Longitudinal study on quality of life following cervical cancer treatment in Botswana by Natalie Taylor, Doreen Ramogola-Masire, Karen Canfell, Katharine A Rendle, Lesego Gabaitiri, Surbhi Grover, Nicola Zetola, Memory Bvochora-Nsingo, Sebathu Chiyapo, Dawn Balang, Lilie L Lin, Mark N Polizzotto, Erle Robertson, Salman Khan, Rohini K Bhatia, Shalini Vinod, Paseka Tladi

“…Per QLQ-C30, the mean global health status score (72.21 vs 78.37; p<0.01) and the symptom (12.70 vs 7.63; p=0.04) and functional scales (88.34 vs 91.85; p<0.01) improved significantly from the EOT to the 24 month follow-up for all patients; however, using the QLQ-Cx24 survey, no significant differences in the symptom burden (12.53 vs 13.67; p=0.6) or functional status (91.23 vs 89.90; p=0.53) were found between these two time points.Conclusion The QoL increased significantly for all patients undergoing CRT, underscoring the value of pursuing curative CRT, regardless of the HIV status.…”
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Gender-Specific Differences in Diastolic Dysfunction and HFpEF: Pathophysiology, Diagnosis, and Therapeutic Strategies by Francesca Coppi, Gianluca Pagnoni, Francesca Grossule, Ashraf Nassar, Arianna Maini, Giuseppe Masaracchia, Francesco Sbarra, Elisa Battigaglia, Enrico Maggio, Daniela Aschieri, Federica Moscucci, Marcello Pinti, Anna Vittoria Mattioli, Francesco Fedele, Susanna Sciomer

“…Significant gender-specific differences are observed, with women, particularly post-menopausal, experiencing higher prevalence and distinct clinical profiles compared to men. …”
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The effects of early exercise on cardiovascular biomarkers in patients with congestive heart failure by Yanxiang Sun, Xuansheng Huang, Bing Hu, Zidi Wu, Yanchun Zhang, Yong Yuan, Li Feng

“…Abstract Background Exercise training improves functional outcomes in chronic heart failure (HF), but the effects of early in‐hospital physical activity on cardiovascular biomarkers and prognosis in acute congestive heart failure (AHF) patients remain unclear. …”
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A double-blind, placebo-controlled, randomized, multi-centre, phase III study of MLC901 (NeuroAiDTMII) for the treatment of cognitive impairment after mild traumatic brain injury. by Pavel I Pilipenko, Anna A Ivanova, Yulia V Kotsiubinskaya, Vera N Grigoryeva, Alexey Y Khrulev, Anatoly V Skorokhodov, Maxim M Gavrik, Nona N Mkrtchan, Marek Majdan, Peter Valkovic, Daria Rabarova, Suzanne Barker-Collo, Kelly Jones, Valery L Feigin

“…Although up to 40% of adults with mild TBI experience persistent functional deficits, there is no proven-effective treatment to facilitate recovery after it.…”
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Comparative Effectiveness of Different Frequencies of Spinal Cord Stimulation for the Treatment of Patients with Failed Back Surgery Syndrome: Systematic Review and Network Meta-An... by Qin YY, Zhang CP, Tang SS, Wu JP, Zhu LX, Li YH, Xu F

“…High-frequency SCS (10 kHz) was associated with higher SUCRA values for back pain (99.7%; P < 0.05 vs comparators; consistency χ²=1.41, P = 0.703) and leg pain (93.2%; P < 0.05 vs low-frequency SCS), suggesting a potential advantage. For functional outcomes, high-frequency SCS correlated with better ODI scores (SUCRA=85.0%), while subperception SCS showed higher probability for improved EQ-5D metrics (SUCRA=80.3%). …”
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SIU-ICUD: Principles and Outcomes of Focal Therapy in Localized Prostate Cancer by Alessandro Marquis, Jonathan Olivier, Tavya G. R. Benjamin, Eric Barret, Giancarlo Marra, Claire Deleuze, Lucas Bento, Kae J. Tay, Hashim U. Ahmed, Mark Emberton, Arnauld Villers, Thomas J. Polascik, Ardeshir R. Rastinehad

