Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia by Todia P. Setiabudiawan, Lika Apriani, Ayesha J. Verrall, Fitria Utami, Marion Schneider, Agnes R. Indrati, Pauline P. Halim, Paulina Kaplonek, Hadar Malca, Jessica Shih-Lu Lee, Simone J. C. F. M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Leo A. B. Joosten, Mihai G. Netea, Bachti Alisjahbana, Ryan P. McNamara, Galit Alter, Arjan van Laarhoven, James E. Ussher, Katrina Sharples, Valerie A. C. M. Koeken, Philip C. Hill, Reinout van Crevel

“…Neither circulating concentrations of Mtb-specific antibodies nor functional antibody activity associated with IGRA status at baseline or follow-up. …”
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Proteomics‐Empowered Microfluidic‐SERS Immunoassay for Identifying and Detecting Biomarkers of Micropapillary Lung Adenocarcinoma by Dechun Zhang, Kaiming Peng, Hui Xu, Yanping Chen, Jing Wang

“…To enable sensitive, multiplex detection of 4 upregulated DEPs, the nanomixing effect is leveraged to enhance target protein‐SERS barcode interactions while minimizing nonspecific binding to antibody‐functionalized gold electrodes. …”
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PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection by Katie M. Bryant-Hudson, Daniel J. J. Carr

“…In contrast, anti-PD-L2 treatment had no effect on viral replication or changes in the MLN population. …”
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Initial presentation of early rheumatoid arthritis. by Lauri Weman, Henri Salo, Laura Kuusalo, Johanna Huhtakangas, Johanna Kärki, Paula Vähäsalo, Maria Backström, Tuulikki Sokka-Isler

“…<h4>Objectives</h4>To study the joint distribution and clinical picture of rheumatoid arthritis (RA) at the initial presentation in seropositive (anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) positive) and negative patients and the effect of duration of symptoms on the clinical picture.…”
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Prolonging calcineurin inhibitor therapy post kidney allograft failure: a prospective study by Rita Leal, Pedro Fragoso, João Venda, José Gomes, Maria Inácio, Maria Guedes Marques, Luís Rodrigues, Lídia Santos, Catarina Romãozinho, Francisco Caramelo, Helena Oliveira Sá, António Martinho, Arnaldo Figueiredo, Rui Alves

“…This study evaluated the effects of prolonged calcineurin inhibitor (CNI) therapy on HLA sensitization, graft intolerance syndrome (GIS), and key clinical outcomes.Methods We conducted a prospective cohort study involving 90 adult patients with kidney allograft failure who were candidates for re-transplantation. …”
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Study protocol for a randomized double-blinded placebo-controlled trial on mepolizumab for patients with chronic rhinosinusitis with nasal polyps, NSAID exacerbated respiratory dis... by Annina Lyly, Annina Lyly, Johanna Sahlman, Johanna Sahlman, Karoliina Pajala, Karoliina Pajala, Maija Salminen, Maija Salminen, Saara Sillanpää, Saara Sillanpää, Jura Numminen, Jura Numminen, Tanzeela Hanif, Tanzeela Hanif, Tanzeela Hanif, Anu Laulajainen-Hongisto, Mika Mäkelä, Paula Kauppi, Iiris Kangasniemi, Markus Lilja, Markus Lilja, Sari Hammaren-Malmi, Paula Virkkula, Sanna Toppila-Salmi, Sanna Toppila-Salmi, Sanna Toppila-Salmi

“…Mepolizumab is a humanized monoclonal anti-IL-5 antibody shown to be effective in treating severe eosinophilic asthma and CRSwNP. …”
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Enhancing the purity and intrinsic properties of ovine dermal papilla cells through flow cytometry sorting and cellular interactions by Yuan Gou, Tingyan Hu, Lijuan Zhu, Xiaoyang Lv, Yutao Li, Rui Su, Zhenghai Song, Shanhe Wang, Wei Sun

