Magnetically sensitive nanocomposites for targeted antitumor therapy with application of gemcitabine by N. M. Korniichuk, S. P. Turanska, A. L. Petranovska, M. V. Abramov, P. P. Gorbyk, N. Yu. Luk'yanova, N. V. Kusyak, V. F. Chekhun

“…To study the direct cytotoxic/cytostatic effect of a series of experimental samples of MF based on PS, Fe3O4 NP, GEM, HER2 AB, as well as MF components in mono- or complex use, onto MDA-MB-231 cells in vitro, IC50 index was determined. …”
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Semi‐Mechanistic Population Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Dupilumab on Pre‐Bronchodilator Forced Expiratory Volume in 1 Second (FEV1) in Uncontrolled Moderate... by Li Zhang, John D. Davis, Vanaja Kanamaluru, Christine Xu

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ASSISTED REPRODUCTIVE TECHNOLOGY AND ANTIPHOSPHOLIPID SYNDROME by J. Kh. Khizroeva, T. M. Mashkova

“…The antiphospholipid antibodies (APA) exert multiple effects on the hemostasis system causing damage to all of its protective components including the endothelial barrier, natural anticoagulant function and endogenous fibrinolysis and activating the platelet phase of hemostasis, which is associated with numerous obstetrical complications andinfertility. …”
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Hyposensitizing effect of high altitude and immunogenetic law by R. S. Galiev, A. V. Droblenkov

“…Moreover, the animals kept in highlands exhibited lower contents of T and B lymphocytes, and IgE antibodies than in the control group. On the contrary, the numbers of phagocytically active neutrophils, as well as total effect of phagocytosis, proved to be higher in this group. …”
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Functional Characterization of Dual-Initiation Codon-Derived V2 Proteins in Tomato Yellow Leaf Curl Virus by Zhiyuan Wang, Pan Gong, Siwen Zhao, Fangfang Li, Xueping Zhou

“…V2-2 acted as an auxiliary factor, and its deletion attenuated symptoms but kept the virus infection. Host-specific effects were observed—V2-1 deletion led to lower viral DNA/coat protein levels in <i>N. benthamiana</i> than in tomato, suggesting host-dependent regulation. …”
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Structural and Functional Analysis of Hemoglobin Binding to the Peritrophic Matrix During Blood Digestion in <i>Aedes aegypti</i> by Karla Barreto da Silva Orozimbo, Desiely da Silva Gusmão Tauil, Aline Melila Licurgo, Felipe Figueirôa Moreira, Jucélia da Silva Araújo, Maria Aparecida Aride Bertonceli, Sérgio Henrique Seabra, Olga Lima Tavares Machado, Francisco José Alves Lemos

“…Thus, hemoglobin may perform a function similar to that of peritrophins. Further experiments demonstrated the protective role of the PM against hemoglobin proteolysis during blood digestion. …”
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EFFECT OF FISH OIL ON HUMORAL IMMUNITY OF BROILER CHICKS by Ali Abd Saham AL-Mayah

“…These results showed that 50 gm/kg of diet fish oil accelerates antibody production and maintain proper immune function in chickens fed after vaccination against Newcastle disease with LaSota type vaccine at 35th day of age.…”
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Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbs by Sanjay Kalra, Shahjada Selim, Dina Shrestha, Noel Somasundaram, Syed Abbas Raza, Manash P. Baruah, Saptarshi Bhattacharya, Sharvil Gadve, Ganapathi Bantwal, Rakesh Sahay

“…Abstract Graves' disease (GD) is an autoimmune disorder characterized by activation of the TSH receptor by stimulatory autoantibodies (TSH Receptor Antibodies, or TRAbs), leading to unregulated thyroid hormone production. …”
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Advancing kidney transplantation in black patients: a genetics-based and personalized approach under NICE, KDIGO, and ERBP guidelines by Hatem Ali, Wisit Cheungpasitporn, Franco H. Cabeza Rivera, Yahya Makkeyah, Shafi Malik, Ákos G. Pethő, Pradeep Vaitla, Tibor Fülöp

“…Induction therapy is a critical component of renal transplantation, aimed at reducing delayed graft function (DGF) and improving graft survival. This review assesses the impact of leading large national and international guidelines: National Institute for Health and Care Excellence (NICE), Kidney Disease: Improving Global Outcomes (KDIGO), and European Renal Best Practice (ERBP) propositions, focusing on their applicability to high-risk groups, specifically, on Black patients and those with donor-specific antibodies (DSAs). …”
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Two Novel Single-Chain Variable Fragments, EB211 and EB279, Exert Antibacterial Activity Against Acinetobacter baumannii by Destabilizing the Outer Membrane by Eilnaz Basardeh1, Farzaneh Nazari1, Abolfazl Fateh1, Seyed Davar Siadat1, Akbar Oghalaie2, Masoumeh Azizi3, Fatemeh Rahimi-Jamnani1*

