Physiology and Pathophysiology of Marathon Running: A narrative Review by Lorin Braschler, Pantelis T. Nikolaidis, Mabliny Thuany, Daniela Chlíbková, Thomas Rosemann, Katja Weiss, Matthias Wilhelm, Beat Knechtle

“…Overall, marathon training offers several benefits for different organ systems and reduces all-cause mortality. As such, it improves cardiovascular risk factors, leads to favorable cardiac adaptations, enhances lung function, and improves quality of life in chronic kidney disease patients. …”
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TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury by Yunsheng Zhang, Yunsheng Zhang, Yunsheng Zhang, Yulian Zhang, Hanhan Dang, Hanhan Dang, Chuanpeng Zhang, Chuanpeng Zhang, Kun He, Kun He, Xu Yang, Xu Yang, Zixi Wang, Zixi Wang, Li Zhang, Li Zhang, Li Zhang, Yanbing Yu, Yanbing Yu, Yanbing Yu

“…Pharmacological targeting of TREM-1 attenuates neuroinflammation, reduces cerebral edema, preserves blood-brain barrier integrity, and improves functional recovery. These effects are mediated through suppression of TREM-1-dependent NF-κB signaling and pyroptosis. …”
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Digital education and exercise therapy versus minimal intervention for young people at high risk of early onset knee osteoarthritis after ACL reconstruction: a study protocol for t... by Jackie L. Whittaker, Amanda Cammalleri, Candice Archibald, Alexandra Brooks-Hill, Patrick Chin, Sarah Clark, Jennifer C. Davis, Alison M. Hoens, Michael A. Hunt, Karin Kausky, Angelina Ko, Lise Leveille, Linda C. Li, Parth Lodhia, Justin M. Losciale, Maxi Miciak, Amber D. Mosewich, Adnan Sheikh, Trish Silvester-Lee, Linda K. Truong, Dominic Wade, David R. Wilson, Hui Xie, Xian He Yan, Ewa M. Roos

“…This study will assess if a digital education and exercise therapy intervention is superior to minimal intervention for improving knee-related symptoms, function, and quality of life in young people after ACLR. …”
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A low-cost upper limb exoskeleton assistive device based on elbow torque feedback by Jiaxin Huang, Fan Wu, Baoyi Ding, Jiasheng Yin, Guang Yang, Zhigong Song

“…It offers an opportunity to enhance the quality of life for users by aiding in the recovery or improvement of upper limb function. …”
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Intermittent Abdominal Pressure Ventilation: An Alternative for Respiratory Support by Giuseppe Fiorentino, Anna Annunziata, Antonietta Coppola, Antonella Marotta, Francesca Simioli, Pasquale Imitazione, Maurizia Lanza, Rosa Cauteruccio, Antonio M. Esquinas

“…We performed baseline and post-IAPV respiratory function assessment. All patients, two years later, are still using intermittent abdominal ventilation. …”
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Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL‐AD preclinical testing core study by Kristen D. Onos, Sara K. Quinney, David R. Jones, Andrea R. Masters, Ravi Pandey, Kelly J. Keezer, Carla Biesdorf, Ingrid F. Metzger, Jill A. Meyers, Johnathon Peters, Scott C. Persohn, Brian P. McCarthy, Amanda A. Bedwell, Lucas L. Figueiredo, Zackary A. Cope, Michael Sasner, Gareth R. Howell, Harriet M. Williams, Adrian L. Oblak, Bruce T. Lamb, Gregory W. Carter, Stacey J. Sukoff Rizzo, Paul R. Territo

