Neuroprotective Effects of Asparagus officinalis Stem Extract in Transgenic Mice Overexpressing Amyloid Precursor Protein by Zhanglong Peng, Supinder Bedi, Vivek Mann, Alamelu Sundaresan, Kohei Homma, Gregory Gaskey, Minoru Kowada, Shahid Umar, Anil D. Kulkarni, Holger K. Eltzschig, Marie-Francoise Doursout

“…We hypothesize that the neuroprotective effects of ETAS®50, a standardized extract of Asparagus officinalis stem produced by Amino Up Co., Ltd. …”
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Modeling schizophrenia endophenotypes in drosophila melanogaster: effects of ketamine on anxiety, aggression, locomotion and inflammatory responses by Abdulrahman Adesola Bello, Royhaan Olamide Folarin

“…</div><div>The results showed a dose-dependent induction of aggressive behavior. Motor function assays demonstrated that ketamine impaired these functions in a dose-dependent manner. …”
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Bispecific c-Met/PD-1 CAR-T Cells Have Enhanced Therapeutic Effects on Solid Tumor by HuanRan Yang BM, YanJun Zhang MS, YanQiu Li MS, Shang Peng MS, Ran An MS, NaNa Du MS, JiaWei Cao BM, Fei Chu MS, JingTing Min MS

“…It was demonstrated that CAR-T autocrine PD-1 antibody could alleviate immune checkpoint inhibition and enhance the anti-tumor effect of T cells. …”
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A Bayesian analysis of birth pulse effects on the probability of detecting Ebola virus in fruit bats by Pleydell, David R.J., Ndong Bass, Innocent, Mba Djondzo, Flaubert Auguste, Meta Djomsi, Dowbiss, Kouanfack, Charles, Peeters, Martine, Cappelle, Julien

“…Bats have long been hypothesised to function as important hosts for ebolavirus maintenance, however the transmission ecology for these viruses remains poorly understood. …”
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The Therapeutic Effect of Traditional LiuJunZi Decoction on Ovalbumin-Induced Asthma in Balb/C Mice by Wenting Xu, Rui Zhao, Bin Yuan

“…To investigate the therapeutic effect of LiuJunZi decoction (LJZD) in an experimental model of asthma and uncover its potential mechanism. …”
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Effect of decitabine on PD-L2 methylation in whole blood of iodine-induced autoimmune thyroiditis rats by Baiming Jin, Yanbo Qi, Hong Chao, Xiaolei Yang, Hongjie Li, Siyuan Wan

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Rituximab Effectiveness and Safety for Treating Primary Sjögren's Syndrome (pSS): Systematic Review and Meta-Analysis. by Francine Bertolais do Valle Souza, Gustavo José Martiniano Porfírio, Brenda Nazaré Gomes Andriolo, Julia Vajda de Albuquerque, Virginia Fernandes Moça Trevisani

“…Therapeutic options include mainly symptomatic and supportive measures, and traditional immunosuppressant drugs have shown no effectiveness in randomized trials. Rituximab (RTX) is a chimeric antibody anti-CD20 that leads to B cell depletion by diverse mechanisms. …”
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Peripheral B Cell Subsets in Autoimmune Diseases: Clinical Implications and Effects of B Cell-Targeted Therapies by Wanlin Jin, Zhaohui Luo, Huan Yang

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Divergent Roles of p75NTR and Trk Receptors in BDNF's Effects on Dendritic Spine Density and Morphology by Christopher A. Chapleau, Lucas Pozzo-Miller

“…Considering the opposing actions of p75NTR and Trk receptors in several BDNF actions on CNS neurons, we tested whether these receptors also have divergent actions on dendritic spine density and morphology. A function-blocking anti-p75NTR antibody (REX) did not affect spine density by itself but it prevented BDNF’s effect on spine density. …”
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Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN. by Simon P Hart, Adriano G Rossi, Christopher Haslett, Ian Dransfield

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Dose-response effects of multiple Ascaris suum exposures and their impact on lung protection during larval ascariasis. by Chiara Cássia Oliveira Amorim, Denise Silva Nogueira, Ana Clara Gazzinelli-Guimarães, Thais Leal-Silva, Fernando Sérgio Barbosa, Fabrício Marcus Silva Oliveira, Lucas Rocha Kraemer, Raquel Martins de Almeida, Jorge Lucas Nascimento Souza, Luisa Mourão Dias Magalhães, Remo Castro Russo, Marcelo Vidigal Caliari, Soraya Gaze, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara

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Effect of inclusion of zinc-glycine chelate and zinc sulphate on live performance, immunity and lipid peroxidation in broilers by Sina Gul, Ibrahim A. Alhidary