“…The safety profile is excellent, with high rates of urinary continence and sexual function preservation. Post-treatment surveillance integrates PSA measurements, imaging, and histological assessment. …”
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Cell therapy with placenta-derived mesenchymal stem cells for secondary progressive multiple sclerosis patients in a phase 1 clinical trial by Ameneh Shokati, Mohsen Nikbakht, Mohammad Ali Sahraian, Roghayyeh Saeedi, Elnaz Asadollahzadeh, Nasim Rezaeimanesh, Bahram Chahardouli, Zeinab Gharaylou, Seyed Asadollah Mousavi, Jafar Ai, Abdorreza Naser Moghadasi

“…Furthermore, fMRI analysis showed significant enhancements in brain connectivity and cognitive function. Immunologically, CD20/CD19 B cell markers decreased significantly (P = 0.0077), and anti-inflammatory cytokine IL-10 increased alongside reductions in pro-inflammatory TNFα, IL-6, and IL-17 (P < 0.0001) three months post-therapy. …”
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Therapeutic effects of forest bathing on older adult patients with essential hypertension: evidence from a subtropical evergreen broad-leaved forest by Aibo Li, Aibo Li, Yu Liu, Yu Liu, Haiyuan Qian, Kun Sun, Kun Sun, Ziqing Zhao, Ziqing Zhao, Iwao Uehara, Guofu Wang, Benzhi Zhou, Benzhi Zhou

“…Specifically, tension-anxiety scores decreased significantly, while vigor-activity scores increased (p &lt; 0.05).DiscussionThese findings suggest that forest bathing can serve as an effective non-pharmacological intervention for reducing blood pressure, improving autonomic function and mental health among older adult patients with essential hypertension. …”
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Regulation of mitochondrial oxidative phosphorylation through tight control of cytochrome c oxidase in health and disease – Implications for ischemia/reperfusion injury, inflammato... by Lucynda Pham, Tasnim Arroum, Junmei Wan, Lauren Pavelich, Jamie Bell, Paul T. Morse, Icksoo Lee, Lawrence I. Grossman, Thomas H. Sanderson, Moh H. Malek, Maik Hüttemann

“…COX and Cytc have been shown to be regulated by all three main mechanisms, which we discuss in detail: allosteric regulation, tissue-specific isoforms, and post-translational modifications for which we provide a comprehensive catalog and discussion of their functional role with 55 and 50 identified phosphorylation and acetylation sites on COX, respectively. …”
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The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies by Dongqi Li, Xiangyu Chu, Weikang Liu, Yongsu Ma, Xiaodong Tian, Yinmo Yang

“…RBPs may exhibit either anti-tumour or pro-tumour functions by influencing the TIME through the modulation of mRNAs and non-coding RNAs expression, as well as post-transcriptional modifications, primarily N6-methyladenosine (m6A). …”
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Abstract 145: Hyperacute Virtual Reality Augmented Rehabilitation (VRAR) in the Neurological ICU: A Safety and Feasibility Study by Galadu Subah, Fangyi Lin, Tiffany Ming, Kevin Clare, Akihiko Oishi, Akash Thacker, Sarah Bulbul, Anaz Uddin, Eric Feldstein, Bridget Nolan, Jose Dominguez, Sabrina Zeller, Simon Hanft, Chirag Gandhi, Fawaz Al‐Mufti

“…Introduction Virtual reality (VR) has shown great promise in stroke rehabilitation, providing interactive exercises that target motor and cognitive impairments with minimal adverse events and positive outcomes in improving motor function, balance, and patient motivation. …”
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Catch-up growth following early-life stunting in a low-resource area in rural Tanzania: the MAL-ED Metabolic study by Estomih Mduma, Samwel Jatosh, Mark D DeBoer, Eric R Houpt, Kiya Nemati, Yotham Z Michael, Bernadetha P Hhando

“…The results offer valuable insights towards improving child health outcomes in similar contexts.Trial registration number NCT02441426 (post-results) and NCT05121935.…”
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Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis by Weiping Xiao, Yibing Yang, Lu Bai, Peixuan Yang, Runze Li, Daizhi Yang, Fanying Li, Lingzhi Quan, Qiupeng Liang, Yan Yan, Tiewei Qi, Feng Liang

“…These changes led to improvements in memory, motor function, and anxiety- and depression-like behaviors. …”
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Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study. by Andrew Sommerlad, Séverine Sabia, Archana Singh-Manoux, Glyn Lewis, Gill Livingston

“…Results were consistent in a series of post hoc analyses, designed to assess potential biases. …”
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Risk factors for postoperative complications in patients with pulmonary tuberculosis by Bing Wang, Li Yao, Jian Sheng, Xiaoyu Liu, Yuhui Jiang, Lei Shen, Feng Xu, Qibin Liu, Sheng Bao, Chao Gao, Xiyong Dai

