Understanding the impact of amyloid beta targeted therapies on biomarkers and clinical endpoints in Alzheimer's disease by Ronald C. Petersen, Ana Graf, Alexandra S. Atkins, Miroslaw Brys, Jennifer Murphy, David S. Miller, Larisa Reyderman, Eric Siemers, Janice Smith, Maria C. Carrillo, Christopher J. Weber

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Functionalized gold nanoflowers on carbon screen-printed electrodes: an electrochemical platform for biosensing hemagglutinin protein of influenza A H1N1 virus by Carlos Enrique Torres-Méndez, Sharmilee Nandi, Klara Martinovic, Patrizia Kühne, Yifan Liu, Sam Taylor, Maria Lysandrou, Maria Ines Berrojo Romeyro Mascarenhas, Viktoria Langwallner, Javier Enrique Sebastián Alonso, Ivana Jovanovic, Maike Lüftner, Georgia-Vasiliki Gkountana, David Bern, Abdul-Raouf Atif, Ehsan Manouchehri Doulabi, Gemma Mestres, Masood Kamali-Moghaddam

“…The electrochemical signal was amplified by functionalization of the gold nanoflowers with 4-aminothiophenol, which resulted in a 100-fold decrease of the charge transfer resistance due to a tunneling effect. …”
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Maksar hepatoprotector is an effective corrector of prednisolone immunosuppressive action at experimental toxic hepatitis by A. I. Vengerovsky, L. M. Ogorodova, T. V. Perevozchikova

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Our first experiences in applying an original method for removal of ABO-isoagglutinins in ABO-incompatible kidney recipients by Ignjatović Ljiljana, Kovačević Zoran, Jovanović Dragan, Vavić Neven, Paunić Zoran, Radojević Milorad, Rabrenović Violeta, Obrenčević Katarina, Mijušković Mirjana, Draškovic-Pavlović Biljana, Ostojić Gordana, Balint Bela, Bokonjić Dubravko

“…Our method for removal of ABO antibodies was effective in a limited series of patients and short-term follow-up.…”
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Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer’s disease: a systematic review and network meta-analysis of... by Wenting Cai, Wenting Cai, Hui Zhang, Hui Zhang, Yan Wu, Yan Wu, Yao Yao, Jinping Zhang

“…By investigating the effects of monoclonal antibodies on cognitive function, disease progression, and overall quality of life in patients with AD, which can provide valuable insights into their potential as a therapeutic option for this devastating neurodegenerative disorder.MethodsThe randomized controlled trials (RCTs) investigating the efficacy of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in Alzheimer’s disease (AD) were systematically searched across PubMed, Embase, Web of Science and Cochrane Library, up to May 2024. …”
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Peptide-directed interference of PD-1/PD-L1 binding increases B lymphocyte function after infectious bursal disease viral infection by Qiuyu Zhang, Guopeng Sun, Feng Yue, Zhike Liu, Peng Li, Yanping Zhu, Yangzhao Zhu, Ruiyan Niu, Zilong Sun, Xuannian Wang, Gaiping Zhang

“…Together, these results demonstrate that gCK-16 treatment can potentially enhance B lymphocyte function against IBDV infection, guiding the development of vaccine adjuvants to effectively prevent IBDV-induced avian immunosuppression.…”
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Tumor cell-released autophagosomes (TRAPs) induce PD-L1-decorated NETs that suppress T-cell function to promote breast cancer pulmonary metastasis by Jing Chen, Ning Pan, Li-Xin Wang, Xiaohe Zhou, Chengdong Wu, Xuru Wang, Xiaotong Sun, Bohao Chen, Shiya Zheng, Yiting Wei, Yuyang Wu, Fengjiao Zhu, Jinpeng Chen, Huabiao Chen

“…The therapeutic potential of targeting TRAP-induced NETs and their immunosuppressive functions was evaluated using DNase I and αPD-L1 antibodies. …”
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High-yield and Functional IgY Anti-S1 SARS-CoV-2 Delta Variant from Chicken Immunized with In-house Recombinant Protein by Kamaluddin Zarkasie, Teridah Ernala Ginting, Andrea Hynan Poeloengan, Febi Andriani, Aksar Chair Lages, Vina Cornelia, Anggah Nugraha, Bustanur Rosidi, Setyarina Indrasari, Chairul Anwar Nidom, Irawan Yusuf

“…BACKGROUND: During COVID-19 pandemic, effective preventive and therapeutic strategies was urgently necessary, especially with the emerging Delta variants. …”
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Exploration of virulence and immune evasion functions of the candidate vaccine antigen SpyAD in the globally disseminated M1T1 group A Streptococcus strain by Alexandra Stream, Samira Dahesh, Lamar Thomas, Nina J. Gao, Elisabet Bjånes, Kalisa Kang, Truman Koh, Neeraj Kapoor, Victor Nizet

