Autograft vs Allograft With Bone Marrow Aspirate Concentrate as an Osteotomy Gap Filler in Lateral Column Lengthening for Progressive Collapsing Flatfoot Deformity by Ramesh Radhakrishnan MBBS, MRCS(Eng), Don Thong Siang Koh MBBS, BSc(Hon), MRCS, MMED(Ortho), Eric Wei Liang Cher MD, MRCS, MMed(Ortho), FRCSEd(Ortho), Wenxian Png MBBS, MMed(Ortho), MRCSEd, FRCSEd(Ortho), Inderjeet Rikhraj Singh MBBS, FRCS, FAMS, MHPE (Maastricht)

“…Background: Progressive collapsing flatfoot deformity (PCFD) is a complex condition characterized by hindfoot valgus, midfoot varus, and forefoot abduction, leading to functional impairment and pain. Surgical correction often includes lateral column lengthening (LCL), which addresses structural deformity and restores alignment. …”
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Patient-reported challenges in spinal cord injury rehabilitation and integration within the community of a lower middle-income country: opportunities for changing lives by Rajani Mullerpatan, Aamreen Ryain, Neha Padia, K.R. Salgotra

“…Introduction: Rehabilitation of individuals with spinal cord injury (SCI) is improving in tertiary-healthcare settings of low-middle-income countries (LMICs). …”
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UC-MSCs Secretome Induces Proliferation of CD4+ T Cells, CD8+ T Cells, NK Cells, and Increases sPD-1 Levels in Severe COVID-19’s Whole Blood by Winna Soleha, Heri Wibowo, Murdani Abdullah, Saraswati Pradipta, Lucky Novita Syari, Isabella Kurnia Liem, Arleni Bustami, Anna Rozaliyan

“…Materials and methods: Twelve whole blood samples from healthy individuals and severe COVID-19 patients were analyzed for lymphocyte count and functional activation using flow cytometry, along with sPD-1 level measurement in pre-treatment and post-secretome conditions. …”
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Rapid, high-throughput isolation of tumor specific small extracellular vesicles using radial flow microfluidic chip with IEDDA chemistry (ExoOnco ChipEpCAM−TCO) by Nnaemeka Onukwugha, Henry McEacheron, Scott Smith, Harrison Ball, Nithya Ramnath, Sunitha Nagrath

“…By implementing the rapid IEDDA chemistry and functional disulfide bridge, the improved ExoOnco Chip facilitates the isolation and release of rare TDEs, enabling further investigation of their bioactive constituents. …”
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Advancing higher education on sustainable land use: designing socioscientific inquiry-based learning units on oil palm cultivation by Finn Kristen Matthiesen, Jacqueline Dischereit, Raissa Mataniari, Fitta Setiajiati, Fitta Setiajiati, I Nengah Suparta, Susanne Bögeholz, Susanne Bögeholz

“…We systematically analyzed curricular needs, objects of recent scientific research, teaching and learning frameworks, and evaluation approaches to determine design principles. A pre-post-follow-up evaluation (N = 943) showed that the units, when integrated into curricular courses, increased and sustained students’ self-reported knowledge and interest, with improvements from pilot to implementation cycles. …”
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The effects of a large-scale nature-based solution on the macroinvertebrate diversity in a gravel river in The Netherlands by Maya M. Daumal, Rosan van Halsema, Dorine T.B.M. Dekkers, Roy H.J. Erkens, Edwin T.H.M. Peeters

“…A functional, ecosystem-based approach is essential for improving biodiversity outcomes in large river restoration projects.…”
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Balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: short- and long-term results from a cohort in Brazil by Fabio Solano de Freitas Souza, Marcelo Gottschald Ferreira, Iury Andrade Melo, Marta Ferreira Leite de Sá, Camila Melo Coelho Loureiro, Rosalvo Abreu, Paulo Henrique Alves de Carvalho, Mateus dos Santos Viana, Valdemar Oliveira Jr, Luiz Eduardo Fonteles Ritt

“…There was an increase in the six-minute walk distance and an improvement in functional class. Acute lung injury with clinical manifestations was observed after 7% of the BPA sessions. …”
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Analysis of Factors Influencing the Development of Community-Based Tourism in Rural Areas, Case Study: Villages Targeted by Tourism in the Markazi Province by Hamid Afshari, Behrouz Mohammadi Yeganeh, Hossein Farahani, Mehdi Cheraghi

“…Out of the total number of interviewees, 6 people (24%) have diplomas and post-diplomas, 11 people (44%) have bachelors, 6 people (24%) have post-graduate degrees, and 2 people (8%) have PhDs. …”
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Perception of facial esthetics and cephalometric correlations in Class II patients: a comparison between two-phase and one-phase treatments by Wener Chen, Chaoning Zhan, Sze Man Chung, Yifan Lin

“…Eighty profile silhouettes (pre- and post-treatment) were assessed by 64 raters, including 23 orthodontists, 21 general dental practitioners, and 20 laypersons. …”
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BUILDING RESEARCH COMPETENCE OF PHD STUDENTS: AN ANALYSIS OF EXPERIENCE OF A PHD SCHOOL by T. А. Strokova

“…However, the total number of this key resource of the higher education system, which guarantees its stable functioning and further forward development, has been reduced in recent years. …”
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A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis by Kan Li, Michael J. Rudy, Yanmei Hu, Haozhou Tan, George Lambrinidis, Xiangmeng Wu, Kyriakos Georgiou, Bin Tan, Joshua Frost, Courtney Wilson, Penny Clarke, Antonios Kolocouris, Qing-yu Zhang, Kenneth L. Tyler, Jun Wang

