Effects of Muscarinic Acetylcholine 3 Receptor208-227 Peptide Immunization on Autoimmune Response in Nonobese Diabetic Mice by Lin Yang, Jinzhe Ju, Wei Zhang, Fengfeng Lv, Chunyan Pang, Guoan Yang, Yongfu Wang

“…In the current study, we sought to investigate the effect of M3R208–227 peptide immunization on autoimmune response in NOD/LtJ mice. …”
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Effect of Hypoxia on Siglec-7 and Siglec-9 Receptors and Sialoglycan Ligands and Impact of Their Targeting on NK Cell Cytotoxicity by Husam Nawafleh, Nagwa Zeinelabdin, Michelle K. Greene, Anitha Krishnan, Linus Ho, Mohamed Genead, Derek Kunimoto, Christopher J. Scott, Michael Tolentino, Salem Chouaib

“…To assess Siglec-7 and Siglec-9 receptor expression, U937, NK-92, and primary NK cells were stained with PE-labeled antibodies against CD328 Siglec-7/9. Interactions between Siglec-7/9 and their sialylated ligands, along with their functional impact on NK cell activity, were evaluated using polymeric nanoparticles coated with a sialic acid mimetic. …”
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Alzheimer's disease: part 2 – the present by Ricardo Nitrini

“…These monoclonal antibodies have had a greater effect on the reduction of amyloid plaques in the brain assessed by positron emission tomography (PET), and on the concentration of biomarkers in the cerebrospinal fluid (β-amyloid peptide with 42 amino acids and hyperphosphorylated tau protein) than in the neuropsychological and functional assessments. …”
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Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. by Dror Luger, Yu-An Yang, Asaf Raviv, Douglas Weinberg, Subhadra Banerjee, Min-Jung Lee, Jane Trepel, Li Yang, Lalage M Wakefield

“…We propose that CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy.…”
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EFFECT OF AVIAN BURSA FABERICA EXTRACT ON THE COMPENSATORY CAPACITY OF BONE MARROW, SPLEEN AND THYMUS CELLS IN CYCLOPHOSPHAMIDINE-INDUCED MICE by N. A. Kolberg, E. A. Mukhlynina, S. A. Brilliant, I. F. Gette, V. A. Chereshnev, I. G. Danilova

“…But anticancer chemotherapeutic drugs can also cause the development or aggravate immunodeficiency, affecting the bone marrow function. Previous studies have shown that the bioorganocomplex obtained from the chickens’ Fabricius bursa has an antioxidant and immunotropic effect. …”
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Effects of Zataria multiflora, Salvia officinalis and Probiotics on Intestinal Microbial Colonization, Immunocompetence, Jejunal Histology and Performance of Laying Hens by Vahid Khosravi, Amir Hossein Mahdavi, Nasim Hatamzade Esfahani

“…ABSTRACT Medicinal plants and probiotics affect the productive performance of avian species through comparable biological mechanisms, including modifications to the intestinal microbiome, alterations in histomorphology and effects on the immune system and blood metabolites. …”
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The Clinical Role of SIRT-3 in the Acute Rejection Process of Kidney Transplantation and Its Effects on Graft Outcomes: Evaluation of Biomarker Potential by Necip Altundaş, Eda Balkan, Murat Kizilkaya, Murat Altunok, Elif Demirci, Nurhak Aksungur, Salih Kara, Gürkan Öztürk, Abdullah Uyanik

“…<i>Background and Objectives</i>: The aim of this study was to investigate the changes in the SIRT family, the effects of sirtuins on kidney graft function, and their potential as biomarkers in patients who develop rejection after kidney transplantation. …”
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Effects of diet on blood rheological indices, cytokine concentrations, and emergence of metabolic disorders in the persons with increased body mass index by P. S. Novikov, N. A. Cherevko, V. V. Klimov, S. E. Kondakov, M. Yu. Rozenshteyn, A. Z. Rozenshteyn, E. A. Motlokhova, D. S. Zagreshenko

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Determining the Bioavailability Percentage of Bone Ash Phosphorus Compared to Monocalcium Phosphate and Its Effect on Performance, Bone Quality and Phosphorus Digestibility in Broi... by Mohammad Sedghi, Zahra Sarrami, Raziye Ghasemi, Mahdi Zanghae

“…Also, factorial analysis of the data related to the production of antibody titer against sheep red blood cells, we observed that the only significant difference in the main effects was for the total antibody titer and IgG in the secondary response; So that the antibody titer produced in the secondary response was significantly higher in chickens fed with monocalcium phosphate than in chickens fed with bone ash (P<0.05). …”
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JAK-STAT-activated, fratricide-resistant CAR-T cells targeting membrane-bound TNF effectively treat AML and solid tumors by Yang Li, Taeko Hayakawa, Shinsuke Iida, Toshiaki Yoshikawa, Yusuke Ito, Satoshi Inoue, Yuichi Ishikawa, Takahiro Nakashima, Tetsuya Matsukawa, Hitoshi Kiyoi, Yuki Kagoya, Hitomi Kasuya, Haosong Zhang, Tsunenori Ouchida

