High‐resolution definition of humoral immune response correlates of effective immunity against HIV by Galit Alter, Karen G Dowell, Eric P Brown, Todd J Suscovich, Anastassia Mikhailova, Alison E Mahan, Bruce D Walker, Falk Nimmerjahn, Chris Bailey‐Kellogg, Margaret E Ackerman

“…Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. …”
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Combinatorial Fc modifications for complementary antibody functionality by Yannic C. Bartsch, Nicholas E. Webb, Eleanor Burgess, Jaewon Kang, Douglas A. Lauffenburger, Boris D. Julg

“…Therapeutic monoclonal antibodies (mAbs) can be functionally enhanced via Fc engineering. …”
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Tuning antibody stability and function by rational designs of framework mutations by Joseph C. F. Ng, Alicia Chenoweth, Maria Laura De Sciscio, Melanie Grandits, Anthony Cheung, Tooki Chu, Alexandra McCraw, Jitesh Chauhan, Yi Liu, Dongjun Guo, Semil Patel, Alice Kosmider, Daniela Iancu, Sophia N. Karagiannis, Franca Fraternali

“…This highlighted the effects of FW on immunological functions engendered in distal areas of the antibody, and the importance of considering attributes other than binding affinity when assessing antibody function. …”
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Effect of glucocorticoid treatment on ovarian morphology and function in experimental autoimmune oophoritis by T. V. Tupitsyna, O. A. Tikhonovskaya, S. A. Nevostruyev, M. L. Dmitrieva, S. V. Logvinov

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Antibody-independent functions of B cells during viral infections. by Vinit Upasani, Izabela Rodenhuis-Zybert, Tineke Cantaert

“…The humoral immune response and antibody-mediated functions of B cells during viral infections are well described. …”
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Effect of estradiol valerate on humoral immune function in BALB/c mice after total hysterectomy by Penghuan Chang, Hui Huang, Peijian Huang, Hongru Yi, Wenhua Zhong, Zhaoxin Yang

“…This study aimed to establish a total hysterectomy mouse model and investigate the effect of estradiol valerate on humoral immune function in BALB/c mice. …”
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HLA antibodies and their value during renal transplantation by M. Sh. Khubutia, N. V. Borovkova, R. V. Storozhev, N. V. Doronina, M. V. Storozheva, A. S. Pertsev, A. V. Pinchuk

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Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies by Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, Yuansheng Yang

“…Numerous T-bsAb formats have been developed, each with advantages and disadvantages in terms of developability, immunogenicity, effector functions, and pharmacokinetics. Here, we systematically compared T-bsAbs produced using eight different formats, evaluating the effect of molecular design of T-bsAbs on their manufacturability and functionality. …”
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Tat-specific antibodies associated with better HIV-associated motor function by Catarina E. Hioe, Clauvis Kunkeng Yengo, Xiaomei Liu, Reuben Davis, Gospel Enyindah-Asonye, Jéromine Klingler, Alex F. Tang, Juan C. Bandres, Anuradha Ganesan, Tahaniyat Lalani, Joseph Yabes, Brian K. Agan, Xiaokun Liu, David J. Volsky, Susan Morgello, Jessica Robinson-Papp

“…This disparity was evident in plasma and cerebrospinal fluid, and was also seen in early infection, before antiretroviral therapy. When the effects of antibodies on Tat function were evaluated, PWH plasma had no activity against Tat-induced transactivation, while Tat-immunized mouse and rabbit sera exhibited a potent inhibitory activity. …”
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Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI by Isabelle Pachmayr, Luciano A. Masullo, Susanne C. M. Reinhardt, Jisoo Kwon, Maite Llop, Ondřej Skořepa, Sylvia Herter, Marina Bacac, Christian Klein, Ralf Jungmann

