Enhancing the Total Terminal Galactosylation of CHO Cell-Derived TNF-α Blocker-IgG1 Monoclonal Antibody Using Time-Dependent Galactose Supplementation by Mallikarjuna Pulipeta, Pradeep Kumar Iyer, Rajendra Kumar Palakurthy, Narasimha Pullaguri, Rajasekhar Pinnamaneni, Srinivas Reddy Chilukuri

“…The IgG1 subclass is the most potent among all the immunoglobulin gamma (IgG) antibodies, inducing Fc-related effector functions. …”
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Donor – recipient selection using epitope mismatches in kidney transplantation by A. V. Vatazin, A. B. Vatazin, V. A. Stepanov

“…If a recipient with a functioning graft died, the observation was censored. …”
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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies by Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu, Yongqiang Shan

“…With more than 20 anti-PD-1/PD-L1 antibodies currently marketed, anti-PD-1 therapy has become a cornerstone of tumor immunotherapy. …”
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Near-term anti-CD25 monoclonal antibody administration protects murine liver from ischemia-reperfusion injury due to reduced numbers of CD4+ T cells. by Jinghui Yang, Xiaoyu Wang, Shaohua Song, Fang Liu, Zhiren Fu, Quanxing Wang

“…The purpose of current study is to demonstrate the effect of antecedent near-term anti-CD25 monoclonal antibody treatment on IR-induced liver injury by modulation of CD4(+) T cells.…”
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DRUG-INDUCED ENCEPHALOPATHY WITH IMPAIRED COGNITIVE FUNCTIONS DURING TOCILIZUMAB USE by P. A. Shesternya, S. V. Prokopenko, E. Yu. Mozheiko, O. D. Gritsenko, T. V. Tupaeva, E. M. Kurts

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Expression and Functional Analysis of Storage Protein 2 in the Silkworm, Bombyx mori by Wei Yu, Meihui Wang, Hanming Zhang, Yanping Quan, Yaozhou Zhang

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Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection. by Sama Adnan, R Keith Reeves, Jacqueline Gillis, Fay E Wong, Yi Yu, Jeremy V Camp, Qingsheng Li, Michelle Connole, Yuan Li, Michael Piatak, Jeffrey D Lifson, Wenjun Li, Brandon F Keele, Pamela A Kozlowski, Ronald C Desrosiers, Ashley T Haase, R Paul Johnson

“…Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. …”
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Case Report: Extracorporeal photopheresis for BK virus nephropathy as a novel treatment for high-risk rejection kidney transplant recipient by Marilena Gregorini, Marilena Gregorini, Claudia Del Fante, Tefik Islami, Maria Antonietta Grignano, Nicoletta Serpieri, Cesare Perotti, Gianluca Viarengo, Alessia Locurcio, Giuseppe Lanotte, Alessandro Tragni, Emma Diletta Stea, Chiara Martinelli, Alessandro Marchi, Valentina Portalupi, Andreana De Mauri, Elisabetta Margiotta, Eleonora Francesca Pattonieri, Grazia Soccio, Teresa Rampino, Teresa Rampino

“…Currently, there is no effective antiviral treatment for BKVAN. Additionally, the development of donor-specific antibodies (DSAs) and the risk of acute and chronic rejection complicate the reduction of immunosuppressive therapy (IS). …”
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An updated review of immunotherapy in esophageal cancer: PD-L1 footprint by Juan Yao, Xiaoyan Tan, Yanping Sha, Yurao Chen, Ronghuai Chen, Dongping Shi

“…Specifically, monoclonal antibodies can target specific markers of esophageal cancer tumor cells, keeping other normal cells safe. …”
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FB5P-seq-mAbs: monoclonal antibody production from FB5P-seq libraries for integrative single-cell analysis of B cells by Sakina Ado, Chuang Dong, Noudjoud Attaf, Myriam Moussa, Agathe Carrier, Agathe Carrier, Pierre Milpied, Jean-Marc Navarro