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IMMUNOHISTOCHEMICAL STUDY OF PROTEINS PROX1, CD133 AND CD38 IN GLIOBLASTOMAS OF THE VENTRICULARSUBVENTRICULAR ZONE AND THEIR EFFECT ON THE LIFE EXPECTANCY OF PATIENTS by B. E. Galkovsky, L. B. Mitrofanova, Iu. S. Lakhina, D. A. Gulyaev, V. Y. Chirkin, N. A. Mitrofanov, I. V. Chistova

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Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis by Alexandra T. Matola, Dorottya Csuka, Ágnes Szilágyi, Michael Rudnicki, Zoltán Prohászka, Mihály Józsi, Barbara Uzonyi

“…Autoantibodies were studied in functional assays to analyze their effects on C3 convertase, complement deposition, cofactor activity, C3b binding, and hemolysis. …”
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Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model by Wei PS, Chou PY, Hsu HY, Chen M, Chen YJ, Tsai TH, Wen BY, Sheu MT, Chuang KH, Lin HL

“…Furthermore, all nsTPPgels effectively achieved T-cell recruitment to lymph nodes and tumor sites in tracking studies.Conclusion: In conclusion, we developed relatively convenient injectable thermosensitive D2gel with a desirable gelation temperature window, which have the potential to be used for antibody drug delivery in several biomedical applications. …”
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KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression by Jonathan A. Cohen, Ashlyn A. Buzzelli, Gabrielle Quickstad, Lixin Yang, Ichiro Misumi, Karl B. Shpargel, Jason K. Whitmire

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Impact of NF-κB and reactive oxygen species on intracellular BAFF/APRIL expression in ANCA-associated vasculitis: focusing on the effect of resveratrol by Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Yoshiki Sekijima

“…We previously demonstrated the efficacy of resveratrol (RVL) in restoring the function of regulatory T cells in AAV. This study examined the effects of RVL on the expression of BAFF and APRIL in monocytes as well as their related signaling factors in patients with AAV. …”
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Prolonged effects of adenoviral vector priming on T-cell cytokine production in heterologous adenoviral vector/mRNA COVID-19 vaccination regimens by Masanori Isogawa, Taishi Onodera, Akira Ainai, Ryutaro Kotaki, Takayuki Kanno, Shinji Saito, Minoru Tobiume, Kenzo Tokunaga, Megumi Hara, Yoshio Hirota, Tadaki Suzuki, Yoshimasa Takahashi, Tomomi Tsuru

“…The priming and boosting effects on various immune parameters were comparably assessed between mRNA and adenoviral vector platforms. …”
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Therapeutic effects of CTLA4Ig-overexpressing mesenchymal stem cell-derived extracellular vesicles in a mouse model of rheumatoid arthritis by Eun Wha Choi, I-Rang Lim, Ji Hong Park, Jiwoo Song, Bongkum Choi, Sungjoo Kim

“…Conclusions CT-EV demonstrated superior therapeutic effects compared with ASC-EV in the CIA model, highlighting its potential as an effective treatment strategy for RA.…”
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A Novel Dual Bruton's Tyrosine Kinase/Janus Kinase 3 Inhibitor Wj1113 and its Therapeutic Effects on Rheumatoid Arthritis by Chunyu Zhang, Fangfang Lai, Hang Gong, Shuying Li, Nan Xiang, Liuyi Que, Nina Xue, Mengyao Hao, Enjia Zhou, Xiaojian Wang, Taigang Liang, Jing Jin

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Engineered E. coli OMVs Carrying the Membrane-Binding hGC33 Fragment Precisely Target Liver Cancer and Effectively Treat Tumor by Deng Y, Yang B, Yang Z, Xiao H, Zou Y, Zou C, Yang S, Sun X, Wang Y, Bai J, Fang L, Wang Z

“…Meanwhile, hGC33-OMVs suppressed HepG2 cell proliferation, induced G1-phase arrest, and reduced Wnt3a, β-catenin, Cyclin D1, and C-myc expression.Conclusion: Engineered E. coli hGC33-OMVs effectively target HCC via the hGC33-GPC3 interaction, inhibit tumor growth by suppressing Wnt signaling, and demonstrate potential for use as a versatile platform for antibody delivery. …”
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A novel methodology for the extraction, purification and characterization of immunoglobulin G (IgG) nanoparticles from bovine colostrum: implications for food and therapeutic indus... by Fawze Alnadari, Yusof A.Y.A. Mohammed, Mustapha Muhammad Nasiru, Amirah S. Alahmari, Mohammed A. Alqahtani, Osama Abdulaziz, Isaiah Henry Ibeogu, Rongchang Wang, Chao Chen, Salem Baldi, Ibrahim Khalifa, Mohamed Abdin, Ahmed M. Saad, Mohamed T. El-Saadony

“…These findings position IgG NPs as a groundbreaking alternative for biomedical and pharmaceutical applications, offering enhanced stability, biocompatibility, and cost-effectiveness. Future research could explore their use in targeted drug delivery, immunomodulation, and functional food formulations, paving the way for innovative solutions in healthcare and biotechnology.…”
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