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VISTA functions as a protective immune checkpoint in indirect acute respiratory distress syndrome by modulating systemic and compartmentalized inflammation by Baoji Hu, Baoji Hu, Baoji Hu, Chun-Shiang Chung, Chyna Gray, Yaping Chen, Jihong Jiang, Jihong Jiang, Jianrong Guo, Jianrong Guo, Alfred Ayala

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Am80‐GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia‐associated infection and mortality by Lin Li, Xiaotian Qi, Weili Sun, Hisham Abdel‐Azim, Siyue Lou, Hong Zhu, Nemani V Prasadarao, Alice Zhou, Hiroyuki Shimada, Koichi Shudo, Yong‐Mi Kim, Sajad Khazal, Qiaojun He, David Warburton, Lingtao Wu

“…Abstract Neutrophils generated by granulocyte colony‐stimulating factor (GCSF) are functionally immature and, consequently, cannot effectively reduce infection and infection‐related mortality in cancer chemotherapy‐induced neutropenia (CCIN). …”
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Oncolytic adeno-immunotherapy improves allogeneic adoptive HER2.CAR-NK function against pancreatic ductal adenocarcinoma by Greyson Biegert, Amanda Rosewell Shaw, Daisuke Morita, Caroline Porter, Ryu Matsumoto, Lisa Jatta, Noah Crooks, Mae Woods, Qizhi Cathy Yao, Robin Parihar, Masataka Suzuki

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Functional implications of respiratory syncytial virus F sequence variability: a comparative analysis using contemporary RSV isolates by Kim Stobbelaar, Lotte Jacobs, Francisco I. Serrano-Cano, Axelle Fransen, Winke Van der Gucht, Annemieke Smet, Benedicte Y. De Winter, Paul Cos, Winnok de Vos, Kim Van Hoorenbeeck, Stijn Verhulst, Peter L. Delputte

“…Ongoing monitoring of RSV is critical to ensure current and future vaccines remain effective.…”
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Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. by Liqun Wang, Haihua Luo, Xiaohuan Chen, Yong Jiang, Qiaobing Huang

“…In this present study, the effects of homo S100A8, S100A9 and their hetero-complex S100A8/A9 on endothelial barrier function were tested respectively in cultured human umbilical venous endothelial cells (HUVECs). …”
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Improving the N-glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297 by Kathrin Göritzer, Valentina Ruocco, Ulrike Vavra, Shiva Izadi, Omayra C. Bolaños-Martínez, Thareeya Phetphoung, Nuttapat Pisuttinusart, Waranyoo Phoolcharoen, Richard Strasser

“…Monoclonal antibodies are crucial recombinant biopharmaceuticals, with N-glycosylation at Asn297 essential for their functionality. …”
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Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl by Thomas Bauer, Thomas Bauer, Susanne Richter-Eder, Nighat Yasmin, Jennifer Jurkin, René Köffel, Herbert Strobl

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PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation

“…Immunofluorescence microscopy was performed on whole blood smear to visualize MPAs using the following CD41-FITC, CD62P-Alexa Fluor 647, and CD14-Alexa Fluor 594 antibodies. Results: Whole blood CytoFLEX SRT cytometry proved to be an effective method for distinguishing MPAs of varying sizes from free circulating platelets. …”
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PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function by Tongfeng Liu, Shuwen Cheng, Bo Peng, Haojing Zang, Xiaofeng Zhu, Xuetong Wang, Xujie Zhao, Yinmin Gu, Yongbo Pan, Hongbo Hu, Shan Gao

“…The effects of TDE-PD-L2 on tumor is restored by antibodies targeting PD-L2. …”
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AuNRs-PPAR&amp;gamma;mAb Induce Targeted Adipocyte Apoptosis Through Photothermal Effects for Effective Localized Fat Reduction by Hu Y, Xiao K, Chen Z, Ou S, Sima C, Wang H, Zhang J, Zhang Z, Li X

“…Hematological parameters, as well as liver and kidney function, remained unchanged, confirming the biocompatibility and fat-reducing efficacy of the treatment.Conclusion: AuNRs-PPARγmAb, when exposed to 808nm NIR laser irradiation, effectively targets and induces apoptosis in adipocytes, leading to significant fat reduction. …”
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