Tensor‐structured decomposition improves systems serology analysis by Zhixin Cyrillus Tan, Madeleine C Murphy, Hakan S Alpay, Scott D Taylor, Aaron S Meyer

“…CMTF outperforms standard methods like principal components analysis in the extent of data reduction while maintaining equivalent prediction of immune functional responses and disease status. Under CMTF, model interpretation improves through effective data reduction, separation of the Fc and antigen‐binding effects, and recognition of consistent patterns across individual measurements. …”
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The effect of benralizumab on inflammation in severe asthma: a real-life analysis by Dina Visca, Francesco Ardesi, Martina Zappa, Sarah Grossi, Patrizia Pignatti, Marco Vanetti, Laura Pini, Giovanni Sotgiu, Rosella Centis, Giovanni Battista Migliori, Antonio Spanevello

“…Few studies investigated its role in airway inflammation and its correlation with lung function. Objectives: The aim of the present study is to assess its effect after 1 year of treatment, focusing on airway inflammation. …”
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Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review by Yusif Mubarik, Shadrach Tetteh Boyetey, Anastasia Rosebud Aikins, Mohamed Mutocheluh

“…Studies have demonstrated that exposure to OTA disrupts the functions of immune system organs, resulting in weight loss, histological lesions and a decrease in antibody-secreting cells. …”
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The effects of disease activity on sleep disorders in ankylosing spondylitis patients by Ali Karataş, Tahsin Murat Turgay, Orhan Küçükşahin

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Current and Novel Therapies for Cluster Headache: A Narrative Review by Bruna de Freitas Dias, Christopher L. Robinson, Maria Dolores Villar-Martinez, Sait Ashina, Peter J. Goadsby

“…Comprehensive, multifaceted treatment strategies are essential to improve the daily functioning and quality of life for individuals with CH.…”
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Effect of Zinc Nano Oxide on the Quality of Turkey Sperm in Liquid State by Vahid Lotfi vafa, Khalil Mirzadeh, Saleh Tabatabaei Vakili, Amin Kazemizadeh

“…It also exhibits antioxidant effects by inhibiting lipid peroxidation and reducing antisperm antibody levels. …”
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The effect of TIM1+ Breg cells in liver ischemia-reperfusion injury by Yu Zhang, Cheng Zhang, Beng Yang, Chuanhui Peng, Jie Zhou, Shenli Ren, Zhenhua Hu

“…Abstract Liver transplantation is the only effective method for end-stage liver disease; however, liver ischemia reperfusion injury (IRI) seriously affects donor liver function after liver transplantation. …”
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EFFECT OF TOXOCARA CANIS SECOND STAGE LARVAE ON THE HOST IMMUNE SYSTEM

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Itaconate derivative 4-OI inhibits M1 macrophage polarization and restores its impaired function in immune thrombocytopenia through metabolic reprogramming by Qiang Liu, Anli Liu, Shaoqiu Leng, Xiaoyu Zhang, Xiaolin Wang, Zhang Cheng, Shuwen Wang, Jun Peng, Qi Feng, Sihan Zhou, Xiuyuan Hao

“…This study aimed to evaluate the immunoregulatory effects of an itaconate derivative on macrophages in patients with ITP. …”
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The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration by Xiao-Kai Guo, Yuan-Feng Liu, Yu Zhou, Xiu-Yuan Sun, Xiao-Ping Qian, Yu Zhang, Jun Zhang

“…Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. …”
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Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma by Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong

“…Multiplex immunofluorescence (mIHC) analysis of a CRC tissue microarray confirmed the promoting effect of CX3CL1 on Treg infiltration. Additionally, the therapeutic efficacy of CX3CR1 inhibitor monotherapy and combination therapy is validated with the PD‐1 antibody in the humanized subcutaneous CRC mouse model. …”
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Trastuzumab emtansine in locally advanced or metastatic HER2 positive breast cancer; GENESIS-SEFH drug evaluation report by Patricia Miranda Romero, Roberto Marín Gil

“…Trastuzumab emtansina (T-DM1) is an antibody-drug conjugate directed against the HER2 for the treatment of HER2+ mestastatic breast cancer (MBC), who has previously received trastuzumab plus a taxane. …”
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Pro-cognitive efficacy of Prospekta in a rat model of age-associated cognitive impairment by Elena Kardash, Nataliya Petrova, Ksenia Ganina, Sergey Tarasov, Oleg Epstein

