Case Report: Sequential treatment with rituximab and belimumab in a pediatric patient of type 1 diabetes mellitus complicated with systemic lupus erythematosus by Fangfang Li, Yuci Zhang, Jing Yin, Linsheng Zhao, Chongwei Li

“…High-titer antinuclear antibody and anti-double-stranded DNA were detected. …”
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Differential Adjuvant Activity by Flagellins from <i>Escherichia coli</i>, <i>Salmonella enterica</i> Serotype Typhimurium, and <i>Pseudomonas aeruginosa</i> by Shengmei Pang, Mei Liu, Longlong Wang, Mingqing Shao, Guoqiang Zhu, Qiangde Duan

“…(1) <b>Background</b>: The adjuvant properties of flagellin from various bacterial species have been extensively studied; however, a systematic comparison of the immunoadjuvant effects of flagellins from different bacterial species is lacking. …”
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Recent advances in diagnosis and treatment of primary membranous nephropathy by HU Xiaofan, XU Jing

“…In terms of advances in prognostic assessment, PMN exhibits remarkable heterogeneity in its natural course, with approximately one-third of patients achieving spontaneous remission and another one-third progressing to renal function decline. Age, proteinuria level, eGFR, PLA2R antibody titer, and the extent of tubulointerstitial lesions are key prognostic predictors. …”
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Efficacy and Safety of Anti-Interleukin-5 Therapy in Patients with Asthma: A Systematic Review and Meta-Analysis. by Fa-Ping Wang, Ting Liu, Zhu Lan, Su-Yun Li, Hui Mao

“…Further trials required to establish to clarify the optimal antibody for different patients.…”
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Erythromycin Suppresses the Cigarette Smoke Extract-Exposed Dendritic Cell-Mediated Polarization of CD4+ T Cells into Th17 Cells by Jifeng Liu, Xiaoning Zhong, Zhiyi He, Jianquan Zhang, Jing Bai, Guangnan Liu, Yi Liang, Leilei Ya, Xianglin Qin

“…Previous studies have demonstrated the anti-inflammatory effects of macrolides. However, the effects of macrolides on the cigarette smoke extract- (CSE-) induced immune response are unclear. …”
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Herbal and mineral composition for the management of thyroid dysfunction by O.M. Didushko, I.O. Kostitska, I.V. Cherniavska, N.R. Artemenko, T.V. Romaniv

“…Under such conditions, it is relevant to use pharmacological preparations based on plant materials that would have a wide range of effects on thyroid function. The purpose of the study was to evaluate the effectiveness, safety and tolerability of dietary supplements containing L-tyrosine, brown algae extract (Phaeophyceae), zinc, copper, and folate, as well as dry extract of roots and rhizomes of white cinquefoil (Potentilla alba L.), dry extract of black chokeberry fruits (Aronia melanocarpa), dry extract of flowers and fruits of redhaw hawthorn (Crataegus sanguinea), sodium selenite and possibilities of their combination. …”
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T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein. by Emily K Forbes, Simone C de Cassan, David Llewellyn, Sumi Biswas, Anna L Goodman, Matthew G Cottingham, Carole A Long, Richard J Pleass, Adrian V S Hill, Fergal Hill, Simon J Draper

“…We demonstrate that i) C-terminal fusion of an oligomerization domain can enhance the quantity of antigen-specific CD4(+) and CD8(+) T cell responses induced in mice after only a single immunization of recombinant AdHu5, and that the T cells maintain similar functional cytokine profiles; ii) an adjuvant effect is observed for AdHu5 vectors expressing either the 42 kDa C-terminal domain of Plasmodium yoelii merozoite surface protein 1 (PyMSP1(42)) or the 83 kDa ectodomain of P. falciparum strain 3D7 apical membrane antigen 1 (PfAMA1), but not a candidate 128kDa P. falciparum MSP1 biallelic fusion antigen; iii) following two homologous immunizations of AdHu5 vaccines, antigen-specific T cell responses are further enhanced, however, in both BALB/c mice and New Zealand White rabbits no enhancement of functional antibody responses is observed; and iv) that the T cell adjuvant activity of C4 bp is not dependent on a functional Fc-receptor γ-chain in the host, but is associated with the oligomerization of small (<80 kDa) antigens expressed by recombinant AdHu5. …”
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Oncogenic activation of SMYD3-SHCBP1 promotes breast cancer development and is coupled with resistance to immune therapy by Lihua Mo, Min Deng, Ragini Adhav, Yuni Chan, Josh Haipeng Lei, Sek Man Su, Xin Zhang, Tingting An, Jianlin Liu, Jianjie Li, Xiaodong Shu, Jun Xu, Yuqing Wang, Lin Chen, Yan-Gao Man, Ning-Yi Shao, Tingxiu Xiang, Chu-Xia Deng, Xiaoling Xu

“…We further demonstrated that the combinatory treatment of trametinib together with PD1 antibody enhances the function of effector T cells, sensitizing tumors with elevated Smyd3 and Shcbp1 signaling to αPD1 treatment. …”
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Immunotoxicity assessment of multiwalled carbon nanotubes following whole-body inhalation exposure for 30 and 90 days in B6C3F1/N mice and 30 days in HSD:Harlan Sprague Dawley SD®... by Victor J. Johnson, Nigel J. Walker, Michael I. Luster, Gary R. Burleson, Michelle Cora, Gregory L. Baker, Barney Sparrow, Dori R. Germolec