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Steroid-Sparing Effect of Omalizumab in Stage IV (Corticosteroid Dependent) Allergic Bronchopulmonary Aspergillosis by P. C. Kathuria, Manisha Rai, Neelam Kathuria

“…The dose of systemic corticosteroids was reduced by 50% in the 1st year and by 70% in the 2nd year although lung function failed to improve.…”
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Evaluating the effect of liver copper concentration on vaccine response in lightweight dairy-beef steers by Jacob A. Henderson, Olivia N. Genther-Schroeder, Jodi L. McGill, Stephanie L. Hansen

“…These results suggest excessive liver copper concentrations may cause more rapid antibody production in response to certain antigens; however, more research is needed to determine the effects of increased liver Cu concentration on inflammation and immune system function.…”
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Successful total hip arthroplasty in patients with anca-associated systemic vasculitis by T. V. Beketova, E. A. Naryshkin, E. V. Arsenyev, M. A. Makarov

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Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies by Idil Hutter-Karakoc, Eleni Maria Varypataki, Aparna Neelakandhan, Simone Lang, Vesna Kramar, Ahmet Varol, Sasha Simons, Marine Richard, Mudita Pincha, Dario Venetz, Johannes Sam, Nicole Joller, Christian Münz, Pablo Umana, Christian Klein, Maria Amann

“…T cell exhaustion, induced by prolonged antigen exposure, is known to compromise T cell-based immunotherapies, but its effect on TCB efficacy remains unclear. Herein, we assessed the TCB efficacy on tumor-specific T cells, emphasizing their functional status. …”
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Sodium benzoate treatment decreased amyloid beta peptides and improved cognitive function among patients with Alzheimer’s disease: secondary analysis of a randomized clinical trial... by Chieh-Hsin Lin, Hsien-Yuan Lane

“…Abstract With the recent approval of anti-amyloid beta (Aβ) monoclonal antibody infusion therapies for Alzheimer’s disease (AD), more feasible and safter Aβ-reducing approaches are anticipated. …”
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MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity by Naoko Imai, Hiroshi Shiku, Yoshihiro Miyahara, Linan Wang, Takuma Kato, Hiroshi Fujiwara, Hiroshi Miwa, Meiou Liu, Yasushi Akahori, Kohei Negishi

“…In particular, Hybrid MA-TCR-T cells significantly inhibited tumor growth in an immunodeficient mouse model more effectively than MA-CAR-T cells. Ex vivo analyses indicated that their enhanced therapeutic efficacy might result from higher infiltration of functionally active, less differentiated Hybrid MA-TCR-T cells in tumor tissues.Conclusions These findings suggest that leveraging the TCR machinery is a promising strategy for enhancing pMHC-targeted CAR-T cell therapy for solid tumors, potentially leading to more effective treatments.…”
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Optimization of the treatment of patients with severe chronic urticaria by Ye.M. Dytiatkovska, N.O. Nedohybchenko

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INFLUENCE OF THE ENRICHED KEFIR PRODUCTS ON ENTEROBAKTERIA DEVELOPMENT by Kontareva V.Y., Kryuchkova V.V.

“…The analysis of the research results demonstrates that kefir products enriched with lactulose (which stimulates growth and development of bifido- and lactobacteria, that are present in the kefir drink and have antagonistic effect on enterobacteria) and immunoglobulin «Lactoglobulin» (which has antibodies to the potentially pathogenic bacteria and salmonella) are most capable of suppressing the development of pathogenic and potentially pathogenic enterobacteria, inhibiting their growth and multiplication, in comparison with the reference sample. …”
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Heart transplant rejection pathology by Stojićević Andrea, Jovanović Milena, Matković Miloš, Nestorović Emilija, Stanojević Nemanja, Dožić Branko, Glumac Sofija

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Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer by Shotaro Ito, Jun Sakakibara‐Konishi, Mineyoshi Sato, Tetsuaki Shoji, Megumi Furuta, Hirofumi Takahashi, Kosuke Tsuji, Daisuke Morinaga, Masahiro Kashima, Hidenori Kitai, Junko Kikuchi, Eiki Kikuchi, Kanako C. Hatanaka, Yutaka Hatanaka, Kyoko Hida, Takuro Noguchi, Satoshi Konno

“…Methods MDK expression was analyzed in vitro and in vivo through ELISA, immunohistochemistry, and western blotting. Its effects on cell proliferation, as well as the effects of cisplatin, were evaluated using the MTT assay. …”
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ProbC: joint modeling of epigenome and transcriptome effects in 3D genome by Emre Sefer

“…Moreover, histone modifications are more effective than transcription factor binding sites in explaining the genome’s 3D shape through these interactions. …”
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