MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury by Lei Yuan, Duo Wang, Yale Su, Long Yuan, Mixia Li, Dongdong Zheng, Cuilin Zhu, Hulin Piao, Yong Wang, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu

“…Through systematic validation, we identified the most representative hub gene. Subsequent functional studies, including gene knockdown and overexpression experiments, were conducted to elucidate its role and underlying mechanisms in oxidative stress-induced cardiomyocyte injury.ResultsIntegrated bioinformatics analysis and experimental validation identified MAFF as the most differentially expressed hub gene between pre- and post-CPB conditions. …”
Get full text

Noninvasive anatomical assessment for ruling out hemodynamically relevant coronary artery anomalies in adults – A comparison of coronary-CT to invasive coronary angiography: The NA... by Marius R. Bigler, Anselm W. Stark, Isaac Shiri, Joel Illi, Matthias Siepe, Federico Caobelli, Andreas A. Giannopoulos, Ronny R. Buechel, Andreas Haeberlin, Dominik Obrist, Lorenz Räber, Christoph Gräni

“…As the sole presence of AAOCA does not always imply a revascularization, a detailed anatomical and functional analysis is crucial for clinical decision-making. …”
Get full text

Gene expression profiling in pure neural leprosy: insights into pathogenesis and diagnostic biomarkers by Mariana Martins de Athaide, Thyago Leal-Calvo, Tatiana Pereira Da Silva, Thabatta Leal Silveira Andrezo Rosa, Helen Ferreira, Bernardo Miguel de Oliveira Pascarelli, Ana Caroline Siquara de Sousa, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro

Get full text

Conservative or surgical treatment? Optimizing management strategies in medial hypertensive intracerebral hemorrhages by M.Ye. Polishchuk, A.A. Kaminskyi, A.A. Oblyvach, D.V. Shchehlov, O.M. Honcharuk, A.V. Muravskyi

“…In the conservative group, 50% of patients showed mRS improvement, exceeding the 30% improvement rate in the surgical group. …”
Get full text

Inhaled ciclesonide in adults hospitalised with COVID-19: a randomised controlled open-label trial (HALT COVID-19) by Peter Ueda, Johan Hansson, Johan Ljungberg, Anders Krifors, Björn Johansson, Martin Larsson, Per Tornhammar, Daniel Peter Andersson, Daniel Brodin, Eli Westerlund, Simon Athlin, Sandra Wojt, Olof Elvstam, Anca Neumann, Arsim Elshani, Julia Giesecke, Jens Edvardsson-Källkvist, Sayam Bunpuckdee, Christian Unge, Jonas Lindell, Ola Blennow

Get full text

AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models by Richard Novak, Tiffany Lin, Shruti Kaushal, Megan Sperry, Frederic Vigneault, Erica Gardner, Sahil Loomba, Kostyantyn Shcherbina, Vishal Keshari, Alexandre Dinis, Anish Vasan, Vasanth Chandrasekhar, Takako Takeda, Rahul Nihalani, Sevgi Umur, Jerrold R. Turner, Michael Levin, Donald E. Ingber

“…Abstract Background Many neurodevelopmental genetic disorders, such as Rett syndrome, are caused by a single gene mutation but trigger changes in expression of numerous genes. This impairs functions of multiple organs beyond the central nervous system (CNS), making it difficult to develop broadly effective treatments based on a single drug target. …”
Get full text

Promoting the wellbeing of the whole person: a within-subjects mixed-methods study exploring the effects of the flourishing intervention among individuals with depressive symptoms by Camilla Casaletti Braghetta, Juliane Piasseschi de Bernardin Gonçalves, Willyane de Andrade Alvarenga, Richard G. Cowden, Richard G. Cowden, Clarice Gorenstein, Clarice Gorenstein, Giancarlo Lucchetti, Homero Vallada

“…The study also seeks to understand participants’ experiences, acceptability, and satisfaction with the intervention.MethodsA quasi-experimental pre-post mixed-methods design was used, incorporating an embedded approach in which descriptive qualitative data complemented quantitative data. …”
Get full text

