Selumetinib in Adult Neurofibromatosis 1 with Plexiform Neurofibroma by Carlen A. Yuen, Eleanor Chu, Ryan O’Connell, Bryan K. Sun, Raj Vyas, Michelle Zheng, Emma Elliott, Changrui Xiao

“…<b>Background/Objectives:</b> Neurofibromatosis Type 1 (NF1) plexiform neurofibroma (PN) can cause morbidity, including disfigurement that can negatively impact social functioning. Historically, the mainstay treatment is surgical resection. …”
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Development and evaluation of spirometry reference equations at high altitude by Yanyan Li, Zhenzhen Xing, Xiangda Zhang, Yanlu Hu, Yanfei Guo

“…The reference equations utilise age and height as independent variables, with improved accuracy achieved through spline functions. …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Yan Yi Chan, Pui Yan Ho, Carla Dib, Leah Swartzrock, Maire Rayburn, Hana Willner, Ethan Ko, Katie Ho, Julian D. Down, Adam C. Wilkinson, Hiro Nakauchi, Morgane Denis, Taylor Cool, Agnieszka Czechowicz

“…Subsequent efforts have built upon this work to develop various combination approaches, though none are optimal and how any of these mAbs fully function is unknown. Methods To improve efficacy of mAb-based conditioning as a stand-alone conditioning approach for all HSCT settings, it is critical to understand the mechanistic action of αCD117 mAbs on HSCs. …”
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Current advances in the development of microRNA-integrated tissue engineering strategies: a cornerstone of regenerative medicine by Luis Germán Castañón-Cortés, Luis Alberto Bravo-Vázquez, Grecia Santoyo-Valencia, Sara Medina-Feria, Padmavati Sahare, Asim K. Duttaroy, Sujay Paul

“…Regenerative medicine is an innovative scientific field focused on repairing, replacing, or regenerating damaged tissues and organs to restore their normal functions. A central aspect of this research arena relies on the use of tissue-engineered scaffolds, which serve as structural supports that mimic the extracellular matrix, providing an environment that orchestrates cell growth and tissue formation. …”
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Podoplanin-positive cell-derived small extracellular vesicles contribute to cardiac amyloidosis after myocardial infarction by Maria Cimini, Ulrich H.E. Hansmann, Carolina Gonzalez, Andrew D. Chesney, May M. Truongcao, Erhe Gao, Tao Wang, Rajika Roy, Elvira Forte, Vandana Mallaredy, Charan Thej, Ajit Magadum, Darukeshwara Joladarashi, Cindy Benedict, Water J. Koch, Çağla Tükel, Raj Kishore

“…Inhibition of SAA3 aggregation by retro-inverso D-peptide, specifically designed to bind SAA3 monomers, prevents the deposition of SAA3 amyloid fibrils and improves heart function post MI.…”
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Application of ferrofluids for enhanced oil recovery: Impact on heavy and light oils in heterogeneous and homogeneous micromodels by Milad Khashay, Tarek Ganat, Ehsan Esmaeilnezhad

“…Additionally, their magnetic properties allow for easy post-recovery separation, enhancing environmental sustainability and reusability. …”
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Market Regime Identification and Variable Annuity Pricing: Analysis of COVID-19-Induced Regime Shifts in the Indian Stock Market by Mohammad Sarfraz, Guglielmo D’Amico, Dharmaraja Selvamuthu

“…Advanced methodologies, including regime-switching hidden Markov models, artificial neural networks, and Monte Carlo simulations, were applied to analyze pre- and post-COVID-19 market behavior. The regime-switching hidden Markov models effectively capture latent market regimes and their transitions, which traditional models often overlook, while neural networks provide flexible functional approximations that enhance pricing accuracy in highly non-linear environments. …”
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Lower-Limb Amputees and Family Caregivers: Challenges, Needs, and Strategies for Empowerment—A Qualitative Study by Diana Rodrigues, Luís Carvalho, Cristina Pinto

“…Tailored interventions such as peer support, home adaptations, and multidisciplinary care are essential for resilience, independence, and improved quality of life. <b>Conclusions</b>: Family centered empowerment strategies are vital for improving the outcomes of amputees and caregivers. …”
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Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review by Eliane C. Miotto, Alana X. Batista, Sharon S. Simon, Benjamin M. Hampstead

“…However, comparatively little is known about the neural mechanisms associated with such cognitive improvement. Objective. The primary aim of the current review was to examine neurophysiological changes measured by functional magnetic resonance imaging (fMRI) and possible cognitive changes following COTs in those with MCI. …”
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Comparison of Quality of Life in Transfemoral Amputee Using Bone‐Anchored Prostheses vs. Socket Prostheses: A Systemic Review and Meta‐Analysis by Janice Tan, Nafisa Zilani, Rezaul Karim, Bijendra Patel

