Long-Term Safety of Anti-TNF Adalimumab in HBc Antibody-Positive Psoriatic Arthritis Patients: A Retrospective Case Series of 8 Patients by R. Laurenti, F. Giovannangeli, E. Gubinelli, M. T. Viviano, A. Errico, L. Leoni, E. Ballanti, A. Migliore

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Impact of Chemotherapy on Vaccine Immunogenicity and Revaccination Response of Acute Lymphoblastic Leukemia—A Systematic Review and Meta-Analysis by Yuyuan Zeng, Chuanyu Yang, Xihan Li, Qi An, Bo Zhou, Wenquan Niu, Yu Tian, Yifei Cheng, Lin Wang

“…Background: Chemotherapy, a cornerstone treatment for Acute Lymphoblastic Leukemia (ALL), can compromise immune function, leading to impaired immune memory function and diminished responses to revaccination. …”
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Discovery and in vitro characterization of a human anti-CD36 scFv by Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez

“…Analysis of scFv binding and blocking function was evaluated by flow cytometry in macrophage-like THP-1 cells and hepatocellular carcinoma HepG2 cells. …”
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Modulating ion channels with nanobodies by Sher Ali, Ashley Suris, Yun Huang, Yubin Zhou

“…Nanobodies have introduced new opportunities for exploring ion channel structure-function relationships and offer a promising alternative to conventional drugs, which often face challenges such as off-target effects and toxicity. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Yet, the molecular and cellular mechanisms by which either receptor functions to mediate its inhibitory effects are still poorly understood. …”
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Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten by Rin Yoshizato, Mariko Miura, Kiyomi Shitaoka, Yuri Matsuoka, Akifumi Higashiura, Akima Yamamoto, Yun Guo, Hitoshi Azuma, Yohei Kawano, Shouichi Ohga, Tomoharu Yasuda

“…Our mAb production system allows flexible switching of IgG1 to any other isotype with the same paratope, enabling the absolute quantification of antigen-specific serum antibody titers and affinity maturation. Additionally, we established a protocol for the production of IgM and IgA, retaining their functional pentamer and dimer structures. …”
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Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers by Salman Shahid, Sharanbasappa S. Karade, S. Saif Hasan, Rui Yin, Liqun Jiang, Yanxin Liu, Nathaniel Felbinger, Liudmila Kulakova, Eric A. Toth, Zhen-Yong Keck, Steven K. H. Foung, Thomas R. Fuerst, Brian G. Pierce, Roy A. Mariuzza

“…Abstract Global elimination of hepatitis C virus (HCV) will require an effective cross-genotype vaccine. The HCV E2 envelope glycoprotein is the main target of neutralizing antibodies but also contains epitopes that elicit non-neutralizing antibodies which may provide protection through Fc effector functions rather than direct neutralization. …”
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Efficacy for the Annual Relapse Rate after the Immunosuppressive Therapy in Patients Associated with Anti-AQP4 or Anti-MOG Antibody-Positive Optic Neuritis by Sotaro Mori, Takuji Kurimoto, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Norio Chihara, Yuko Yamada-Nakanishi, Makoto Nakamura

“…We also evaluated the dosage of prednisolone, complications of immunosuppressants, and other visual functional ophthalmologic parameters. Results. Eleven cases in total had AQP4 antibody (9 cases) and/or MOG antibody (3 cases). …”
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A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow by Tian Zhao, Yuqing Lei, Chang Liu, Dong Zhang, Kaiyi Li, Sisi Shan, Chenyu Li, Zimeng Wei, Yuhan Yang, Ting Zhang, Kai Sun, Haoran Sun, Linqi Zhang, Peng Liu

“…Abstract Antigen‐specific B cells play a crucial role in the long‐term immune response following infection or vaccination, differentiating into antibody‐secreting cells (ASCs) and memory B cells (MBCs). …”
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NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) by A. V. Shatalova, A. S. Yakubova, V. V. Palimpsestov, I. B. Esmagambetov

“…Goal of the paper consists of the description of structural and functional properties of nanobodies and its effective application.Conclusion. …”
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CD1d expression in paneth cells and rat exocrine pancreas revealed by novel monoclonal antibodies which differentially affect NKT cell activation. by Elisa Monzon-Casanova, Birte Steiniger, Stefanie Schweigle, Holger Clemen, Daniela Zdzieblo, Lisa Starick, Ingrid Müller, Chyung-Ru Wang, Sara Rhost, Susanna Cardell, Elwira Pyz, Thomas Herrmann

“…In order to analyze CD1d expression and function in the rat, the first rat CD1d-specific monoclonal antibodies (mAbs) were generated.…”
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Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice by Victor J. Johnson, Cynthia V. Rider, Michael I. Luster, Cynthia J. Willson, Shawn Harris, Billie Stiffler, James Blake, Esra Mutlu, Veronica Godfrey, Brian Burback, Reshan Fernando, Suramya Waidyanatha, Gary R. Burleson, Dori R. Germolec

