Evaluating the efficiency of teaching basic cardiopulmonary resuscitation among medical university students in Ukraine by H.Yu. Tsymbaliuk, A.M. Chervatiuk, V.O. Krylyuk

“…It is shown that to improve the quality of education and the confidence of students in their actions in future professional activities, it is critically necessary to add more simulation technologies and psychological preparation to avoid stress when providing assistance in real-life BCPR situations.…”
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Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability by Jiaao Su, Abdullah Hashsham, Nandan Kodur, Carla Burton, Amanda Mancuso, Anjan Singer, Jennifer Wloszek, Abigail J. Tomlinson, Warren T. Yacawych, Jonathan N. Flak, Kenneth T. Lewis, Lily R. Oles, Hiroyuki Mori, Nadejda Bozadjieva-Kramer, Adina F. Turcu, Ormond A. MacDougald, Martin G. Myers, Alison H. Affinati

“…Tetanus-toxin based chronic silencing and acute optogenetic activation were followed by analysis of hepatic glucose metabolism and white adipose tissue lipolysis. …”
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Environmental disease monitoring by regional Environmental Health Centers in Korea: a narrative review by Myung-Sook Park, Hwan-Cheol Kim, Woo Jin Kim, Yun-Chul Hong, Won-Jun Choi, Seock-Yeon Hwang, Jiho Lee, Young-Seoub Hong, Yong-Dae Kim, Seong-Chul Hong, Joo Hyun Sung, Inchul Jeong, Kwan Lee, Won-Ju Park, Hyun-Joo Bae, Seong-Yong Yoon, Cheolmin Lee, Kyoung Sook Jeong, Sanghyuk Bae, Jinhee Choi, Ho-Hyun Kim

“…During the initial phase (May 2007–February 2009), the 10 centers concentrated on research-driven activities, shifting from a media-centered to a receptor-centered approach. …”
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Anthocyanin-loaded complexes of glycated dual milk-derived proteins: thermal stability, storage stability, and simulated digestion by Shuangshuang Wang, Zhenzhu Li, Qingshuang Qiu, Huilin Lv, Haokun Zhang, Hang Wang, Rongzu Nie, Wupeng Ge, Peifeng Li

“…Anthocyanin (ACN) have attracted considerable scholarly attention owing to exceptional biological activities. Nonetheless, their limited stability and bioavailability present significant challenges to practical applications. …”
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Innovations in Medical Education in Gastrointestinal Surgery Using Interactive Anatomical Tables by A. D. Kashtanov, E. O. Stetsyk, S. S. Dydykin, O. V. Kytko, E. M. Trunin, O. Yu. Aleshkina, A. N. Lavrentieva, A. N. Andreeva, D. S. Alekseeva, A. A. Muratova, A. Yu. Kharina, V. V. Tatarkin, A. S. Sokolova, V. N. Filatov, I. L. Samodova, E. A. Makeeva, E. S. Pekeldina, M. Yu. Kapitonova, T. S. Bikbaeva, I. A. Polkovova, B. A. Volel, T. M. Litvinova, E. N. Dudnik, N. V. Kireeva, K. V. Ivashkin, Yu. L. Vasil’ev

“…At the end of classes on individual topics, participants completed exit testing, as well as a questionnaire.Results. The analysis of learning outcomes shows a significantly higher level of absorption of the material among students in groups where 3D anatomical models were used during classes. …”
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Exploring perceptions and awareness of artificial light: A qualitative study among medical and non-medical college students in an urban area of Southern India by Mithra Prasanna, Thapar Rekha, Mallya Ajay, Prabhakar Madhu Malar, Pandey Sonali, Agrawal Yash, Vats Anmol, Agarwal Shreya, Maurya Sarthak, Patel Sneha, Mohanty Marmit, Hooda Divya

“…Methodology: This qualitative analysis included two focus group discussions (FGD) conducted between April and May 2023. …”
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Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype by Xu Wu, Honglei Wang, Chenlong Li, Yaying Zhu, Qixuan Wang, Tianyu Zhang, Yaoyao Fu, Aijuan He

