Differences in allergen‐specific basophil activation and T cell proliferation in atopic dermatitis patients with comorbid allergic rhinoconjunctivitis treated with a monoclonal ant... by Anne‐Sophie Layritz, Jorge Galicia‐Carreón, Said Benfadal, Natalija Novak

“…The use of a monoclonal anti‐IL‐4Rα antibody has been effective in controlling moderate to severe AD symptoms. …”
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Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. by Xiaowei Zhang, Xiaohong Wang, Hongyan Zhu, Evangelia G Kranias, Yaoliang Tang, Tianqing Peng, Jiang Chang, Guo-Chang Fan

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Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor g... by Dipti Thakkar, Lillian Liu, Bhushan Dharmadhikari, Shalini Paliwal, Siyu Guan, Shreya Kar, Nikhil K Tulsian, Joshua J Gruber, Leah DiMascio, Konrad H Paszkiewicz, Piers J Ingram, Jerome D Boyd-Kirkup

“…However, uncertainty around the cognate VISTA ligand has made the development of effective anti-VISTA antibodies challenging. The expression of VISTA on normal immune cell subtypes argues for a neutralizing non-depleting antibody, however, previous reported anti-VISTA antibodies use IgG1 Fc isotypes that deplete VISTA+ cells by antibody dependent cellular cytotoxicity/complement dependent cytotoxicity and these antibodies have shown fast serum clearance and immune toxicities.Method Here we used a rational antibody discovery approach to develop the first Fc-independent anti-VISTA antibody, HMBD-002, that binds a computationally predicted functional epitope within the C-C-loop, distinct from other known anti-VISTA antibodies. …”
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A comparative study evaluating three line immunoassays available for serodiagnosis of equine Lyme borreliosis: Detection of Borrelia burgdorferi sensu lato-specific antibodies in s... by Cornelia V Broeckl, Stephanie Hiereth, Reinhard K Straubinger

“…Specific vaccine-induced antibodies against LB, providing an effective protection against the infection, complicate the issue further. …”
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Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress by Guan H, Huang L, Liu Y, Zhu E, Chen L, Li W, Wu H, Zhang X, Qin R, Zheng J, Mo Y, Zhong M, Xu B, Dai X, Wei Q, Chen Y, Wang Q, Zheng Z, Ma K, Tang C

“…NAC and BAPN treatment restored the phagocytotic function of human and murine macrophages.Conclusion: Our results indicate that PS-IgG immune-complex can directly impair macrophage phagocytotic functions via LOX mediated-oxidative stress and may serve as a novel biomarker for SLE.Keywords: systemic lupus erythematosus, anti-phospholipid antibodies, immune complex, macrophages…”
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NK cell dysfunction in antiphospholipid syndrome by Anush Martirosyan, Eva Kriegova, Gayane Manukyan, Gayane Manukyan

“…In this process, NK cells recognize and bind to the Fc portion of antibodies that have attached to target cells. With their immunoregulatory properties in the uterus, NK cells play a crucial role in facilitating endometrial tissue remodeling, supporting vascular function, and contributing to placental formation, all of which are essential for a successful pregnancy. …”
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Impact of rituximab therapy on endothelial function and other markers of atherosclerosisin patients with active rheumatoid arthritis by Aleksandr Vital'evich Volkov, O G Lineva, K Kh Kuzikyants, G V Lukina, E L Nasonov, Aleksandr Vitalyevich Volkov, O G Lineva, K Kh Kuzikyants, G V Lukina, E L Nasonov

“…Objective. To evaluate the effect of RTM on endothelial function in patients with active RA. …”
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Complexity of immunobiology of tumor necrosis factor and novel anti-TNF therapy by S. А. Nedospasov

“…Systemic anti-cytokine therapy is known to be accompanied by undesirable side effects, which can hypothetically be explained by the neutralization of these protective functions. …”
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Immunogenic Activity of Secreted Protein-Based Compounds Staphylococcus aureus № 6 by I. M. Gruber, E. A. Astashkina, O. V. Lebedinskaya, N. B. Egorova, M. V. Kiselevsky, F. V. Donenko, N. E. Yastrebova, O. M. Ignatova, E. A. Kurbatova, L. S. Cherkasova

