Mechanism of Bone-metastatic LUAD Cells Promoting Angiogenesis 
Through HGF/YAP Signaling Pathway by Yan DENG, Rong QIU, Xingyu LIU, Yingyang SU, Yang XUE, Yuzhen DU

“…The addition of HGF neutralizing antibodies to BM3-CM inhibited the promoting effect of BM3-CM on HUVEC (P<0.05), while the addition of recombinant HGF to A549-CM reproduced that promoting effect of BM3-CM on HUVEC (P<0.05). …”
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TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy by Lin Wu, Yang Liu, Ziqi Fu, Honglei Guo, Kang Liu, Jiafa Ren, Zhimin Huang, Fang Yang, Huijuan Mao

“…Functional assays in mouse podocyte cells revealed that Dex@NBs-TRPC6 significantly outperformed free Dex and non-targeted nanobubbles (Dex@NBs) in mitigating cell apoptosis and inflammation. …”
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Influence of Ovophospholipids on Lymphocyte Subsets and Humoral Immune Response in Mice by Magdalena Lis, Marianna Szczypka, Agnieszka Suszko-Pawłowska, Aleksandra Pawlak, Łukasz Bobak, Bożena Obmińska-Mrukowicz

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Double-negative T cells in combination with ursodeoxycholic acid ameliorates immune-mediated cholangitis in mice by Chunpan Zhang, Guangyong Sun, Hua Jin, Yunxiong Wei, Shimeng Zheng, Xiyu Wang, Xinyan Zhao, Dong Zhang, Jidong Jia

“…In addition, DNT exhibited a strong killing effect on liver T cells and strong inhibition of their proliferation, but did not significantly improve the histology of PBC liver. …”
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Characterization of private mutations in the spike protein of SARS-CoV-2 correlates with viral prevalence by Shuo Wang, Ziyang Hao, Yuhan Ding, Heng Rong, Shuo Ning, Qiao Qiao, Xiaojuan Zhu, Tao Wu, Kangchen Zhao, Liguo Zhu, Jingxin Li, Yiyue Ge, Lunbiao Cui

“…Conclusions Continuous monitoring and functional analysis of SARS-CoV-2 private mutations can be an effective approach for explaining patterns of viral prevalence. …”
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Differential modulation of SARS-CoV-2 infection by complement factor H and properdin by Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag

“…In A549-hACE2+TMPRSS2 cells, the effect of FP on viral cell entry and binding was counteracted by anti-FP antibody treatment. …”
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Anti‐androgen enzalutamide enhances prostate cancer neuroendocrine (NE) differentiation via altering the infiltrated mast cells → androgen receptor (AR) → miRNA32 signals by Qiang Dang, Lei Li, Hongjun Xie, Dalin He, Jiaqi Chen, Wenbing Song, Luke S. Chang, Hong-Chiang Chang, Shuyuan Yeh, Chawnshang Chang

“…Mechanism dissection found infiltrated mast cells could function through positive feedback to enhance PCa to recruit more mast cells via modulation of the androgen receptor (AR) → cytokines IL8 signals, and interruption by AR‐siRNA or neutralizing anti‐IL8 antibody could partially reverse the recruitment of mast cells. …”
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Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer by Claudia Duranti, Jessica Iorio, Valeria Manganelli, Giacomo Bagni, Rossella Colasurdo, Tiziano Lottini, Michele Martinelli, Chiara Capitani, Giulia Boso, Franco Nicolas D’Alessandro, Maurizio Sorice, Andrea Becchetti, Roberta Misasi, Tina Garofalo, Annarosa Arcangeli

“…Treatment with a single chain bispecific antibody—scDb-hERG1-β1—specifically targeting the complex significantly potentiates the effects of both MβCD and statins on intracellular signaling. …”
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SYNOPSIS AND PROSPECTS OF AUTOIMMUNOLOGY DEVELOPMENT WORLDWIDE (AFTER THE MATERIALS OF THE 11th INTERNATIONAL CONGRESS IN LISBON, MAY 16-20, 2018). PROCEEDING I: FIRST ACADEMY OF A... by E. A. Korneva, A. V. Petyaeva, T. V. Fedotkina, L. P. Churilov, Y. Shoenfeld

“…The main regularities of the phenomenon of immunological memory are formulated. The questions of antibody production and B lymphocyte functions are considered taking into account recently discovered mechanisms of intracellular penetration of immunoglobulins and details of affinity maturation of lymphoid clones. …”
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Human iPSC-derived NK cells armed with CCL19, CCR2B, high-affinity CD16, IL-15, and NKG2D complex enhance anti-solid tumor activity by Yuma Fukutani, Kenji Kurachi, Yu-suke Torisawa, Kotoko Miyata, Makoto Hayashi, Kaoru Sasaki, Kodai Saitoh, Sono Watanabe, Yudai Hasegawa, Yoichi Naritomi, Yuka Igarashi, Kumiko Goto, Yuka Sato, Noriko Uesugi, Hidetaka Murai, Tetsuya Sakurai, Toru Ozaki, Norihiro Tsuneyoshi, Masashi Yamada, Yuriko Takeno, Tomonori Hosoya, Fusako Nishigaki, Hironobu Kimura, Kouichi Tamura

