Human anti-D immunoglobulin preparations: potency standardisation milestones by N. S. Vildanova, E. S. Kormshchikova, E. N. Kalinina, K. A. Vorobiev, I. V. Paramonov, E. Yu. Kudasheva

“…The effectiveness of immune suppression is a direct function of the active ingredient dose received with the medicinal product. …”
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First line treatment with subcutaneous efgartigimod in impending myasthenic crisis: a case report by Isabelle Kwiedor, Martina Menacher, Monika Ellßel, Markus Naumann, Antonios Bayas

“…This rapid response was accompanied by a marked reduction in AChR antibody level by 89.8% within 4 weeks. This case supports the potential of efgartigimod as a fast-acting and effective treatment option for managing iMC, offering an alternative to existing therapies.…”
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Serologic Presentation of Lamotrigine-Induced Lupus by Hannah Dempsey, Gabriella Aitcheson, Gretchen Goble, Riley Snook

“…Initial workup revealed acute pancreatitis, elevated liver function enzymes (LFTs), and abnormal anti-double-stranded DNA antibody (anti-dsDNA) 1 : 640. …”
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Optimizing clinical outcomes: The journey of twins with CRIM-negative infantile-onset Pompe disease on high-dose enzyme replacement therapy and immunomodulation by Angie H. Fares, Ankit K. Desai, Laura E. Case, Cassie Sharon, Amy Klinepeter, Amelia Kirby, Matthew T. Lisi, Rebecca L. Koch, Priya S. Kishnani

“…Enzyme replacement therapy (ERT) with alglucosidase-alfa is lifesaving, but its effectiveness is influenced by the patient's cross-reactive immunologic material (CRIM) status, dose of ERT, and the development of high antibody titers, which can reduce the therapy's efficacy. …”
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CXCL16 Induces the Progression of Pulmonary Fibrosis through Promoting the Phosphorylation of STAT3 by Sheng Zuo, Zhen Zhu, Yi Liu, Hong Li, Shuang Song, Shaojun Yin

“…The aim of present study is to examine the function of CXCL16 in PF. Materials and Methods. In this study, we constructed the PF model on mouse by using bleomycin and analyzed the effect of the mouse recombinant protein CXCL16 on mouse lung fibroblast L929 (LF) as well. …”
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Tissue eosinophilia induced by recombinant human interleukin-5 in the hamster cheek pouch membrane by M. Minnicozzi, W. N. Durán, D. Kim, G. J. Gleich, J. Wagner, R. W. Egan

“…Interleukin-5 (IL-5) is a cytokine that preferentially effects the development and function of eosinophils, and is considered important in the pathophysiology of allergic inflammation. …”
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Belimumab in the treatment of systemic lupus erythematosus: 20 years of basic research, 10 years of clinical practice by E. L. Nasonov, T. V. Popkova, A. M. Lila

“…Currently, strong evidence has been obtained for the fundamental role of pathological activation of B cells in the pathogenesis of immunoinflammatory (autoimmune) rheumatic diseases (IMRD), and drugs that specifically modulate the function or cause depletion of various subpopulations of B cells and plasma cells are considered a promising direction. pharmacotherapy of these diseases. of particular interest is belimumab (BLM), a human monoclonal antibody (mAb) (IgG1λ) to BAFF (B cell-activating factor belonging to the TNF family), which is the first “targeted” biological drug specially developed for the treatment of systemic lupus erythematosus (SLE). …”
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Analysis of influencing factors on Turner syndrome combined with autoimmune thyroid disease by Yingmei Cen, Wei Wei, Yinchun Huang, Yiying Qi, Gendie E. Lash, Li Li

“…The effects of age, body mass index (BMI), karyotype, fasting insulin, blood lipids and other factors that may affect thyroid function were analyzed, and the possible risk factors associated with AITD in TS patients explored.ResultsOf the 63 TS patients, 24 (38.10%) had normal thyroid function and 39 (61.90%) patients had TgAb and/or TPOAb. …”
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Interleukin 17A inhibitor secukinumab in the treatment of patients with psoriatic arthritis by N. A. Shostak, D. Yu. Andriyashkina, A. S. Dvornikov, N.  M. Babadaev, D. V. Somov

“…Secukinumab is the first antibody against IL 17 approved in many countries for PsA treatment in adult patients. …”
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Proteomics and transcriptomics combined reveal specific immunological markers in autoimmune thyroid disease by Xia Chen, Hui Chen

“…Enrichment analysis revealed that these differentially expressed genes and proteins are primarily associated with immune function, antigen-antibody binding, and alterations in immune cells. …”
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Research status and prospects of psycho-vaccine by DAI Qin, DAI Zongpei

“…There still exist some problems in the current research of psycho-vaccine, including uncertain specificity, unclear threshold of natural stress vaccination, uncertain chain-relationship of psycho-virus—psycho-vaccine—psycho-antibody, and unclear effect of novel psycho-vaccination. …”
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Case Report: Dual immunomodulatory and hematologic benefits of rituximab in refractory anemia of ANCA-associated vasculitis by Ningjun Shao, Lingxiong Chai, Xu Bai, Qun Luo

