Safety, pharmacokinetics, and potential benefits of TSH-receptor-specific monoclonal autoantibody K1-70TM in Japanese Graves’ disease patients: results of a phase 1 trial by Jaeduk Yoshimura Noh, Natsuko Watanabe, Koichi Ito, Mika Tsuiki, Yuki Ishihara, Tetsuya Tagami, Ichiro Yamauchi, Ai Kozaki, Toshu Inoue, Bernard Rees Smith

“…Twelve patients were enrolled, divided into four dosage cohorts (5 mg, 25 mg, 75 mg, and 150 mg), and monitored for 100 days post-administration. The primary objective was to assess safety and tolerability, and the secondary objectives were evaluation of PK and thyroid function. …”
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Empowering pediatric, adolescent, and young adult patients with cancer utilizing generative AI chatbots to reduce psychological burden and enhance treatment engagement: a pilot stu... by Joe Hasei, Mana Hanzawa, Akihito Nagano, Naoko Maeda, Shinichirou Yoshida, Makoto Endo, Nobuhiko Yokoyama, Motoharu Ochi, Hisashi Ishida, Hideki Katayama, Tomohiro Fujiwara, Eiji Nakata, Ryuichi Nakahara, Toshiyuki Kunisada, Hirokazu Tsukahara, Toshifumi Ozaki

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Effects of high-intensity interval training under hypoxic conditions on energy system performance in collegiate football players by Dr. Jukdao Potisaen, Traimit Potisan, Supanithi Khumprommarach

“…This aligns with existing literature on the role of hypoxia in enhancing oxygen transport, mitochondrial function, and endurance capacity. Conclusions: Simulated hypoxic HIIT effectively enhances aerobic capacity and selectively improves anaerobic performance. …”
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The Efficacy and Safety of Single Injections of Hybrid HA in the Treatment of Symptomatic Knee Osteoarthritis: A Case Series by Marcin E. Domzalski, Klaudia Marchewa

“…While decrease in pain and joint function improvement were not as pronounced at the end of follow-up, they were still statistically better than at baseline. …”
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Comparison of clinical features and 3-month treatment response among three different choroidal thickness groups in polypoidal choroidal vasculopathy. by Mingui Kong, Sung Min Kim, Don-Il Ham

“…They were also classified into three thickness groups, and the short-term post-treatment improvement in visual acuity and central retinal thickness were compared among groups. …”
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Kidney transplant program in Irkutsk Region by A. V. Novozhilov, S. E. Grigoriev, O. Yu. Yakovleva, S. A. Yezhikeev

“…Kidney transplantation (KT) is often considered the best option for renal replacement therapy (RRT), significantly improving patient outcomes. Post-transplant, life expectancy doubles, and mortality decreases more than 4-fold compared to other RRT modalities. …”
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Contribution of brain pericytes to neuroinflammation following repetitive head trauma by Arianna Cembran, Maxwell Eisenbaum, Daniel Paris, Michael Mullan, Fiona Crawford, Scott Ferguson, Corbin Bachmeier

“…As the platelet-derived growth factor (PDGF) pathway is critical to pericyte function, we also assessed the effect of PDGF-BB stimulation on the inflammatory response in pericytes. …”
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Effect of saffron aqueous extract during resistance training on the expression of fibronectin type III domain-containing protein 5 in the hippocampus of rats with type 2 diabetes by Farzad Baratyan, Vahid Valipour dehnou, Amir Khosravi

“…Introduction: It has been demonstrated that fibronectin type III domain-containing protein 5 (FNDC5) improves cognitive function by increasing neurotrophic factors. …”
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Reduced Albuminuria and Potassemia Indicate Early Renal Repair Processes after Resynchronization Therapy in Cardiorenal Syndrome Type 2 by Agnieszka Gala-Błądzińska, Janusz Romanek, Danuta Mazur, Tomasz Stepek, Marcin Braun, Piotr Szafarz, Marcin Chlebuś, Andrzej Przybylski

“…Reduced albuminuria and blood potassium are biomarkers of improving T2-CRS in the early post-CRT period.…”
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Robot-assisted percutaneous pedicle screw fixation in thoracolumbar burst fractures: a comparative study by Peng Liu, Jiang Hu, Wei Zhang, Shu Lin, Yang Yu, Liuyi Tang, Fei Wang

“…It also effectively prevents endplate collapse and kyphosis recurrence post-surgery, though short-term functional recovery is similar between both methods. …”
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Examining acquired brain injury-associated symptoms and fluid-based biomarkers in females surviving intimate partner violence: An observational pilot study protocol by Michelle Patch, Allison Jacobi-Dorbeck, Tamar Rodney, Gabor Kelen, Jacquelyn C Campbell, Leah H Rubin, Chelsea Wagner, Nancy Perrin, Jessica Gill

