Real-World Evaluation of Dupilumab in the Long-Term Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: A Focus on IL-4 and IL-13 Receptor Blockade by Nicola Lombardo, Aurelio D’Ecclesia, Emanuela Chiarella, Corrado Pelaia, Debbie Riccelli, Annamaria Ruzza, Nadia Lobello, Giovanna Lucia Piazzetta

“…<i>Conclusions</i>: These results indicate that dupilumab may be an effective treatment for CRSwNP, offering significant symptom relief, improved olfactory function, and enhanced quality of life. …”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

“…Additionally, we showed that the combination of F1929-1458 and the anti-PD-1 antibody exhibited a synergistic anti-tumor effect. …”
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AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE by N. B. Egorova, E. A. Kurbatova

“…The therapeutic effect is accompanied by sufficient positive dynamics of immunological parameters, e.g., phagocytic activity of macrophages, increase in lymphocytes bearing CD4, CD8, CD16, CD72, CD21 markers, enhanced IFNγ and IFNα production, correction of Ig synthesis, increased antibody titers and affinity. …”
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PD-1 inhibition disrupts collagen homeostasis and aggravates cardiac dysfunction through endothelial-fibroblast crosstalk and EndMT by Zejin Zhang, Zejin Zhang, Zhenzhen Yan, Zhenzhen Yan, Tao Yuan, Tao Yuan, Xiaona Zhao, Xiaona Zhao, Minghui Wang, Minghui Wang, Guoqing Liu, Guoqing Liu, Lijun Gan, Wei Qin, Wei Qin, Wei Qin

“…Collagen plays a crucial role in maintaining cardiac structure, elasticity, and signal transduction; however, the effects and mechanisms of PD-1 inhibitor on cardiac collagen remodeling remain poorly understood.MethodsC57BL/6 mice were injected with anti-mouse PD-1 antibody to create a PD-1 inhibitor-treated model. …”
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DEVELOPMENT OF OPTIMAL EXPERIMENTAL THERAPEUTIC REGIMENS ADMINISTRATION OF IMMOBILIZED INTERFERON α-2b by O. G. Shitikova, E. Yu. Sherstoboev, N. V. Masnaya, M. G. Danilets, E. S. Trofimova, A. A. Ligacheva, P. G. Madonov, D. N. Kinsht, K. I. Ershov, M. A. Shilova

“…Experimental evaluation of immunotropic properties of immobilized interferon α-2b was carried out at in vivoexperiments in outbred CD1 male mice with using of following tests: the study of drug effect on the phagocytic activity of peritoneal leukocytes (the relative number of phagocytes and the number of bacteria which were assimilated by phagocytes were assessed); the study of drug effect on the humoral immune response (the total number of splenocytes, the relative and absolute number of antibody-forming cells and their functional activity were determined); estimation of drug effect on the cellular immune response with the using of delayed-type hypersensitivity test induced by sheep red blood cells. …”
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Severe Digoxin Toxicity in a Child Managed with Cholestyramine. A Case Report by Suman Noorani, Nadeem ullah Khan, Shahan Waheed, Hadia Iftikhar

“…Digoxin toxicity is a common problem in clinical practice because its therapeutic window is relatively narrow (from 0.5 to 2 ng/ml). The toxic effects occur at concentrations &gt; 2.8 ng/ml and are mainly related to disturbances of cardiac function and of circulatory system as well as GI and CNS disturbances. …”
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Impact of dietary-nucleotides and Saccharomyces cerevisiae-derivatives on growth-performance, antioxidant-capacity, immune-response, small-intestine histomorphometry, caecal-Clostr... by Tamer Mohamed Abo-Sriea, Elshaimaa Ismael, Basant Mohsen Sobhi, Neven H. Hassan, Ebtihal M. M. Elleithy, Sherif AbdElmonam Omar, Ahmed M Soliman, Khaled Nasr El-Din Fahmy, Amer Ramadan

“…Nucleotides and yeast cell-wall products are essential nutrients for broiler performance, gut function, and immune response. Antibiotics, like florfenicol, negatively affect the immune system. …”
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Rituximab induced lung injury by Rohit Chari, Youmna Abdelghany, Madeleine Purcell, Blaine Kenaa

“…Conclusion Rituximab and Cyclophosphamide are well described causes of acute pneumonitis post R-CHOP administration. Given curative effect of R-CHOP, careful changes in management plan and co-treatment with steroids could help preserve lung function while allowing for full continuation of the chemotherapy regimen.…”
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Preventing Candida albicans from subverting host plasminogen for invasive infection treatment by Si-Min Chen, Zui Zou, Shi-Yu Guo, Wei-Tong Hou, Xi-Ran Qiu, Yu Zhang, Li-Jun Song, Xin-Yu Hu, Yuan-Ying Jiang, Hui Shen, Mao-Mao An

“…Base on this finding, we discovered a mouse monoclonal antibody (mAb) 12D9 targeting C. albicans Eno1, with high affinity to the 254FYKDGKYDL262 motif in α-helices 6, β-sheet 6 (H6S6) loop and direct blocking activity for C. albicans capture host plasminogen. mAb 12D9 could prevent C. albicans from invading human epithelial and endothelial cells, and displayed antifungal activity and synergistic effect with anidulafungin or fluconazole in proof-of-concept in vivo studies, suggesting that blocking the function of cell surface Eno1 was effective for controlling invasive infection caused by Candida spp. …”
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MYST2 histone acetyltransferase promotes lung adenocarcinoma progression by regulating the p38 MAPK signaling pathway by Zhiang Huang, Wanru Zhang, Ping Wang, Mengyao Wu, Yipu Guo, Jingying Chen