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Reno-protective effect of IL-34 inhibition on cisplatin-induced nephrotoxicity in mice. by Yukihiro Wada, Masayuki Iyoda, Kei Matsumoto, Taihei Suzuki, Shohei Tachibana, Nobuhiro Kanazawa, Hirokazu Honda

“…In vitro, mouse renal proximal TECs (MRPTEpiC) were cultured to analyze the inhibitory effects of IL-34 on CP-induced TEC apoptosis.<h4>Results</h4>Compared to vehicle treatment, anti-IL-34 Ab treatment significantly suppressed the intra-renal expression of IL-34 and its two receptors, cFMS and PTP-ζ, and significantly improved renal function, ameliorated tubulointerstitial injury, suppressed macrophage infiltration, and reduced apoptotic cell numbers in CP-N mice. …”
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Coronavac inactivated vaccine triggers durable, cross-reactive Fc-mediated phagocytosis activities by Lili Wang, Chuang Li, Wanting Li, Liwei Zhao, Tiantian Zhao, Lin Chen, Ming Li, Jing Fan, Jiayan Li, Chao Wu, Yuxin Chen

“…Although humoral responses elicited by infection or vaccine lost the ability to prevent transmission against Omicron, vaccine-induced antibodies may still contribute to disease attenuation through Fc-mediated effector functions. …”
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Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties by Nilufer P. Seth, Rui Xu, Matthew DuPrie, Amit Choudhury, Samuel Sihapong, Steven Tyler, James Meador, William Avery, Edward Cochran, Thomas Daly, Julia Brown, Laura Rutitzky, Lynn Markowitz, Sujatha Kumar, Traymon Beavers, Sayak Bhattacharya, Hsin Chen, Viraj Parge, Karen Price, Yang Wang, Siddharth Sukumaran, Yvonne Pao, Katie Abouzahr, Fiona Elwood, Jay Duffner, Sucharita Roy, Pushpa Narayanaswami, Jonathan J. Hubbard, Leona E. Ling

“…Nipocalimab selectively reduces circulating IgG levels without detectable effects on other adaptive and innate immune functions. …”
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Effects of Brain-Derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat by Yongjun Jiang, Ning Wei, Juehua Zhu, Tingting Lu, Zhaoyao Chen, Gelin Xu, Xinfeng Liu

“…BDNF also increased DNA-binding activity of nuclear factor-kappa B. BDNF antibody, which blocked the activity of endogenous BDNF, showed the opposite effect of exogenous BDNF. …”
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Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma by Mayuna Nakamura, Yuka Tanaka, Keishi Hakoda, Masahiro Ohira, Tsuyoshi Kobayashi, Kenji Kurachi, Kouichi Tamura, Hideki Ohdan

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CARDIOPROTECTIVE EFFECT OF TUMOR NECROSIS FACTOR ALPHA ANTAGONIST IN DOXORUBICIN MYOCARD TOXICITY by M. I. Popovich, L. M. Cheban, L. A. Taku, V. М. Ivanov, I. М. Popovich, M. V. Ivanov, V. А. Rotaru, L. S. Mikhalchan, V. A. Kobets

“…In other series, to the animals together with Dox every day during 2 weeks intraabdominally the TNF-a antagonist was loaded — monoclonal antibody (ma-TNF-a) dosage 5,0 mg/kg. Cardioprotective effect ma-TNF-a was evaluated on the perfusion model of the isolated heart with assessment of: (1) inotropic response of myocardium on stimulation by noradrenalin and endothelin-1 (ET-1); (2) coronary functional reserve on acetylcholine, adenosine, bradikinine and hydrogen peroxide influence; (3) dynamics of end diastolic pressure (EDP) of the left ventricle in the ischemia-reperfusion syndrome.Results. …”
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Glutoxime, as an Inhibitor of Multiple Drug Resistance Phenotype Associated with Pgp Expression by T. A. Bogush, E. A. Dudko, E. A. Bogush, V. YU. Kirsanov, V. G. Antonov

“…It was shown that the Glutoxime effect on the Pgp expressing tumor cells resulted in a decrease of the cell specific fluorescence intensity, conditioned by binding of the monoclonal antibodies to the transport protein. …”
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