Efficacy of low-magnitude high-frequency vibration (LMHFV) on musculoskeletal health of participants on wheelchair: a study protocol for a single-blinded randomised controlled stud... by Ronald Man-Yeung Wong, Simon Kwoon Ho Chow, Chung Yan Ho, Hiu Wun Wong, Yu Ning Chim, Wing Hoi Cheung

“…It is hypothesised that new design of LMHFV is beneficial to wheelchair users in terms of vertebral BMD, muscle health and musculoskeletal functions.Methods This study is a single-blinded randomised controlled trial to investigate the effect of LMHFV on vertebral BMD, muscle health, balancing ability and functional ability in wheelchair users (mainly on wheelchair for outdoor activities). …”
Get full text

Survey of postoperative practices for lumbar spinal stenosis surgery among canadian spinal surgeons and rehabilitation professionals by Lu Hsi Chen, BHSc, MD(c), Nora Bakaa, DC, PhD, Raja Rampersaud, MD, FRCSC, Marcia Correale, PT, Lisa Carlesso, PT, PhD, Luciana Macedo, PT, PhD

“…ABSTRACT: Background: Postoperative rehabilitation for lumbar spine stenosis (LSS) surgery has been shown to improve functional status postoperatively. However, there is a lack of clinical guidelines on postsurgical recommendations, movement restrictions and rehabilitation practices, which can lead to variations in care. …”
Get full text

Novel Artificial 5′UTR Increase Modified mRNA Translation When Injected into Mouse Heart by Ann Anu Kurian, Matteo Ghiringhelli, Eyal Shalom, Gayatri Mainkar, Magdalena M. Żak, Matthew Adjmi, Jeffrey Downey, Seonghun Yoon, Nicole Dubois, Filip K. Swirski, Lior Zangi

“…<b>Results:</b> This design significantly improves modRNA translation efficiency in cardiomyocytes (CMs) and heart cells both in vitro and in vivo. …”
Get full text

Arginine-Mediated Liver Immune Regulation and Antioxidant Defense in Largemouth Bass (<i>Micropterus salmoides</i>): Multi-Omics Insights into Metabolic Remodeling During <i>Nocard... by Yu-Long Sun, Shuai-Liang Zhang, Feng-Feng Zhou, Yuan-Xin Qian, Yang He, Run-Zhe Zhang, Fen Dong, Qiang Chen, Han-Ying Xu, Ji-Teng Wang, Yu-Ting Deng, Tao Han

“…In this study, we constructed a model of largemouth bass (<i>Micropterus salmoides</i>) infected with <i>Nocardia seriolae</i> by injection to explore the immune and antioxidant functions of the liver. The results showed that <i>N. seriolae</i> infection caused severe pathological changes in the liver, including cell necrosis, granuloma formation, and leukocyte infiltration. …”
Get full text

Home-use transcranial direct current stimulation (tDCS) as a safe, effective, and feasible application in depression: A randomized, single-blind, placebo-controlled trial by Tuba Aktürk, Mehmet Yücel Ağargün, Sümeyye Özdemir, Esra Dalmızrak, Bahar Güntekin

“…Introduction: Anodal transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (DLPFC) alleviates depression symptoms and enhances cognitive functions in major depressive disorder (MDD) patients. …”
Get full text

Comparative Analysis of Ratoon-Competent and Ratoon-Deficient Sugarcane by Hormonal and Transcriptome Profiling by Liping Zhao, Maoyong Ran, Jing Zhang, Peifang Zhao, Fenggang Zan, Jun Zhao, Wei Qin, Qibin Wu, Jiayong Liu, Xinlong Liu

Get full text

Modulating food craving-related neural oscillations using tACS: study protocol for a randomized sham-controlled trial by Milos Ljubisavljevic, Milos Ljubisavljevic, Fransina C. King, Fransina C. King, Fatima Yousif Ismail, Yauhen Statsenko, Yauhen Statsenko, Shahid Bashir, Osama Abdullah, Osama Abdullah, Bas Rokers, Bas Rokers

“…Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) will be conducted pre- and post-intervention. …”
Get full text

