RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes by Shruti Chopra, Janine Siegl, Verena Kopfnagel, Sylvia Dreyer, Franziska Rademacher, Juliane Lokau, Christoph Garbers, Jürgen Harder, Thomas Werfel, Katinka Döhner

“…R7 increased the release of the cytokines IL-6 and IL-24 by keratinocytes. Using a function-blocking antibody against IL-6 we showed that the R7-induced IL-24 secretion was triggered by IL-6. …”
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Dupilumab for Chronic Rhinosinusitis with Primary Nasal Polyps: a Case Report and Literature Review by Deng M, Fu R, Lv M, Feng Y

“…Mingrui Deng, Rao Fu, Mei Lv, Ya Feng Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of ChinaCorrespondence: Mei Lv, Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of China, Email Lv_mei@163.com Ya Feng, Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of China, Email fengya1102@sina.comPurpose: To report the efficacy of a case of IL-4 receptor subunit (IL-4Rα) monoclonal antibody (dupilumab) in treating primary chronic rhinosinusitis with nasal polyps (CRSwNP) refractory repeated short-term oral corticosteroids.Patients and Methods: The clinical efficacy, subjective and objective scores, and adverse events before and after dupilumab treatment were evaluated to determine the effect of dupilumab on CRSwNP.Results: The patient’s Lund‒Mackay score on sinus Computed Tomography (CT) at the first visit was 21. …”
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Serologic and molecular biology analysis of a rare Pk phenotype by GAO Huanhuan, ZHANG Na, GENG Wei, KONG Fansheng

“…PROVEAN, SIFT, PolyPhen2 and Mutation Taster were used to analyze the effect of mutations on the protein. [Results] Serological test results suggested that the proband was a P2k type, including anti-P antibody in his serum, and his son was the P2 phenotype. …”
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Daily high doses of atorvastatin alter neuronal morphology in a juvenile songbird model. by Shuk C Tsoi, Alicia C Barrientos, David S Vicario, Mimi L Phan, Carolyn L Pytte

“…The use of statins in children and adolescents has received less attention than in older adults, with few studies on potential unintended effects in young brains. We examined neurons in the juvenile zebra finch songbird in telencephalic regions that function in song perception and memory (caudomedial nidopallium, NCM) and song production (HVC). …”
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Dupilumab, a Potential Novel Treatment for Hailey–Hailey Disease by Liliana Gabriela Popa, Calin Giurcaneanu, Florentina Zaharia, Andreea Grigoras, Alexandra Denisa Oprea, Cristina Beiu

“…Recent studies have evaluated the effect of dupilumab, a human monoclonal antibody that blocks interleukin-4 and -13 receptor in refractory HHD, with very promising results. …”
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GAD2 on chromosome 10p12 is a candidate gene for human obesity. by Philippe Boutin, Christian Dina, Francis Vasseur, Séverine Dubois, Laetitia Corset, Karin Séron, Lynn Bekris, Janice Cabellon, Bernadette Neve, Valérie Vasseur-Delannoy, Mohamed Chikri, M Aline Charles, Karine Clement, Ake Lernmark, Philippe Froguel

“…SNP +83897 T>A was associated with lower fasting insulin and insulin secretion, as assessed by the HOMA-B% homeostasis model of beta-cell function (p = 0.009 and 0.01, respectively). These data support the hypothesis of the orexigenic effect of GABA in humans and of a contribution of genes involved in GABA metabolism in the modulation of food intake and in the development of morbid obesity.…”
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Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction. by Marianne K O Grant, Ibrahim Y Abdelgawad, Christine A Lewis, Davis Seelig, Beshay N Zordoky

“…In the current work, there were no statistically significant differences in the positive inotropic and chronotropic effects of isoproterenol between male and female C57Bl/6NCrl. …”
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LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunity by D Gareth Rees, Robert W Wilkinson, Mark Cobbold, Georgina Bowyer, Kathy Mulgrew, Simon J Dovedi, Fernanda Arnaldez, Des C Jones, Lorraine Irving, Marcin Wolny, Seraina Blümli, Stacy Pryts, Michael Kierny, Sonja Hess, Rebecca Dudley, Elisavet I Chatzopoulou, Shreya Ahuja, Alan M Sandercock, Saravanan Rajan, Reena Varkey, Andrew Kayserian, Saly Songvilay, Kamila Bienkowska, Matthew S Glover

