The effects of 8 wk intensive judo training on the humoral immune system in judo fighters by Bakhtyar Tartibian, Asghar Abbasi, Hirash Nouri

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A randomized, open-label study on the effect of nipocalimab on vaccine responses in healthy participants by Marta Cossu, Carolina Bobadilla Mendez, Amanda Jackson, Eugene Myshkin, Grace Liu, Edwin Lam, Ulf H. Beier, Kathleen Weisel, Brittney Scott, Jocelyn H. Leu, Sheng Gao, Dessislava Dimitrova

“…Nipocalimab, a human immunoglobulin G (IgG) 1 monoclonal antibody, selectively binds the IgG-binding site on the neonatal Fc receptor (FcRn) and blocks IgG recycling, reducing IgG levels without impacting antigen presentation or T-/B-cell functions. …”
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Neuroprotective effect of L-DOPA-induced interleukin-13 on striatonigral degeneration in cerebral ischemia by Eunhae Jeon, Myeong-Seong Seo, Enkhmaa Lkhagva-Yondon, Yu-Ree Lim, Seung-Woo Kim, Yu Jeong Kang, Jun Seok Lee, Byoung Dae Lee, Rayul Wi, So-Yoon Won, Young Cheul Chung, Eun S. Park, Eunhee Kim, Byung Kwan Jin, Myung-Shin Jeon

“…Abstract Levodopa (L-DOPA) treatment is a clinically effective strategy for improving motor function in patients with ischemic stroke. …”
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Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults by Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, Chang-Yuil Kang, Sang Hwan Seo, Jae-Ouk Kim, Deok Ryun Kim, Nathaniel S. Hwang, Jae Seung Yang, Jerome H. Kim, Byoung-Shik Shim, Manki Song

“…These findings underscore the importance of considering diverse humoral immune responses when evaluating vaccine efficacy and provide insights for optimizing adenovirus vector-based SARS-CoV-2 vaccine doses.IMPORTANCEOptimization of vaccine dose is crucial for eliciting effective immune responses. In addition to neutralizing antibodies, non-neutralizing antibodies that mediate Fc-dependent effector functions play a key role in protection against various infectious diseases, including coronavirus disease 2019. …”
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Spike-specific IgG4 generated post BNT162b2 mRNA vaccination is inhibitory when directly competing with functional IgG subclasses by Jerry C.H. Tam, Abbie C. Sibayan, Jeffrey Seow, Carl Graham, Ashwini Kurshan, Blair Merrick, Richard J. Stanton, Katie J. Doores

“…Both neutralizing and effector-function activities of Spike-specific antibodies are important for their protective activity. …”
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Assessment of functional safety of blood forming organs in research of toxicological properties of medicinal products (Review). Part 1. Features of the hematopoietic organs of labo... by N. M. Faustova, A. E. Saloponova, M. V. Miroshnikov, M. N. Makarova, V. G. Makarov

“…The paper discusses the mechanisms of development of hematotoxicity of drugs, among which 4 main ones can be distinguished: cytotoxic effects on hematopoietic progenitor cells; direct damage to mature cells;  indirect damage to blood or bone marrow cells due to undesirable immune reactions against and changes in the activity of cell surface receptors; change in the activity of enzyme systems necessary for the normal functioning of cells. …”
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Cytokines, reverse genetics and anti-cytokine therapy by M. S. Drutskaya, E. O. Gubernatorova, E. A. Gorshkova, K.-S. N. Athertkhany, M. A. Nosenko, V. S. Gogoleva, O. A. Namakanova, R. V. Zvartsev, A. A. Kruglov, S. A. Nedospasov

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Effect of different doses of paricalcitol on the expression of vitamin D receptors in mice liver tissue by T. P. Sataieva, V. Yu. Malygina, A. A. Davydova, M. A. Kriventsov, A. K. Gurtovaya

“…The effect of this drug on metabolic pathways, parathyroid hormone secretion, asthma and liver fibrosis is known, which confirms its wide clinical potential. …”
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Hybrid immunity and host factors: implications on serostatus induced by COVID-19 vaccines by Franklin E. Torres-Jiménez, Evelyn Mendoza-Torres, Adalgisa E. Alcocer-Olaciregui, María F. Torres-Ferias, Daniel A. Mendoza-Zapata, Mariangel Cantillo-Barrios, David J. Echeverría-Bernal, Valentina Varón-Toscano, Giselle P. Pineda-Awadalla

“…No significant differences in antibody concentrations were found between groups (p = 0.830). …”
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An in vivo study of the ameliorative effect of supplementation with Lacticaseibacillus paracasei Glory LP16 in immunocompromised mice by Weiwei Ma, Yanan Wu, Hang Sun, Yiyang Zhao, Lili Huang

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The Effect of Probiotics on the Response to Vaccination in Older Adults: A Systematic Review of Randomised Controlled Trials by Hediye Arioz Tunc, Philip Calder