“…Abstract Monoclonal antibodies (mAb) are key therapeutic agents in cancer immunotherapy and exert their effects through Fc receptor-dependent and -independent mechanisms. …”
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WCN24-2170 EFFECT OF DIFFERENT TREATMENT REGIMENS ON KIDNEY GRAFT FUNCTION AND MORTALITY IN PATIENTS WITH A DIAGNOSIS OF ANTIBODY MEDIATED REJECTION by Hugo Leonardo Reynoso de la Torre, Jorge Andrade Sierra, Ana Cristina Hernández Pugh, José Ignacio Cerrillos Gutierrez, Enrique Rojas Campos

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Photocatalyzed elaboration of antibody-based bioconjugates by Marine Le Stum, Eugénie Romero, Gary A. Molander

“…Antibody–drug conjugates (ADCs) represent a promising class of targeted therapeutics, combining the specificity of antibodies with the potency of cytotoxic drugs to enhance therapeutic efficacy while minimizing off-target effects. …”
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Cancer therapy via neoepitope-specific monoclonal antibody cocktails by Colin J. Hartman, Asmaa O. Mohamed, Girja S. Shukla, Stephanie C. Pero, Yu-Jing Sun, Roberto S. Rodríguez-Jimenez, Nicholas F. Genovese, Nico M. Kohler, Thomas R. Hemphill, Yina H. Huang, David N. Krag, Margaret E. Ackerman

“…We demonstrate proof-of-concept for a pipeline that supports rapid isolation and functional enhancement of multiple neoepitope peptide-targeted monoclonal antibodies and demonstrate their robust binding to B16F10 cells and potent effector functions in vitro. …”
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The effect of COVID-19 on the presentation of thyroid antibodies. Case report by Afrim Zeqiraj

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Fc-effector functional antibody assays for SARS-CoV-2 variants of concern by Xuemin Chen, Grace Li, Caroline Ciric, Theda Gibson, Larry J. Anderson, Larry J. Anderson, Christina A. Rostad, Christina A. Rostad

“…This study evaluated the effect COVID-19 XBB.1.5 booster vaccination on Fc-effector antibody responses to SARS-CoV-2.MethodsWe developed four assays to evaluate the Fc-effector functions of SARS-CoV-2 antibodies. …”
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The development of functional opsonophagocytic assays to evaluate antibody responses to Klebsiella pneumoniae capsular antigens by Robert Lawrence, Emma Bownes, Marina Johnson, Heather Fox, Drew Huff, Ivan Olave, Anup Datta, David Goldblatt, Nathalie Karaky

“…In order to evaluate natural immunity and assess the immunogenicity of novel vaccines, we set out to develop functional assays that effectively measure the immune response of K. pneumoniae anti-capsular antibodies in vitro. …”
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Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. by Kwok-Ho Lam, Jacqueline M Tremblay, Kay Perry, Konstantin Ichtchenko, Charles B Shoemaker, Rongsheng Jin

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High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions by André Luiz Lourenço, Shih-Wei Chuo, Markus F. Bohn, Byron Hann, Shireen Khan, Neha Yevalekar, Nitin Patel, Teddy Yang, Lina Xu, Dandan Lv, Robert Drakas, Sarah Lively, Charles S. Craik

“…Altogether, the strategy identified unique cross-reactive antibodies with ADCC, ADC, and functional inhibitory effects by targeting cell-surface uPAR, that can be tested in safety studies and serve as potential immunotherapeutics.…”
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Non-neutralizing monoclonal antibody targeting VP2 EF loop of Coxsackievirus A16 can protect mice from lethal attack via Fc-dependent effector mechanism by Ruixiao Du, Chaoqiang An, Xin Yao, Yiping Wang, Ge Wang, Fan Gao, Lianlian Bian, Yalin Hu, Siyuan Liu, Qiaohui Zhao, Qunying Mao, Zhenglun Liang

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Real-world clinical utility (effectiveness) of omalizumab as add-on therapy in patient with difficult-to-treat severe allergic asthma by Rowshne Jahan, Ziaul Huq

“…Its impact in Bangladeshi patients is unknown, and this study aimed to evaluate its effectiveness in improving lung function in severe allergic asthma (SAA) patients. …”
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