EFFECT OF «TREAT-TO-TARGET» ANTIRHEUMATIC THERAPY ON DIASTOLIC DYSFUNCTION OF THE LEFT AND RIGHT VENTRICLES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS DURING 18 MONTHS OF OBSERVAT... by I. G. Kirillova, D. S. Novikova, T. V. Popkova, Yu. N. Gorbunova, E. I. Markelova, Yu. O. Korsakova, O. A. Fomicheva, A. V. Volkov, E. L. Luchikhina, N. V. Demidova, K. A. Kasumova, S. A. Vladimirov, M. A. Kanonirova, G. L. Lukina, A. A. Novikov, E. N. Aleksandrova, D. E. Karateev, E. L. Nasonov

“…Aim. To study the effect of «treat-to-target» antirheumatic therapy on diastolic dysfunction of the left (DDLV) and right (DDLV) ventricles in patients with early rheumatoid arthritis (RA) during 18 months of observation.Material and methods. …”
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DYNAMICS OF CYTOKINE PROFILE IN PATIENTS WITH RHEUMATOID ARTHRITIS AS INFLUENCED BY INFLIXIMAB (REMIKEID) ADMINISTRATION by E. S. Zhugrova, V. I. Mazurov, A. M. Lila, K. A. Syssoev, S. V. Lapin, Areg A. Totolian

“…These events were accompanied by more significant improvement of RА course and increased functional abilities of joints. In patients from group III (absence of clinical effects), the level of antibodies to Infliximab before therapy was high, and it was increased by 22 week of treatment. …”
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Comparative evaluation of anesthesia methods for reconstructive carotid surgery by M. I. Neymark, V. V. Shmelyov, Z. A. Titova, S. A. Khaustova, B. A. Shadymov

“…The objective: to assess the impact of total intravenous and combined anesthesia (consisting of regional block and inhalation anesthesia with sevoflurane) on higher mental functions, frequency and nature of postoperative complications in carotid endarterectomy.Subjects and methods. …”
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Effects of Maackia amurensis seed lectin (MASL) on OSCC cell morphology, PDPN expression, growth, and motility in a phase 1 clinical trial by Ariel C. Yin, Cayla J. Holdcraft, Tyler J. Helmig, Eamonn J. Brace, David I. Suster, Alan J. Shienbaum, Dylan Roden, Evelyne Kalyoussef, Ghayoour Mir, Eugenio Capitle, Soly Baredes, Rabie M. Shanti, Mika K. Kaneko, Yukinari Kato, Hisataka Kobayashi, Aki Furusawa, Mahnaz Fatahzadeh, Gary S. Goldberg

“…Abstract Background Podoplanin (PDPN) has emerged as a functionally relevant biomarker and chemotherapeutic target expressed by OSCC cells. …”
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Cardio–Renal and Systemic Effects of SGLT2i Dapagliflozin on Short-Term Anthracycline and HER-2-Blocking Agent Therapy-Induced Cardiotoxicity by Vincenzo Quagliariello, Annabella Di Mauro, Gerardo Ferrara, Francesca Bruzzese, Giuseppe Palma, Antonio Luciano, Maria Laura Canale, Irma Bisceglia, Martina Iovine, Christian Cadeddu Dessalvi, Carlo Maurea, Matteo Barbato, Alessandro Inno, Massimiliano Berretta, Andrea Paccone, Alfredo Mauriello, Celeste Fonderico, Anna Chiara Maratea, Nicola Maurea

“…Cardiac function was assessed using echocardiography (VEVO 2100). …”
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Small-molecule inhibitors of the CD40–CD40L costimulatory interaction are effective in pancreatic islet transplantation and prevention of type 1 diabetes models by Sung-Ting Chuang, Oscar Alcazar, Brandon Watts, Midhat H. Abdulreda, Midhat H. Abdulreda, Midhat H. Abdulreda, Midhat H. Abdulreda, Peter Buchwald, Peter Buchwald