“…Nonetheless, how metabolic patterns shift during in vitro expansion, and whether metabolic modulation can stabilize the chondrocyte phenotype, remain insufficiently explored.To address these questions, we first utilized single-cell RNA sequencing combined with bulk transcriptomic analysis to profile the metabolic reprogramming of chondrocytes during in vitro expansion. …”
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The PhoR/PhoP two-component system regulates fengycin production in Bacillus subtilis NCD-2 under low-phosphate conditions by Qing-gang GUO, Li-hong DONG, Pei-pei WANG, She-zeng LI, Wei-song ZHAO, Xiu-yun LU, Xiao-yun ZHANG, Ping MA

“…Bacillus subtilis strain NCD-2 is an excellent biocontrol agent for plant soil-borne diseases, and the lipopeptide fengycin is one of the active antifungal compounds in strain NCD-2. The regulator PhoP and its sensor kinase PhoR compose a two-component system in B. subtilis. …”
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Natural product Erianin: mitigating FOLFOX toxicity and enhancing against colorectal cancer by Fuqin Yang, Zeqiao Li, Haishan Zhang, Mingxiao Zhang, Zhenwei He, Xiaoqin Zheng, Yingru Zhu, Pei Long, Ruirui Ding, Zhengbin Lin, Lijuan Deng, Lijuan Deng

“…In addition, the tumor size was significantly reduced in the combination group, and the expression of the apoptosis marker Cleaved Caspase-3 was up-regulated, and the proliferation markers Ki67/PCNA were down-regulated.DiscussionErianin can enhance the anti-CRC effect of FOLFOX, and mitigates FOLFOX-induced toxicity by activating the AKT1/mTOR pathway.…”
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Targeting STARD4/EGFR axis inhibits growth and overcomes lenvatinib resistance in hepatocellular carcinoma by Mengting Liu, Yixin Liu, Jiahui Zheng, Xiangping An, Jiayong Wen, Fengchi Zhu, Jin Jia, Dan Guo, Nana Chen

“…Moreover, cholesterol depletion attenuated these effects, suggesting STARD4 activates EGFR/PI3K/AKT signaling in a cholesterol-dependent manner. …”
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Improved longevity and in vivo performance of neurotransmitter detection using 30 µm cone-shaped carbon fiber microelectrode by Haeun Kwon, Hyun-U Cho, Jeongeun Sim, Kyung-Jun Boo, Kyung-Jun Boo, Yumin Kang, Sangmun Hwang, Youngjong Kwak, Jaehyun Jang, Kyung Min Kim, Se Jin Jeon, Chan Young Shin, Kevin E. Bennet, Kevin E. Bennet, Yoonbae Oh, Yoonbae Oh, Hojin Shin, Hojin Shin, Kendall H. Lee, Kendall H. Lee, Dong Pyo Jang, Dong Pyo Jang

“…Electrode longevity was assessed, and biocompatibility was evaluated via immunofluorescence analysis of brain tissue. In vitro, the 30 µm bare CFMEs showed 2.7-fold higher sensitivity (33.3 ± 5.9 pA/µm2, n = 5) compared to 7 µm CFMEs (12.2 ± 4.9 pA/µm2, n = 5). …”
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Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency by Yanquan Li, Feng Chen, Wei Zhao, Di Sun, Li Zhang, Rui Qiao, Qianhui Hu, Songmao Li, Boyuan Chen, Haixia Ding, Meiling Zhang, Qing Zhang, Fanghao Guo, Wen Li

“…ADSC-EVs are highly enriched in mRNA of Kit and PI3K, and both transcriptomic and proteomics enrichment analysis predominantly focused on PI3K/AKT pathway. …”
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Unveiling the influence of CAR-negative T-cells: enhancing efficacy and ensuring safety in CAR-T therapies by Belén Sierro-Martínez, Beatriz Guijarro-Albaladejo, Ricardo Fernández-Cisnal, Alfonso Rodríguez-Gil, Paola Hernández-Díaz, María de la Rosa-Garrido, Inmaculada Carrasco-Brocal, Maribel Lara-Chica, Virginia Escamilla-Gómez, Raquel Muñoz-García, Ángela Bella, Francisco Jose García-Cózar, Jose Antonio Pérez-Simón, Estefanía García-Guerrero

“…CAR-pos T cells exhibited increased expression of activation and exhaustion markers. Comparative analyses of CAR-pos and CAR-neg showed an increased cytotoxic effect in purified samples with 100% CAR-pos T cells compared to non-purified product. …”
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c-MET Inhibition Reverses the Osimertinib Resistance in Lung Circulating Tumor Cell Clusters and Suppresses Metastasis by Zhipeng Zhang, Xinyi Lu, Jianhui Tian, Jiaxuan Li, Shihui Liu, Jiajun Liu, Bin Luo, Jialiang Yao, Yao Liu, Yanhong Wang, Wang Yao, Yun Yang, Wenji Shangguan, Zujun Que

