies has shown promising results in cytokine storm therapy, but the effects on lung gas exchange function have not yet been studied.Aim. …”
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EFFECT OF SUBCUTANEOUS METHOTREXATE ON THE STRUCTURE AND FUNCTION OF THE VASCULAR WALL IN PATIENTS WITH RHEUMATOID ARTHRITIS by L. A. Knyazeva, N. S. Meshcherina, L. I. Knyazeva, I. I. Goryainov, M. A. Stepchenko, V. I. Ponkratov

“…Objective: to evaluate the effect of a subcutaneous methotrexate (MT) formulation (methoject), on the structure and function of the vascular wall in patients with rheumatoid arthritis (RA).Subjects and methods. …”
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The Impact Of COVID-19 on Asthma Control and Lung Function in Patients with Severe Asthma by Margarida Gomes, Júlia Cunha Silva, Sara Morgado, Ana Craveiro, Ana Rita Presa, Carlos Lopes, Ana Mendes

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