The Effect of Xanthine Oxidase Inhibitors in the Prevention and Treatment of Stroke: A Systematic Review and Meta-Analysis by Lin Bai, Gerhard Litscher, Xiaoning Li

“…While XOIs did not significantly reduce the risk of stroke (RR: 0.89; 95% CI: 0.59–1.34), they improved post-stroke functional outcomes, with a reduction in the modified Rankin scale scores (mean difference: −0.6; 95% CI: −0.8 to −0.4), decreased intercellular adhesion molecule-1 levels (mean difference: −15.2 ng/mL; 95% CI: −22.3 to −8.1), improved augmentation index (AIx) by 4.2% (95% CI: 2.5–5.9%), reduced central blood pressure (mean reduction: 4.8 mmHg; 95% CI: 2.6–6.9), and delayed carotid intima-media thickness progression (mean difference: −0.05 mm/year; 95% CI: −0.08 to −0.02).…”
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Patient-Reported Continued Benefits in Patients Treated with Pexidartinib for Tenosynovial Giant Cell Tumor Based on a Real-World Study in the United States by Margaret Wooddell PhD, MBA, Dong Dai PhD, Feng Lin PhD, Irene Pan MS, Klaus Freivogel PhD, Xin Ye PhD, Kristen Tecson PhD, William D. Tap MD

“…Since the start of the study, the majority (85.7%) of respondents experienced improved overall symptoms. Conclusion: In this study, most TGCT patients reported symptom improvement in physical function, stiffness and pain during pexidartinib treatment. …”
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THRIVE Prevent Postoperative Hypoxemia in Elderly Patients Undergoing Laparoscopic Surgery in PACU: A Randomized Controlled Clinical Trial by Chen X, Gu K, Yang Y, Zhou B, Mo Y, Tu Y

“…It facilitates pulmonary function recovery, enhances patient comfort, and may serve as a valuable intervention in the PACU setting.Keywords: THRIVE, laparoscopic surgery, elderly patients, hypoxemia…”
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Mobile-phone-based e-diary derived patient reported outcomes: Association with clinical disease activity, psychological status and quality of life of patients with multiple scleros... by Daniel Golan, Smadar Sagiv, Lea Glass-Marmor, Ariel Miller

“…An e-diary derived bodily function summary score (eBF) was defined as the sum of scores depicting vision, limbs function, pain, bowl/ bladder dysfunction, pseudobulbar affect and spasticity. …”
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Treatment-related toxicity, utility and patient-reported outcomes of head and neck cancer patients treated with proton therapy: A longitudinal study by Yi Hsuan Chen, Michiel Kroesen, Mischa Hoogeman, Matthijs Versteegh, Carin Uyl-de Groot, Hedwig M. Blommestein

“…Most of the functions recovered within six months and improved beyond baseline. …”
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A 24‐week double‐blind placebo‐controlled study of the efficacy and safety of the AMPA modulator S47445 in patients with mild to moderate Alzheimer's disease and depressive symptom... by Katy Bernard, Sylvie Gouttefangeas, Sylvie Bretin, Stéphanie Galtier, Philippe Robert, Vjera Holthoff‐Detto, Jeffrey Cummings, Maria Pueyo

“…An improvement on neuropsychiatric symptoms assessed by NPI was evidenced at the lower dose 5 mg/d (Δ ‐2.55, P = .023, post hoc analysis) compared to placebo. …”
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Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study by Thomas E. Sharp III, Amy L. Scarborough, Amelia G. Haydel, J. Stephen Jenkins, Marloe Prince, Aashish Gupta, Florian Rader, Zhen Li, David J. Lefer, Traci T. Goodchild

“…Preservation of the myocardial performance Tei index indicated preserved systolic and diastolic function 2 weeks post AMI. The beneficial effects of uRDN were independent of any reductions in blood pressure. …”
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Changes in the extracellular matrix under the influence of anticoagulant therapy in patients with Q-myocardial infarction after thrombolysis by S. M. Kyselov

“…That was accompanied by improvement in left ventricular systolic function and transformation of diastolic dysfunction into a pseudonormal type.…”
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Influence of renin-angiotensin-aldosterone system block on the systemic inflammation activity and left ventricle remodeling in patients with Q-myocardial infarction after thromboly... by S. M. Kyselov

“…Under the influence of the treatment reduction of systemic inflammatory markers activity was showed, which accompanied by improvement of left ventricular systolic function and low frequency of left ventricle aneurysm and thrombus formation.…”
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Effects of Bilateral Transcutaneous Electrical Acupoint Stimulation Combined with Stepped Task-Oriented Training on Upper Limb Dysfunction in Stroke Patients by XIANG Yuzhi, WANG Hewei, LIU Lanlan, CHEN Yihao, CAO Yefan, CHEN Yao