“…A tumor cell/macrophage/T cell co-culture assay was developed to evaluate the effect of AZD2796, as a single agent and in combination with an anti-PD-1 antibody, on the cytolytic activity of antigen-specific T cells. …”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Although direct‐acting antiviral agents effectively inhibit HCV infection, cell–cell transmission remains a critical venue for HCV persistence in vivo. …”
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Systemic Administration of a Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits and Neuroinflammation in Mice by Amit Kumar Madeshiya, Brandi Quintanilla, Carl Whitehead, Stephen Tomlinson, Anilkumar Pillai

“…These findings suggest that site-targeted complement inhibition could offer a promising, safe, and effective strategy for treating chronic stress induced behavioral and immune function disorders.…”
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Preliminary Evidence of Enhanced Immunogenicity of Hepatitis B Virus Vaccines When Co-Administered with Calcium Phosphate, Aluminum Hydroxide, and Cytosine Phospho-Guanine Oligodeo... by Oumou Ouattara, Josephine W. Kimani, James H. Kimotho

“…The safety evaluations revealed no adverse impact on liver and kidney function, with normal ALT, AST, urea, and creatinine levels (<i>p</i> < 0.55). …”
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Neonatal lupus erythematosus: an acquired autoimmune disease to be taken seriously by Wenqiang Sun, Changchang Fu, Xinyun Jin, Changda Lei, Xueping Zhu

“…Implantation of a pacemaker is effective in maintaining cardiac function in children with complete atrioventricular block. …”
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BTN1A1 is a novel immune checkpoint mutually exclusive to PD-L1 by Young-Seung Kim, Bong-Ki Hong, Steven H Lin, Seung-Hoon Lee, Stephen S Yoo, Chunai Wu, Andrew H Park, Hyunjin Jung

“…Background While Programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) blockade is a potent antitumor treatment strategy, it is effective in only limited subsets of patients with cancer, emphasizing the need for the identification of additional immune checkpoints. …”
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Microvascular Ultrasonography Vascularity Index as a Rapid and Simplified Assessment Tool for Differentiating Graves’ Disease from Destructive Thyroiditis and Managing Thyrotoxicos... by Han-Sang Baek, Chaiho Jeong, Jeonghoon Ha, Dong-Jun Lim

“…We evaluated a new technology, microvascular ultrasonography (MVUS) to effectively differentiate between GD and DT, and observe the MVUS changes during follow-up. …”
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CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype by Binle Tian, Zhilong Wang, Mei Cao, Na Wang, Xuebing Jia, Yuanyuan Zhang, Jingyi Zhou, Sijia Liu, Wen Zhang, Xiao Dong, Zheng Li, Junli Xue, JianFei Wang, Guo-Huang Fan, Qi Li

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Prostate-specific membrane antigen–directed nanoparticle targeting for extreme nearfield ablation of prostate cancer cells by Seung S Lee, Philip JR Roche, Paresa N Giannopoulos, Elliot J Mitmaker, Michael Tamilia, Miltiadis Paliouras, Mark A Trifiro

“…We have functionalized multi-walled carbon nanotubes by conjugating an antibody against prostate-specific membrane antigen. …”
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Adult Living Donor Liver Transplantation with ABO-Incompatible Grafts: A German Single Center Experience by Armin D. Goralczyk, Aiman Obed, Andreas Schnitzbauer, Axel Doenecke, Tung Yu Tsui, Marcus N. Scherer, Giuliano Ramadori, Thomas Lorf

“…Despite different treatments ALDLT could safely be performed in three patients and all patients had good initial graft function without signs for antibody-mediated rejection (AMR). …”
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Pro-Fibrotic Macrophage Subtypes: SPP1+ Macrophages as a Key Player and Therapeutic Target in Cardiac Fibrosis? by Moritz Uhlig, Sebastian Billig, Jan Wienhold, David Schumacher

“…These interventions have effectively reduced fibrosis and improved cardiac function in animal models. …”
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Severe Acute Hepatitis B Treated with Entecavir by Giuseppe Vittorio Luigi De Socio, Alessio Sgrelli, Andrea Tosti, Franco Baldelli

“…We present here a case of a 62-year-old man affected by severe acute hepatitis B with progressive worsening of clinical and hepatic function. The patient was treated with entecavir without critical side effects. …”
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The potential of pamrevlumab in diseases with underlying mechanisms of fibrotic processes and its prospects in ophthalmology by Lely Retno Wulandari, Edwin Damar Prabowo, Happy Kurnia Permata Sari, Hidayat Sujuti, Sri Winarsih

“…Introduction: Pamrevlumab, a monoclonal antibody targeting CTGF, is considered a potential therapy for eye diseases involving fibrosis. …”
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