“…Abstract Introduction Hyperexcitability and epileptiform activity are commonplace in Alzheimer's disease (AD) patients and associated with impaired cognitive function. The anti‐seizure drug levetiracetam (LEV) is currently being evaluated in clinical trials for ability to reduce epileptiform activity and improve cognitive function in AD. …”
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Activation of endogenous full-length utrophin by MyoAAV-UA as a therapeutic approach for Duchenne muscular dystrophy by Ruo Wu, Peng Li, Puhao Xiao, Shu Zhang, Xiaopeng Wang, Jie Liu, Wenjie Sun, Yue Chang, Xiuyi Ai, Lijiao Chen, Yan Zhuo, Jiaojian Wang, Zhengbo Wang, Shangang Li, Yuanyuan Li, Weizhi Ji, Wenting Guo, Shiwen Wu, Yongchang Chen

“…Systemic administration of MyoAAV-UA in male mdx mice leads to substantial upregulation of utrophin at the sarcolemma, resulting in significant improvements in skeletal muscle function and a slowing of heart function deterioration. …”
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Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure by Nyzil Massey, Suraj S. Vasanthi, Claire Holtkamp, Christina Meyer, Nikhil S. Rao, Luis G. Gimenez-Lirola, Chong Wang, Hyunmook Im, Avinash S. Bevoor, Sridhar Kannurpatti, Thimmasettappa Thippeswamy

“…Results SAR treatment attenuated the soman-induced anxiety/fear-like behavioral changes and motor impairment and modulated the severity of spontaneous seizures. Despite improved hippocampal functional connectivity (fMRI), SAR did not mitigate soman-induced cognitive deficits at 5–7 weeks. …”
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High Genetic Diversity Among <i>Bacillus cereus</i> Isolates Contaminating Donated Milk at a Canadian Human Milk Bank by Mathew Gene, Jennifer L. Guthrie, Kevin Li, Sarah Teatero, Aimee Paterson, Angel Li, Alain Doyen, Deborah Yamamura, Sarah Khan, Jocelyn A. Srigley, Debbie Stone, Deborah L. O’Connor, Susan Poutanen, Sharon Unger, Allison McGeer, Nahuel Fittipaldi

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Comparison of the effectiveness of intra-infrapatellar fat pad and intra-articular glucocorticoid injection in knee osteoarthritis patients with Hoffa’s synovitis: protocol for a m... by Yiwei Chen, Changqing Zhang, Tao Gao, Hongyi Zhu, Qiuke Wang, Qianying Cai, Junqing Lin, Jiali Lin, Longxiang Shen

“…Secondary outcomes include Hoffa’s synovitis score at 2 weeks post-injection, pain intensity with the numerical rating scale, WOMAC questionnaire score improvements (function, joint stiffness and total score), improvement rates in effusion synovitis at 2 and 24 weeks, articular cartilage thickness changes at 2 and 24 weeks, Intermittent and Constant Osteoarthritis Pain score, quality of life measured with the EuroQol-5D, OARSI-OMERACT response indicators, co-interventions and side effects at 2, 4, 8, 12 and 24 weeks.Ethics and dissemination Ethical approval has been granted by the Medical Ethics Committee of the Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (2023–178). …”
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Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know? by Veronica Maria Tagi, Veronica Maria Tagi, Martina Tosi, Martina Tosi, Ilenia Pia Greco, Eliana Stucchi, Elvira Verduci, Elvira Verduci, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti

“…Post-streptococcal autoimmune neuropsychiatric disorders (PANDAS) are a group of pathological condition characterized by sudden-onset obsessive-compulsive and tic disorders following beta-hemolytic Streptococcus group A (GAS) infection, hypothesized to be caused by autoimmune mechanisms targeting the basal ganglia. …”
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Reconfigurable Mixed‐Dimensional Transistor With Semimetal CNT Contacts by Xuanzhang Li, Yuheng Li, Zhen Mei, Liang Liang, Qunqing Li, Shoushan Fan, Yang Wei

“…Abstract Reconfigurable low‐dimensional devices are attractive for electronics in the post‐Moore era. However, their performance and function design are limited by the metal–semiconductor contacts for the Fermi level pinning and fixed Schottky barrier height (SBH). …”
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Progress in the study of bioactivity, chemical composition and pharmacological mechanism of action in Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb by Qi Xiong, Zhuoran Li, Defeng Yang, Xinze Liu, Wanxu Pu, Xitao Yue, Kaikai Jia, Xilin Wan, Xilin Wan, Yuanjun Zou

