KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity by Yixin Li, Li Peng, Yang Zhou, Yan You, Jin Jiang, Yong Luo

“…In ischemic stroke (IS), microglia exhibit dynamic functional shifts, contributing to tissue damage during the acute phase and promoting repair in the chronic phase. …”
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Two-Centre Retrospective Analysis on Selective Sensory Denervation of Shoulder Joint by Means of Cooled Radiofrequency in Chronic Shoulder Pain by Santi C, Haag T, Cooke C, Schatman ME, Tinnirello A

“…Medication intake (non-steroidal anti-inflammatory drugs (NSAIDS) and/or opioids) significantly decreased at all follow ups.Conclusion: Cooled radiofrequency denervation can be an effective procedure to manage chronic shoulder pain, providing sustained pain relief and functional improvement in more than 50% of the patients.Keywords: radiofrequency, neuromodulation, shoulder pain, pain management…”
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First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries by Masakazu Ishikawa, Shunya Tsuji, Goki Kamei, Kyohei Nakata, Akinori Nekomoto, Naofumi Hashiguchi, Tomoyuki Nakasa, Atsuo Nakamae, Naosuke Kamei, Keiichiro Inoue, Shingo Kawabata, Keiko Ueda, Nobuo Adachi

“…While meniscal repair is the preferred method for preserving knee function, it often has a high failure rate in avascular zones. …”
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Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement by Duvuru Geetha, Frank B. Cortazar, Annette Bruchfeld, Andreas Kronbichler, Alexandre Karras, Georges N. Nakhoul, Peter A. Merkel, Sarah Bray, Alana M. Bozeman, David R.W. Jayne, C. Au Peh, A. Chakera, B. Cooper, J. Kurtkoti, D. Langguth, V. Levidiotis, G. Luxton, P. Mount, D. Mudge, E. Noble, R. Phoon, D. Ranganathan, A. Ritchie, J. Ryan, M. Suranyi, A. Kronbichler, A. Rosenkranz, K. Lhotta, N. Demoulin, C. Bovy, R. Hellemans, J. Hougardy, B. Sprangers, K. Wissing, C. Pagnoux, S. Barbour, S. Brachemi, S. Cournoyer, L. Girard, L. Laurin, P. Liang, D. Philibert, M. Walsh, C. Rigothier, J. Augusto, A. Belot, D. Chauveau, D. Cornec, N. Jourde-Chiche, M. Ficheux, P. Zaoui. Paris, A. Karras, A. Klein, F. Maurier, R. Mesbah, O. Moranne, A. Neel, T. Quemeneur, D. Saadoun, B. Terrier, P. Zaoui, M. Schaier, U. Benck, R. Bergner, M. Busch, J. Floege, F. Grundmann, H. Haller, M. Haubitz, B. Hellmich, J. Henes, B. Hohenstein, C. Hugo, C. Iking-Konert, F. Arndt, T. Kubacki, I. Kotter, P. Lamprecht, T. Lindner, J. Halbritter, H. Mehling, U. Schönermarck, N. Venhoff, V. Vielhauer, O. Witzke, I. Szombati, G. Szucs, G. Garibotto, F. Alberici, E. Brunetta, L. Dagna, S. De Vita, G. Emmi, A. Gabrielli, L. Manenti, F. Pieruzzi, D. Roccatello, C. Salvarani, H. Dobashi, T. Atsumi, S. Fujimoto, N. Hagino, A. Ihata, S. Kaname, Y. Kaneko, A. Katagiri, M. Katayama, Y. Kirino, K. Kitagawa, A. Komatsuda, H. Kono, T. Kurasawa, R. Matsumura, T. Mimura, A. Morinobu, Y. Murakawa, T. Naniwa, T. Nanki, N. Ogawa, H. Oshima, K. Sada, E. Sugiyama, T. Takeuchi, H. Taki, N. Tamura, T. Tsukamoto, K. Yamagata, M. Yamamura, P. van Daele, J. de Zoysa, A. Rutgers, Y. Teng, R. Walker, I. Chua, M. Collins, K. Rabindranath, J. de Zoysa, M. Svensson, B. Grevbo, S. Kalstad, M. Little, M. Clarkson, E. Molloy, I. Agraz Pamplona, J. Anton, V. Barrio Lucia, S. Ciggaran, M. Cinta Cid, M. Diaz Encarnacion, X. Fulladosa Oliveras, M. Jose Soler, H. Marco Rusinol, M. Praga, L. Quintana Porras, A. Segarra, A. Bruchfeld, M. Segelmark, I. Soveri, E. Thomaidi, K. Westman, T. Neumann, M. Burnier, T. Daikeler, J. Dudler, T. Hauser, H. Seeger, B. Vogt, D. Jayne, J. Burton, R. Al Jayyousi, T. Amin, J. Andrews, L. Baines, P. Brogan, B. Dasgupta, T. Doulton, O. Flossmann, S. Griffin, J. Harper, L. Harper, D. Kidder, R. Klocke, P. Lanyon, R. Luqmani, J. McLaren, D. Makanjuola, L. McCann, A. Nandagudi, S. Selvan, E. O'Riordan, M. Patel, R. Patel, C. Pusey, R. Rajakariar, J. Robson, M. Robson, A. Salama, L. Smyth, J. Sznajd, J. Taylor, P. Merkel, A. Sreih, E. Belilos, A. Bomback, J. Carlin, Y. Chang Chen Lin, V. Derebail, S. Dragoi, A. Dua, L. Forbess, D. Geetha, P. Gipson, R. Gohh, G.T. Greenwood, S. Hugenberg, R. Jimenez, M. Kaskas, T. Kermani, A. Kivitz, C. Koening, C. Langford, G. Marder, A. Mohamed, P. Monach, N. Neyra, G. Niemer, J. Niles, R. Obi, C. Owens, D. Parks, A. Podoll, B. Rovin, R. Sam, W. Shergy, A. Silva, U. Specks, R. Spiera, J. Springer, C. Striebich, A. Swarup, S. Thakar, A. Tiliakos, Y. Tsai, D. Waguespack, M. Chester Wasko

