Endoplasmic Reticulum Stress‐Induced triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Downregulation Exacerbates Platelet Activation and Myocardial Infarction in Patients W... by Xiaowen Wu, Guanxing Pan, Lin Chang, Qian Liu, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi, Jianjun Zhang, Ruyi Xue, She Chen, Hu Hu, Jianzeng Dong, Si Zhang, Zhongren Ding

“…Transcriptional repression of TREM2 by excessive ER stress was evaluated using luciferase assay, chromatin immunoprecipitation, and electrophoretic mobility shift assay. The effects of TREM2 deficiency on platelet function, mouse FeCl3‐induced mesenteric arterial thrombosis, and myocardial infarction were explored. …”
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Risk factors for delayed kidney graft function from a deseased donor by A. V. Shabunin, P. A. Drozdov, I. V. Nesterenko, D. A. Makeev, O. S. Zhuravel, S. A. Astapovich

“…The effect of delayed kidney graft function on graft survival was statistically significant (p=0.01), while overall recipient survival did not differ between the groups.Conclusion. …”
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Revealing the role of regulatory b cells in cancer: development, function and treatment significance by Ruyu Ye, Sijia Li, Yuxiao Li, Kaixin Shi, Li Li

“…This paper reviews the existing literature on Bregs, examining their development, phenotypes, functions, and the mechanisms through which they exert their regulatory effects. …”
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Detection of Immunochemical Reactions Using Piezoquartz Immunosensor. Regeneration of the Electrode Bio-layer (Review) by S. S. Gogina, E. A. Smirnova, Ya. M. Stanishevskii, A. M. Stoinova

“…An analysis of scientific literature underscores the pivotal role of biosensor regeneration in maintaining functionality and reusability. The strength of the antigen-antibody interaction determines the conditions, which must be tailored individually for each antigen-antibody pair. …”
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The negative impacts of bisphenols on thyroid function in adults with bisphenol A exposure level exceeding the tolerable daily intake by Ziwei Pei, Lei Zhang, Yan Bao, Jingguang Li, Qin Zhuo

“…In order to explore the health risk to thyroid function of BPs, in this study, we assessed the internal exposure levels of BPs and the relationships between urinary BPs and thyroid function in general adults. …”
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Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. by Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero-Melendez, Fulvio D'Acquisto, Elliot J Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti, Federica M Marelli-Berg, Claudio Mauro

“…Recent findings have identified lactate as an active metabolite in cell signalling, although its effects on immune cells during inflammation are largely unexplored. …”
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KLRG1 expression induces functional exhaustion of NK cells in colorectal cancer patients by Cairui Xu, Kangli Cao, Along Ma, Meijuan Zheng, Yuanhong Xu, Ling Tang

“…An in vitro study was performed to investigate the blocking effect of KLRG1 antibody on peripheral blood NK cells in CRC patients. …”
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Clinical performance of AMA‐M2, anti‐gp210 and anti‐sp100 antibody levels in primary biliary cholangitis: When detected by multiplex bead‐based flow fluorescent immunoassay by Zhan Wang, Yongxin Li, Lisheng Ren, Yujie Li, Tiantian Xu, Wenshuai Li, Weize Gao, Guirong Sun, Mingjun Liu

“…The relationship between three antibody levels and cirrhosis, liver function, cholestasis markers and therapeutic effect to ursodesoxycholic acid (UDCA) was evaluated in PBC. …”
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Magnitude and durability of ProC6C-AlOH/Matrix-Mtm vaccine-induced malaria transmission-blocking antibodies in Burkinabe adults from a Phase 1 randomized trial by Mohammad Naghizadeh, Kazutoyo Miura, Ebenezer Addo Ofori, Carole Long, Issaka Sagara, Alfred B. Tiono, Jordan Plieskatt, Michael Theisen

“…The Phase 1 clinical trial (PACTR202201848463189) conducted in Burkina Faso, showed ProC6C-AlOH/Matrix-M was safe, well tolerated, immunogenic and generated a functional antibody response to all three constituent antigens at the primary output (D70). …”
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Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells by Kelly-Anne Masterman, Oscar L Haigh, Kirsteen M Tullett, Ingrid M Leal-Rojas, Carina Walpole, Frances E Pearson, Jonathon Cebon, Christopher Schmidt, Liam O'Brien, Nikita Rosendahl, Ghazal Daraj, Irina Caminschi, Eric H Gschweng, Roger P Hollis, Donald B Kohn, Mireille H Lahoud, Kristen J Radford