“…In a neonatal mouse model of EV-D68 infection, Jun6504 significantly improves paralysis score and weight gain when administered immediately or 24 hours post-infection. …”
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Spatial optimization of agricultural production from the perspective of “Greater Food Concept” in Yangzhou, China by Xin Li, Xin Xu, Ru Meng Yin

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Mycoplasma pneumoniae and Schistosoma mansoni co-infection in a young patient with extensive longitudinal acute transverse myelitis by Hassan Ali Alayafi, Mubarak Alruwaili, Talal Khalid Aljumah, Ali Alshehri, Deema Alrasheed, Muhannad Faleh Alanazi, Raed AlRuwaili, Naif H Ali, Anas Mohammad Albarrak, Barakat M AlRashdi, Ahmed E Taha

“…Spastic paraplegia, impaired sphincter functions, and sensory loss, with sensory level, are the clinical manifestations of this devastating disorder. …”
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Assembly of MSCs into a spheroid configuration increases poly(I:C)-mediated TLR3 activation and the immunomodulatory potential of MSCs for alleviating murine colitis by Chao-Ting Ho, Ying-Chi Kao, Yueh-Ming Shyu, I-Ching Wang, Qiao-Xuan Liu, Shao-Wen Liu, Shih-Chen Huang, Han Chiu, Li-Wen Hsu, Tzu-Sheng Hsu, Wan-Chen Hsieh, Chieh-Cheng Huang

“…However, the therapeutic efficacy of these cells remains suboptimal, primarily due to the harsh peritoneal microenvironment, which compromises MSC viability and functional capacity after transplantation. Methods To address these limitations, this study aimed to improve MSC engraftment and functionality by assembling MSCs into three-dimensional (3D) spheroids and priming them with the Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly(I:C)). …”
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Enhancing psychological wellbeing in hip surgery patients through psychological interventions: a scoping review by Lindsay Sullivan, Ellie Ritter, Emily Williams, James P. Moley, Tyler Barker, Sonal Singh, Jennifer Carter, Jay Patel, Marcia Edwards, William K. Vasileff

“…Conclusion Psychological interventions were generally found to be helpful in improving psychological wellbeing and patient-reported outcomes, such as functional status and health-related quality of life, following hip surgery. …”
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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial by Sun YY, Wang ML, Zhao RH, Hao MY, Song S, Zhou Y, Zhang N

“…The primary efficacy indicator will be the change in NRS score after four weeks of treatment, with secondary outcomes including WOMAC, STAI, and safety assessments. fMRI observations will employ independent component analysis, brain network construction, and functional connectivity, complemented by Pearson correlation analysis to explore the relationship between brain responses and clinical improvements.Conclusion: This study will initially uncover how acupuncture intervention for chronic KOA pain centrally regulates and exerts therapeutic effects through the modulation of abnormal brain network functional connectivity patterns, with a demonstrated long-term effect.Ethics and Dissemination: This study has been approved by the ethics committee of Shandong University of Traditional Chinese Medicine Affiliated Hospital ((2024) Lunshen No. (028) - KY).Clinical Trial Registration: This study has been approved by registered in the Chinese Clinical Trial Registry (ChiCTR2400083695).Keywords: acupuncture, knee osteoarthritis, neuroimaging, RCT, protocol…”
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Artificial Intelligence as Assessment Tool in Occupational Therapy: A Scoping Review by Christos Kokkotis, Ioannis Kansizoglou, Theodoros Stampoulis, Erasmia Giannakou, Panagiotis Siaperas, Stavros Kallidis, Maria Koutra, Christina Koutra, Anastasia Beneka, Evangelos Bebetsos

“…Occupational therapy (OT) is vital in improving functional outcomes and aiding recovery for individuals with long-term disabilities, particularly those resulting from neurological diseases. …”
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Integrative GWAS and transcriptomics reveal GhAMT2 as a key regulator of cotton resistance to Verticillium wilt by Long Wang, Long Wang, Long Wang, Yonglin Yang, Jianghong Qin, Qifeng Ma, Kaikai Qiao, Shuli Fan, Yanying Qu

“…Transcriptomic profiling revealed that GhAMT2 was significantly upregulated at 12 hours post-inoculation with V. dahliae, coinciding with the activation of immune signaling pathways. …”
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Prevention and treatment of transient dry eye following excimer laser surgery by V. V. Pogorelovа, I. S. Malyutina, R. R. Dolzhich, E. G. Kharchenko, I. A. Efimova, M. I. Danilchenko, I. V. Bubnov

“…Results: It was demonstrated that excimer laser surgery provokes transient dry eye in all patients, therefore, artificial tears are required for 2 months and more after the surgery. Post-operative lubricant eye drops use improves tear film stability, tear production, tear osmolarity, and objective signs of dry eye. …”
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Artificial intelligence-guided therapy: Clinic versus home users. Long-term differences in patient-reported outcomes in patients with low back pain by Kenan Alzouhayli, Nathan D. Schilaty, Takashi Nagai, Luca Rigamonti, April L. McPherson, Benjamin Holmes, Nathaniel A. Bates

“…Outcomes of interest were pain, functional status, and kinesiophobia. Results: Group (Home vs. …”
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