TFAP4 exacerbates pathological cardiac fibrosis by modulating mechanotransduction by Jie Liu, Jingjing Feng, Jingxuan Zhao, Xiangjie Kong, Zhangyi Yu, Yuanru Huang, Zechun He, Mengxin Liu, Zheng Liu, Zhibing Lu, Li Wang

“…Silencing Itga11 and Piezo2 reverses the pro-fibrotic effects of TFAP4, while TFAP4 downregulation in vivo reduces fibrosis and improves cardiac function post-MI. These findings identify TFAP4 as a pivotal link between mechanotransduction and fibrosis, suggesting it as a potential therapeutic target to mitigate fibrosis and enhance cardiac recovery following MI.…”
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Multiple dimensions of the quality of life among Asian American breast cancer survivors: The impact of a technology-based program by Eun-Ok Im, Wonshik Chee, Sudeshna Paul, Seo Yun Kim, Mi-Young Choi, Jun J. Mao, Giang T. Nguyen, Marilyn M. Schapira, Connie M. Ulrich, SeonAe Yeo, Janet A. Deatrick, Jillian Inouye, Grace Ma, Salimah Meghani, David Shin, Ting Bao

“…Results: The FACT-B total and subscale scores of the intervention group increased from pre-test (T0) to post 3-months (T2), while those of the control group decreased. …”
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Photobiomodulation reduces spinal cord edema by decreasing the expression of AQP4 in the astrocytes of male spinal cord injury rats via the JAK2/STAT3 signaling pathway by Tingyu Wu, Yangguang Ma, Yongyong Yang, Zhihao Zhang, Jie Zhou, Cheng Ju, Xiaoshuang Zuo, Xuankang Wang, Xueyu Hu, Zhe Wang

“…Results: The results indicate that PBM reduces tissue swelling in rats with SCI, improves motor function recovery, and inhibits the upregulation of AQP4 and GFAP associated with SCI. …”
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Visceral leishmaniasis in kidney transplant recipients and candidates: an integrative review of the last 20 years by Osvaldo Mariano Viana Neto, Ednaldo Pereira Lima Sobrinho, Beatriz Fontenele Felix, Gustavo Ferreira da Silva, Pedro Yago Lima de Mesquita, Francisco Mikael Alves Mota, Evelyne Santana Girão, Maria Alice Sperto Ferreira Baptista, Celia Sebastiana de Jesus Fazzio, Elizabeth De Francesco Daher, Wanessa Trindade Clemente

“…Early detection and prompt treatment are crucial for improving outcomes. While renal function impairment is common, it rarely leads to graft rejection. …”
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Endovascular thrombectomy in acute stroke with a large ischemic core: A systematic review and meta-analysis of randomized controlled trials. by Chun-Hsien Lin, Meng Lee, Bruce Ovbiagele, David S Liebeskind, Borja Sanz-Cuesta, Jeffrey L Saver

“…<h4>Conclusions</h4>Among patients with acute stroke and a larger moderate or large ischemic core due to ICA or MCA M1 occlusion who were nondisabled before stroke, EVT plus medical care, compared with medical care alone, may be associated with improved functional independence, reduced disability, and reduced rates of severe disability or death at 90 days post-stroke. …”
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Efficacy and safety of Lignosus rhinocerus (Cooke) Ryvarden TM02® supplementation for immune-challenged patients with localised breast cancer in remission: a randomised controlled... by Jie Yi Eng, Po Lin Ooi, Mariam Zafirah, Mahmoud Danaee, Marniza Saad, Muhammad Fazril Mohamad Razif, Nor Aishah Taib, Chee Loong Lam, Zamri Chik, Shin-Yee Fung

“…Conclusions Our study found that TM02®, a natural supplement containing standardized compounds from Lignosus rhinocerus, is well tolerated in patients with localized breast cancer post-adjuvant chemotherapy. TM02® supplementation showed a positive trend towards improved physical functioning and reduced fatigue scores.…”
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CX43-mediated mitochondrial transfer maintains stemness of KG-1a leukemia stem cells through metabolic remodeling by Huihui Fu, Xiaoqing Xie, Liuyue Zhai, Yi Liu, Yifeng Tang, Sanxiu He, Jun Li, Qing Xiao, Guofa Xu, Zailin Yang, Xiaomei Zhang, Yao Liu

“…Seahorse, RNA-seq, and LC-MS assessed mitochondrial function, transcriptomes, and metabolites post-coculture. …”
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AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model by Muhammad S. Khan, Douglas Smego, Jing Li, Yuki Ishidoya, Emmanuel Offei, Martha Sofia Ruiz Castillo, Annie M. Hirahara, Pia Balmaceda, Jennifer Hunter, Anand Athavale, Monica P. Revelo, Joseph A. Palatinus, Craig H. Selzman, Ravi Ranjan, TingTing Hong, Derek J. Dosdall, Robin M. Shaw

“…In contrast, the AAV9-cBIN1-treated group reveals a significant improvement in LV function, with a noticeable improvement in LVEF (29 ± 3% vs. 42 ± 2%, p = 0.0095) and global longitudinal strain (−7.1 ± 0.9% vs. −12.5 ± 1.6%, p = 0.0095). …”
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Sodium-Dependent Glucose Transporter-2 Inhibitor Enhances the Hypotensive Effect of Renal Denervation by Inhibiting Sympathetic Activity and Inflammatory Reaction by Hao Zhang, Zhuqing Li, Wei Cai, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Qi Li, Ning Yang, Chengzhi Lu, Yuming Li