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Efficacy and safety of sarilumab in combination with methotrexate in patients with active rheumatoid arthritis and inadequate effect of methotrexate monotherapy (results of phase I... by E. L. Nasonov, M. L. Stanislav, T. A. Raskina, G. V. Kuropatkin, I. V. Shirinsky, A. P. Rebrov, N. A. Shostak, B. A. Alikhanov, E. N. Ushakov, R. G. Kamalova, S. A. Smakotina, V. I. Simanenkov, A. S. Pavsun, I. I. Zaharjan, S. S. Yakushin, M. Yu. Sandin

“…The adverse events observed in this study were consistent with the effects of the IL6 blockade.…”
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Enhancing immune response in broiler chicks against newcastle disease virus using lemongrass and geranium oils: A comprehensive study on biochemical and antioxidant effects by Saif W. Bahgat, Mohamed A. Lebda, Nabil M. Taha, Mohamed S. Elfeky, Mustafa Shukry, Mohamed Soliman, Aml E. Hashem

“…Summary: This study evaluated the effects of lemongrass oils (LO) and geranium oils (GO) on the immune response to NDV in 250 one-day-old Cobb broiler chicks. …”
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Beneficial Effects of Coculturing Synovial Derived Mesenchymal Stem Cells with Meniscus Fibrochondrocytes Are Mediated by Fibroblast Growth Factor 1: Increased Proliferation and Co... by Xuanhe Song, Yaoping Xie, Yang Liu, Ming Shao, Wenbo Wang

“…Data from BrdU staining and ELISA demonstrated that conditioned medium of SSCs enhanced the proliferation and collagen synthesis of me-CH, and this effect was blocked by neutralizing antibody against fibroblast growth factor 1 (FGF1). …”
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HIGH-SENSITIVITY TEST SYSTEMS BASED ON CONJUGATES «POLYMER MICROSPHERES – BIOLIGANDS» FOR RAPID PROTEINOPATHY DIAGNOSTICS by S. A. Kedik, I. A. Gritskova, N. I. Prokopov, Ya. M. Stanishevsky, A. V. Panov, V. V. Suslov, E. A. Petrova

“…The main approaches to the creation of highly sensitive test systems based on polymeric microspheres with immobilized bioligands intended for rapid diagnostics of proteinopathy were considered. The effect of these test systems is based on the latex agglutination reaction between the antigens grafted to the surface of polymeric microspheres and antibodies contained in a biological sample. …”
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Enhancement effect of nasal mucosal adjuvant LTB-Rg1 on an inactivated porcine reproductive and respiratory syndrome virus vaccine in mice and its biological safety evaluation by SU Fei, XUE Yin, XU Lihua, LI Junxing, YU Bin, YUAN Xiufang

“…LTB-Rg1 had no effects on body mass, hepatic or renal functions. …”
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Non-CpG Oligonucleotides Exert Adjuvant Effects by Enhancing Cognate B Cell-T Cell Interactions, Leading to B Cell Activation, Differentiation, and Isotype Switching by Melinda Herbáth, Krisztián Papp, Anna Erdei, József Prechl

“…Notably, nucleic acids are known to modulate immune function via several different pathways and various cell types, necessitating a complex interpretation of their effects. …”
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Lymphocytic Hypophysitis: Differential Diagnosis and Effects of High-Dose Pulse Steroids, Followed by Azathioprine, on the Pituitary Mass and Endocrine Abnormalities — Report of a... by Lorenzo Curtò, Maria L. Torre, Oana R. Cotta, Marco Losa, Maria R. Terreni, Libero Santarpia, Francesco Trimarchi, Salvatore Cannavò

