Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): a randomised controlled trial to in... by Sophie Parker, Lydia Pearson, Rebekah Carney, Richard P. Bentall, Matthew R. Broome, Emma Cernis, Timothy Clarke, Steven Jones, Katherine Moran, Jonathan Wilson, Isabel Coleman, Catherine Hewitt, Wendy Jones, Heather Law, Sarah Peters, Gemma Shields, David Shiers, Luke Strachan, Anton Strong, Judith Watson, Chris J. Sutton

“…Discussion Our efficacy hypotheses are CBTBAR + TAU (compared to TAU alone) will lead to improvement in mood swings, a reduction in the likelihood of transition to BD, and improvements to functioning and quality of life. …”
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Analgesic efficacy and safety of erector spinae plane block versus serratus anterior plane block in breast surgery—a meta-analysis and systematic review of randomized controlled tr... by Samiullah Shaikh, Umm E Salma Shabbar Banatwala, Paranshi Desai, Muhammad Arham Khan, Rimsha Bint-e-Hina, Sidra Samad, Muhammad Hamza Sikandari, Ali Nawaz, Rana Ijaz, Shayan Asmat, Abeer Fatima, Harim Mirza, Noor Mahal Azam, Qurat Ul Ain Muhammad, Satesh Kumar, Mahima Khatri

“…Many undergoing breast surgery experience postoperative pain compromising their functionality and quality of life. While multiple pain management strategies are available, evidence comparing the erector spinae (ESPB) and serratus anterior plane blocks (SAPB) for improving post-surgical pain management in breast cancer surgery patients is limited. …”
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Fall risk perception toolkit based on “digital human” for community-dwelling older patients with stroke: development and validation by Jiang Nan, Yi Hou, Manyao Sun, Xueying Huang, Jing Gao, Xueqiong Zou, Zhongyi Chen, Yuyu Jiang

“…The usability test contained Post-Study System Usability Questionnaire (PSSUQ), Customer Effort Score (CES), Net Promoter Score (NPS), and user interviews. …”
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Feasibility of a Web-Based and Mobile-Supported Follow-Up Treatment Pathway for Adult Patients With Orthopedic Trauma in the Netherlands: Concurrent Mixed Methods Study by Gijs J A Willinge, Jelle F Spierings, Kim A G J Romijnders, Elke G E Mathijssen, Bas A Twigt, J Carel Goslings, Ruben N van Veen

“…Semistructured interviews were performed at 10‐12 weeks post injury. Anonymous data from a pre-existing database were used to compare health care resource use between the digital treatment pathways and traditional treatment. …”
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Aging Population and the Changing Paradigm of Hip Fracture Management by Amit Sharma

“…Centralized hip fracture wards with standardized protocols have better outcomes than fragmented care models.4 A key change in hip fracture management is the emphasis on early surgery, ideally within 36 hours of admission, which has been shown to decrease mortality and improve functional outcomes. Delays should be avoided, even for chronic conditions that cannot be immediately addressed. …”
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Impact of the COVID-19 pandemic on outcomes of acute ischemic stroke patients treated with endovascular therapy: A multicenter Canadian study. by Shenghua Zhu, Ammar Alam, Rebecca Thornhill, Vered Tsehmaister-Abitbul, Grant Stotts, Hailey Pettem, Richard Aviv, Ronit Agid, Aleksandra Pikula, Jai Jai Shiva Shankar, Genevieve Milot, Brian Van Adel, Samuel Yip, Manraj Heran, Robert Fahed, Fabio Settecase, Marlise P Dos Santos

“…Patients were more likely to have favourable outcomes (mRS at 90 days score of ≤ 2) post-EVT pre-pandemic than pandemic (53% vs 44%; p = 0.02). …”
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Integrating vosoritide therapy with limb surgery in paediatric patients with achondroplasia: real-life experiences by Anna Elsa Maria Allegri, Maria Francesca Bedeschi, Maria Beatrice Bocchi, Valentina Camurri, Michaela Veronika Gonfiantini, Chiara Leoni, Milena Mariani, Osvaldo Palmacci, Matteo Porro, Simone Riganti, Caterina Tedesco, Berardo Rinaldi, Emanuela Scarano, Concetta Schiavariello, Angelo Selicorni, Stefano Stagi, Fabio Verdoni, Giuseppe Zampino, Mohamad Maghnie, Roberta Onesimo