“…Conclusion: In patients with GPA or MPA with kidney involvement, treatment with an avacopan regimen compared with a prednisone taper regimen achieved similar rates of remission, improved recovery of kidney function, led to faster reduction in albuminuria and hematuria, and lowered GC-related toxicity, with an acceptable safety profile.…”
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Comparative Impact of Aerobic vs Resistance Training on Fatigue, Mobility, and Disability in Cancer Patients by Azzam Alarab, Nabeel Hroub, Ratib Abu Shameh

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Safety and efficacy of plasmapheresis in treatment of acute fatty liver of pregnancy—a systematic review and meta-analysis by Sujata Siwatch, Arka De, Bandhanjot Kaur, Divjot Singh Lamba, Simarpreet Kaur, Virendra Singh, Aravind Gandhi Periyasamy

“…We performed systematic review and meta-analysis to estimate the clinical parameters that included mortality rates and improvement of the biochemical parameters including Liver and Renal function enzymes, coagulopathy factors of AFLP patients.MethodsWe searched PubMed, Ovid MEDLINE, Cochrane, CINAHL and Scopus, ClinicalTrials.gov. …”
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Sex Differences in Sleep Architecture After Traumatic Brain Injury: Potential Implications on Short-Term Episodic Memory and Recovery by Stefanie N. Howell, Grace S. Griesbach

“…Melatonin utilization had a positive impact on REM duration. Improvements in understanding the impact of sleep-wake disturbances on post-TBI outcome will aid in defining targeted interventions for this population. …”
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Closed-loop rehabilitation of upper-limb dyskinesia after stroke: from natural motion to neuronal microfluidics by Honggang Wang, Junlong Guo, Yangqi Zhang, Ze Fu, Yufeng Yao

“…This review highlights the promise of closed-loop strategies in achieving unprecedented integration of subdomains and improving post-stroke upper-limb rehabilitation outcomes.…”
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Impact of action observation therapy on motor and cognitive outcomes in older adults with mild cognitive impairment: a randomized controlled study by Miriam Martin-Blazquez, Miriam Martin-Blazquez, M. Dolores Sosa-Reina, M. Dolores Sosa-Reina, Angye Micaela Andrade-Granda, Ismael Sanz-Esteban, Ismael Sanz-Esteban, Javier López-Ruiz, Javier López-Ruiz, Cecilia Estrada Barranco, Cecilia Estrada Barranco

“…The intervention comprised physical and cognitive exercises over 5 weeks, with assessments before and after.Resultssignificant differences in post-intervention improvement were found between the groups, excluding the Box and block test. …”
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The Impact of Prolotherapy and Steroid Injection on De Quervain's Tenosynovitis: A Retrospective Outcome Study by Hakan Zora, Gökhan Bayrak

“…This difference continued at sixth-week post-treatment; VAS (p=0.007), QuickDASH (p=0.003), and HAQ (p=0.011) were found to be significantly lower in steroid injection than in the prolotherapy.Conclusion:Our findings underscore the superior effectiveness of steroid injection compared to prolotherapy in reducing wrist pain and improving functional outcomes in patients with DQT. …”
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Addition of Modified Lemaire Lateral Extra-Articular Tenodesis in a Single stage Revision Anterior Cruciate Ligament Reconstruction using Peroneus Longus Tendon: A Prospective Stud... by Sonarkar SS, Stanley A, Kumar-Singh S, Garg R, Narula A, Raj M

