Is there an alternative to diclofenac i/m injections for rapid relief of severe pain? Results of randomized controlled and partially blind forsage study by A. E. Karateev, E. Yu. Pogozheva, E. S. Filatova, A. M. Lila, V. N. Amirdjanova, V. A. Nesterenko

“…Final assessment in the morning on day 4 showed significant pain reduction by 4.5±2.6 cm VAS in Group 1 vs baseline, and by 3.6±1.4 cm VAS in Group 2 (p=0.545). Functional improvement in both groups reached 3.7±1.9 and 3.3±1.3 cm VAS, respectively (p=0.837). …”
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Postgraduate Clinical Residency: The Impact of Multiple-Choice Question Quality on Exam Success Rates by Mohammed OEAH, Srinivasamurthy SK, Bhat R, Alhassan YAM, Hamdy Elshamly HA, Mohammed F, Hamad B

“…MCQs were evaluated using standard item analysis parameters: questions were considered acceptable range if they had a difficulty index (DIF) between 0.30– 0.70, a discrimination index ≥ 0.2, and at least two functioning distractors.Results: Out of 175 candidates who appeared for the QRE, only 19 (10.86%) passed. …”
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Effect of low-intensity resistance training at different levels of blood flow restriction on pain, proprioception and muscle strength in patients with knee osteoarthritis: a random... by Yongjie Li, Shenyu Fu, Dakuan Zhang, Mengling Liu, Hongju Liu

“…Abstract Background Low-intensity resistance training(LIRT) combined with blood flow restriction(BFR) has significant potential for promoting functional recovery in patients with knee osteoarthritis(KOA). …”
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Efectos de seis semanas de entrenamiento isoinercial sobre la capacidad de salto, velocidad de carrera y equilibrio postural dinámico (Effects of six weeks of isoinertial training... by Eric Sáez-Michea, Miguel Alarcón-Rivera, Pablo Valdés-Badilla, Eduardo Guzman Muñoz

“…Keywords: strength training; muscular strength; motor skills; Postural control; functional physical performance. …”
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The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study by Daniel Uher, Gerhard S. Drenthen, Christianne M. Hoeberigs, Rick H.G.J. van Lanen, Albert J. Colon, Roy A.M. Haast, Vivianne H.J.M. van Kranen-Mastenbroek, Guido Widman, Paul A.M. Hofman, Louis G. Wagner, Jan C. Beckervordersandforth, Jacobus F.A. Jansen, Olaf E.M.G. Schijns, Walter H. Backes

“…This case study illustrates that advanced image processing of ultra-high field structural and resting-state functional MRI scans may enhance the detection of subtle epileptogenic lesions in presurgical evaluation, potentially improving post-operative seizure outcome and associated quality of life.…”
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Multi‐omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development by Mengxue He, Dongxue Wang, Yong‐Jiang Xu, Jiachen Shi, Aiyang Liu, Xiaoxi Zhao, Yunlai Gao, Yuan He, Yu Zhang, Ru‐Xing Wang, Yuanfa Liu

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A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…Linear mixed-effects models determined significant improvements in PHQ-9 and GAD-7 scores for participants across both conditions (ps < 0.001). …”
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History and development direction of iterative upgrading of deep coalbed methane reservoir reconstruction technology：Taking the Daji Block in the eastern margin of the Ordos Basin... by Fengyin XU, Huaibin ZHEN, Shuguang LI, Feng WANG, Lei ZHANG, Yubin WANG, Weichu YU, Weiping ZHU, Borui XU, Yun YANG, Haifeng ZHAO, Kunsen BAI