“…Conclusion This study highlights the effectiveness of antibody labeling and flow cytometry for isolating functionally pure DPCs, as well as the potential of conditioned media to maintain the functional properties of these cells.…”
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Clinical observation of different ways of blood purification combined with immune inhibitors for the treatment of serious lupus nephritis by LIU Lei, LI Liang-zhi, HU Wan-mei, TANG Yue-wu, HE Xian-hong, LIU Chun-qiu

“…Objective To observe the immune function and clinical curative effect of the different ways of blood purification combined immunosuppressor for the treatment of patients with serious lupus nephritis.Methods 35 patients diagnosed with serious lupus nephritis were divided into continuous veno-venous hemofiltration(CWH)+conventional medical treatment group(treatment group) and hemodialysis(HD)+conventional medical treatment group(control group).The changes in ANA titer,anti-ds-DNA antibodies,C3,erythrocyte sedimentation rate(ESR),serum creatinine(SCr) and24-h urinary protein quantity were compared between the two groups before and after treatment The therapeutic effect and pathological changes of the renal biopsy were statistically compared between two groups.Results The ANA titer,anti-ds-DNA antibodies,C3,ESR,SCr and 24-h urinary protein quantity had no statistically significant difference between the two groups on the first day after admission(P>0.05).After treatment for 1 month,the ANA titer,anti-ds-DNA antibodies,ESR,SCr and 24-h urinary protein quantity in the two groups were decreased significantly as compared with those pre-treatment(P<0.05).There was significant difference in the ANA titer,anti-ds-DNA antibodies,ESR and SCr between two groups(P<0.05),but there was no significant difference in the24-h urinary protein quantity(P>0.05).After treatment for 1 month,C3 levels were elevated,and there was significant difference in the treatment group before and after treatment,and between two groups(P<0.05).The respective index(AI),chronic index(CI) and tubulointerstitial lesions(TIL)scores had no statistically significant difference between the two groups.The dialysis days were shorter,and the treatment efficiency after 6 months was higher in the treatment group than in the control group.Conclusions CWH therapy can improve the patients immune indexes,has good clinical efficacy,compared with ordinary HD therapy treatment time shortened,the earlier from dialysis,could help patients with renal function recovery,and the illness is more stable.…”
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CULTIVATION OF INFLUENZA A VIRUS IN PRIMARY CELL CULTURE OF TURKEY EMBRYONIC FIBROBLASTS by Firas Taha Mansour Al-Mubarak

“…This cell type will have normal cell characters and maintain many of the important markers and functions seen in vivo. Results showed that the level of susceptibility to infection was comparable between turkey embryonic fibroblasts and MDCK cell line based on incubating with peroxidase labelled monoclonal IgG antibody to viral nucleoprotein. …”
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Comparative efficacy of intravenous immunoglobulin and protein A immunoadsorption in severe anti-NMDAR encephalitis by Xuhui Tang, Xuhui Tang, Yu Liu, Gaoya Zhou, Ewen Tu, Cheng Yu, Meishan Xiong, Cong Lin

“…ObjectiveTo compare the differential effects of intravenous immunoglobulin (IVIg) and protein A immunoadsorption (PAIA) on neurological functional improvement in patients with severe anti-NMDAR encephalitis.MethodsWe retrospectively evaluated patients with severe anti-NMDAR encephalitis (modified Rankin scale, mRS ≥ 3) at the Second People’s Hospital of Hunan from January 1, 2019, to December 31, 2024. …”
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L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages. by Sarah De Clercq, Ciska Boucherie, Joël Vandekerckhove, Jan Gettemans, Aude Guillabert

“…Gelsolin nanobodies had no effect on podosome formation or function but proved very effective in tracing distinct gelsolin populations. …”
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Lecanemab in clinical practice: real-world outcomes in early Alzheimer’s disease by Noa Bregman, Talya Nathan, Dror Shir, Nurit Omer, Mori Hai Levy, Aya Bar David, Orna Aizenstien, Eyal Lotan, Yifat Alcalay, Anan Abu Awad, Avi Gadoth, Elissa Ash, Tamara Shiner

