FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgeryResearch in context by Marie Patt, Isabel Karkossa, Laura Krieg, Lucas Massier, Kassem Makki, Shirin Tabei, Thomas Karlas, Arne Dietrich, Martin Gericke, Michael Stumvoll, Matthias Blüher, Martin von Bergen, Kristin Schubert, Peter Kovacs, Rima M. Chakaroun

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Evaluation of the efficacy of integrating digital therapeutics with home-based cardiac rehabilitation on cardiovascular health in high-risk post-PCI patients (DTx-HBCR): Study prot... by Shuangliang Ma, Zhongxiu Chen, Junyan Zhang, Jiani Liu, Lin Xu, Baotao Huang, Mingang Zhou, Hua Wang, Yong Chen, Mian Wang, Chen Li, Yong He

“…Outcome assessments will be conducted at baseline and at 3, 6, and 12 months post-randomization. The primary outcome is the between-group difference in functional capacity at 6 months, assessed by the 6-minute walk test. …”
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Effects of repetitive transcranial magnetic stimulation on learning and memory cognitive function in rats with vascular cognitive impairment and its neural induction mechanism by Jiati Wang, Huan Gao

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Major ozonated autohemotherapy promoted functional recovery following spinal cord injury in adult rats via the inhibition of oxidative stress and inflammation by Xia Liwei, Sun Yongming, Zhou Yue, Yang Qian, Huang Jianhan, Liu Dong

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Where there is no nurse: an observational study of large-scale mentoring of auxiliary nurses to improve quality of care during childbirth at primary health centres in India by Swati Srivastava, Krishna D Rao, Nicole Warren, Kaveri Mayra, Aboli Gore, Aritra Das, Saifuddin Ahmed

“…This study examines if a long-term mentoring programme improved the ability of auxiliary nurse-midwives (ANMs), who function as paramedical community health workers, to provide quality care during childbirth, and how they compared with staff nurses.Design Quasi-experimental post-test with matched comparison group.Setting Primary health centres (PHC) in the state of Bihar, India; a total of 239 PHCs surveyed and matched analysis based on 190 (134 intervention and 56 comparison) facilities.Participants Analysis based on 335 ANMs (237 mentored and 98 comparison) and 42 staff nurses (28 mentored and 14 comparison).Intervention Mentoring for a duration of 6–9 months focused on nurses at PHCs to improve the quality of basic emergency obstetric and newborn care.Primary outcome measures Nurse ability to provide correct actions in managing cases of normal delivery, postpartum haemorrhage and neonatal resuscitation assessed using a combination of clinical vignettes and Objective Structured Clinical Examinations.Results Mentoring increased correct actions taken by ANMs to manage normal deliveries by 17.5 (95% CI 14.8 to 20.2), postpartum haemorrhage by 25.9 (95% CI 22.4 to 29.4) and neonatal resuscitation 28.4 (95% CI 23.2 to 33.7) percentage points. …”
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Ipsilateral Autologous Peroneus Longus and Bone Patellar Tendon Graft for Revision Anterior Cruciate Ligament Reconstruction Leads to Similar Functional Outcome by Vivek Kumar Gupta, Harish Mahesan, Vignesh Murali, Parthiban Jeganathan, Suresh Perumal, Arumugam Sivaraman

“…There was not a significant difference in the two groups’ functional results at follow-up, although both groups’ functional outcomes improved and all patients recovered to their pre-injury activity level. …”
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Early experience with percutaneous photodynamic nails for sacral metastatic disease and insufficiency fractures: a retrospective cohort analysis of functionality and pain relief by Marilee J. Clunk, Marcos R. Gonzalez, Sonia E. Ubong, Alisha Sodhi, Joseph O. Werenski, Hayley M. Denwood, Daniel G. Tobert, Santiago A. Lozano-Calderon

“…Primary outcomes included post-operative complications, pain relief, opioid consumption, and function. …”
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Effect of acute hyperglycemia on left ventricular contractile function in diabetic patients with and without heart failure: two randomized cross-over studies. by Roni Nielsen, Helene Nørrelund, Ulla Kampmann, Hans Erik Bøtker, Niels Møller, Henrik Wiggers

“…Indices of increased myocardial systolic contractile function were significant in both T2D-HF (Vmax: 14%, p = 0.02; S'max: 10%, p = 0.04), T2D-nonHF (Vmax: 12%, p<0.01; S'max: 9%, p<0.001) and in post exercise S'max (7%, p = 0.049) during hyperglycemia as opposed to normoglycemia. …”
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Impact of Long‐Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function Using 31P/1H MRS and MRI by Antoine Naëgel, Magalie Viallon, Hélène Ratiney, Thu Nguyen, Benjamin Leporq, Djahid Kennouche, Thomas Grenier, Franziska Grundler, Robin Mesnage, Jean‐Michel Guy, Robin Schultze, Françoise Wilhelmi de Toledo, Pierre Croisille

“…Mitochondrial oxidative capacity and PCr resynthesis rates in muscle were maintained. Females improved their mitochondrial function by D + 12, with τPCr decreasing to 29.61 s (p < 0.01), surpassing males and demonstrating better fat oxidation capabilities. …”
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Acceptability of the content and functionality of a just-in-time adaptive intervention for gambling problems: a mixed-methods evaluation of gambling habit hacker by S. N. Rodda, S. S. Merkouris, C. J. Greenwood, A. C. Thomas, D. I. Lubman, N. A. Dowling

“…Qualitative and quantitative findings suggest future optimisation should include customising the timing and frequency of EMAs and adopting a hybrid push–pull approach to intervention delivery. Functionality improvements could also include the ability to save and adjust action plans in real time to enhance responsiveness in high-risk situations. …”
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Development of Bioactive Cotton, Wool, and Silk Fabrics Functionalized with <i>Origanum vulgare</i> L. for Healthcare and Medical Applications: An In Vivo Study by Aleksandra Ivanovska, Anica Petrović, Tamara Lazarević-Pašti, Tatjana Ilic-Tomic, Katarina Dimić-Mišić, Jelena Lađarević, Jovana Bradić