“…Additionally, the proportions of inflammatory mononuclear cell subsets and the levels of inflammatory factors improved. Although DAPA reduced inflammation and sympathetic nerve overexcitation alone, it could not completely reverse blood pressure (BP) or cardiac function. …”
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Real-world outcomes of spinal muscular atrophy treatment with onasemnogene abeparvovec in Croatia: a comprehensive case series and literature review by Ivan Lehman, Ivan Lehman, Matija Matošević, Lovro Lamot, Lovro Lamot, Branka Bunoza, Branka Bunoza

“…Onasemnogene abeparvovec-xioi, an adeno-associated viral vector-based gene therapy delivering a functional copy of the SMN1 gene, has shown significant efficacy in improving motor function and survival rates. …”
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Intravitreal Dexamethasone Implant in Anti-Vascular Endothelial Growth Factor Pretreated Diabetic Macular Edema—A Swiss Cohort Study by Ferhat Turgut, Gábor M. Somfai, Christoph Tappeiner, Katja Hatz, Irmela Mantel, Aude Ambresin, Guy Donati, Viviane Guignard, Dana Nagyová, Isabel B. Pfister, Christine Schild, Justus G. Garweg

“…Conclusions: In real-world clinical settings, the addition of DEX to anti-VEGF therapy in DME patients significantly reduces treatment burden and retinal fluid while maintaining visual function. Treatment decisions should balance anatomical and functional outcomes, considering individual patient needs.…”
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Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation by Teng Wan, Qi-Cheng Li, Feng-Shi Zhang, Xiao-Meng Zhang, Na Han, Pei-Xun Zhang

“…Furthermore, observations at 12 weeks post-implantation revealed improvements in electrophysiological performance, alleviation of gastrocnemius muscle atrophy, increased peripheral nerve regeneration, and motor function restoration. …”
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Verification of Lactobacillus brevis tolerance to simulated gastric juice and the potential effects of postbiotic gamma-aminobutyric acid in streptozotocin-induced diabetic mice by Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Maha Bikheet, Rokayya Sami, Hassan Mohamed, Xiangchen Meng

“…Based on the blood plasma analysis, L. brevis strains improved good cholesterol properties, liver and kidney functions, where most of these parameters fall within the average the reference range and prevent the development of symptoms of type 1 diabetes in vivo. …”
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SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults by Carolyn A. Cohen, Ludivine Grzelak, Susan S. Chiu, David SC Hui, Mike YW Kwan, Owen TY Tsang, Wai Hung Chan, Yat Sun Yau, Kelly WK Lee, Masashi Mori, Gaya K. Amarasinghe, Samuel MS Cheng, Leo LM Poon, Malik Peiris, Sophie A. Valkenburg

“…Abstract As intrinsic differences in humoral immune response to SARS-CoV-2 between children and adults remain unclear, we improved characterisation by defining the kinetics, specificity and function of antibodies to SARS-CoV-2 in children (n = 146, aged 9.4 ± 4.8 years with n = 257 samples) compared to adults (n = 85, aged 39.5 ± 15.2 years with n = 122 samples). …”
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Colistin Sulfate-Based Combination Therapy for Infections Caused by Carbapenem-Resistant Organisms in Intensive Care Units: A Multicenter, Prospective, Observational Clinical Trial by Fan Zhang, Danyang Peng, Faming He, Ying Liu, Binbin Zang, Yanqiu Gao, Chao Qin, Suping Guo, Yawei Qi, Xisheng Zheng, Lin Guo, Tingting Zhao, Yue Jin, Rongqi Su, Juan Du, Jiazhan Pan, Bingyu Qin, Huanzhang Shao

“…Nephrotoxicity was reported in 13.1% of patients not receiving continuous renal replacement therapy (CRRT), with no significant duration-dependent increase. Post-treatment serum creatinine (Scr) levels remained stable or improved across all renal function subgroups. …”
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Task difficulty modulates motor learning benefits of balance exercises in community-dwelling older adults by Kazunori Akizuki, Kosuke Takeuchi, Kazuto Yamaguchi, Ryohei Yamamoto, Wataru Nakano, Jun Yabuki

“…Results: While both groups showed improved balance performance with practice, the low-difficulty group demonstrated greater motor learning benefits at the 24-h post-test (p < 0.001). …”
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Measuring the impact of community-based interventions on type 2 diabetes control during the COVID-19 pandemic in Cape Town – A mixed methods study by Neal J. David, Graham Bresick, Natasha Moodaley, Klaus B. von Pressentin

“…The mean glycaemic control was suboptimal both at baseline and post-lockdown in both groups. Interviews with 83 study patients confirmed the acceptability of the home delivery intervention. …”
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Femtolaser refractive autokeratoplastic: first results and prospects by H. V. Sitnik, A. Yu. Slonimsky, Yu. B. Slonimsky

“…Between 3 to 6 months after surgery, we observed the increasing of visual functions (like UCVA and BCVA). The improvement of BCVA was observed in 94.1 %, and in 76.5 % of cases the increase was more than 3 lines. …”
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Probiotic treatment induces sex-dependent neuroprotection and gut microbiome shifts after traumatic brain injury by Morgan Holcomb, Austin G. Marshall, Hannah Flinn, Mariana Lozano-Cavazos, Sirena Soriano, Fernando Gomez-Pinilla, Todd J. Treangen, Sonia Villapol

“…Immunohistochemical, in situ hybridization, and histological analyses were performed to assess neuroinflammation post-TBI, while behavioral assessments were conducted to evaluate sensorimotor and cognitive functions. …”
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Application of anterior bilateral sacrospinous fixation in the treatment of apical genital prolapse by A. A. Popov, S. A. Gadzhieva

“…The frequency of intra- and postoperative complications, patient complaints, and relapse rates were assessed post-surgery. Functional outcomes were assessed using the PFDI-20 questionnaire (Pelvic Floor Distress Inventory-20) at 3, 6 and 12 months after treatment. …”
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