Effect and mechanism of HER2 antibody-drug conjugate combined with anti-PD-1 antibody in mouse bladder cancer models by HE Shuo, TAO Lu, WU Yue

“…Objective‍　‍To investigate the synergistic therapeutic effects of HER2 antibody-drug conjugate (HER2-ADC) combined with anti-PD-1 antibody (anti-PD-1) on HER2-expressing bladder cancer and elucidate its regulatory mechanisms on the tumor immune microenvironment. …”
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Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase by Ilya V. Smirnov, Danica F. Besavilla, Karin Schön, Hannes Axelsson, Davide Angeletti

“…In this study, we propose kinetic MUNANA assay as a tool to identify monoclonal antibodies (mAbs) that specifically target functional epitopes on NA. …”
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Protective Potential and Functional Role of Antibodies Against SARS-CoV-2 Nucleocapsid Protein by Alexandra Rak, Ekaterina Bazhenova, Polina Prokopenko, Victoria Matyushenko, Yana Orshanskaya, Konstantin V. Sivak, Arina Kostromitina, Larisa Rudenko, Irina Isakova-Sivak

“…Here, the protective effect of anti-N antibodies was studied in Syrian hamsters passively immunized with polyclonal sera raised to N(B.1) recombinant protein. …”
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Targeted delivery of doxorubicin to B-cell lymphoma using monoclonal antibody-functionalized Chaetoceros biosilica by Ghazal Salari, Ahmad Shadi, Amirhossein Ahmadi, Javid Esfandyari, Hossein Nikmanesh

“…This study investigates the effectiveness of porous biosilica derived from the diatom Chaetoceros sp., functionalized with hydrophilic GPTMS, labeled with CD-19 antibody, and loaded with doxorubicin in targeting Raji cells, a B lymphoid cell line. …”
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Estimating per-infection cost and burden for dengue and Zika as a function of antibody-dependent enhancement. by Christopher M Kribs

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IL-17-neutralizing antibody mitigates functional and structural changes in cigarette smoke-induced COPD model by Alyne Riani Moreira, Camila Uchoa da Silva, Leticia de Paula Costa Mattos, Jussara Jesus Simão, Veronica Camargo Berti, Luan Henrique Vasconcelos Alves, Alex Ferreira da Silva, Franciele Jesus Lima, Suellen Karoline Moreira Bezerra, Cintia Nascimento Silva, Maria Isabel Cardoso Allonso- Vale, Iolanda de Fatima Lopes Calvo Tiberio, Francine Maria Almeida, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Fernanda Degobbi Tenorio Quirino dos Santos Lopes

“…Administration of the IL-17-neutralizing antibody reversed these structural and functional alterations. …”
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Design of a prodrug bispecific antibody masked by a functional molecule for lymphocyte activation for cancer therapy by Daimei Miura, Yuki Kato, Masahiro Yasunaga, Izumi Kumagai, Ryutaro Asano

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A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function by Wael Bahnan, Lotta Happonen, Hamed Khakzad, Vibha Kumra Ahnlide, Therese de Neergaard, Sebastian Wrighton, Oscar André, Eleni Bratanis, Di Tang, Thomas Hellmark, Lars Björck, Oonagh Shannon, Lars Malmström, Johan Malmström, Pontus Nordenfelt

“…Such antibodies are typically non‐opsonic. However, one antibody could effectively promote vital immune functions, including phagocytosis and in vivo protection. …”
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Antibody-functionalized iron-based nanoplatform for ferroptosis-augmented targeted therapy of HER2-positive breast cancer by Jingchao Gao, Tong Ye, Hongkun Miao, Mingjiang Liu, Li Wen, Yi Tian, Zhiguang Fu, Li Sun, Lihong Wang, Yu Wang

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Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function by Maria Piera Panozzo, Antonio Antico, Nicola Bizzaro

“…Recent evidence has suggested that, in monitoring A-CAG, parietal cell antibodies should be associated with an evaluation of gastric function through biochemical and hormonal tests, such as pepsinogens and gastrin 17. …”
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Preparation of polyclonal antibodies against the EIL3 protein and its expression in soybean seedlings by CHENG Yunqing, WU Zhaoyang, LI Yujie, BAN Meihan, LIU Jianfeng