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Effective cellular and neutralizing immunity against SARS-CoV-2 after mRNA booster vaccination is associated with pDC and B cell activation by Dorit Fabricius, Carolin Ludwig, Carolin Ludwig, Matthias Proffen, Matthias Proffen, Janina Hägele, Janina Hägele, Judith Scholz, Judith Scholz, Christiane Vieweg, Christiane Vieweg, Immanuel Rode, Immanuel Rode, Simone Hoffmann, Simone Hoffmann, Sixten Körper, Sixten Körper, Hubert Schrezenmeier, Hubert Schrezenmeier, Bernd Jahrsdörfer, Bernd Jahrsdörfer

“…Cellular immunity was assessed by IFN-γ release assays, and flow cytometry was employed to analyze B cell and pDC frequencies, viability, and activation markers. Functional pDC-mediated T cell activation was evaluated in mixed lymphocyte cultures.ResultsmRNA booster vaccination stabilized high anti-SARS-CoV-2 IgG titers and neutralizing activity against wildtype virus across all regimens, with the homologous mRNA group showing the highest antibody titers and Omicron neutralization capacity. …”
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P74 | EXPRESSION OF PISCIDIN, TLR-4, ERK2 AND P-P38 MAPK IN THE ZEBRAFISH GUT EXPOSED TO PCB-126 AND POSSIBLE PROTECTIVE EFFECTS OF GINESTEIN

“… Polychlorinated biphenyls (PCBs) represent one of the main categories of persistent organic pollutants, capable of altering intestinal function and immune response. PCB-126 is a potent, immunotoxic, and bioaccumulative dioxin-like agent1. …”
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Immunoadsorption study Mainz in adults with post-COVID syndrome (IAMPOCO)—a single-blinded sham-controlled crossover trial to evaluate the effect of immunoadsorption on post-COVID... by Marco Stortz, Pascal Klimpke, Andreas Kommer, Philipp Gründer, Livia Steenken, Christian Dresel, Daniel Kraus, Irene Schmidtmann, Arndt Weinmann, Julia Weinmann-Menke

“…We conceived the IAMPOCO trial to evaluate the therapeutic effect of immunoadsorption in patients with PCS. Methods IAMPOCO is a single-center randomized sham-controlled trial with a crossover design which will enroll 40 participants with PCS and a symptom severity of at least 2 on post-COVID functional scale. …”
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Transgenic <i>Schizochytrium</i> as a Promising Oral Vaccine Carrier: Potential Application in the Aquaculture Industry by Ke Ma, Lei Deng, Yuanjie Wu, Yuan Gao, Jianhua Fan, Haizhen Wu

“…Thus, <i>S. limacinum</i> SR21 is a natural and highly promising oral vaccine carrier that not only provides essential nutrients as a functional feed ingredient but also offers specific immune protection to aquatic animals. …”
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Castor oil-based molecularly imprinted nanoparticles for the detection of cardiac troponin I: Towards green molecularly imprinted nanoreceptors by Pinar Cakir Hatir, Alice Marinangeli, Alessandra Maria Bossi, Gokhan Cayli

“…Molecularly imprinted polymers (MIPs) are synthetic materials that selectively recognize target molecules, offering cost-effective and stable alternatives to antibodies. While MIP nanoparticles are ideal for biomedical applications for their high surface area and their biomolecule-compatible size, traditional monomers used in their synthesis can pose issues in biocompatibility. …”
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A comparative study of the therapeutic effect of bone marrow mesenchymal stem cells versus insulin on mandibular dento-alveolar complex collagen formation and beta-catenin expressi... by Rania Osama M. Mohsen, Rabab Hassan

“…Conclusions: Streptozotocin has a destructive effect on the dento-alveolar complex structure and function. …”
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Assessment of the damage index and its dynamics in patients with non-systemic variants of juvenile arthritis during the treatment with biologics by Z. A. Kolkhidova, I. P. Nikishina, S. I. Glukhova

“…The CHAQ (Childhood Health Assessment Questionnaire) questionnaire and X-ray are often used to assess functional impairment and the degree of irreversible damage, but both methods have limitations. …”
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