hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke by Zengyu Zhang, Rong Ji, Zhuohang Liu, Zhiwen Jiang, Min Chu, Yong Wang, Jing Zhao

“…Conclusions Our findings delineate a novel HMGB1-TREM1-p38 MAPK axis through which hUMSC-Exos mitigate post-stroke neuroinflammation. By delivering HMGB1, hUMSC-Exos inhibit TREM1-dependent NF-κB/p38 activation, reprogram microglial function, and confer neuroprotection. …”
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Effectiveness of Low‐Cost, Virtual Sexual Health Education and Educational Leaflets on Reducing Anxiety and Enhancing Sexual Function Among Infertile Women: A Pilot Randomized Cont... by Mahdiyeh Karimi, Fatemeh Heshmatnia, Sara Azima, Marzieh Akbarzadeh, Subash Thapa

“…ABSTRACT Background and Aims Anxiety is one of the common mental illnesses affecting sexual functions among infertile women. Information and education interventions might be effective in facilitating their coping with anxiety disorder which lead to improved sexual functions and psychological wellbeing. …”
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Balance Improvement and Fall Risk Reduction in Stroke Survivors After Treatment With a Wearable Home-Use Gait Device: Single-Arm Longitudinal Study With 1-Year Follow-Up by Brianne Darcy, Lauren Rashford, David Huizenga, Kyle B Reed, Stacy J M Bamberg

“…Previous research with the iStride gait device (Moterum Technologies, Inc) showed that functional balance improved immediately following 4 weeks of treatment. …”
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Single-center experience in kidney transplantation: outcomes, conclusions, and perspectives by M. Sh. Khubutia, I. V. Dmitriev, A. G. Balkarov, Yu. A. Anisimov, N. V. Shmarina, N. V. Zagorodnikova, N. V. Borovkova, M. G. Minina, D. V. Lonshakov, V. O. Aleksandrova, V. Smirnova, A. U. Rustambek

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Combining a guided self-help and brief alcohol intervention to improve mental health and reduce substance use among refugee men in Uganda: a cluster-randomized feasibility trial by M. Claire Greene, Lena S. Andersen, Marx R. Leku, Teresa Au, Josephine Akellot, Nawaraj Upadhaya, Raymond Odokonyero, Ross White, Peter Ventevogel, Claudia Garcia-Moreno, Wietse A. Tol

“…Participant outcome measures, including symptoms of psychological distress, functional impairment, self-defined problems, depressive symptoms, post-traumatic stress symptoms, overall substance use risk, substance specific risk (alcohol, cannabis, stimulants and sedatives) and well-being, were sensitive to change. …”
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‘Time is of the essence’: upper-body aerobic exercise to improve cardiovascular health during inpatient rehabilitation within the first year following spinal cord injury – protocol... by Samuel J E Lucas, Tom E Nightingale, Naveen Kumar, Shin-Yi Chiou, Afroditi Stathi, Manish Kalla, Daniel D Hodgkiss, Shane J T Balthazaar, Aheed E F Osman, Srinivasa C Budithi, Joy Roy Chowdhury

“…While general exercise guidelines are promoted for SCI individuals, when and how to incorporate exercise during the subacute phase post-SCI remains unclear. Consequently, early aerobic exercise to reduce CVD risks is not standard practice in subacute SCI care, potentially missing an opportunity for optimal cardiovascular rehabilitation, especially given observed reductions in cardiac structure and function within the first year post-SCI. …”
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The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized para... by Yuan Wen, Yuanyuan Zhang, Qingquan Lv, Weiqun Lan, Yi Shu, Qiuhuan Qi, Hongping Hu, Othman Zakaria Saleh

“…This regimen has demonstrated its ability to enhance the clinical therapeutic effect, reduce the total load of myocardial ischemia, improve pulmonary function indices and cardiac function, and decrease the incidence of cardiovascular adverse events. …”
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Recidivism, health and social functioning following release to the community of NSW prisoners with problematic drug use: study protocol of the population-based retrospective cohort... by Reem Zeki, James Brown, Elizabeth Sullivan, Stephen Ward, Sarah Wayland, Juanita Sherwood, Alex Wang, Faye Worner, Sacha Kendall, Sungwon Chang

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Global Trends in the Relationship Between Chronic Air Pollution Exposure, Physical Activity and Lung Function in Youth Aged 5–18 Years With and Without Asthma: A Systematic Review... by Samanta Gudziunaite, Kelly A. Mackintosh, Gwyneth A. Davies, Kathryn A. Jordan, Paul D. Lewis, Chris J. Griffiths, T. Alexander Swain, Melitta A. McNarry

“…Notably, there was a reduction in FEV1 at both three- and four-days post-exposure to CO, PM10, and NO2. Conclusions There is a pressing need to reduce the impact of air pollution on lung function to improve health and realise the full benefits of physical activity. …”
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Angiotensin-(1-7) Provides Potent Long-Term Neurorepair/Neuroregeneration in a Rodent White Matter Stroke Model: Nonarteritic Ischemic Optic Neuropathy (rNAION) by Kwang Min Woo, Yan Guo, Zara Mehrabian, Thomas Walther, Neil R. Miller, Steven L. Bernstein