“…Practical application of finely tailored fracturing designs based on geological characteristics has yielded remarkable results.However, the paper identifies five key challenges and areas for improvement in deep coal reservoir stimulation: High water consumption and difficulties in managing flowback fluids during ultra-large-scale fracturing; The need for breakthroughs in intelligent fracturing technologies; Immaturity of collaborative fracturing methods; The urgent requirement to establish fracturing technology systems for deep, medium-to-low-rank coal seams; Incomplete functionality of fracturing fluids.To address these challenges, six development directions are proposed:① Advancing water-reducing fracturing techniques; ② Conducting research on fishbone horizontal wells combined with matrix acidizing for large-scale water-reduction and production enhancement; ③ Expanding the application of artificial intelligence in intelligent fracturing and post-fracturing evaluation; ④ Developing and implementing collaborative fracturing techniques to optimize well-to-fracture network integration; ⑤ Strengthening research and development and application of stimulation technologies for deep, medium-to-low-rank coal reservoirs; ⑥ Innovating new fracturing materials to further reduce costs, improve efficiency, and enhance recovery rates for deep CBM.…”
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Building Emotional Awareness and Mental Health (BEAM): study protocol for a hybrid implementation-effectiveness trial of the BEAM app-based program for parents with clinical mental... by Kaeley M. Simpson, Robert J. W. McHardy, J. Grace Zhou, Sydney Levasseur-Puhach, Cynthia M. Côté, Millie Braun, Fiona Clement, Anna L. MacKinnon, Nathan Nickel, Tracie O. Afifi, Gerald F. Giesbrecht, Ryan Giuliano, Laurence Y. Katz, Lauren E. Kelly, Terry P. Klassen, Catherine Lebel, Aislin Mushquash, Kristin Reynolds, Elizabeth Decaire, Wajihah Mughal, Frances Chartrand, Olena Kloss, Jennifer M. Hensel, James M. Bolton, Jo Ann M. Unger, Mandy Archibald, Philip Fisher, Ashley Pharazyn, Lianne Tomfohr-Madsen, Leslie E. Roos

“…Assessments of parent and child mental health symptoms will occur at pre-test before BEAM begins (T1), immediately after the last week of the BEAM intervention (post-test, T2), 6-month follow-up (T3), and 12-month follow-up (T4). …”
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A social media listening study of patients’ experiences relating to metabolic dysfunction-associated steatotic liver disease: The LISTEN-MASLD study by Jeffrey V. Lazarus, William Alazawi, Ron Basuroy, Laurent Castera, Dmitry Estulin, Yiannoula Koulla, Preethy Prasad, Manuel Romero-Gomez, Hirokazu Takahashi, Vincent Wai-Sun Wong, Jörn M. Schattenberg

“…An emotional analysis revealed that patients were worried and frustrated about their condition but were also hopeful and determined to improve their health. Nearly 38 % of the posts mentioned that patients were emotionally affected by negative feelings, especially those with multiple comorbidities. …”
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Expression Profile of Human Cytomegalovirus <i>UL111A</i> cmvIL-10 and LAcmvIL-10 Transcripts in Primary Cells and Cells from Renal Transplant Recipients by Giovana W. C. Almeida, Martha T. Oliveira, Isabella G. L. Martines, Giuliano C. Fiori, Michael M. Nevels, Ian J. Groves, John Sinclair, José Medina-Pestana, Rayra Sampaio da Silva, Monica Nakamura, Lucio Requião-Moura, Emma Poole, Maria C. Carlan da Silva

“…Other isoforms are produced (C to H) but have unknown functions. Here, we investigated the expression of the most abundant transcripts, cmvIL-10 and LAcmvIL-10, in productively and latently infected cells and in peripheral blood mononuclear cells from renal transplant recipients up to 60 days post-transplantation. …”
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Construction and validation of frailty risk prediction model in elderly patients with colorectal cancer by Yuxiao Xia, Mengzhang He, Yiqun Guo, Fenghua Zhang, Xiongting Wu, Rong Chen, Linli Duan, Fang Chen, Xuewei Yang, Xiuli Feng

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Regulation of plant gene expression by tsRNAs in response to abiotic stress by Chunmei Li, Jing Zhu, Han Jin, Haotian Feng, Haimin Zhuang, Zijun Du, Guolin Zhu, Haiyang He, Fuyang Ye, Zhaohui Mo, Qingtao Hu, Zhenbang Chen, Kai Liu, Xiaorong Wan

“…This review aims to summarize recent advances in the classification, biogenesis, and biological functions of tsRNAs, with a focus on their roles in plant stress responses and the methodologies for investigating these molecules. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…Organisations should ensure that there is training for post-incident reviews including debriefing and post-incident support. …”
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A mechanism-based group psychotherapy approach to aggressive behavior (MAAP) in borderline personality disorder: a multicenter randomized controlled clinical trial by Christine Sigrist, Andreas Bechdolf, Katja Bertsch, Robin Bullenkamp, Martin Busse, Ute gr. Darrelmann, Astrid Dempfle, Martin Driessen, Thomas Frodl, Jan-Michael Kersting, Jessica Kesik, Burkhart Matzke, Corinne Neukel, Eva Niessen, Svenja Nückel, Viola Oertel, Frank Padberg, Alexandra Philipsen, Dorothee Pink, Andreas Reif, Matthias Reinhard, Carolin Steuwe, Larissa Wolkenstein, Sabine C. Herpertz, the MAAP Consortium

