An engineered adipose formulation decreases hepatic inflammation and fibrosis in a rodent model of metabolic dysfunction-associated steatotic liver disease by Youngshim Choi, Yinyan Ma, Samson Tom, Alla Danilkovitch, Liqing Yu

“…Adipose tissue plays a key role in metabolic health and MASLD pathogenesis through its regulation of energy metabolism and endocrine function. Metabolic dysfunction is often associated with a chronic state of low-grade inflammation in the body including adipose tissue.MethodsIn this study, we tested an engineered adipose formulation (AF) composed of a combination of culture-expanded adipose stromal vascular fraction (SVF) cells and adipose tissue particulates in the treatment of MASLD. …”
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Distinct Roles Between Eotaxin 1 and Eotaxin 2 in Asthmatic Airways by Soyoon Sim, Eun‐mi Yang, Yoo Seob Shin, Seon Beom Kim, Youngwoo Choi, Hae‐Sim Park

“…To assess neutralization effects, anti‐EOT1 or anti‐EOT2 antibodies were intranasally administered. …”
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Purification and Inhibitor Screening of the Full-Length SARS-CoV-2 Nucleocapsid Protein by Chen Chen, Zhengfu Zhang, Qiao Zheng, Yingshun Zhou, Shujun Zhang

“…The neutralizing ability of the antibodies produced in the human body during previous infections is decreased against some of these mutants, which poses a severe challenge to the preventive and therapeutic effectiveness of vaccines and antibody drugs. …”
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An innovative biosensing approach for Aflatoxin B1 detection via electrical impedance measurement by Recep Üstünsoy, Tahsin Ertaş, Hülya Eraslan Gültekin, Ali Fuat Ergenç, Bircan Dinç, Muhammet Bektaş

“…Scanning Electron Microscopy (SEM) shows the current functionalization of tungsten wires with antibodies and multi-walled carbon nanotubes (MWCNTs). …”
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Efficacy, Safety and Predictors of Response to Rituximab in Treatment of Iraqi Patients with Active Rheumatoid Arthritis by Sarah Tareq Abdulazeez, Sami Salman, Faiq I. Goria

“…Background: Rituximab (RTX) is an anti-CD20 chimeric monoclonal antibody which effectively depletes B cells and is used for treating rheumatoid arthritis (RA). …”
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Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic E. coli adhesin. by Zachary T Berndsen, Marjahan Akhtar, Mahima Thapa, Tim J Vickers, Aaron Schmitz, Jonathan L Torres, Sabyasachi Baboo, Pardeep Kumar, Nazia Khatoon, Alaullah Sheikh, Melissa Hamrick, Jolene K Diedrich, Salvador Martinez-Bartolome, Patrick T Garrett, John R Yates, Jackson S Turner, Renee M Laird, Frédéric Poly, Chad K Porter, Jeffrey Copps, Ali H Ellebedy, Andrew B Ward, James M Fleckenstein

“…EtpA, is a secreted glycoprotein adhesin that functions as a blood group A lectin to promote critical interactions between ETEC and blood group A glycans on intestinal epithelia for effective bacterial adhesion and toxin delivery. …”
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Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling. by Rinat Sharir, Jonathan Semo, Sara Shimoni, Tamar Ben-Mordechai, Natalie Landa-Rouben, Sofia Maysel-Auslender, Aviv Shaish, Michal Entin-Meer, Gad Keren, Jacob George, Jacob George

“…Compared with PBS, adoptive Treg transfer to mice with experimental infarction reduced infarct size and improved LV remodeling and functional performance by echocardiography. Treg deletion with blocking anti-CD25 antibodies did not influence infarct size or echocardiographic features of cardiac remodeling.…”
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Milk matters: soluble Toll-like receptor 2 (sTLR2) in breast milk significantly inhibits HIV-1 infection and inflammation. by Bethany M Henrick, Kakon Nag, Xiao-Dan Yao, Anna G Drannik, Grace M Aldrovandi, Kenneth L Rosenthal

“…Notably, immunodepletion does not allow for the complete removal of sTLR2 from BM, thus functional testing shown here may underestimate the total effect elicited by sTLR2 against HIV-1 and synthetic bacterial ligand. …”
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The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model. by Georgia Schäfer, Reto Guler, Graeme Murray, Frank Brombacher, Gordon D Brown

“…Deficiency of SR-B1 also had no effect on resistance to disease under conditions of varying dietary cholesterol. …”
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Optimized chemical labeling method for isolation of 8-oxoG-modified RNA, ChLoRox-Seq, identifies mRNAs enriched in oxidation and transcriptome-wide distribution biases of oxidation... by Matthew R. Burroughs, Philip J. Sweet, Lydia M. Contreras