“…Future research should focus on translating these findings into evidence-based practice to improve outcomes for women with ABI, particularly those resulting from IPV.…”
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Bioelectrical impedance analysis–derived phase angle predicts possible Sarcopenia in patients on maintenance hemodialysis: a retrospective study by Ying Zeng, Yang Chen, Yujie Yang, Ying Qiu, Ping Fu, Huaihong Yuan

“…Measurements were taken post-dialysis to ensure consistency. The whole-body phase angle was measured using the InBody S10 device, grip strength was measured using an electronic grip strength tester, and physical function was assessed by the Short Physical Performance Battery (SPPB). …”
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Application of different approaches in interventional thrombolysis of deep vein thrombosis of lower extremities by YUAN Xiaopu, YANG Lili, WU Hongfang

“…Conclusion：Both the popliteal vein approach and the infrapatellar vein approach for interventional thrombolysis effectively clear thrombus, improve coagulation function, and reduce limb swelling in DVT patients, with good long-term effects and safety. …”
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ELAVL1-mediated USP29 mRNA degradation activates TAK1 driving M1 microglial polarization and neural stem cell differentiation dysregulation in spinal cord injury by Chunhe Sha, Feng Pan, Xiaodong Liu, Zhiqing Wang, Guohui Liu, Kai Huang

“…In vivo downregulation of ELAVL1 promoted the differentiation of NSCs into neurons by inhibiting M1 polarization and promoting M2 polarization, thereby improving motor function, alleviating nerve injury, and facilitating spinal cord repair. …”
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The effects of Tai Chi on clinical outcomes and gait biomechanics in knee osteoarthritis patients: a pilot randomized controlled trial by Jing Pan, Zhonghao Xie, Siting Ye, Huifang Shen, Zhiguan Huang, Xiaohui Zhang, Bagen Liao

“…Secondary outcomes, such as pain, stiffness, function (WOMAC), balance (BBS), and quality of life (SF-12), were also assessed pre- and post-intervention. …”
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Two-party cooperative blind signature based on SM2 by Xue BAI, Baodong QIN, Rui GUO, Dong ZHENG

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Theoretical Analyses of Different Nonlinear Compensation Methods Based on Perturbation Theories in the Unrepeatered System With Raman Amplification by You Wang, Wei Li, Muyang Mei, Zhongshuai Feng, Hao Zheng, YaoBing Chen

“…Additionally, we demonstrate an experiment with signal modulation of 16 QAM and baud-rate of 10 GBaud. The improvements of the Q²-factor of the RP-based and ERP-based post-NLC are about 0.6 dB and 1 dB compared with the electronic dispersion compensation (EDC).…”
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Efficacy of Yijinjing-inspired exercises on sleep disorders in Parkinson’s disease: a controlled fNIRS study by Zekai Hu, Jing Shi, Jinyan Wang, Ting Liu, Yujia Li, Han Xue, Xueming Jin, Yiting Xue, Jie Wang, Xinhao Liu, Jun Hu

“…The control group showed no statistically significant changes post-correction (all P > 0.01).DiscussionYijinjing training may improve sleep quality in Parkinson's disease patients, with preliminary evidence of neuroplastic adaptation. …”
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Real-World effectiveness of eculizumab in atypical hemolytic uremic syndrome: a retrospective study from Western China by Yun Hu, Yanyan Zhang, Wei Wang, Guisen Li, Shasha Chen

“…To evaluate timing effects, patients were categorized as Early Initiators (treatment within 7 days of symptom onset, n=9) versus Delayed Initiators (treatment beyond 7 days, n=8) The main outcome measures included hematological parameters, renal function, and adverse events.ResultsThe cohort (n=17, 76.5% female, mean age 43.2 ± 20.0 years) demonstrated significant improvements post-eculizumab: creatinine decreased from 647.0 (439.0, 915.0) to 198.5 (86.5, 749.5) μmol/L, eGFR increased from 8.0 (5.0, 11.0) to 22.1 (6.4, 55.1) mL/min/1.73m², platelets rose from 75 ± 11 to 143 ± 33×109/L, and LDH declined from 787.5±908.0 to 232.8 ± 70.0 U/L (all P<0.001). …”
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Investigating the Safety of Fampridine in Patients with Different Stages of Multiple Sclerosis by Saeed Vaheb, Mahour Farzan, Alireza Afshari-Safavi, Narges Ebrahimi, Vahid Shaygannejad, Omid Mirmosayyeb

“…Background: Fampridine is the only drug approved by the US Food and Drug Administration (FDA) for people with multiple sclerosis (MS) to improve their movement and has exhibited a clinically significant improvement in gait function in a subset of MS patients with Expanded Disability Status Scale (ESDSS) from 4 to 7. …”
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