“…This finding helps us identify problems, improve operations, and reduce potential postoperative complications.…”
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Metabolome integrated with transcriptome, and genome analysis revealed higher accumulations of phytoalexins enhance resistance against Magnaporthe oryzae in new Zhefang rice variet... by Owais Iqbal, Xingrun Yang, Ruoping Wang, Chun Wang, Dandan Li, Jiancheng Wen, Jiasheng Ding, Sauban Musa Jibril, Chengyun Li, Yi Wang

“…The insights gained from this study offer valuable resources for enhancing rice breeding strategies and improving disease management in agriculture.…”
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Regulating effect of empagliflozin plus liraglutide on glucose/lipid metabolism and serum levels of SFRP5， Irisin and tAPN in obese type 2 diabetics by Gao Rui-chao, Li Min, Jin Peng-ran, Liu Xuan, Feng Xue, Tan Zeng-huan

“…At pre-treatment and 3 months post-treatment， two groups were compared regarding the parameters of weight loss ［weight， waist circumference （WC）， body mass index （BMI）］， glucose metabolism ［glycated hemoglobin （HbA1c）， fasting blood glucose （FPG）， 2 h postprandial blood glucose （2 hPG）］， lipid metabolism ［low-density lipoprotein cholesterol （LDL-C）， high-density lipoprotein cholesterol （HDL-C）， triglycerides （TG）， total cholesterol （TC）］， insulin sensitivity ［homeostasis model islet β cell function index （HOMA-β）， homeostasis model insulin resistance index （HOMA-IR）］， serum levels of SFRP5， Irisin and tAPN and occurrences of adverse reactions.ResultsAfter 3-month treatment， body weight ［（74.93±2.68） <italic>vs</italic> （78.21±3.47） kg］， WC ［（90.40±2.17） <italic>vs</italic> （93.28±2.53） cm］ ，BMI ［（26.57±0.94） <italic>vs</italic> （27.94±1.06） kg/m²］ ，HbA1c ［（6.03±0.59）% <italic>vs</italic> （6.76±0.68）%］， FPG ［（6.24±0.73） <italic>vs</italic> （6.97±0.95） mmol/L］， 2 hPG ［（8.06±1.25） <italic>vs</italic> （8.83±1.50） mmol/L］， LDL-C ［（2.27±0.21） <italic>vs</italic> （2.58±0.27） mmol/L］， TG ［（1.83±0.34） <italic>vs</italic> （2.20±0.48） mmol/L］， TC ［（5.36±0.42） <italic>vs</italic> （5.92±0.53） mmol/L］ and HOMA-IR （2.35±0.24 <italic>vs</italic> 2.69±0.31） were lower in observation group than those in control group（<italic>P</italic>&lt;0.05）. …”
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The Influence of Fracture Defect Size on Treatment Outcomes in Distal Femur Fractures: A Comparative Study Between Lateral Locking Plate and Double Plate Fixation by Meng Li, Taoguang Wu, Zicheng Zhang, Xiaomeng Ren, Mengmeng Hu, Dong Zhang, Wei Zhang

“…ABSTRACT Objective Double plate (DP) fixation does not significantly improve outcomes compared to lateral locking plate (LLP‐only) fixation for distal femur fractures (DFFs). …”
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Serum and urinary biomarkers for early detection of acute kidney injury following Hypnale spp. envenoming. by Eranga Sanjeewa Wijewickrama, Fahim Mohamed, Indika B Gawarammana, Zoltan H Endre, Nicholas A Buckley, Geoffrey K Isbister

“…Levels of five novel biomarkers, the functional marker serum Cystatin C and the damage markers urinary NGAL, cystatin C, β2-microglobulin and clusterin, were elevated in patients who developed moderate/severe acute kidney injury. sCysC performed the best at 0-4 h post-bite in predicting moderate to severe AKI (AUC-ROC 0.95;95%CI:0.85-1.0) and no biomarker performed better than sCr at later time points.…”
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Nasal Rehabilitation in a Patient After Basal Cell Carcinoma and Radiotherapy: A Case Report by Tamana Barakati, Hedayatullah Ehsan, Omid Humkar, Hassina Shadab, Munir Ahmad Ibrahimkhil

“…This case underscores the importance of an integrated approach combining surgical precision, prosthodontic expertise, and psychological support to improve patient satisfaction and quality of life following nasal rehabilitation post‐BCC and radiotherapy.…”
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