“…Post-operatively, there was significant improvement in the anterior knee laxity. …”
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rTMS for enhancing cognitive reserve: A case report by Chiara Di Fazio, Eugenio Scaliti, Mario Stanziano, Anna Nigri, Greta Demichelis, Marco Tamietto, Sara Palermo

“…Our findings suggest that rTMS may be a well-tolerated and potentially effective intervention for improving cognitive function and stabilizing mood in older adults experiencing age-related cognitive decline and mood disorders.…”
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An Update on the Effects and Complications of BoNT-A in the Management of Third, Fourth, and Sixth Nerve Palsies: A Narrative Review by Mohammad Reza Talebnejad, Roghayyeh Baghban, Alireza Attar, Aidin Meshksar, Mansoureh Bagheri, Mohammad Reza Khalili

“…BoNT-A injection is an effective option to manage different types of cranial nerve palsies and improve binocular function. Furthermore, it plays an integral role in preventing antagonist muscle contracture and, hence, the need for future surgical intervention. …”
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Application and Research of Left Bundle Branch-Optimized Cardiac Resynchronization Therapy in Ischemic Cardiomyopathy by Denghong Zhang, Mingjian Lang, Benjamin Samraj Prakash Earnest, Ihab Elsayed Mohamed Ali Abdou

“…Six months post-surgery, both groups showed modest improvements in NYHA class, LVEF, and LVEDD, with the LOT-CRT group demonstrating significant improvements (p < 0.001). …”
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Intelligent Approaches to Computer Testing of Perception and Production Skills of Russian EFL Speakers by Marina Kolesnichenko, Vitalii Kapitan

“…Participants rated the tool as useful and interesting, although they suggested improving the speech recognition function due to minor technical flaws. …”
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In ovo delivery of carvacrol triggers expression of chemotactic factors, antimicrobial peptides and pro-inflammatory pathways in the yolk sac of broiler chicken embryos by Mila M. Y. Meijer, Henry van den Brand, Shahram Niknafs, Eugeni Roura

“…Therefore, the aim of this study was to improve early immune function in chicken embryos, and it was hypothesized that in ovo delivery of carvacrol would result in immunomodulatory effects in the yolk sac, potentially improving post-hatch resilience. …”
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Significance of Omega-3 Fatty Acids in the Prophylaxis and Treatment after Spinal Cord Injury in Rodent Models by Piotr Wojdasiewicz, Łukasz A. Poniatowski, Paweł Turczyn, Justyna Frasuńska, Agnieszka Paradowska-Gorycka, Beata Tarnacka

“…On the other hand, the therapeutic properties (post-SCI) include the increased production of endogenous antioxidants such as carnosine and homocarnosine, the maintenance of elevated GSH concentrations at the site of injury, reduced concentrations of oxidative stress marker (MDA), autophagy improvement (via increasing the expression of LC3-II), and p38 MAPK expression reduction in the superficial dorsal horns (limiting the sensation of neuropathic pain). …”
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Clinical and genetic characteristics of type 3 lissencephaly caused by a mutation in the TUBA1A gene (OMIM: 611603) by D. M. Guseva, T. V. Markova, L. A. Bessonova, S. S. Nikitin, E. L. Dadali, O. A. Shchagina

“…Lissencephaly (LIS) is a spectrum of malformations of the cerebral cortex that occur as a result of impaired migration of neuronal precursors to the cortical plate and the formation of furrows and convolutions in the post‑migration period of embryonic development. In recent years, a significant role of hereditary factors in the occurrence of LIS has been shown due to the improvement of methods of molecular genetic diagnostics. …”
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Transcatheter PDA recanalization and interatrial septal stenting as a bridge to arterial switch operation in a late-presenting infant with D-transposition of the great arteries by Revan Satrio, Priyandini Wulandari, Hiradipta Ardining, Brian Mendel, Indriwanto Sakidjan Atmosudigdo, Radityo Prakoso, Bambang Widyantoro

“…Abstract Background Dextro-transposition of the great arteries with intact ventricular septum (d-TGA/IVS) requires early arterial switch operation (ASO) to preserve left ventricular function, but delayed presentations complicate outcomes due to LV regression and hypoxemia. …”
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Antioxidant and Ultrastructural Alterations in Wheat During Drought-Induced Leaf Senescence by Turana Y. Isgandarova, Samira M. Rustamova, Durna R. Aliyeva, Fuad H. Rzayev, Eldar K. Gasimov, Irada M. Huseynova

“…In this study, we investigated biochemical, functional, and ultrastructural changes during leaf senescence in wheat genotypes with contrasting drought tolerance. …”
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