“…However, in most cases, the specificity and affinity of the B cell antigen receptor cannot be inferred from its sequence. Antibody cloning and expression from single B cells is then required for functional assays. …”
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Surface functionalized on polystyrene-gold urchin for determining brain injury biomarker by Ming Qiao, Yan Peng, Ting Yan, Jie Liu, JingFang Yue, Qing Zhu, XueGang Peng, Shuangxia Xiong, Gang Wen

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The immune exhaustion paradox: activated functionality during chronic bacterial infections by María L Ruiz-de la Cruz, Mario César Salinas-Carmona

“…Immune checkpoint molecules function as a “brake” to protect the host from the pathological effects of the immune response during chronic bacterial infections, which contrasts with the concept of exhaustion in the context of cancer. …”
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The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation by Syeda Nayab Fatima Abidi, Sara Chan, Kerstin Seidel, Daniel Lafkas, Louis Vermeulen, Frank Peale, Christian W Siebel

“…The sebaceous gland (SG) is a vital appendage of the epidermis, and its normal homeostasis and function is crucial for effective maintenance of the skin barrier. …”
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The role of proline P325 residue in the recognition of the MX35 epitope of the sodium-dependent phosphate transporter NaPi2b by monoclonal antibodies in ovarian carcinoma cells by L. F. Bulatova, I. A. Slidzuk, A. V. Kilunov, V. S. Skripova, R. G. Kiyamova

“…Substitution p.P325A in the NaPi2b transporter does not have a significant effect on the recognition of the MX35 epitope by antibodies or the formation of disulfide bonds in the NaPi2b large ECD. …”
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The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangi... by Ya-Fei Xu, Yuan Yao, Min Ma, Shu-Han Yang, Peng Jiang, Jinjun Wang, Koichi Tsuneyama, Chan Wang, Xiangdong Liu, Liang Li, Zhe-Xiong Lian

“…Elevated serum proinflammatory cytokines, serum anti-mitochondrial antibodies (AMAs), liver inflammation, and fibrosis are also hallmarks of PBC disease. …”
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Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of... by John M Powers, Zoe L Lyski, Whitney C Weber, Michael Denton, Magdalene M Streblow, Adam T Mayo, Nicole N Haese, Chad D Nix, Rachel Rodríguez-Santiago, Luisa I Alvarado, Vanessa Rivera-Amill, William B Messer, Daniel N Streblow

“…To specifically assess the role of the E2 B domain in cross-neutralization, we depleted Mayaro and Chikungunya virus E2 B domain specific antibodies from convalescent sera, finding E2B depletion significantly decreases Mayaro virus specific cross-neutralizing antibody titers with no significant effect on chikungunya virus neutralization, indicating that the E2 B domain is a key target of cross-neutralizing and potentially cross-protective neutralizing antibodies.…”
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SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE by O. O. Obukhova, A. N. Trunov, O. M. Gorbenko, A. P. Shvajuk, A. V. Obukhov, S. M. Chornaja

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ILC3 Function as a Double-Edged Sword in EV71 Infection by Chang Zhang, Linlin Bao, Feifei Qi, Qi Lv, Fengdi Li, Chuan Qin

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Nucleated Red Blood Cells Secrete Haptoglobin to Induce Immunosuppressive Function in Monocytes by Shusuke Takeuchi, Satoshi Fujiyama, Motomichi Nagafuji, Miyuki Mayumi, Makoto Saito, Mana Obata-Yasuoka, Hiromi Hamada, Yayoi Miyazono, Hidetoshi Takada

“…Nucleated red blood cells (NRBCs) are precursors of red blood cells (RBCs), but also possess variety of immunomodulatory effects. However, among the three types of NRBCs, the immunological effects of human CD45− NRBCs remain largely unknown. …”
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Features of the functioning of the natural defense mechanisms of piglets under the influence of immunotropic substances by D. M. Masiuk, V. S. Nedzvetsky, A. V. Kokariev

“…The study was carried out to establish characteristics of phenotypic and functional characteristics of the immune cells and establishment of adaptive immunity in piglets. …”
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