Differential metabolic pathways underlie THC- and CBD-mediated inhibition of B-cell activation in both young and aged mice by Zhanna Yekhtin, Dmytro Petukhov, Iman Khuja, Natalya M. Kogan, Reuven Or, Osnat Almogi-Hazan

“…These cannabinoids exert diverse and potent biological effects primarily through the endocannabinoid system (ECS), which also plays a key role in mature B-cell function. …”
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Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice by Tiago H. Zaninelli, Victor Fattori, Olivia K. Heintz, Kristeena R. Wright, Philip R. Bennallack, Danielle Sim, Hussain Bukhari, Kathryn L. Terry, Allison F. Vitonis, Stacey A. Missmer, Avacir C. Andrello, Raymond M. Anchan, Stephen K. Godin, Dara Bree, Waldiceu A. Verri Jr., Michael S. Rogers

“…To evaluate potential toxicity, we measured the effect of entrectinib dose and schedule on body weight, liver and kidney function, and bone structure (via micro-CT). …”
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Features of blocking HLA-DR and HLA-G BY the human IgG fraction from the plasma of multiparous women by A. V. Shabaldin, N. S. Deeva, A. S. Sukhikh, G. V. Vavin

“…To obtain a purified IgG preparation from the plasma of multiparous women and to evaluate its functional activity towards HLA-DR and HLA-G molecules.Materials and Methods. …”
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Omalizumab for Chinese patients with moderate-to-severe allergic asthma in real-world clinical setting: a prospective, observational study by Wen Wang, Yue Guo, Jieying Li, Congying Zou, Lifang Zhao, Ya Zhu, Feiran Wang

“…Background We aimed to investigate the effectiveness of omalizumab, a monoclonal anti-immunoglobulin E antibody, in Chinese patients with moderate-to-severe allergic asthma in real-world clinical practice.Methods This single-centre, prospective, observational study included Chinese patients aged 14–75 years with moderate-to-severe allergic asthma according to the Global Initiative for Asthma criteria. …”
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IL-2/α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment. by Benedikt Mahr, Lukas Unger, Karin Hock, Nina Pilat, Ulrike Baranyi, Christoph Schwarz, Svenja Maschke, Andreas Michael Farkas, Thomas Wekerle

“…Adding IL-2 complexes to an otherwise effective regimen involving recipient irradiation (1Gy) but no Treg transfer indeed actively triggered donor BM rejection at higher doses (0/8 with IL-2 complexes vs. 9/11 without, p<0.01) and had no detectable effect at two lower doses (3/5 vs. 9/11, p>0.05). …”
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SIRT6 Ameliorates Cancer Cachexia–Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice by Kang Xu, Yida Wang, Fang Wang, Yannan Guo, Yu Ren, Vivien Low, Sungyun Cho, Qingfei Liu, Ying Qiu, Xue Li, Kang Yu, Zhongchi Li, Zhao Wang

“…We evaluated the in vitro effect of a SIRT6 activator by treatment of MDL800. …”
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The importance of human FcgammaRI in mediating protection to malaria. by Richard S McIntosh, Jianguo Shi, Richard M Jennings, Jonathan C Chappel, Tania F de Koning-Ward, Tim Smith, Judith Green, Marjolein van Egmond, Jeanette H W Leusen, Maria Lazarou, Jan van de Winkel, Tarran S Jones, Brendan S Crabb, Anthony A Holder, Richard J Pleass

“…The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. …”
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A Case of Systemic Lupus Erythematosus in a Patient Presenting with Libman-Sacks Endocarditis by Mariann Al-Jehani, Faisal Al-Husayni, Ahmed Almaqati, Jomanah Shahbaz, Saad Albugami, Wail Alameen

“…The patient suffered some warfarin adverse effects a year later but did well otherwise. Conclusion. …”
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Human umbilical cord mesenchymal stem cells improve disease characterization of Sjogren's syndrome in NOD mice through regulation of gut microbiota and Treg/Th17 cellular immunity by Yao Zou, Wei Xiao, Dongzhou Liu, Xianyao Li, Lihua Li, Lijuan Peng, Ying Xiong, Haina Gan, Xiang Ren

“…UC‐MSCs and UC‐MSCs‐exo partially restored salivary secretion function, reduced Ro/SSA antibody and α‐Fodrin immunoglobulin A levels, reduced inflammatory cell infiltration in the intestine and submandibular gland, raised proportion of Treg cells, decreased IFN‐γ, IL‐6, IL‐2, IL‐17, lipopolysaccharide, and tumor necrosis factor‐alpha levels, and raised IL‐10, Foxp3, and TGF‐β1 levels by affecting co‐cultured T cells. …”
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Manganese-based immunotherapy synergized with novel supramolecular hydrogel: Advancing localized immune activation strategies in squamous cell carcinoma by Tianqing Wang, Xiaopei Hu, Xin Tian, Ying Wang, Shiyu Zhang, Silu Sun, Ning Ji, Xiaobo Luo, Qianming Chen, Xin Zeng, Hang Zhao, Jing Li