“…Until 2021, there were no precision treatments available, and in some countries, elective surgery was considered a standard approach to increase height, improve body proportions, enhance functionality, and correct deformities in a selected group of patients. …”
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The effect of acute beetroot juice consumption prior to climbing on lower-body isokinetic and isometric strength, aerobic power, and muscle soreness among mountain climbers by Alireza Daneshparvar, Mohammad Hemmatinafar, Mohsen Salesi, Rasoul Rezaei, Babak Imanian, Sepideh Pirmohammadi

“…One week later, during the climbing session, they consumed 70 mL of BRJ (400 mg nitrate), PLA, or water 2.5 hours before ascending to 3720 meters. Functional tests (HJ, wall-sit, and estimated VO₂max) were performed at the altitude. …”
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Tribological properties of polymer like carbon coatings on NBG-18 nuclear graphite under nitrogen environment by HAN Hai, LIU Huichuan, CHENG Jinjuan, CHEN Xinchun, LIU Pengxiao, QI Wei, TANG Xian

“…Simultaneously, the lubrication and failure mechanisms of the PLC coatings were investigated.ResultsThe experimental results demonstrate a significant increase in the hardness of NBG-18 nuclear graphite, from 0.44 GPa to 4.16 GPa, marking an 845% improvement post-PLC coating deposition. The elastic modulus rose from 9.00 GPa to 27.21 GPa, reflecting a 202% enhancement. …”
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In Vitro Evaluation of the Efficient Passage of PLGA-Formulated Trastuzumab for Nose-to-Brain Delivery by Léa Kengne Kamkui, Clémence Disdier, Amaury Herbet, Narciso Costa, Anne-Cécile Guyot, Didier Boquet, Aloïse Mabondzo

“…Importantly, the TZB released from the nanoparticles retained all of its physicochemical properties and functionality. We observed that the NP-TZB formulation results in at least a nine-fold increase in TZB permeability across the nasal epithelium 24 h post-exposure, depending on the exposure conditions, but shows no significant improvement across the BBB model. …”
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POSSIBILITIES OF SURGICAL CORRECTION OF INTERNAL CAROTID ARTERY THROMBOSIS IN PATIENTS WITH ACUTE ISCHEMIC STROKE by V. A. Lukyanchikov, E. V. Udodov, N. A. Polunina, A. S. Tokarev, V. A. Dalibaldyan, O. Y. Nakhabin, E. V. Grigoryeva, Y. I. Shatokhina, N. Y. Kudryashova, G. K. Guseynova, E. A. Khodykin, V. G. Dashyan, V. L. Lemenyov, V. V. Krylov

“…The excellent outcomes were seen in 7 (33.4%) patients, good outcomes — in 11 (52.3%) and satisfactory outcomes were observed in 3 (14.3%) patients. The improvement of functional deficit in the early post-operative period was 4.85 scores according to NIHSS, 1.2 scores according to Rankin scale and 2.3 scores according to Rivermead mobility index. …”
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Do Progressive Intensities of Transcranial Direct Current Stimulation with and Without 40 Hz Binaural Beats Change Pre-Frontal Cortex Hemodynamics? A Randomized Controlled Trial by Maria de Cassia Gomes Souza Macedo, Kariny Realino do Rosário Ferreira, Paula Almeida Meira, Arthur Ferreira Esquírio, Michelle Cristina Sales Almeida Barbosa, Gabriela Lopes Gama, Alexandre Wesley Carvalho Barbosa

“…The hemodynamic effect was assessed using a functional near-infrared intracranial spectroscope (fNIRS) positioned on the left supraorbital region (Fp1). …”
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Network Pharmacology Approaches to Myocardial Infarction Reperfusion Injury: Exploring Mechanisms, Pathophysiology, and Novel Therapies by Joy Das, Ashok Kumar Sah, Ranjay Kumar Choudhary, Rabab H. Elshaikh, Utpal Bhui, Shreya Chowdhury, Anass M. Abbas, Manar G. Shalabi, Nadeem Ahmad Siddique, Raji Rubayyi Alshammari, Navjyot Trivedi, Khoula Salim Ali Buwaiqi, Said Al Ghenaimi, Pranav Kumar Prabhakar