“…Zinc (Zn) is a biologically significant trace mineral, serving as a cofactor in various metabolic functions. This study aimed to assess the relative effectiveness of organic and inorganic Zn on the growth performance, lipid peroxidation and humoral immune response in broiler chickens (Ross 308). …”
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IFN-γ-Secreting-Mesenchymal Stem Cells Exert an Antitumor Effect In Vivo via the TRAIL Pathway by Xinyuan Yang, Jingchun Du, Xia Xu, Chun Xu, Wu Song

“…The IFN-γ-modified MSCs effectively secreted functional IFN-γ, which led to long-term expression of TRAIL. …”
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Efficacy and safety of a novel multivalent mRNA vaccine against SARS-CoV-2 in experimental animals by Seung Eui Min, Eun-Young Gu, Min Seong Jang, Young-Ju Lee, Ji-Seok Han, Woo Ghil Lee, Seong In Jeong, Ji Young Song, In-Chul Lee, Hyung-Jun Kwon, Young-Bae Ryu, Kyong-Cheol Ko, Byung Sun Min, Yong-Bum Kim, Kang-Hyun Han

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Effects of Dioscorea oppositifolia L. on growth performance, biochemical indicators, immunity, and intestinal health of weaned piglets by Xiang-Yi Pan, Xiang-Yi Pan, Xiang-Yi Pan, Zheng-Ying Qiu, Zheng-Ying Qiu, Zheng-Ying Qiu, Chen Liu, Chen Liu, Chen Liu, Chuan Wang, Xiaowu Wang, Li-Na Huang, Si-Fan Li, Si-Fan Li, Si-Fan Li, Xiong-Wei Shi, Xiong-Wei Shi, Xiong-Wei Shi, Shao-Guang Ge, Shao-Guang Ge, Shao-Guang Ge, Rui-Hua Xin, Rui-Hua Xin, Rui-Hua Xin

“…(Chinese yam, YAM) has activities such as boosting immunity and regulating gastrointestinal function. In order to explore the potential efficacy of YAM on weaned piglets, this study aimed to investigate the effects of growth performance, immune function, intestinal health and intestinal flora composition of weaned piglets.MethodsForty-eight 28-day-old weaned piglets were randomly divided into a control group, YAML group and YAMH group, with 0, 1 and 2% YAM added to the basal diet, respectively. …”
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Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice by Bingna Zhou, Jing Hu, Yuanyuan Yu, Lei Sun, Yanye Wang, Qian Zhang, Yan Jiang, Ou Wang, Xiaoping Xing, Weibo Xia, Luyao Wang, Ge Zhang, Mei Li

“…Conclusions The novel aptamers Apc001OA and Apc001OA‐d6, targeting sclerostin loop3, could significantly increase BMD and improve bone microarchitecture, bone biomechanics, muscle function and histological properties of muscle and bone in ORX mice, without adverse cardiovascular effects. …”
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Unveiling the Solvent Effect: DMSO Interaction with Human Nerve Growth Factor and Its Implications for Drug Discovery by Francesca Paoletti, Tjaša Goričan, Alberto Cassetta, Jože Grdadolnik, Mykola Toporash, Doriano Lamba, Simona Golič Grdadolnik, Sonia Covaceuszach

“…By characterizing DMSO-NGF interactions, this study provides valuable insights for the development of NGF-targeting small molecules, supporting their potential as effective alternatives to monoclonal antibodies for treating pain, inflammation, and neurodegenerative diseases.…”
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4-1BBL-Armed Oncolytic Herpes Simplex Virus Exerts Antitumor Effects in Pancreatic Ductal Adenocarcinoma by Wenrui Gao, Zhuoqian Zhao, Ying Bi, Jinghua Li, Na Tian, Cuizhu Zhang, Shuyuan Pan, Li Deng, Yuntao Zhang

“…To amplify the therapeutic effect, we further combined oHSV-4-1BBL with PD-1 antibody. …”
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Effect of Different Levels of Postbiotic and Phytobiotic Combination on Growth Performance, Economic Production, and Immune Response of Broiler Chickens by Jamil Mobarak Mahmoud Doski, Karwan Yaseen Kareem

“…As probiotics digest prebiotics, they produce postbiotics, which are essentially the remnants of probiotic function. Postbiotics, as non-living cells, enhance broiler performance by providing organic and fatty acids, minerals, and vitamins. …”
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Long‐term immune changes after COVID‐19 and the effect of BCG vaccination and latent infections on disease severity by Kamila Bendíčková, Ioanna Papatheodorou, Gabriela Blažková, Martin Helán, Michaela Haláková, Petr Bednář, Erin Spearing, Lucie Obermannová, Julie Štíchová, Monika Dvořáková Heroldová, Tomáš Tomáš, Roman Panovský, Vladimír Šrámek, Marco De Zuani, Marcela Vlková, Daniel Růžek, Marcela Hortová‐Kohoutková, Jan Frič

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