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Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Tri... by Agricola Joachim, Agricola Joachim, Asli Bauer, Sarah Joseph, Christof Geldmacher, Patricia J Munseri, Said Aboud, Marco Missanga, Philipp Mann, Britta Wahren, Guido Ferrari, Victoria R Polonis, Merlin L Robb, Jonathan Weber, Roger Tatoud, Leonard Maboko, Michael Hoelscher, Eligius F Lyamuya, Gunnel Biberfeld, Eric Sandström, Arne Kroidl, Muhammad Bakari, Charlotta Nilsson, Sheena McCormack

“…Functional antibodies detected using an infectious molecular clone virus/peripheral blood mononuclear cell neutralization assay, a pseudovirus/TZM-bl neutralization assay or by assays for antibody-dependent cellular cytotoxicity (ADCC) were not significantly boosted. …”
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Immunogenicity, Pathogenesis, and Host’s Immuno-Responses to Marburg Virus Infection by Emmanuel Edwar Siddig, Nicaise Ndembi, Ayman Ahmed, Claude Mambo Muvunyi

“…These gaps in knowledge are limiting our understanding of the disease and the implementation of cost-effective prevention and control measures including case management through safe and effective therapeutic modalities. …”
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IN VITRO CELLULAR INTERACTIONS DURING IMMUNE RESPONSE TO T CELLINDEPENDENT TYPE 2 ANTIGENS by M. V. Gavrilova, I. N. Chernyshova, D. A. Khochenkov, E. V. Sidorova

“…It was shown that DCs augmented viability of B1 and B2 lymphocytes. Functional activity of the B1 and B2 lymphocytes was determined by ELISPOT method, as relative numbers of antibody- and immunoglobulin-forming cells (AFCs and IFCs, respectively) detectable after four days in culture. …”
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Sex hormones and allergies: exploring the gender differences in immune responses by Jesús Alberto Gutiérrez-Brito, José Álvaro Lomelí-Nieto, José Francisco Muñoz-Valle, Edith Oregon-Romero, Jazz Alan Corona-Angeles, Jorge Hernández-Bello

“…Sex hormones control the reproductive system and have several immuno-modulatory effects affecting immune cells, including T and B cell development, antibody production, lymphoid organ size, and lymphocyte death. …”
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Duplication of the Rabies Virus Glycoprotein Enhances the Virus Propagation Rate and Immunogenicity by Ashkan Alamdary, Alireza Gholami, Mohammad Azizi, Zahra Noormohammadi

“…Glycoprotein (G) is a structural protein of the rabies virus that plays a crucial function in host protection against the virus. This study assessed the effects of integrating an extra copy of the glycoprotein gene into the rabies virus genome using reverse genetics on the immunogenicity and titer of the recombinant virus. …”
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An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics by Shaobo Wang, Qiong Zhang, Hui Hui, Kriti Agrawal, Maile Ann Young Karris, Tariq M. Rana

“…An inhibitory receptor KLRG1 was identified in a HIV-1 specific exhausted CD8+ T cell population expressing KLRG1, TIGIT, and T-betdimEomeshi markers. Ex-vivo antibody blockade of KLRG1 restored the function of HIV-specific exhausted CD8+ T cells demonstrating the contribution of KLRG1+ population to T cell exhaustion and providing an immunotherapy target to treat HIV chronic infection. …”
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Booster vaccination against the SARS-CoV-2: mechanisms and efficiency by S. A. Berns, A. V. Veremeyev, A. A. Savicheva, A. Yu. Gorshkov, O. M. Drapkina

“…In addition, the immune system function in response to COVID-19 is considered, while the role of memory cells, antibody and cellular immunity reactions are emphasized.…”
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Modeling systems-level regulation of host immune responses. by Juilee Thakar, Mylisa Pilione, Girish Kirimanjeswara, Eric T Harvill, Réka Albert

“…We compare and discuss the effect of the species-specific virulence factors on disrupting the immune response during their infection of naive, antibody-treated, diseased, or convalescent hosts. …”
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Intrinsic PD‐L1 Degradation Induced by a Novel Self‐Assembling Hexapeptide for Enhanced Cancer Immunotherapy by Hongxia Zhang, Ming Ji, Yamei Wang, Mengmeng Jiang, Zongyu Lv, Gongyu Li, Lulu Wang, Zhen Zheng

“…This work addresses these challenges by developing a hexapeptide, KFM (Lys‐Phe‐Met‐Phe‐Met‐Lys), capable of both directly downregulating PD‐L1 and self‐assembling into a ROS‐responsive supramolecular hydrogel. This dual functionality allows Gel KFM to function as a localized drug delivery system and a PD‐L1 inhibitor. …”
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Use of rituximab in connective tissue disease-associated interstitial lung disease: a narrative review by Chenhao Xu, Zewei Xu, Jin Ren

“…The article synthesizes findings from studies assessing rituximab’s effects on lung function, clinical outcomes, and safety across distinct subtypes of connective tissue disease. …”
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