“…Methods Using the human lung adenocarcinoma CTC line CTC-TJH-01, we performed transcriptome analysis to identify differentially expressed genes. …”
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Circulating Hsp70: a tumor biomarker for lymph node metastases and early relapse in thoracic cancer by Dominik Lobinger, Nicholas Taylor, Verena Messner, Sophie Seier, Johannes Bodner, Erika Roberts, Ali Bashiri Dezfouli, Alan Graham Pockley, Seyer Safi, Gabriele Multhoff

“…It has also been shown that Hsp70 can be actively released into the circulation by mHsp70 positive, viable tumor cells in the form of extracellular lipid microvesicles expressing mHsp70, the levels of which might therefore act as a potential biomarker for tumor aggressiveness in lung malignancies. …”
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Risk Factors for Stiffness After Fixation of Tibial Tubercle Fractures: A Multicenter Study From the TITUS Group by Konstantin Brnjoš, MD, O. Folorunsho Edobor-Osula, MD, MPH, John S. Blanco, MD, Lindsay M. Crawford, MD, Dustin A. Greenhill, MD, FAOA, Alexander H. Griffith, BS, Neil K. Kaushal, MD, David M. Kell, BA, Abhi Rashiwala, MD, John A. Schlechter, DO, Evelyn S. Thomas, DO, Haley N. Tornberg, BS, Brendan A. Williams, MD, Neeraj M. Patel, MD, MPH, MBS

“…Persistent stiffness after operative treatment of tibial tubercle fractures (TTFs) can inhibit functional recovery and interfere with activities of daily living. Given the rare nature of this fracture, little data exist to help identify risk factors for this complication. …”
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Comparison of eight weeks of resistance training and high-intensity intermittent aerobic training on the expression of microRNAs associated with adipose tissue angiogenesis and ant... by Hamid Sadeghian, Marefat Siahkohian, Mohsen Akbarpour Beni, Lotfali Bolboli

“…Sampling of mesenteric adipose tissue was performed immediately after killing the animals. Data analysis was performed using independent t-test, one-way and two-way ANOVA at the significant level (P ≥ 0.05). …”
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The Monitoring of European Territorial Cooperation Projects in Italy: Critical Aspects and Innovative Solutions by Viviana Russo, Filippo La Vecchia, Agostina Rita Rocca, Simona Trento, Paolo Galletta

“…The second part of the present article is focused on the principal critical aspects of the monitoring activities. Playing its role as national authority for the implementation of ETC Programmes and thanks to the experience gained in the last years in the fields of data collecting and of reporting at national level, the Agency for Territorial Cohesion puts in evidence some difficulties affecting nowadays monitoring and assessment processes. …”
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Recent Sarcopenia Definitions‐Variability in Prevalence and Disability Associations in Peritoneal Dialysis Patients by Sasiwimon Meenetkum, Sarinya Boongird, Piyatida Chuengsaman, Sirinapa Songsrakaew, Sirarat Katesomboon, Kanda Sriudom, Prapimporn Chattranukulchai Shantavasinkul, Wisit Chaveepojnkamjorn, Jiraluck Nontarak, Chagriya Kitiyakara

“…Functional disability was assessed using the Barthel Activities of Daily Living (ADL) score. Associations with dependency were evaluated using multivariable logistic regression. …”
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Novel multimodal mechanical stimulation is superior to TENS to treat and prevent chronic low back pain: a randomized controlled trial by Amy Lynn Baxter, Amy Lynn Baxter, Jena L. Etnoyer-Slaski, Owen Tucker, Jessica Allia Rice Williams, Kevin Swartout, Lindsey L. Cohen, M. Louise Lawson

“…Exploratory analyses examined higher-severity subgroups, including those meeting NIH Research Task Force (RTF) criteria, obesity, longer pain duration, and an integrated analysis with common criteria for intractable inoperable mechanical cLBP.ResultsFor 44 aLBP and 115 cLBP participants [mean age 42.6, 54% female, BMI 30.9 (SD 6.19), NRS 5.51 (SD 2.15)], M-Stim was noninferior to TENS for initial and 10-day relief. …”
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