“…In rats, there was a slight decrease in humoral immunity coinciding with an increase in the number of splenic T cell and NK cell populations.ConclusionAlthough pulmonary macrophage activity increased in mice following exposure to L-MWNT-1020, systemic immune function for the most part remained unaffected. In contrast, rats demonstrated a slight decrease in humoral immune function as well as an increase in spleen cell numbers, T cell, and NK cell populations suggesting species-specific effects on systemic immunity, however, these effects were small and their biological significance with respect to altering disease susceptibility is unclear.…”
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Denosumab-Induced Osteonecrosis of the Jaw with FDG PET/CT imaging features. by SALONI RAJKOTIA, RITESH SUTHAR, ABHISHEK PALSAPURE

“… Denosumab is a monoclonal antibody that inhibits receptor activator of nuclear factor-kappa B ligand (RANKL), which plays a crucial role in osteoclast formation, function, and survival. …”
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DNA Vaccine Treatment in Dogs Experimentally Infected with Trypanosoma cruzi by Minerva Arce-Fonseca, Ana C. Carbajal-Hernández, Mónica Lozano-Camacho, Silvia del C. Carrillo-Sánchez, Francisco-Javier Roldán, Alberto Aranda-Fraustro, José Luis Rosales-Encina, Olivia Rodríguez-Morales

“…Chagas disease is a chronic and potentially lethal disorder caused by the parasite Trypanosoma cruzi, and an effective treatment has not been developed for chronic Chagas disease. …”
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Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity by Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui

“…Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. We therefore sought to target IGF-1 to growth plate cartilage by generating fusion proteins combining IGF-1 with single-chain human antibody fragments that target matrilin-3, a cartilage matrix protein. …”
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Global Properties of a General Latent Pathogen Dynamics Model with Delayed Pathogenic and Cellular Infections by A. M. Elaiw, A. A. Almatrafi, A. D. Hobiny, K. Hattaf

“…This paper studies the global dynamics of a general pathogenic infection model with two ways of infections. The effect of antibody immune response is analyzed. We incorporate three discrete time delays and both latently infected cells and actively infected cells. …”
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Optimization of prokaryotic expression of Tobacco curly shoot virus replication-associated protein gene by PAN Bin, WU Jian-xiang, LI Gui-xin, ZHOU Xue-ping

“…The optimized expression conditions of Rep will be useful for future research on function of Rep.…”
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ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa by Z A Barday

“…None of the patients experienced clinical rejection, and all had good graft kidney function at discharge and at the time of writing. …”
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Host genetic factors and vaccine-induced immunity to hepatitis B virus infection. by Branwen J Hennig, Katherine Fielding, John Broxholme, Mathurin Diatta, Maimuna Mendy, Catrin Moore, Andrew J Pollard, Pura Rayco-Solon, Giorgio Sirugo, Marianne A van der Sande, Pauline Waight, Hilton C Whittle, Syed M Zaman, Adrian V Hill, Andrew J Hall

“…<h4>Background</h4>Vaccination against hepatitis B virus infection (HBV) is safe and effective; however, vaccine-induced antibody level wanes over time. …”
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Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a m... by Ernest Choy, Kerenza Hood, Emma Thomas-Jones, Eleanor Barnes, Keith Wilson, Christian H Ottensmeier, Debbie Harris, Adrian Hill, Mark Tuthill, Richard Adams, Catherine Porter, Katie Ewer, Sian Griffin, Rebecca Tangney, Joanne Euden, Shirley Pringle, Lawrence Raisanen, Ruby Ray, Lisette Sheena Nixon, Melanie Varley, Craig Bodman, Paola Cicconi, Vivien Dagley, Steven Knapper

“…Participant samples will be taken at baseline and at multiple timepoints after the administration of AZD7442.Analysis The participant samples will be analysed to measure the function and magnitude of SARS-CoV-2 specific antibody and T-cell responses at baseline and at multiple timepoints after the administration of AZD7442. …”
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Tissue-specific knockdown of OMM protein via GFP nanobody-mediated degradation by Xiaojie Wang, Qiyue Zhang, Suhong Xu

“…Injection of these plasmids into wild-type C. elegans and subsequent crossbreeding with the fzo-1:GFP knock-in strain allows for effective FZO-1 targeting, providing tissue-specific insights into mitochondrial protein function. …”
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Exercise-induced Nogo-A influences rodent motor learning in a time-dependent manner. by Jörg H Stehle, Zhiyuan Sheng, Laura Hausmann, Philipp Bechstein, Oliver Weinmann, Juha Hernesniemi, Joseph S Neimat, Martin E Schwab, Ajmal Zemmar

“…In a skilled motor task (forelimb-reaching), administration of Nogo-A function-blocking antibodies over the course of the first training week led to improved motor learning. …”
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Tacrolimus and mycophenolate mofetil in corticosteroid-resistant hepatitis secondary to tislelizumab: a case report by Chang Jiang, Shanxian Guo

“…Tislelizumab is a monoclonal antibody with high binding affinity for programmed death-1 (PD-1) receptors. …”
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