“…The aim of this study was to prepare EIL3 antibodies, verify their effectiveness and preliminarily explore the biological function of EIL3 in the development of soybean seedlings. …”
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Effect Of Aegle marmelos on IgM And IgG Antibody Titers in Rattus norvegicus by Kadeq Novita Prajawanti, Arif Rahman Nurdianto, Novia Rahmawati, Yohanes Ardian Kapri Negara

“…Literature studies reveal many functional and bioactive compounds, such as alkaloids, phenolics, coumarins, flavonoids, terpenoids, and other antioxidants. …”
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Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies by Frank R. Brennan, J. Ryan Polli, Jean Sathish, Melissa Ramones, Babette Wolf, Tilman Schlothauer, Shirley J. Peters, Curtis C. Maier, Changhua Ji, David L. Wensel, Derrick Witcher, Patricia C. Ryan, T. Scott Manetz, Adriano Flora, Brian Soper, Birgit Fogal, Lindsey Dzielak, Xiaoting Wang, Prathap Nagaraja Shastri, Karen Price, Michael Doyle, Nidhi Sharda, Mary Struthers, Maximilian Brinkhaus, Bianca Balbino, Eric Stefanich, Masaki Honda, Jan Terje Andersen, Shermaine Mitchell-Ryan, David P. Humphreys

“…For Fc-modified mAbs, the choice of in vitro and in vivo nonclinical pharmacology and safety models need to account for species differences in FcR expression and function, potentially divergent effects of Fc modifications in humans versus nonclinical species, impact of target and cognate ligand expression patterns, and potential impact of emergent anti-drug antibodies directed against the mAb. …”
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Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody. by Frank Sainsbury, Markus Sack, Johannes Stadlmann, Heribert Quendler, Rainer Fischer, George P Lomonossoff

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Evaluating the immune effector functions induced by humanized anti-CD99 antibody in eliminating T lymphoblastic leukemia/lymphoma cells by Kamonporn Kotemul, Ratthakorn Chaiwut, Chaochetdhapada Putpim, Supansa Pata, Witida Laopajon, Chatchai Tayapiwatana, Watchara Kasinrerk, Nuchjira Takheaw

“…Abstract Monoclonal antibodies (mAbs) have emerged as targeted immunotherapies with clinical effectiveness and low adverse effects for various cancers. …”
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Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum. by Ashfaq Ghumra, Pongsak Khunrae, Ricardo Ataide, Ahmed Raza, Stephen J Rogerson, Matthew K Higgins, J Alexandra Rowe

“…Antibodies to the N-terminal region (NTS-DBL1α) were the most effective in all assays. …”
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PD-1 monoclonal antibodies as an effective treatment for rare cutaneous malignancies: a case report by Ryan Falk, Wolfram Samlowski, Wolfram Samlowski, Wolfram Samlowski, Amin Hedayat, Amin Hedayat, Amin Hedayat

“…The checkpoint inhibitors pembrolizumab and cemiplimab have been effective treatments for a number of cutaneous malignancies. …”
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Multivariate quantitative analysis of glycan impact on IgG1 effector functions by Tamara Cvijić, Matej Horvat, Jakob Plahutnik, Ana Golob, Jaka Marušič

“…To the best of our knowledge, this is the first report of a systematic approach to quantitatively understand the multivariate impact of glycosylation on the effector functionality of therapeutic monoclonal antibodies, providing valuable tools for advancing therapeutic protein development.…”
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Characteristics of Older Individuals with Asthma Being Treated with Biologics by Aetou M, Kiskinov Y, Ratsimba SFN, Barth M, Pizarro C, Bergs I, Spiesshoefer J, Skowasch D, Dreher M

“…Participants aged ≥ 60 years used self-injection less than those aged 50– 59 years.Conclusion: These data help to characterize the specific population of older people receiving biologic therapy for severe asthma, and showed a high rate of comorbidities, polypharmacy, and poor diffusion capacity in this group.Keywords: antibodies, asthma, biologics, elderly, lung function…”
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Assessment of fetal left ventricular function in pregnancies with Anti-Ro/SSA or Anti-La/SSB antibodies using velocity vector imaging by Min Hou, Dan Xie, Jie Wan, Pin Li, Xuan Zhou

“…Conclusion VVI-derived parameters effectively reflect early alterations in myocardial mechanics in fetuses exposed to anti-Ro/SSA or anti-La/SSB antibodies. …”
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