“…Background: Ageing comes with alterations in many body functions, including the deterioration of the immune system, referred to as immunosenescence. …”
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91 The Effect of Pesticide Exposure on Immunological Responses in Children Against SARS-CoV-2 by Derek Werthmann, Elizabeth Norton, Felicia Rabito

“…Immunological response was measured using neutralizing, phagocytizing, and NK-activating antibody responses biomarkers using plasma antibody isotyping, effector functions, T-cell activation-induced marker (AIM), and recall cytokine secretion assays on lysed, whole blood. …”
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<i>In vitro</i> and <i>in vivo</i> Immunoadjuvant Effects of the Enzymatically Modified Fucoidan by T. A. Kuznetsova, T. A. Smolina, L. A. Ivanushko, E. V. Persiyanova, A. S. Silchenko, N. N. Besednova

“…The comparative study of fucoidans from the brown alga Fucus evanescens (F1 and F2) effects on the effector functions of innate and adaptive immunity cells loaded with ovalbumin (OVA) in vitro and in vivo. …”
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Immunomodulatory Effects of Polysaccharides from <i>Porphyra haitanensis</i> in Hydrocortisone-Induced Immunocompromised Mice by Chunying Du, Chun Wang, Wenwen Zong, Zhaopeng Shen, Peng Wang

“…Immunocompromised mice were treated with varying doses of PHP and the effects on macroscopic indicators, macrophage function, and both cellular and humoral immune functions were comprehensively assessed. …”
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Differential effects of synbiotic delivery route (Feed, water, combined) in broilers challenged with Salmonella Infantis by Victoria Drauch, Mahdi Ghanbari, Nicole Reisinger, Michaela Mohnl, Claudia Hess, Michael Hess

“…Infantis) presents a persistent and multi-drug-resistant threat to poultry production, highlighting the need for effective control strategies. This study evaluated the impact of a S. …”
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Predicting and Controlling Multiple Transmissions of Rotavirus Using Computational Biomedical Model in Smart Health Infrastructures by Titus Ifeanyi Chinebu, Kennedy Chinedu Okafor, Omowunmi Mary Longe, Kelvin Anoh, Henrietta Onyinye Uzoeto, Victor Onukwube Apeh, Ijeoma Peace Okafor, Bamidele Adebisi, Chukwunenye Anthony Okoronkwo

“…Finally, we show multiple Internet of Things applications in SHI to control rotavirus transmission effectively.…”
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The effects of <i>Non3</i> mutations on chromatin organization in <i>Drosophila melanogaster</i> by A. A. Yushkova, A. A. Ogienko, E. N. Andreyeva, A. N. Pindyurin, A. E. Letiagina, E. S. Omelina

“…The nucleolus is a large membraneless subnuclear structure, the main function of which is ribosome biogenesis. However, there is growing evidence that the function of the nucleolus extends beyond this process. …”
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<em>Fasciola gigantica</em> Recombinant Abelson Tyrosine Protein Kinase (r<em>Fg</em>Abl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells by Min Zhao, Yu Zou, Wanting Chen, Dongqi Wu, Chengjun Xian, Haoqing Yang, Jiacheng Tan, Wenda Di, Wende Wu, Dongying Wang

“…To investigate the immunoregulatory function of Abl in <i>Fasciola gigantica</i>, we cloned and expressed the <i>Fasciola</i> gigantica Abl protein and assessed its effect on specific immune functions of buffalo peripheral blood mononuclear cells (PBMCs). …”
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B-lymphocyte subpopulations in patients with rheumatoid arthritis and the effect of an interleukin-6 receptor inhibitor on them. by E. V. Gerasimova, T. V. Popkova, A. P. Aleksankin, A. V. Martynova, E. L. Nasonov

“…Preliminary reports have shown that B cell function and a humoral immune response may be modulated by an IL-6 receptor inhibitor.Objective: to assess the effect of 12-month tocilizumab (TCZ) therapy on B-cell phenotype and gene expression in RA and to analyze the association between B-cell subsets and RA activity.Subjects and methods. …”
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Development of the ELISA Test System for Quantitative Determination of IgG to the Varizella zoster virus in Human Serum and Assessment of its Diagnostic Efficiency by L. N. Lukhverchyk, G. L. Alatortseva, L. N. Nesterenko, V. Y. Kabargina, V. V. Dotsenko, I. I. Amiantova, O. B. Vylivannaya, A. V. Sidorov, A. V. Milovanova, O. S. Oksanich, S. Y. Konanykhina, V. V. Zverev

“…Comparative trials of the developed test system and its commercial analog, the Anti-VZV ELISA (IgG) reagent kit, did not reveal statistically significant differences between their functional characteristics. Conclusions. The developed test system for determining of the AB-VZV concentration in human serum/plasma in terms of its functional characteristics meets the GOST requirements, is characterized by high diagnostic efficiency, can be used to monitor the effectiveness of vaccine prophylaxis and strength of population immunity, as well as to assess the immune response in chickenpox and Herpes zoster.…”
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