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Lactoferrin promotes intestinal stem cell‐mediated epithelial regeneration by activating Wnt signaling by Weiru Yu, Yingying Lin, Yao Lu, Yuqi Wang, Dan Zhang, Heng Quan, Yujia Luo, Yuning Zhang, Zhengqiang Jiang, Juan Chen, Yixuan Li, Huiyuan Guo

“…Abstract Nutritional intervention can greatly benefit people who suffer from side effects of medical treatments by improving intestinal post‐damage recovery. The recovery process is dependent on the regeneration of intestinal epithelial cells, which is driven by Lgr5+ intestinal stem cells (ISCs). …”
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Evaluation of Walkability Index for Embedded Community Services from an Age-Friendly Perspective: A Case Study of Mapple Community in Chengdu, China by Jing Yang, Yuqiu Wu, Xuemei Chen, Binjie Luo, Ran Wu, Rong Lin

“…Key contributions include the following: (1) developing mobility-attenuated accessibility models tailored to distinct age groups, overcoming the limitations of traditional single-function approaches; (2) establishing a multidimensional evaluation system that bridges accessibility theory and usability metrics; (3) empirically demonstrating the spatial equity improvements through embedded facility optimization. …”
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Unraveling the potential of hypothalamic deep brain stimulation for obesity: Impacts on memory, neuroplasticity and brain metabolism in the Zucker rat by Marta Casquero-Veiga, Meritxell Llorca-Torralba, Clara Bueno-Fernandez, Diego Romero-Miguel, Nicolás Lamanna-Rama, Christine Winter, Esther Berrocoso, Juan Nacher, Manuel Desco, Mª Luisa Soto-Montenegro

“…These findings suggest that alternative DBS protocols may help restore hippocampal function, warranting further investigation.…”
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Case report: A case of type 1 diabetes with diabetic ketoacidosis induced by envafolimab treatment in hepatocellular carcinoma by Youjia Li, Kai Qu, Xiuli Li, Xin Yang, Kanghuai Zhang, Jiao Xie

“…We advocate for the establishment of long-term follow-up plans, including regular monitoring for potential irAEs and endocrine function assessments, to address the chronicity of conditions post-ICI treatment. …”
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Efficacy of Segmental Muscle Vibration on Pain Modulation in Patients with Primary Cervical Dystonia Treated with Botulinum Type-A Toxin: A Protocol for a Randomized Controlled Tri... by Riccardo Buraschi, Paolo Pedersini, Giacomo Redegalli, Rosa Pullara, Joel Pollet, Marina Rossi, Massimiliano Gobbo, Sara Gueli, Maurizio Falso

“…The primary outcomes include changes in pain intensity and function, assessed at baseline, mid-treatment, and post-treatment using validated scales. …”
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Design of a Wearable Vibrotactile Stimulation Device for Individuals With Upper-Limb Hemiparesis and Spasticity by Caitlyn E. Seim, Brandon Ritter, Thad E. Starner, Kara Flavin, Maarten G. Lansberg, Allison M. Okamura

“…Vibratory stimulation may improve post-stroke symptoms such as spasticity; however, current studies are limited by the large, clinic-based apparatus used to apply this stimulation. …”
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Study protocol for an observational research study with an embedded N-of-1 design: Increasing the availability of goal-oriented cognitive rehabilitation for people living with deme... by Caoimhe Hannigan, Antoine Lemercier, Garret McDermott, Helena Lydon, Sean P Kennelly, Michelle Kelly

“…<h4>Background</h4>Goal-Oriented Cognitive Rehabilitation (GREAT-CR) is an evidence-based early intervention for people with mild-moderate dementia that improves goal attainment and functional outcomes. In Ireland, this intervention is not widely available, likely due to resource shortages within memory services. …”
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