“…Difficulties in the therapy of infection, caused by S. aureus, depends on the resistance of staphylococci to antibiotics, proceeding to chronicity of the diseases and the development on that background the depression of innate immunity functions and decreasing of the host resistance to the infection. …”
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Expression and functional characterization of an anti-CD22 scFv targeting B-cell malignancies by Monireh Gholizadeh, Shahriyar Abdoli, Shafieeh Mansoori, Arash Arashkia, Farhad Riazi-Rad, Amir Ali Hamidieh, Mohammad Nouri, Zahra Sharifzadeh

“…Conclusion and implications: This study established a scalable and cost-effective strategy for producing functional CD22-scFv with high specificity and anti-proliferative effects. …”
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Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI) by Jie Liu, Heleen vanBeusekom, Xian‐Le Bu, Gong Chen, Paulo Henrique Rosado de Castro, Xiaochun Chen, Xiaowei Chen, Andrew N. Clarkson, Tracy D. Farr, Yuhong Fu, Jianping Jia, Jukka Jolkkonen, Woojin Scott Kim, Paula Korhonen, Shen Li, Yajie Liang, Guang‐Hui Liu, Guiyou Liu, Yu‐Hui Liu, Tarja Malm, Xiaobo Mao, Joaquim Miguel Oliveira, Mike M. Modo, Pedro Ramos‐Cabrer, Karsten Ruscher, Weihong Song, Jun Wang, Xuanyue Wang, Yun Wang, Haitao Wu, Lize Xiong, Yi Yang, Keqiang Ye, Jin‐Tai Yu, Xin‐Fu Zhou, Marietta Zille, Colin L. Masters, Piotr Walczak, Johannes Boltze, Xunming Ji, Yan‐Jiang Wang

“…Hence, solely removing Aβ from the brain may be insufficient to combat neurodegeneration and preserve cognition. To attain effective treatment for AD, it is necessary to (1) conduct extensive research on various mechanisms that cause neurodegeneration, including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level; (2) identify neuroprotective intervention targets against different neurodegeneration mechanisms; and (3) discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD patients. …”
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Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review by Charalampos Voros, Despoina Mavrogianni, Aspasia Minaoglou, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Dimitris Mathiopoulos, Panagiota Kondili, Menelaos Darlas, Agni Pantou, Sophia Sina, Antonia Athanasiou, Diamantis Athanasiou, Dimitrios Loutradis, Georgios Daskalakis

“…Eligible studies investigated the effects of SARS-CoV-2 on ovarian function, including the hormonal indicators anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH), oocyte quality, and ovarian reserve. …”
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Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb by Tsega L. Solomon, Frank Delaglio, John P. Giddens, John P. Marino, Yihua Bruce Yu, Marc B. Taraban, Robert G. Brinson

“…To this end, here we used a forced degradation method, time-dependent oxidation by hydrogen peroxide, on the model biotherapeutic NISTmAb and evaluated the effects on HOS with orthogonal analytical methods and a functional assay. …”
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Modern approaches to the immunotherapy of <i>Clostridioides difficile</i> by K. E. Popruga, V. V. Makarov

“…Having a lower cost compared to monoclonal antibodies, high affinity for the antigen, and unique structural and functional properties, nanoantibodies are a promising strategy for the immunotherapy of diseases associated with C. difficile.…”
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Application of predictive models in boosting power of Alzheimer's disease clinical trials: A post hoc analysis of phase 3 solanezumab trials by Ali Ezzati, Christos Davatzikos, David A. Wolk, Charles B. Hall, Christian Habeck, Richard B. Lipton