“…One patient experienced symptomatic ARIA, required hospitalization with intravenous treatment, and discontinued therapy. A mixed-effects model showed no significant effect of ARIA on MMSE change (p =.264) and no interaction with time (p =.433). …”
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Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors by Qiang Wang, Qing Yi, Wei Xiong, Rui Duan, Jianfei Qian, Liuling Xiao, Miao Xian, Pan Su, Chuanchao Zhang, Yabo Li, Ling Zhong, Chengyun Zheng

“…Gene expression levels in human MM were analyzed using Gene Expression Omnibus public datasets.Results We found that programmed cell death protein 1 (PD-1) antibody treatment had a therapeutic effect in 5TGM1 mice; it was ineffective in Vk*MYC mice. …”
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Targeting LAT1 with JPH203 to reduce TNBC proliferation and reshape suppressive immune microenvironment by blocking essential amino acid uptake by Yajie Zhao, Chunrui Pu, Kangdong Liu, Zhenzhen Liu

“…A 4T1-BALB/c tumor-bearing mouse model with normal immune function was constructed to investigate the effects of LAT1 targeting on tumor growth and immune microenvironment remodeling in vivo. …”
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An Antimicrobial and Antifibrotic Coating for Implantable Biosensors by Sofia Wareham-Mathiassen, Pawan Jolly, Nandhinee Radha Shanmugam, Badrinath Jagannath, Pranav Prabhala, Yunhao Zhai, Alican Ozkan, Arash Naziripour, Rohini Singh, Henrik Bengtsson, Thomas Bjarnsholt, Donald E. Ingber

“…Biofouling and foreign body responses have deleterious effects on the functionality and longevity of implantable biosensors, seriously impeding their implementation for long-term monitoring. …”
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Helminth Coinfections Modulate Disease Dynamics and Vaccination Success in the Era of Emerging Infectious Diseases by Brice Armel Nembot Fogang, Linda Batsa Debrah, Michael Owusu, George Agyei, Julia Meyer, Jonathan Mawutor Gmanyami, Manuel Ritter, Kathrin Arndts, Derrick Adu Mensah, Tomabu Adjobimey, Achim Hörauf, Alexander Yaw Debrah

“…Helminth infection can also negatively impact vaccine efficacy by suppressing B cell activity, reducing antibody levels, and decreasing vaccine effectiveness against infectious diseases. …”
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CD248-targeted BBIR-T cell therapy against late-activated fibroblasts in cardiac repair after myocardial infarction by Haiting Chen, Ke Hu, Qi Tang, Junzhuo Wang, Qianyu Gu, Jiayu Chen, Jiaxin Hu, Ningxin Peng, Meng Guo, Yaohui Jiang, Qingbo Xu, Jun Xie

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Role of IL-16 in age-related skeletal muscle atrophy: an integrated study by Wenliang Fan, Zhibang Zhao, Liqiang Wang, Qingbo Chu

“…In animal research, mice were treated with IL-16 to identify the effects of IL-16 on muscle function and muscle mass. …”
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Status and frontiers of Fabre disease by Wei Chu, Min Chen, Xiaoqin Lv, Sheng Lu, Changyan Wang, Limin Yin, Linyan Qian, Jiana Shi

“…This article summarizes the existing and potential drugs for treating Fabry disease to facilitate the selection of suitable and effective drugs for treatment.…”
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Immunohistochemical expression of androgen receptors in prostate carcinoma and benign prostatic hyperplasia by Trivunić-Dajko Sandra, Bogdanović Jovo, Fejsa-Levakov Aleksandra, Živojinov Mirjana, Đolai Matilda

“…Through androgen receptors (AR) androgens influence cell growth and function, proliferation, differentiation, apoptosis, lipid metabolism and secretory activity of the prostate, as well as development and progression of PCa. …”
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