“…The pathophysiology of MIRI involves complex, interrelated mechanisms including oxidative stress, calcium overload, mitochondrial dysfunction, inflammatory responses, apoptosis, and dysregulated autophagy. Post-reperfusion recovery is further complicated by structural and functional abnormalities such as microvascular obstruction, endothelial dysfunction, and myocardial stunning. …”
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The influence of dental occlusion on hamstring muscle isokinetic parameters in active competitive soccer athletes: a randomized controlled trial by Stine Hecht, Yoon Jeong Choi, Andrea Stroux, Florian Beuer, Manja von Stein-Lausnitz, Till E. Bechtold

“…IntroductionThe improvement of athletic performance depends on numerous factors including physical health, training status, neuromuscular coordination and psychological state. …”
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Clinical and Ultrasound Evaluation of Hemiplegic Shoulder Pain in Stroke Patients: A Longitudinal Observational Study Starting in the First Hours After Stroke by Filippo Cotellessa, William Campanella, Luca Puce, Maria Cesarina May, Marta Ponzano, Riccardo Picasso, Matteo Mordeglia, Davide Subbrero, Ester Cecchella, Laura Mori, Davide Sassos, Massimo Del Sette, Matteo Formica, Carlo Trompetto

“…This longitudinal study aimed to investigate the clinical and ultrasound characteristics of HSP emerging within the first 72 h (T0) post-stroke, with follow-ups at one month (T1) and three months (T2). …”
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Coeliac plexus radiosurgery for pain management in patients with advanced cancer : study protocol for a phase II clinical trial by Laura A Dawson, Camilla Zimmermann, Aisling Barry, Galia Jacobson, Ronen Fluss, Amira Dany-BenShushan, Talia Golan, Tikva Meron, Marcin Miszczyk, Michael Buckstein, Dayssy Diaz Pardo, Artur Aguiar, Liat Hammer, Adam P Dicker, Maoz Ben-Ailan, Ofir Morag, David Hausner, Zvi Symon, Yaacov R. Lawrence

“…The protocol requires that 90 evaluable patients be accrued, based upon the assumption that a third of patients are non-evaluable (e.g. due to death prior to 3-weeks post-treatment assessment, or spontaneous improvement of pain pre-treatment), it is estimated that a total of 120 patients will need to be accrued. …”
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In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

“…Despite advancements in tendon injury repair techniques, outcomes remain suboptimal due to inferior tissue quality and functionality. Tissue engineering offers a promising avenue for tendon regeneration, with biocompatible scaffolds playing a crucial role. …”
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Diagnosis and treatment of synthetic mid-urethral sling complications by Helen E. O’Connell, Christopher K. Harding, Gaurav Khatri, Phyllis Glanc, Eric Bautrant, Sarah Love-Jones, Karen Ward, Henry H. Yao, Ventia Hoe, Charlotte Korte, Nicolle Germano, Sanjeevan Kalavampara, Sherif Mourad, Hashim Hashim

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Fractionated stereotactic radiotherapy in people with drug-resistant focal epilepsy: first-in-human experience with a healthy tissue-preserving dose-fractionation concept by Cas Stefaan Dejonckheere, Attila Rácz, Gustavo Renato Sarria, Julian Philipp Layer, Julian Philipp Layer, Younèss Nour, Lara Caglayan, Molina Grimmer, Victoria Volkenborn, Fabian Kugel, Thomas Müdder, Tobias Baumgartner, Valeri Borger, Alexander Radbruch, Hartmut Vatter, Frank Anton Giordano, Frank Anton Giordano, Frank Anton Giordano, Eleni Gkika, Rainer Surges, Davide Scafa

“…All patients reported improvements in quality of life and regained independence or displayed functional recovery. …”
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Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with... by K. A. Berdyugin, I. V. Kadyntsev, O. V. Berdyugina, E. A. Taskina, N. G. Kashevarova

“…During treatment, both groups of patients showed improvement (compared to the baseline levels). At the same time, evaluating the intergroup values revealed clear differences: a more pronounced decrease in all WOMAC indicators in Group 1 patients: pain scores, 2 [1; 3] vs. 4 [2; 5] in Group 2 (p<0.001); stiffness, 1 [0; 2] vs. 2 [1; 4] (p<0.001); functional insufficiency, 8 [3; 12] vs. 15.5 [12; 20] (p<0.001); and total WOMAC scores, 12 [7; 13] vs. 21.5 [15; 28] (p<0.001). …”
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