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Key indicators for guiding tocilizumab therapy to prevent orbital decompression surgery in hormone-resistant dysthyroid optic neuropathy by Wenjun Shu, Wenjun Shu, Wenjun Shu, Wenjun Shu, Mingxu Yan, Mingxu Yan, Mingxu Yan, Mingxu Yan, Lu Gan, Lu Gan, Lu Gan, Lu Li, Hongyue Tao, Zhiyu Peng, Zhiyu Peng, Zhiyu Peng, Zhiyu Peng, Jinghan Wang, Jinghan Wang, Jinghan Wang, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Xintong Lin, Xintong Lin, Xintong Lin, Haifeng Chen, Haifeng Chen, Haifeng Chen, Jie Guo, Jie Guo, Jie Guo, Kang Xue, Kang Xue, Kang Xue, Hongguang Cui, Heng Lou, Heng Lou, Heng Lou, Binbin Xu, Binbin Xu, Binbin Xu, Jinwei Cheng, Jinwei Cheng, Jinwei Cheng, Hongying Ye, Yiming Li, Jiang Qian, Jiang Qian, Jiang Qian, Rui Zhang, Rui Zhang, Rui Zhang, Ruiqi Ma, Ruiqi Ma, Ruiqi Ma, Fangfang Zeng

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Value of Functionalized Superparamagnetic Iron Oxide Nanoparticles in the Diagnosis and Treatment of Acute Temporal Lobe Epilepsy on MRI by Tingting Fu, Qingxia Kong, Huaqiang Sheng, Lingyun Gao

“…The purpose of this study was to determine the feasibility of the functionalized SPIONs with anti-IL-1β monoclonal antibody (mAb) attached to render MRI diagnoses and simultaneously provide targeted therapy with the neutralization of IL-1β overexpressed in epileptogenic zone of an acute rat model of TLE. …”
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Semiautomatic Landmark-Based Two-Dimensional—Three-Dimensional Image Fusion in Living Mice: Correlation of Near-Infrared Fluorescence Imaging of Cy5.5-Labeled Antibodies with Flat-... by Christian Dullin, Marta Zientkowska, Joanna Napp, Jeannine Missbach-Guentner, Hans-Willi Krell, Friedemann Muller, Eckhardt Grabbe, Lutz-F. Tietze, Frauke Alves

“…In summary, we developed a novel 2D-3D registration technique for image fusion with NIRF imaging and fpVCT to provide complementary information in tumor models on the in vivo association of functional information with anatomic structures. The combination of fpVCT with NIRF imaging will now allow targeted and effective monitoring of preclinical tumor therapies.…”
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Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor mi... by Sang Hoon Lee, Jonghwa Won, Sora Kim, Wonjun Son, Yangsoon Lee, Yelim Park, Kyeong-Su Park, Hyunseong Youn, Arim Seo, Byungje Sung

“…This study investigated whether ABL112, an Fc-competent bispecific antibody targeting TIGIT and 4-1BB (TIGITx4-1BB), would enhance antitumor activity via Fcγ receptor (FcγR)-mediated macrophage activation and antibody-dependent cell-mediated functions.Methods TIGIT-dependent 4-1BB activation and TIGIT-blocking activity were assessed using reporter Jurkat T cell lines expressing 4-1BB and TIGIT, respectively. …”
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Evaluation of Peri-Implant Bone Repair in Ovariectomized Rats Submitted to the Implant Placement Functionalized with Anti-Sclerostin by Pedro Henrique Silva Gomes-Ferreira, Paula Buzo Frigério, Nathália Dantas Duarte, Juliana de Moura, Naara Gabriela Monteiro, André Luis da Silva Fabris, Roberta Okamoto

“…This study aimed to evaluate the effect of a local anti-sclerostin monoclonal antibody (Scl-Ab) on the functionalization of titanium implant surfaces through a dip-coating technique in peri-implant bone repair. (2) Methods: A total of 32 female rats were separated into four groups (n = 8): SHAM NT (Sham surgery), OVX NT (ovariectomy), SHAM Scl-Ab (SHAM; implants functionalized with Scl-Ab), and OVX Scl-Ab (OVX; implants functionalized with Scl-Ab). …”
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