“…ABSTRACT Amputation has a profound impact on an individual's quality of life (QoL) and functional ability. While socket prostheses are the current first‐line treatment, they often cause socket‐related issues. …”
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A tailored distractor-assisted percutaneous minimally invasive treatment for Sanders II and III calcaneus fractures: a consecutive cohort study with medium-term results by Xiong Liao, Jianliang Deng, Wei Liu, Di You

“…Radiographic measurements revealed significant differences between pre-operation and post-operation in calcaneal height and width, so as to Bohler's angle and Gissane angle (p &lt; 0.05, respectively). …”
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Comparing the effects of computerized versus manual methods of identifying point-specific acupuncture as an adjunct to physiotherapy in the management of knee osteoarthritis: A ran... by Lee Chai Li, Mohd Azzuan Ahmad, Tan Chee Hou, Angeline Low Ann Je, Lee Zi Lin, Tay Yan Ling, Peng Yan

“…<h4>Background</h4>Knee osteoarthritis (KOA) is a prevalent condition causing significant pain and functional impairment. Acupuncture has shown promise as an adjunctive therapy, but conventional manual selection of acupoints lacks standardization. …”
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Effect of Enhanced Exercise Program on Pain and Physical Activity for Patients after Total Knee Arthroplasty by Safaa M. Hamed, Rasha F. M. Gaballah

“…The need for knee replacement is predicted to increase six-fold between 2005 and 2030 to reflect an increasingly yet functionally demanding population. Aim: This study aimed to evaluate the effect of an enhanced exercise program on pain and physical activity after total knee arthroplasty. …”
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Multiphase CFD modeling of alumina nanoparticle drug delivery in bifurcated coronary arteries with stenosis, aneurysm, and bypass conditions by S. Subah, M. M. Billah, M. N. Uddin, K. E. Hoque

“…Nanoparticles raise arterial pressure by 12–20 %, but reduce aneurysmal pressure by 18 % post-bypass, suggesting improved hemodynamic stability. …”
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Enhancing locally employed doctor support and integration: a QIP on a buddy programme at Russells Hall Hospital by Sumaira Malik, Tamar Saeed, Shifa Puri, Sidra Shah, Ayesha Farooq

“…The objective was to improve their transition into the NHS by enhancing peer support mechanisms. …”
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Enhancing Shiga toxin detection using surface plasmon resonance a study of antibody immobilization strategies by Zahra Karbalaee, Ali Hossein Rezayan, Ramezan Ali Taheri, Seyed Ali Mirhosseini, Mohammad Barshan-Tashnizi

“…Mechanistic studies attribute these improvements to protein G’s ability to maintain optimal antibody orientation, thereby: (1) maximizing paratope accessibility, (2) minimizing steric interference, and (3) preserving binding site functionality. …”
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Effects of high intensity training and high volume training on endothelial microparticles and angiogenic growth factors. by Patrick Wahl, Felix Jansen, Silvia Achtzehn, Theresa Schmitz, Wilhelm Bloch, Joachim Mester, Nikos Werner

“…Increased EMP uptake was associated with an improved protection of target cells against apoptosis. …”
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Research on a PTSD Risk Assessment Model Using Multi-Modal Data Fusion by Youxi Luo, Yucui Shang, Dongfeng Zhu, Tian Zhang, Chaozhu Hu

“…Post-traumatic stress disorder (PTSD) is a complex psychological disorder caused by multiple factors, which are not only related to individual psychological states but also closely linked to physiological responses, social environments, and personal experiences. …”
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A Comprehensive Review of the Brain–Gut Microbiota System in Traumatic Brain Injury: Mechanisms, Outcomes, and Emerging Interventions by Venencia Albert, Shweta Kedia, Arulselvi Subramanian

“…Emerging evidence suggests that gut dysbiosis plays a pivotal role in post-TBI complications. The gut microbiome, a diverse community of commensal microorganisms, is integral to gut physiology, performing key functions such as metabolic regulation, maintaining the intestinal barrier, and modulating immune responses. …”
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Retrospective evaluation of the short-term effectiveness of non-enzymatically isolated stromal vascular fraction cells in patients with knee osteoarthritis by Aytan Safarli, Berkay Kirnaz, Derin Kumcuoglu, Vusal Mahmudov, Ziya Karimov, Afig Berdeli

“…Results At the fifth and 12th months post-treatment, it was observed that the WOMAC scores were significantly improved compared with pre-treatment scores. …”
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