“…We demonstrate the high specificity of ChLoRox-Seq for functionalizing 8-oxoG over unmodified nucleobases in RNA and benchmark this specificity to a commonly used antibody-based approach. …”
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<i>Lactobacillus johnsonii</i> modulation of bone marrow-derived dendritic cells generated from mice with null mutation of the Muc2 gene by E. A. Blinova, E. P. Goncharova, G. V. Kalmykova, N. I. Akulova, E. A. Litvinova

“…The gut microbiome plays an important role in regulating host immune function. A lot of research concerned the effect of probiotic on the pathologies associated not only with dysbiosis and metabolic disorders, but there is breakthrough in the treatment of inflammation, oncology and neurodegenerative disorders. …”
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Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency by Shao Yang, Yawei Sun, Wei Luo, Xiaofeng Zhou, Xiao Gu, Wenzhe Zhang, Huashan Zhu, Wenjia Wu, Xueying Wu, Mengru Yu, Shan Wang

“…In vivo experiments demonstrated that ZIF8-GH@ZP3Ab promoted angiogenesis, reduced oxidative stress and apoptosis, and enhanced the secretion of IGF-1 in antral follicles. These effects restored ovarian function and fertility in cisplatin-induced POI in mice. …”
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Toripalimab: A new age in fighting Nasopharyngeal Carcinoma by Taha Ahmad Siddiqui, Aamrah Wakil, Maham Imran

“…The main immune related adverse effects reported were hypothyroidism, hyperthyroidism, abnormal liver function, interstitial lung disease and dermatomyositis.[4][5] In recent years immunotherapy has emerged as a highly effective avenue when used in combination with targeted therapies. …”
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Dietary incorporation of biological curcumin nanoparticles improved growth performance, ileal architecture, antioxidative status, serum lipid profile, and humoral immune response o... by Abdel-Moneim Eid Abdel-Moneim, Noura M. Mesalam, Bing Yang, Mohamed Farouk Elsadek

“…Heat stress greatly impairs poultry productivity, underscoring the urgent need for effective strategies to mitigate these adverse effects and improve overall poultry health. …”
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N-deglycosylation targeting chimera (DGlyTAC): a strategy for immune checkpoint proteins inactivation by specifically removing N-glycan by Li Li, Jiajia Wu, Weiqian Cao, Wei Zhang, Qi Wu, Yaxu Li, Yanrong Yang, Zezhi Shan, Zening Zheng, Xin Ge, Liang Lin, Ping Wang

“…Finally, PD-L1 targeted DGlyTAC showed therapeutic effects on several tumors in vivo, even better than PD-L1 antibody. …”
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Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK by Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen

“…PD‐L1 knockout (KO) or inhibitory PD‐L1 antibody treatment worsens vascular leakage and neoangiogenesis in a laser‐induced NVAMD mouse model, effects reversible by microglia depletion with PLX5622. …”
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Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label by Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun

“…Existing audiologic function and radiographic tests cannot directly demonstrate the integrity of inner ear primary neurons. …”
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Maternal dietary folate imbalance alters cerebellar astrocyte morphology and density in offspring by Philip Maseghe Mwachaka, Peter Gichangi, Adel Abdelmalek, Paul Odula, Julius Ogeng’o

“…Background: Maternal folate usage is essential for neurodevelopment, but its effects on cerebellar structure are unclear. Cerebellum undergoes a protracted period of development, making it sensitive to maternal nutritional imbalances. …”
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Immune responses and recovery from spotty liver disease in layer birds by Sarah Eastwood, Timothy B. Wilson, Jiongrui Huang, Bronwyn E. Campbell, Peter C. Scott, Robert J. Moore, Thi Thu Hao Van

“…Altogether, the results indicate that over time, immune memory, enhanced barrier function, and a balanced immune response developed, resulting in reduced impact of infection on the birds. …”
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Perovskite‐Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for Ultrasensitive Cytokine Detection by Jiaxing Sun, Lin Zhou, Zening Li, Guolin He, Hongju Mao, Jianlong Zhao, John A. Hunt, Xianfeng Chen

“…In the bio‐nano‐photonic filter, a localized surface plasmon resonance (LSPR) is induced by gold nanoparticles (AuNPs) in conjunction with antigen‐antibody binding, tuning the delivery of light passing through the filter and facilitating biotunable functionality with ternary modes. …”
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