“…This hydrogel not only exhibited acceptable biocompatibility and biodegradability but also was able to load and sustain the release of Mn2+ and PD-1 antibody in situ. Finally, we adopted a range of mouse tumor models to reveal that G-TA-I supramolecular hydrogel drug delivery system loaded with Mn2+ and PD-1 antibody could efficiently activate local immunity, effectively combating the occurrence and progression of HNSCC. …”
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CXCL12α/SDF‐1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals by Samuele Negro, Francesca Lessi, Elisa Duregotti, Paolo Aretini, Marco La Ferla, Sara Franceschi, Michele Menicagli, Elisanna Bergamin, Egle Radice, Marcus Thelen, Aram Megighian, Marco Pirazzini, Chiara M Mazzanti, Michela Rigoni, Cesare Montecucco

“…Abstract The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter‐cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins. …”
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Targeted Biologic Therapies in Severe Asthma: Mechanisms, Biomarkers, and Clinical Applications by Renata Maria Văruț, Dop Dalia, Kristina Radivojevic, Diana Maria Trasca, George-Alin Stoica, Niculescu Stefan Adrian, Niculescu Elena Carmen, Cristina Elena Singer

“…Itepekimab, an anti-IL-33 antibody, effectively engages its target and mitigates tissue eosinophilia, while CM310-stapokibart, tralokinumab, and lebrikizumab inhibit IL-4/IL-13 signaling with variable efficacy depending on patient biomarkers. …”
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PO65 | Utilization of emicizumab in acquired hemophilia A: a case report

“…Emicizumab, a bispecific antibody that mimics the function of activated FVIII irrespective of the presence of neutralizing antibodies, demonstrated to prevent bleeds and to allow to postpone or individualize the immunosuppression. …”
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Seroprotection after hepatitis B vaccination in chronic kidney disease patients with modified schedule and dosage by Shireen Siddiqui, Abida Malik, Indu Shukla, Meher Rizvi, Shahzad F. Haque

“…Conclusions: Seroprotection after four doses of 40 µg vaccine at 0, one, two, and six months was found to be better and cost effective in chronic kidney disease patients compared to three doses of 20 µg vaccine given to normal healthy individuals with adequate renal function. …”
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Identification of the feline humoral immune response to Bartonella henselae infection by protein microarray. by Adam Vigil, Rocio Ortega, Aarti Jain, Rie Nakajima-Sasaki, Xiaolin Tan, Bruno B Chomel, Rickie W Kasten, Jane E Koehler, Philip L Felgner

“…The array was probed with a collection of 62 uninfected, 62 infected, and 8 "specific-pathogen free" naïve cat sera, to profile the antibody repertoire elicited during natural Bartonella henselae infection.…”
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Hypocalcemia is associated with disease severity in patients with dengue by Godwin R Constantine, Senaka Rajapakse, Priyanga Ranasinghe, Balasundaram Parththipan, Ananda Wijewickrama, Priyankara Jayawardana

“…Serum free calcium (Ca2+) is known to be important in cardiac and circulatory function. We evaluated association between serum Ca2+ level and severity of dengue. …”
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Red yeast rice-induced severe rhabdomyolysis complicated by acute kidney injury and respiratory failure: a case report by Pengmin Zhou, Yucai Hong, Huabo Cai, Xiaoyu Zhou, Shunpeng He, Haotian Zhou, Jie Yang, Pengpeng Chen, Boming Xia, Xiong Lei, Suibi Yang, Zhongheng Zhang

“…At discharge, she had been weaned from mechanical ventilation and had partially recovered renal and muscle function. At follow-up, she was stable, ambulating, and performing daily functions without symptom recurrence. …”
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Severe Acute Hepatitis B Treated with Entecavir by Andrea Tosti, Alessio Sgrelli, Giuseppe Vittorio Luigi De Socio, Franco Baldelli

“…&lt;/span&gt;&lt;/pre&gt;&lt;pre style="line-height: 200%;"&gt;&lt;span style="line-height: 200%; font-family: " lang="EN-GB"&gt;We present here a case of a 62-year-old man affected by severe acute hepatitis B with progressive worsening of clinical and hepatic function. &lt;/span&gt;&lt;/pre&gt;&lt;pre style="line-height: 200%;"&gt;&lt;span style="line-height: 200%; font-family: " lang="EN-GB"&gt;The patient was treated with entecavir without critical side effects. …”
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Orally Dissolving Film-Based Influenza Vaccines Confer Superior Protection Compared to the Oral Administration of Inactivated Influenza Virus by Keon-Woong Yoon, Jie Mao, Gi-Deok Eom, Su In Heo, Ki Back Chu, Mi Suk Lee, Fu-Shi Quan

“…Humoral responses and antibody functionality were assessed using sera collected post-immunization. …”
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Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

“…The complement system has been implicated in the etiopathogenesis of RA.ObjectiveTo evaluate the effect of systemic IL-6 inhibition on complement pathways functional activity in RA patients treated with TCZ.DesingProspective non-interventional study.MethodsTwenty-seven RA patients included in the TOCRIVAR study who received TCZ (8mg/kg IV/q4w) were evaluated at baseline and at weeks 12, 24 and 52 of treatment. …”
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