“…Concurrently, MPO-ANCA titers decreased from 1:1280 to 1:80, and pulmonary infiltrates resolved. However, renal function remained impaired (serum creatinine: 229 µmol/L) due to irreversible fibrosis.ConclusionsThis case demonstrates RTX’s dual efficacy in suppressing autoimmunity and alleviating anemia, potentially through indirect effects on inflammatory pathways and iron metabolism. …”
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Efficacy of selenium supplementation for patients with Graves' hyperthyroidism during methimazole treatment: protocol for a systematic review and meta-analysis by Mingxing Li, Shuo Yuan, Qing Wen

“…The Cochrane Collaboration’s risk of bias tool will be used to assess the quality of all included studies, and the baseline data of all the studies are extracted by the authors. A random-effects model or a fixed-effects model is used to analyse the outcomes. …”
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Research on the Targeted Treatment of Squamous Cell Carcinoma by Nanographene Drug Delivery System by Xiangyu Zhang, Liwei Guo, Zhenbang Sun, Deming Han, Lihui Zhao

“…Results showed that the NGO-PEG-BPEI-CDDP-Antibody complex had a significant antitumor effect and was able to enter the nude mice and targeted squamous cell carcinoma cell and effectively kill squamous cell carcinoma cells, thus reducing the use of clinical chemotherapeutic drugs, improving the efficacy and providing a new answer for the treatment of squamous cell carcinoma.…”
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Evaluation of Immune Responses to Tdap Booster During Pregnancy in Women Who Received Whole Cell or Acellular Pertussis Vaccines During Childhood by Jesse M. Hall, Kyle J. Caution, Kia J.A. Holt, Yash A. Gupta, Myra Guo, Umul Q. Mir, Tami H. Skoff, Susan Hariri, Xueliang Pan, Brett Worly, Purnima Dubey

“…In contrast, antibody opsonic activity remained unchanged in either priming group. …”
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Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with plasma from Plasmodium falciparum endemic areas of Africa. by Saidou Balam, Kazutoyo Miura, Imen Ayadi, Drissa Konaté, Nathan C Incandela, Valentina Agnolon, Merepen A Guindo, Seidina A S Diakité, Sope Olugbile, Issa Nebie, Sonia M Herrera, Carole Long, Andrey V Kajava, Mahamadou Diakité, Giampietro Corradin, Socrates Herrera, Myriam Arevalo Herrera

“…In addition, BALB/c mice were immunized with the rPvs48/45 protein formulated in Montanide ISA-51 and inoculated with a crude extract of P. falciparum NF-54 gametocytes to evaluate the parasite-boosting effect on rPvs48/45 antibody titers. Specific anti-rPvs48/45 IgG purified from African plasma was used to evaluate the ex vivo TB activity on P. falciparum, using standard mosquito membrane feeding assays (SMFA).…”
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Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart. by Yanbo Tang, Kevin T Kline, Xiaoying S Zhong, Ying Xiao, Haifeng Lian, Jun Peng, Xiaowei Liu, Don W Powell, Guodu Tang, Qingjie Li

“…Mechanistically, cellular experiments identified IL-1β as the inflammatory mediator upregulating cardiac miR-155; this effect was confirmed in adult rats. Furthermore, IL-1β neutralizing antibody ameliorated the DSS-induced increase in miR-155 and concurrent decrease in BDNF in the adult heart, showing therapeutic potential. …”
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Subclinical Myocardial Dysfunction in Pediatric and Adolescent Celiac Disease Patients: A Systematic Review and Meta-Analysis by Elpida Emmanouilidou-Fotoulaki, Maria Kavga, Michail Delis, Evangelia Farmaki, Charalampos Agakidis, Kyriaki Papadopoulou-Legbelou

“…<b>Background/Objectives:</b> This is the first systematic review and meta-analysis investigating early myocardial dysfunction in children/adolescents with celiac disease and the effect of a gluten-free diet by comparing early echocardiographic markers between patients and healthy individuals and between compliant and non-compliant celiac disease patients (based on serum antibody titers). …”
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Influence of Distinct Maternal Cytomegalovirus-Specific Neutralizing and Fc Receptor-Binding Responses on Congenital Cytomegalovirus Transmission in HIV-Exposed Neonates by Itzayana G. Miller, Aakash Mahant Mahant, Jennifer A. Jenks, Eleanor C. Semmes, Eric Rochat, Savannah L. Herbek, Caroline Andy, Nicole S. Rodgers, Justin Pollara, Linda M. Gerber, Betsy C. Herold, Sallie R. Permar

“…Recent work has identified potential immune correlates of protection against cCMV transmission including maternal and placentally transferred antibody levels and their function, which may inform the development of maternal active (vaccine) and passive (mono/polyclonal antibody) immunizations. …”
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Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis by Xiaoyu Huang, Zhouao Zhang, Zhouyi Wang, Tiancheng Luo, Mingjin Yang, Xinyan Guo, Xue Du, Tianyu Ma, Yong Zhang

“…Therefore, we aimed to identify potential novel therapeutic targets that preserve part of B cell function while inhibiting antibody-secreting cells (ASCs). …”
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