“…In BPD, patterns of reactive aggression often lead to functional impairment affecting important areas of life. …”
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Deciphering the tumor ecosystem dynamics undergoing immunochemotherapy therapy across multiple cancer types unveils the immunosuppressive role of S100A4 in fibroblasts by promoting... by Bo Yang, Bo Yang, Ruiji Chen, Ruiji Chen, Mali Zu, Jie Yao, Hong Ren, Hong Ren, Yingxue Lin, Yingxue Lin, Bo Zhang, Tianjiao Ji, Yang Liu

“…BackgroundNeoadjuvant therapy (NAT) has transformed cancer treatment by improving surgical outcomes and survival rates, yet resistance mechanisms across multiple cancer types remain unclear. …”
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About relevance of fundamentalisation of mathematical training of students of the pedagogical directions during the digital era by E. A. Perminov, D. D. Gadjiev, M. M. Abdurazakov

“…Introduction. The era of post-industrial society of knowledge differs from the previous socio-economic period in many important aspects: total digitalisation, automation and robotisation, and furthermore, cross-disciplinary integration of various scientific fields, among which mathematics is of particular relevance. …”
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Genome-Wide Identification of <i>G3BP</i> Family in U’s Triangle <i>Brassica</i> Species and Analysis of Its Expression in <i>B. napus</i> by Alain Tseke Inkabanga, Qiheng Zhang, Shanshan Wang, Yanni Li, Jingyi Chen, Li Huang, Xiang Li, Zihan Deng, Xiao Yang, Mengxin Luo, Lingxia Peng, Keran Ren, Yourong Chai, Yufei Xue

“…The RasGAP SH3 domain binding protein (G3BP) is a highly conserved family of proteins in eukaryotic organisms that coordinates signal transduction and post-transcriptional gene regulation and functions in the formation of stress granules. …”
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Tenecteplase thrombolytic therapy for acute ischaemic stroke in China: a real-world, multicentre, retrospective, controlled study by Peng Li, Qiang Dong, Anqi Zhang, Qiang Li, Hong Zhang, Yibin Fang, Ye Liu, Gang Li, Hui Luo, Xiaoyu Zhou, Chao Wu, Dan li, Yu Yao, Kun Fang, Xiangjun Li, Yin Liu, Jingyu Guo, Huaying Wang, Jianjun Tang, Xin Cheng, Jianhong Yang, Lan Hong, Guozhi Lu, Guang Wu, Rongbo Qu, Yongren Fang, ZhiJiao He, Lian Zuo, Jinchun Wang, Dongya Huang, Ge-Fei Li, Yanzhang Xiao, Zongyan Dang, Yeqiu Jiao, Yang Zhu, Yulei Deng, Linghao Cao

“…A higher proportion of patients achieving early neurological improvement at 24 hours (OR: 1.76, 95% CI: 1.48 to 2.09, p=0.000), better 90-day mRS (OR: 0.67, 95% CI: 0.57 to 0.79, p=0.000) as well as higher percentages of 90-day mRS 0–1 (OR: 1.27, 95% CI: 1.05 to 1.54, p=0.012) and mRS 0–2 (OR: 1.41, 95% CI: 1.14 to 1.75, p=0.001) compared with alteplase.Conclusions Thrombolysis with TNK is not associated with an increased risk of sICH, and may result in better early neurological improvement and 90-day functional outcomes compared with alteplase in patients with AIS.…”
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Impacto del alargamiento de miembros inferiores con clavos telescópicos en la funcionalidad y calidad de vida de pacientes con acondroplasia by M. Galán-Olleros, J. Alonso-Hernández, C. Miranda-Gorozarri, J. García-Fernández, R.M. Egea-Gámez, Á. Palazón-Quevedo

“…Conclusions: Lower limb lengthening reusing TIMNs appears to improve functionality, HRQoL, and self-esteem in patients with achondroplasia compared to their preoperative status. …”
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