“…T cell effector function was measured by expression of IFNγ, MIP-1β, tumor necrosis factor and CD107a and by lysis of target tumor cells.Results CLEC9A-NY-ESO-1 antibodies (Abs) were effective at mediating delivery and cross-presentation of multiple NY-ESO-1 epitopes by CD141+ DCs for activation of NY-ESO-1-specific CD8+ T cells. …”
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Intercellular Epigenomic Signalling via Extracellular Vesicles During B Cell Maturation by Kevin Ho Wai Yim, Ala'a Al Hrout, Richard Chahwan

“…ABSTRACT B cell maturation is crucial for effective adaptive immunity. It requires a complex signalling network to mediate antibody diversification through mutagenesis. …”
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Lymphocyte-activation gene 3 in cancer immunotherapy: function, prognostic biomarker and therapeutic potentials by Ke Ren, Hayam Hamdy, Abdo Meyiah, Eyad Elkord, Eyad Elkord, Eyad Elkord

“…This review discusses the function of LAG-3 in immune suppression, its interactions with ligands, and its potential as a prognostic biomarker for cancers. …”
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Immunology and prospects of immunotherapy against malignant gliomas: humoral immunity by S. A. Kulyova, K. M. Borokshinova, A. E. Druy

“…The cell population infiltrating malignant glioma is impoverished with cytotoxic T cells (CD8+ FOXP3–) and oppositely enriched with regulatory T cells and type 2 macrophages (M2). An effective anti-glioma immune response is resulted in increasing the total number of tumor-infiltrating lymphocytes and the CD8+ cell content; switching the functional activity of macrophages from M2 to M1 type. …”
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clonevdjseq: A workflow and bioinformatics management system for sequencing, archiving, and analysis of VDJ sequences from clonal libraries by Keith Mitchell, Samuel Hunter, Lutz Froenicke, Karl Murray, Matthew Settles, James S. Trimmer

“…The pipeline is built upon a robust, high-throughput library prep protocol, upon which processed data has been verified across thousands of monoclonal antibodies. The results of this effort has yielded sequences used to develop functional recombinant monoclonal antibodies and single chain variable fragments as a part of the NeuroMabSeq initiative where thousands of hybridoma samples were processed (Mitchell et al. in Sci Rep 13(1):16200, 2023) as well as provide additional modeling and extensibility to other modalities. …”
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Evaluation of the Anti-Inflammatory/Immunomodulatory Effect of <i>Teucrium montanum</i> L. Extract in Collagen-Induced Arthritis in Rats by Biljana Bufan, Mirjana Marčetić, Jasmina Djuretić, Ivana Ćuruvija, Veljko Blagojević, Dragana D. Božić, Violeta Milutinović, Radmila Janković, Jelena Sopta, Jelena Kotur-Stevuljević, Nevena Arsenović-Ranin

“…A lower frequency of B cells was accompanied by a lower level of anti-CII antibodies in treated rats. These findings imply the favorable effect of TM extract on the clinical presentation of CIA, suggesting its anti-inflammatory/immunomodulatory action and potential therapeutic effect.…”
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Major royal-jelly proteins intake modulates immune functions and gut microbiota in mice by Hang Wu, Shican Zhou, Wenjuan Ning, Xiao Wu, Xiaoxiao Xu, Zejin Liu, Wenhua Liu, Kun Liu, Lirong Shen, Junpeng Wang

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Characterization and enzymatic function of thioredoxin glutathione reductase in Orientobilharzia turkestanicum isolated from Xizang by Wenqiang Tang, Yongcheng Yue, Bin Shi, Xialing Zhao, Yang Hong

“…RNA interference assays showed that siRNA3 effectively suppressed OtTGR expression in vitro, reducing mRNA levels by 46.1%. …”
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B7-H3: a consistent marker in metastatic colorectal cancer with potential for targeted treatment by Julia M. Ott, Julia M. Ott, Julia M. Ott, Verena Gassenmaier, Verena Gassenmaier, Michael Bitzer, Michael Bitzer, Michael Bitzer, Christian M. Schürch, Christian M. Schürch, Jonas S. Heitmann, Jonas S. Heitmann, Ilona Hagelstein, Ilona Hagelstein, Ilona Hagelstein

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Dual-Oriented Targeted Nanostructured SERS Label-Free Immunosensor for Detection, Quantification, and Analysis of Breast Cancer Biomarker Concentrations in Blood Serum by Mohammad E. Khosroshahi, Christine Gaoiran, Vithurshan Umashanker, Hayagreev Veeru, Pranav Panday

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Understanding the impact of moxifloxacin on immune function: Findings from cytokine analyses and immunological assays in mice. by Mehmood Ahmad, Naeem Rasool, Rana Muhammad Zahid Mushtaq, Sammina Mahmood, Abdur Rauf Khalid, Waqas Ahmad, Bilal Mahmood Beg, Mostafa A Abdel Maksoud, Abdul Aziz Alamri, Adeel Sattar

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