“…ONs were histologically examined for inflammation. Ang-(1-7) improved post-rNAION visual function. Ang-(1-7)-treated animals showed improved visual acuity (ANCOVA: <i>p</i> = 0.0084) and improved fVEP amplitudes (ANCOVA: <i>p</i> = 0.0378) vs vehicle controls. …”
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Effects of inspiratory muscle training on respiratory function, diaphragmatic thickness, balance control, exercise capacity and quality of life in people after stroke: A randomized... by Fang Liu, Alice Y M Jones, Raymond C C Tsang, Timothy T T Yam, William W N Tsang

“…<h4>Background</h4>Stroke is associated with diaphragmatic weakness and impaired respiratory function as well as balance impairment. The role of inspiratory muscle training (IMT) on improvement of respiratory muscle strength in people after stroke has been reported. …”
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Microbiological hazards associated with the use of water in the post‐harvest handling and processing operations of fresh and frozen fruits, vegetables and herbs (ffFVH). Part 2 – A... by EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Lapo Mughini‐Gras, Maarten Nauta, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Jen Banach, Bin Zhou, Maria Teresa daSilva Felício, Laura Martino, Winy Messens, Angela Botteon

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The effect of active release versus ischemic pressure techniques in pain, range of motion, function, and pressure pain threshold on females with piriformis syndrome: a randomised c... by Aya A. Zaghlol, Wadida H. Elsayed, Ahmad H. Azzam, Mariam O. Grase

“…Conclusions The addition of ART or IPT to conventional physical therapy in females with active piriformis trigger points reduces pain intensity, increases internal rotation of the hip, and improves lower extremity functional ability.…”
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New collaborative DDoS defense technology based on NFV by Chuanfeng XU, Hui LIN, Xuancheng GUO, Xiaoding WANG

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The Potential Effects of Sensor-Based Virtual Reality Telerehabilitation on Lower Limb Function in Patients with Chronic Stroke Facing the COVID-19 Pandemic: A Retrospective Case-C... by Mirjam Bonanno, Maria Grazia Maggio, Paolo De Pasquale, Laura Ciatto, Antonino Lombardo Facciale, Morena De Francesco, Giuseppe Andronaco, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò

“…Conclusions: In our study, we highlighted the potential role of sensor-based virtual reality TR in chronic stroke patients for improving lower limb function, suggesting that this approach is feasible and not inferior to conventional home-based rehabilitation.…”
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Evaluation of Integrated Arterial Filter Oxygenator vs. External Arterial Filters on Clinical Outcomes and Neurocognitive Function in Pediatric Cardiac Surgery: A Prospective Rando... by Vishal Vinayak Bhende, Mathangi Krishnakumar, Dushyantkumar Mukundbhai Parmar, Arunkumar Ghanshyambhai Rudakiya, Tanishq Shashikant Sharma, Amit Kumar, Paresh Dilip Nerurkar, Saptak Piyush Mankad, Mamta Roshan Patel

“…Neurological complications post‐cardiac surgery can result from reduced cerebral blood flow, embolic materials, and other factors, including anesthesia. …”
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Clinical efficacy and regulatory mechanisms of Shi Pi Zeng Ye formula in treating functional constipation comorbid with depression: integrating clinical observation, mass spectrome... by Ling Yao, Xiaoqiang Jia, Yufei Li, Haixia Li, Zhuhui Zhang, Longfang Quan, Qiuling Liu, Jie Dai, Xuedi Lei, Huashang Li, Yonghai Li

“…Assessments were conducted at baseline, 4 weeks, and 12 weeks post-treatment. The study also explored the action mechanisms of SPZY through mass spectrometry, network pharmacology, and molecular docking to ascertain the binding affinities of SPZY’s active components to critical targets.ResultsThe study findings indicated significant improvements in WCS (p &lt; 0.0001), HAMD-17 (p &lt; 0.0001), PAC-QOL (p &lt; 0.0001), and HAMA (p &lt; 0.001) scores from baseline to 3 months. …”
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The Effect of Cerebellar Vermal rTMS with TBS Paradigm on Negative Symptoms, Cognitive Function and Serum Inflammatory Factors in Elderly Patients with Chronic Schizophrenia: a Ran... by DONG Xiaomei, ZHAO Hongyan, GENG Zhongli, XU Tianchao, WANG Qi

“…Background The cerebellar vermis is closely related to emotional regulation and cognitive function. There have been few reports on whether repeated transcranial magnetic stimulation (rTMS) of the cerebellar vermis can improve clinical symptoms in elderly patients with chronic schizophrenia (CSZ) . …”
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Shifting from postauricular to transcanal microscopic tympanoplasty may have similar frequency-specific improvements with better air-bone-gap closure at low frequencies and a minim... by Ethan I Huang, Yu-Chieh Wu, Hsiu-Mei Chuang, Tzu-Chi Huang

“…The further analyses on gap change as a function of frequency (0.5, 1, 2, and 4k Hz) show that both of postauricular and transcanal tympanoplasties improved postoperative air-bone gap among the levels of frequency. …”
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Train-your-brain pilot community-based intervention after stroke: cognitive trajectory over 10-month follow-up by Nicole Yun Ching Chen, Xiang Cong Tham, Yanhong Dong, Yanhong Dong

“…Free recall and category-cued recall deteriorated over 10 months, while multiple-choice format recall remained stable. A slight improvement was observed in SDMT scores from pre-TYB to post-TYB, which was relatively maintained after 10 months. …”
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