Effect of Intravenous Tirofiban Versus Placebo on Excellent Outcome in Patients With Acute Ischemic Stroke: The Multicenter, Randomized INSTANT Trial Protocol by Fan Zhang, Minghui Xiao, Cong Zhang, Guangxiong Yuan, Zhiyong Xie, Yi Yin, Ruize Zhou, Shanggui Yuan, Genxiang Xiao, Donghuan Mei, Xiaobing Zeng, Huashi Liu, Huadong Li, Hongwen Liu, Jinchang Tan, Bin Chen, Qingqing Fu, Bin Li, Jinxing Lai, Wei Sun, Shuhua Xie, Zhaohui Lai, Zhongming Qiu, Zidian Jiang, Xianghong Liu, Guoyong Zeng

“…Background It is common that symptoms do not improve or even worsen after intravenous thrombolysis (IVT) in acute ischemic stroke. …”
Get full text

10 kHz spinal cord stimulation vs. traditional low-frequency spinal cord stimulation for the treatment of diabetes peripheral neuropathic pain: study protocol for a multi-center ra... by Chen Li, Chen Li, Chun-Hua Liu, Chun-Hua Liu, Yi-Fan Li, Hui-Min Hu, Hui-Min Hu, Qing Shi, Qing Shi, An-Xiang Liu, An-Xiang Liu, Wen-Hui Liu, Wen-Hui Liu, Yi Zhang, Peng Mao, Bi-Fa Fan

“…Safety evaluations encompass adverse events, laboratory tests, and imaging findings.DiscussionThis study seeks to provide robust evidence on the superiority of HF-SCS in pain relief, functional improvement, and microcirculatory benefits, potentially establishing it as a preferred neuromodulation strategy for DPNP. …”
Get full text

Midterm Outcomes of Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy: A Single‐Center, Observational Study by Xudong Xie, Siyuan Chen, Yawei Cui, Zhenzhen Zhou, Jianhua Lu, Zhi Du, Jie Ding, Kaidi Xing, Yuesheng Zhang, Yijiang Zhou, Jun Li, Xiaogang Guo

“…The primary outcome was the reduction of left ventricular outflow tract gradient after 6 months or more post‐PIMSRA. Secondary outcomes were periprocedural major adverse clinical events. …”
Get full text

Single‐Center Evaluation of the Myval Balloon‐Expandable Transcatheter Heart Valve: A Follow‐Up Study: A Retrospective Cohort Study by Mohammadreza Baay, Ata Firouzi, MohammadHossein MozafaryBazargany, Amir Azimi, Armin Elahifar, Mohammad Javad Alemzadeh‐Ansari, Zahra Hosseini, Seifollah Abdi, Amineh Safairad, Peyman Bashghareh, Ehsan Khalilipur

“…The New York Heart Association (NYHA) functional class showed significant improvement from baseline to discharge (p < 0.0001). …”
Get full text

Effects of kelp phlorotannins on the growth, immunity, intestinal health and disease resistance against Vibrio splendidus of sea cucumber Apostichopus japonicus by Zhikai Zhang, Yan Chi, Yongheng Du, Feng Li, Ning Ma, Song Qin

“…And 0.8 g kg−1 of phlorotannins induced the lowest post-challenge motility, which was about 43 % lower than control group. …”
Get full text

In Silico Analysis of miRNA-mRNA Binding Sites in <i>Arabidopsis thaliana</i> as a Model for Drought-Tolerant Plants by Yryszhan Zhakypbek, Aizhan Rakhmetullina, Zhigerbek Kamarkhan, Serik Tursbekov, Qingdong Shi, Fei Xing, Anna Pyrkova, Anatoliy Ivashchenko, Bekzhan D. Kossalbayev, Ayaz M. Belkozhayev

“…While no direct experimental validation was performed, the results from <i>Arabidopsis thaliana</i> provide a useful genomic framework for hypothesis generation and future functional studies in non-model plant species. This work provides a molecular foundation for improving drought and salt stress tolerance through bioinformatics-assisted breeding and genetic research.…”
Get full text