“…This tunable fabrics’ OE release profile, along with their unique bioactivity, supports targeted applications: OE-functionalized silk for luxury or prolonged therapeutic use (skin-care textiles, post-surgical dressings, anti-aging products), cotton for disposable or short-term use (protective wipes, minor wound coverings), and wool for wound dressings. …”
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Melatonin Implantation Improves the Reproductive Performance of Estrus-Synchronized Ewes During Seasonal Anestrus and Enhances the Antioxidant and Steroidogenic Capacities of Granu... by Zengyi Duan, Menghao Liu, Junjin Li, Kexiong Liu, Qi Qi, Zhixuan Yu, Hadia Akber Samoo, Chunxin Wang, Jian Hou

“…The results demonstrated that MT implantation significantly improved serum levels of total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px), increased post-ovulatory luteal diameter and serum P4 levels, and reduced ovarian apoptosis. …”
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Effects of high-intensity interval training on executive functions and IGF-1 levels in sedentary young women: a randomized controlled trial by Manuel Jesús Jimenez-Roldán, Borja Sañudo Corrales, Luis Carrasco Páez

“…Working memory improvements (DST-B) were significant over time, especially in the HIIT group, but again without significant differences between groups.ConclusionA 12-week HIIT program, with or without increased daily physical activity, can lead to improvements in executive functions in sedentary young women, particularly in working memory and cognitive flexibility. …”
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Comparative effects of dry needing and cross friction massage on pain, mobility and functional status in plantar fasciitis: a randomized clinical trial by Kashaf Ziaullah, Saleh Shah, Muhammad Naveed Babar, Javaria Sharif, Kashan Ahmed, Faiza Gulzar, Fatima Chaudhry

“…Both groups showed significant improvements in pain, mobility, and functional status post-intervention (p =0.001 for PSPF, FHSQ, and FFI). …”
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Does syndesmotic fixation technique impact complication rates and functional outcomes measured by PROMIS scores following operative repair of ankle fractures? by Steven M. Hadley, Rachel Bergman, John J. Peabody, Sarah J. Westvold, Ryan Filler, Muhammad Mutawakkil, Milap Patel, Anish R. Kadakia

“…While this study was underpowered to detect differences in PROMIS, improved PROMIS for SB and STA vs. screws suggest that these techniques may result in better functional outcomes compared to screws.…”
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Effects of vibration therapy with routine physical therapy on pain, balance, and functional disability in diabetic neuropathy patients: a randomised controlled trial by Sajawal Bashir, Ayesha Jamil, Sarwat Ali

“…Intragroup improvements post-intervention were significantly better compared to baseline values (p<0.05). …”
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Transient decline and early recovery of noninvasive myocardial work after kidney transplantation: a prospective study by Yulin Huang, Lin Jin, Xinyan Qiu, Canying Yang, Luyi Ping, Zhengyao Jiang, Hua Zou, Zhihong Zhang, Jiwei Wang

“…Changes in clinical variables, laboratory data, routine transthoracic echocardiography, and noninvasive myocardial work (NIMW) were analyzed at pre-KT, 10 days, and 3 months post-KT. NIMW parameters include global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE).Results 1) Renal function indicators, including blood urea nitrogen, serum creatinine, and estimated glomerular filtration rate improved significantly at 10 days post-KT. …”
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Infarct exclusion repair of postmyocardial infarction ventricular septal rupture with a hybrid patch and septal occluder device compared with patch onlyCentral MessagePerspective by Adam R. Williams, MD, Mary E. Moya-Mendez, MS, MHS, Sachin Mehta, MD, Andrew Vekstein, MD, J. Kevin Harrison, MD, Carmelo A. Milano, MD, Ryan P. Plichta, MD, John Haney, MD, Jacob N. Schroder, MD, Brittany Zwischenberger, MD, Donald Glower, MD, Jeffrey G. Gaca, MD

“…Tricuspid annular systolic excursion and RV:left ventricle diameter ratio, quantitative metrics of RV function, improved after patch/SOD repair. No intraoperative mortality occurred in either group. …”
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Comparative mid-term evaluation of unilateral and bilateral total knee arthroplasty utilizing metal-backed components: An assessment of functional and clinical outcomes by Ponnanna Karineravanda Machaiah, Supreet Bajwa, Ravi Teja Rudraraju, Kunal Aneja, Haresh P. Bhalodiya, Rakesh Kumar Singh, Vividh Makwana, Avtar Singh, Vivek Logani, Buddhadev Chatterjee, Devendra S. Solanki, Hemant Wakankar, Sanjeev Mahajan, Chandra-Shekhar Yadav, Ashokkumar Thakkar, Udita Chandra, Sanaa Ansari, Shivadharshni Sivakumar

“…Objective: This prospective, post-marketing surveillance (PMS) study (Freedom 400) aimed to evaluate the clinical and functional outcomes of both unilateral and bilateral total knee arthroplasty (TKA) utilizing cruciate retaining/posterior stabilized (CR/PS) implants with metal-backed components (MBC). …”
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Analysis of urinary function and prostate volume changes in localized prostate cancer patients treated with carbon-ion radiotherapy; a prospective study by Yoshiyuki Miyazawa, Hiroshi Nakayama, Hidemasa Kawamura, Yuhei Miyasaka, Masahiro Onishi, Takuya Kaminuma, Yoshitaka Sekine, Hiroshi Matsui, Tatsuya Ohno, Kazuhiro Suzuki

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