Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients by Dafeng Liu, Lingyun Zhou, Xinyi Zhang, Yilan Zeng, Lang Bai, Dongbo Wu, Hong Tang

“…Further research should be done to verify the compromised islet β cell function and then to investigate the mechanisms behind the effect of hepatitis B virus infection on islet β cell function in CHB patients.…”
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The first results of combined treatment of giant cell tumor of bone by A. A. Barashev, V. V. Mozulyaka, T. V. Ausheva, Yu. R. Vinnik, L. N. Vashchenko, E. M. Nepomnyashchaya, P. V. Chernogorov

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Functionalized Boron Carbide Nanoparticles as Active Boron Delivery Agents Dedicated to Boron Neutron Capture Therapy by Rudawska A, Szermer-Olearnik B, Szczygieł A, Mierzejewska J, Węgierek-Ciura K, Żeliszewska P, Kozień D, Chaszczewska-Markowska M, Adamczyk Z, Rusiniak P, Wątor K, Rapak A, Pędzich Z, Pajtasz-Piasecka E

“…Therefore, we propose the use of boron carbide (B4C) nanoparticles functionalized with antibodies directed against receptors overexpressed in cancer cells, such as the low-density lipoprotein receptor (LDLR) and the epidermal growth factor receptor (EGFR).Methods: Hydrodynamic diameter measurements confirmed the stability of functionalized B4C nanoparticles in culture media during biological tests lasting up to 72 hours. …”
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In silico model of mechano-biochemical bone remodeling characterizes the therapeutic effects of osteoporosis drugs depending on the action mechanism by Yoshitaka Kameo, Kei Imai, Yuki Miya, Young Kwan Kim, Taiji Adachi

“…Characterizing the therapeutic effects of osteoporosis drugs based on their molecular mechanisms of action is crucial to prevent adverse effects and improve the therapeutic efficacy. …”
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Efficacy of diet restriction with or without probiotic for treatment of patients with IBS‐D: Phase I−II clinical trial by Xian‐Shu Zhao, Li‐Jun Shi, Bao‐Li Ning, Zhi‐Ming Zhao, Xiao‐Xue Li, Meng‐Hua Zhu, Ya‐Bing Zhang, Jun Fu

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Tumor suppressing function of SLC16A7 in bladder cancer and its pan-cancer analysis by Mingjie Xu, Jiatong Zhou, Jiancheng Lv, Yu Zhang

“…The prognostic value of SLC16A7 was confirmed using clinical follow-up data from an independent patient cohort. Functional studies included proliferation assays to investigate the effect of SLC16A7. …”
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Receiver Operating Characteristic Analysis of Liver Function Tests in Patients with Chronic Viral Hepatitis B in Baghdad, Iraq by Rana T. Mohsen

“…The sera of patients were positive for anti-HBc (hepatitis B core antigen) IgG and -HbsAg (hepatitis B surface antigen) antibodies, while they were negative for anti-Hbc IgM antibody. …”
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Association between the newly proposed dietary index for gut microbiota and thyroid function: NHANES 2007–2012 by Ke Peng, Hanjie Guo, Zhiqiang Zhang, Weidong Xiao

“…Notably, thyroglobulin antibodies levels exhibited opposing directional effects between never smokers (negative) and former/current smokers (positive).ConclusionHigher DI-GM scores were negatively correlated with lower FT3, FT4, and TT4 levels, with age and smoking status serving as key factors influencing this association.…”
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Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future by Johan Noble, Johan Noble, Juliette Leon, Arnaud Del Bello, Dany Anglicheau, Gilles Blancho, Gilles Blancho, Simon Ville, Simon Ville, Lionel Couzi, Lionel Couzi, Philippe Grimbert, Philippe Grimbert, Yannick Le Meur, Bruno Moulin, Nassim Kamar, Lionel Rostaing, Florence Herr, Antoine Durrbach, Dominique Bertrand

“…Additionally, belatacept appears to reduce the incidence of donor-specific antibodies. Future directions for the use of belatacept need further exploration, including its role in rescuing poor renal function, its combination with low-dose CNIs, mTOR inhibitors, or tocilizumab, and its application in desensitization protocols. …”
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MOG35 − 55-induced EAE model of optic nerve inflammation compared to MS, MOGAD and NMOSD related subtypes of human optic neuritis by Erin N. Capper, Edward F. Linton, Jeffrey J. Anders, Randy H. Kardon, Oliver W. Gramlich