“…Antibody suppression was associated with significant immune cell loss in the spleen; however, it was clear that the suppression of the TDAR was more sensitive than cell loss indicating that cell function impairments were involved. …”
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Measuring Human Memory B Cells in Autoimmunity Using Enzyme-Linked ImmunoSpot by Georgia Stylianou, Greg A. Kirchenbaum, Paul V. Lehmann, Simon Pearce, Stephen Todryk

“…For several autoimmune diseases (ADs), the targeting of B cells via depleting monoclonal antibodies has proven to be an effective treatment, where B_mem cells are likely being targeted. …”
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A fully human IgG1 antibody targeting connexin 32 extracellular domain blocks CMTX1 hemichannel dysfunction in an in vitro model by Abraham Tettey-Matey, Viola Donati, Chiara Cimmino, Chiara Di Pietro, Damiano Buratto, Mariateresa Panarelli, Alberto Reale, Arianna Calistri, Maria Vittoria Fornaini, Ruhong Zhou, Guang Yang, Francesco Zonta, Daniela Marazziti, Fabio Mammano

“…Single-point mutations (p.S85C, p.D178Y, p.F235C) generate pathological Cx32 HCs characterized by increased permeability (“leaky”) or excessive activity (“hyperactive”). We investigated the effects of abEC1.1-hIgG1, a fully human immunoglobulin G1 (hIgG1) monoclonal antibody, on wild-type (WT) and mutant Cx32D178Y HCs. …”
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A potent and broad CD4 binding site neutralizing antibody with strong ADCC activity from a Chinese HIV-1 elite neutralizer by Yingdan Wang, Ping Ji, Qianying Liu, Nannan Jia, Yunping Ma, Tianyi Yuan, Palizhati Rehati, Jiali Chen, Yumei Wen, Fan Wu, Jinghe Huang

“…Abstract The discovery of broadly neutralizing antibodies (bNAbs) that target conserved epitopes on the HIV-1 envelope glycoprotein (Env) has garnered significant attention for its potential in the development of effective therapeutic and vaccine strategies. …”
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2bRAD-M reveals circulating microbiome in chronic antibody-mediated rejection (CAMR) and IgA nephropathy (IgAN) after kidney transplantation by Yan-Xin Tao, Er-Di Zhang, Jia-Xi Yue, Zheng-Li Wan, Ji-Wen Fan, Yi Li, Yu Fan, Lin Yan

“…Abstract Background Kidney transplantation is currently the most effective method for treating end-stage renal disease. …”
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Immune Aging, Immunosenescence, and Inflammaging: Implications for Vaccine Response in Older Adults by Shahab Falahi, Amir Abdoli, Azra Kenarkoohi

“…ABSTRACT Background and Aims Population aging is a significant demographic change while vaccines are mostly made for children and young adults and their effectiveness might be low in the older population. Age‐associated decline in the immune function (immunosenescence) is a process that may lead to poor vaccine response in the older population. …”
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Cutaneous Vasculitis: A Pragmatic Study on the Dermatological Conundrum by Priyanka Varma, Amina Asfiya, Spandana Prakash Hegde, Manjunath Mala Shenoy

“…Complete hemogram, erythrocyte sedimentation rate, urine analysis, liver and renal function tests, and antinuclear antibody (ANA) testing were done. …”
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Use of a synthetic biosensor for neutralizing activity-biased selection of monoclonal antibodies against atroxlysin-I, an hemorrhagic metalloproteinase from Bothrops atrox snake ve... by Francisco Santos Schneider, Dung Le Nguyen, Karen Larissa Castro, Sandra Cobo, Ricardo Andrez Machado de Avila, Nivia de Assis Ferreira, Eladio Flores Sanchez, Christophe Nguyen, Claude Granier, Pascale Galéa, Carlos Chávez-Olortegui, Franck Molina

“…Hybridomas producing supernatants with inhibitory effect against the proteolytic activity of Atr-I towards the FRET peptide Abz-LVEALYQ-EDDnp were selected. …”
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p54-Fc-Labeled Gold Nanoparticle-Based Lateral Flow Strip-Assisted Portable Devices for Rapid and Quantitative Point-of-Care Detection of ASFV Antibodies by Yang Yang, Yuhao Li, Ziyang Wang, Minglong Tong, Pengcheng Zhu, Juanxian Deng, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Zhongren Zhou, Yafeng Qiu, Zhiyong Ma, Jianchao Wei

“…In summary, our method is rapid, cost-effective, precise, and highly selective. Additionally, it introduces a new approach for constructing IC test strips using SPA protein without antibody preparation, making it a reliable on-site antibody test for ASFV.…”
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