“…We evaluate the antitumor function, including killing activity, antibody-dependent cytotoxicity, migration ability, and recruitment of dendritic cells. …”
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Fumarprotocetraric acid and geraniin were identified as novel inhibitors of human respiratory syncytial virus infection in vitro by Chao Wang, Chao Wang, Yi-Man Huang, Yi-Man Huang, Jun Zhao, Jun Zhao, Yi-Ming Bai, Yi-Ming Bai, Cai-Qin Yan, Cai-Qin Yan, Guan-Hua Du, Guan-Hua Du, Li-Shu Zheng, Li-Shu Zheng, Ai-Lin Liu, Ai-Lin Liu

“…However, disease treatment is limited to preventive care with monoclonal antibodies and supportive care. In this study, natural products were screened to identify novel anti-RSV inhibitors.MethodsThe antiviral effect of 320 compounds on RSV in HEp-2 cells was tested using a Cytopathic effect (CPE) inhibition assay. …”
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Pharmacological Treatment Options for Coronavirus Disease-19 in Renal Patients by null Jonny, Laurencia Violetta, Arief Sjamsulaksan Kartasasmita, Rully Marsis Amirullah Roesli, Coriejati Rita

“…In a global pandemic setting, nephrologists need to consider the appropriate dosage according to the renal function and closely monitor the side effects of different drug combinations to obtain the optimum therapeutic effect while avoiding further renal damage. …”
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Neuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron Disease by Rosario Gulino

“…Lectins such as ricin, volkensin, or modeccin and neuropeptide- or antibody-conjugated saporin represent the most effective toxins used for neuronal lesioning. …”
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HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses by Yuehua Chen, Toshiaki Ohara, Yusuke Hamada, Yuze Wang, Miao Tian, Kazuhiro Noma, Hiroshi Tazawa, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa

“…In vitro, we assessed the effects of HIF-PH inhibitors on human and murine colon cancer cell lines (SW480, HT29, Colon26) and murine T cells. …”
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394 Inclusion of cytomegalovirus viral Fc gamma receptors in a glycoprotein B protein subunit vaccine improves Fc-mediated effector responses by Claire Otero, Mackensie Gross, Savannah Herbek, Megan Connors, Philipp Kolb, Sallie Permar

“…Objectives/Goals: We hypothesized that adding cytomegalovirus (CMV) viral Fc gamma receptors (vFcγRs) to a glycoprotein B (gB) protein subunit vaccine would improve vaccine-elicited Fc mediated effector functions such as antibody dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC), over gB subunit alone. …”
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Covalent Organic Frameworks for Immunoassays: A Review by Suling Yang, Hongmin Liu

“…Immunoassays relying on highly specific antigen–antibody recognition are important tools for effectively measuring the levels of various targets. …”
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Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells by Kyungwha Lee, Jung-Yun Lee, Ji-Hyun Kim, Min Park, Junsik Park, Young Min Oh, Wonjae Lee, Myoung Ho Jang, Young Jun Koh, Sanghee Lee, Jisoo Kim, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Chong Woo Park, Yaein Amy Shim, Young-Gyu Cho, Jongil Kim, Suyoun Park, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Kook Hwan Kim

“…We demonstrated that the functional impairment of IL-2 signaling in CD8+ T cells in these conditions can be reversed by our anti-CD73 antibody (GI-αCD73). …”
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Allergic Rhinitis by Sommers DeK

“…Instead of considering allergic rhinitis as a disease of acute symptoms, it needs to be understood as a chronic inflammatory disease that involves a level of persistent inflammation even in the absence of symptoms. Given the close functional, immunological and clinical link between asthma and rhinitis, it is reasonable to expect that an effective treatment of rhinitis would affect the co-morbid asthma; the occurrence of rhinitis in asthmatic patients ranges from 70% to about 90%. …”
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Allergic Rhinitis by DeK Sommers

“…Instead of considering allergic rhinitis as a disease of acute symptoms, it needs to be understood as a chronic inflammatory disease that involves a level of persistent inflammation even in the absence of symptoms. Given the close functional, immunological and clinical link between asthma and rhinitis, it is reasonable to expect that an effective treatment of rhinitis would affect the comorbid asthma; the occurrence of rhinitis in asthmatic patients ranges from 70% to about 90%. …”
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Retroperitoneal fibrosis in presence of autoimmune coagulation factor XIII deficiency result in recurrent critical post-operative hemorrhage: a case report and molecular research w... by Tomonori Matsushita, Tomonori Matsushita, Mitsuhiro Tachibana, Hiromichi Nakagawa, Shuhei Goto, Koji Nishizawa, Takashi Kobayashi, Takashi Kobayashi, Shigeki Fukuzawa, Kunihiko Itoh

“…The purified IgG antibody samples containing IgG1 and IgG4 were shown to significantly reduce the function of coagulation Factor XIII derived from healthy individuals. …”
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