“…Among the resources utilized to study ON, animal models have emerged as powerful tools to examine the underlying pathophysiology and the effectiveness of proposed therapies. In the current review, we discuss the functional and structural phenotypes related to ON in currently used mouse models, and summarize how the pathophysiology and visual phenotype of the myelin oligodendrocyte glycoprotein 35–55 (MOG35 − 55) experimental autoimmune encephalomyelitis (EAE) mouse model recapitulates clinical features of multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and neuromyelitis optica spectrum disorder (NMOSD). …”
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Influence of environmental exposures on T follicular helper cell function and implications on immunity: a comparison of Bangladeshi and American children by Dana M. Van Fossen, Hyunjae Cho, Lisa E. Wagar, Jennie Z. Ma, Julie Parsonnet, Rashidul Haque, Mark M. Davis, William A. Petri

“…To assess Tfh cell ability to promote antibody responses, we correlated Tfh functionality with antibody concentration post-vaccination and in response to infection with Cryptosporidium, an endemic apicomplexan parasite. …”
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Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein by Ziqi Feng, Jiachen Huang, Sabyasachi Baboo, Jolene K. Diedrich, Sandhya Bangaru, James C. Paulson, John R. Yates, III, Meng Yuan, Ian A. Wilson, Andrew B. Ward

“…Summary: The JN.1-sublineage KP.3.1.1 recently emerged as the globally prevalent SARS-CoV-2 variant, demonstrating increased infectivity and antibody escape. We investigate how mutations and a deletion in the KP.3.1.1 spike protein (S) affect hACE2 binding and antibody escape. …”
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Hypocalcemia and Hypophosphatemia following Concurrent Denosumab Injection and Ferric Carboxymaltose Infusion in a Patient with Normal Renal Function by Naomi Szwarcbard, Chloe Dawson, Lai-Ming Kathleen Pak, Kathryn L. Hackman

“…We present a case of symptomatic hypocalcemia and hypophosphatemia in a 29-year-old woman with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and normal renal function, in the setting of concurrent denosumab and ferric carboxymaltose administration for treatment of glucocorticoid-induced osteoporosis and iron deficiency anemia.…”
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Evaluating the Impact of N-Glycan Sequon Removal in the p27 Peptide on RSV F Protein Immunogenicity and Functionality by Lotte Jacobs, Annelies Leemans, Kim Stobbelaar, Axelle Fransen, Paul Cos, Peter Delputte

“…Surprisingly, all mutants exhibited similar expressions and functionality to the wild-type F protein. All F p27 glycomutants induced neutralizing antibodies and lowered lung viral loads after an RSV challenge in a mouse model. …”
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It is not waste if it is therapy: cellular, secretory and functional properties of reamer–irrigator–aspirator (RIA)-derived autologous bone grafts by S. Häusner, A. Kolb, K. Übelmesser, S. Hölscher-Doht, M. C. Jordan, A. Jauković, F. Berberich-Siebelt, D. V. Spasovski, J. Groll, T. Blunk, M. Herrmann

“…Growth factor and cytokine contents were assessed through antibody arrays. Possible functional and immunomodulatory properties of RIA liquid were evaluated in functional in vitro assays. …”
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Alzheimer’s Disease in the Age of Precision Medicine: Advances in Pathophysiology, Clinical Management and Therapeutic Strategies by Michał Piotrowski, Piotr Serwicki, Szczepan Pośpiech, Jakub Prosowski, Jakub Początek, Jessika Schendzielorz

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Effect of Natural Compounds on NK Cell Activation by Malgorzata Grudzien, Andrzej Rapak

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Electrochemical Immunosensor Using COOH-Functionalized 3D Graphene Electrodes for Sensitive Detection of Tau-441 Protein by Sophia Nazir, Muhsin Dogan, Yinghui Wei, Genhua Pan

“…Early diagnosis of Alzheimer’s disease (AD) is essential for effective treatment; however current diagnostic methods are often complex, costly, and unsuitable for point-of-care testing. …”
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Pre-collecting lymphatic vessels form detours following obstruction of lymphatic flow and function as collecting lymphatic vessels. by Kimi Asano, Yukari Nakajima, Kanae Mukai, Tamae Urai, Mayumi Okuwa, Junko Sugama, Chizuko Konya, Toshio Nakatani

“…Further studies are required to explore the developmental mechanism of the lymphatic detour for treatment and effective care of lymphedema in humans.…”
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Enrichment of decidual CD11c + CD8 + T cells with altered immune function in early pregnancy loss by Ling Guo, Anliang Guo, Yaqiu Guo, Shuwen Han, Cameron Klein, Zi-Jiang Chen, Junhao Yan, Yan Li

“…Functional assays reveal that IFN-γ triggers trophoblast pyroptosis via the NLRP3/Caspase-1/GSDMD pathway, impairing trophoblast invasion. …”
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