Multimodal data integration for biologically-relevant artificial intelligence to guide adjuvant chemotherapy in stage II colorectal cancerResearch in context by Chenyi Xie, Ziyu Ning, Ting Guo, Lisha Yao, Xiaobo Chen, Wanghong Huang, Suyun Li, Jiahui Chen, Ke Zhao, Xiuwu Bian, Zhenhui Li, Yanqi Huang, Changhong Liang, Qingling Zhang, Zaiyi Liu

“…Given the heterogeneity of stage II CRC, we aimed to develop a clinically explainable artificial intelligence (AI)-powered analyser to identify radiological phenotypes that would benefit from chemotherapy. …”
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AAV-mediated transduction of songbird retina by Pranav Kumar Seth, Pranav Kumar Seth, Dominik Heyers, Dominik Heyers, Baladev Satish, Ezequiel Mendoza, Katrin Haase, Lisa Borowsky, Isabelle Musielak, Karl-Wilhelm Koch, Karl-Wilhelm Koch, Regina Feederle, Constance Scharff, Karin Dedek, Karin Dedek, Henrik Mouritsen, Henrik Mouritsen

“…Resultantly, developments of recombinant viral vectors with improved transduction efficiency and further methodological improvements have mostly focused on murine tissue, whereas AAVs successfully targeting avian retinae have remained scarce.MethodologyUsing a custom-designed injection setup, we identified a viral serotype with the capability to successfully induce widespread transduction of the bird retina.ResultsIntravitreal administration of an AAV type 2/9 encoding for enhanced green fluorescent protein (EGFP) in night-migratory European robins (Erithacus rubecula) resulted in transduction coverages of up to 60% within retinal tissue. Subsequent immunohistochemical analyses revealed that the AAV2/9-EGFP serotype almost exclusively targeted photoreceptors: rods, various single cones (UV, blue, green, and red cones), and both (accessory and principal) members of double cones.DiscussionThe consistently high and photoreceptor-specific transduction efficiency makes the AAV2/9 serotype a powerful tool for carrying out genetic manipulations in avian retinal photoreceptors, thus opening a wealth of opportunities to investigate physiological aspects underlying retinal processing in birds, such as physiological recordings and/or post-transductional behavioural readouts for future vision-related research.…”
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Using natural experiments to evaluate population health interventions: a framework for producers and users of evidence by Peter Craig, Mhairi Campbell, Manuela Deidda, Ruth Dundas, Judith Green, Srinivasa Vittal Katikireddi, Jim Lewsey, David Ogilvie, Frank de Vocht, Martin White

“…Clearly report the natural experiment event and all stages of the evaluation, including its planning, protocol, analyses and results, using established reporting standards where available ensuring key details are in plain language appropriate for the evidence users. …”
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Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an... by Mansoor Saleh, Reena Shah, Linda Moranga, Ann Karanu, Jasmit Shah, Viviane Oluoch, Henry Karanja, Alfred Mburu, Julius Mutiso, Peter Betti, Daisy Mugo, Zaitun Nneka, Abdirahman Issak Abdi, Wanzila Usyu Mutinda, George M.Warimwe, Lynette Isabella Ochola-Oyier, James Nyagwange, Yiakon Sein, Francis M. Ndungu, Bernadette Kutima, John N. Gitonga, Philip Bejon, Perpetual Wanjiku, Eunice W. Nduati, Jedidah Mwacharo, Kennedy Mwai, Shahin Sayed, John Kimotho

“…Background Given the low levels of coronavirus disease 2019 (COVID-19) vaccine coverage in sub-Saharan Africa (sSA), despite high levels of natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exposures, strategies for extending the breadth and longevity of naturally acquired immunity are warranted. …”
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Ethics of Procuring and Using Organs or Tissue from Infants and Newborns for Transplantation, Research, or Commercial Purposes: Protocol for a Bioethics Scoping Review [version 1;... by Sebastian Porsdam Mann, Joe Brierley, Jerry Menikoff, Trung Nguyen, Brian D. Earp, Dominic Wilkinson, Julian Savulescu, Xiu Lim, Maide Barış, David Shaw, Melanie T Almonte

“…The extracted data will then be analysed descriptively through qualitative content analysis. …”
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LGBT Actors, Ritual and Martial Arts Groups, and State-Building in Post-Conflict Timor-Leste by Lili Chen, Laura Sjoberg

“…We see, both through our observations and through our interviewees’ eyes, more complexity in and around sex and gender roles and sexed and gendered agency than most media or even scholarly coverage of RAGs and MAGs captures. We suggest that these complexities are meaningful not only for the participation of LGBT members in RAGs and MAGs but also for thinking about what those organisations are and how they work. …”
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The implementation of Safety Management Systems in healthcare: a systematic review and international comparison by Zhivko Zhelev, Sian de Bell, Alison Bethel, Maria Clarke, Rob Anderson, Jo Thompson Coon

“…We included only high-income countries that have publicly funded healthcare systems with universal coverage, as the evidence from such countries is most relevant to the UK context. …”
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Telejornalismo cidadão entre a promessa e a efetivação by Marco Aurelio Reis, Cláudia de Albuquerque Thomé, Elias Arruda, Rafael Otávio Dias Rezende

“…Ce travail répertorie et analyse diverses initiatives qui se présentent comme des exemples de journalisme télévisé citoyen, en explorant plusieurs modalités. …”
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Municipal breast and colorectal–anal cancer mortality in Sardinia, Italy from 2012 to 2020: application of a hierarchical Bayesian method by Laura Maria Beatrice Belotti, Emilio AL Gianicolo, Antonello Russo

“…Causes of death for malignant breast cancer in women and colorectal–anal cancer in both genders were analysed. The epidemiological analysis was based on the direct and indirect standardisation method. …”
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La importancia de la mapificación de los ecosistemas y sus servicios para la planificación urbana = The importance of mapping ecosystems and ecosystem services in urban planning by Cordoba Hernández Rafael

“…The evolution of the characterisation of the territory is analysed based on the different coverages that five European mapping projects such as CORINE Biotopes, CORINE Land Cover, EUNIS, MAES and SIOSE from an ecosystemic point of view.…”
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