“…Scores before and after treatment, as well as within-group changes in scores (post-treatment <italic>minus</italic> pre-treatment), were compared among the three groups.ResultsCompared with pre-treatment, the total score, the proximal function score, and the distal function score of FMA-UE in the three groups all increased after treatment (<italic>P</italic>&lt;0.05); compared with the control group and the bilateral TEAS group, the changes of FMA-UE scores (post-treatment <italic>minus</italic> pre-treatment) in the combined intervention group were significantly greater (<italic>P</italic>&lt;0.05). …”
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Similar outcomes including maximum knee flexion between mobile bearing condylar‐stabilised and fixed bearing posterior‐stabilised prosthesis: a case control study by Jobe Shatrov, Elliot Sappey‐Marinier, Moussa Kafelov, Stanislas Gunst, Cécile Batailler, Elvire Servien, Sébastien Lustig

“…Clinical scores were assessed using Patient‐Reported Outcome Measures (PROMs); International Knee Society (IKS) knee and function scores and satisfaction score. Radiographic assessment was performed pre and post operatively consisting of mechanical femorotibial angle (mFTA), femoral and tibial mechanical angles measured medially (FMA and TMA, respectively) on long leg radiographs, tibial slope and patella height as measured by the Blackburne‐Peel index (BPI). …”
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The effect of neoadjuvant chemoradiotherapy on whole-body physical fitness and skeletal muscle mitochondrial oxidative phosphorylation in vivo in locally advanced rectal cancer pat... by Malcolm A West, Lisa Loughney, Daniel Lythgoe, Christopher P Barben, Valerie L Adams, William E Bimson, Michael P W Grocott, Sandy Jack, Graham J Kemp

“…Differences (95%CI) in all three primary variables were significantly negative post-NACRT: Oxygen uptake at estimated anaerobic threshold -2.4 ml.kg-1.min-1 (-3.8, -0.9), p = 0.004; Oxygen uptake at Peak -4.0 ml.kg-1.min-1 (-6.8, -1.1), p = 0.011; and post-exercise phosphocreatine recovery rate constant -0.34 min-1 (-0.51, -0.17), p<0.001.…”
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Real-Time Monitoring of Cardiac Output Using Non-Invasive Impedance Cardiography in Dogs: A Pilot Study on Heartworm Extraction and Gastric Decompression by Daesik Kim, Seol-Gi Park, Min Su Kim

“…Methods: Cardiac parameters were measured using ICG in healthy controls, HW, and GD groups at baseline, during intervention, and post-treatment. Statistical analyses involved repeated measures ANOVA with post hoc comparisons, and relative changes (%) quantified hemodynamic improvements. …”
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Echocardiographic predictors of mortality in heart failure from Chagas cardiomyopathy: Refining risk stratification with speckle-tracking echocardiography by Marcelo Alves Maia, Ester Cerdeira Sabino, Jose Luiz Padilha da Silva, Cesar Augusto Taconeli, Lea Campos de Oliveira, Omar Ribeiro Santos Junior, Ana Isabel Nobre Maia, Fellipe Colares P.G. Versiani, Ariela Mota Ferreira, Antonio Luiz P. Ribeiro, Maria Carmo P. Nunes

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Our experience in the use of revascularized flaps in the surgical treatment of patients with soft tissue sarcomas by V. V. Ivanov, O. I. Kaganov, A. E. Orlov, A. N. Nikolaenko, S. O. Doroganov, I. V. Bondarenko

“…The use of revascularized flaps in the surgical treatment of patients with soft tissue sarcomas makes it possible to radically remove the tumor and fully replace the post-resection defect, which in turn reduces the risk of relapses and promotes restoration of limb function with a good cosmetic result.…”
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Posterior cruciate-retaining total knee arthroplasty in patients with systemic rheumatoid arthritis - A retrospective observational analysis by Sujoy Bhattacharjee, Arghya Kundu Choudhury, Abhirup Bose, Swapnil Priyadarshi, Somya Tiwari

“…Results: After surgery, the patient reported clinical outcomes improved significantly among the patients which indicates improvement in functionality (p < 0.001) and painless range of motion. …”
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Optimizing Poultry Growth and Meat Quality: Effects of Guanidinoacetic Acid Supplementation in Yellow-Feathered Broilers by Jian Xiao, Lifen Wang, Yuguang Chen, Kai Xiao

“…Higher GAA dosages (900 and 1200 mg/kg) improved post-slaughter pH levels in breast muscle, indicating better meat quality, and significantly enhanced intestinal barrier function by increasing villus height and the villus-to-crypt ratio. …”
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GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY by João Vital Arthur Maradona Oliveira Dias, Vitor Ricardo Alves Pereira de Moraes, Matheus Trindade Bruxelas de Freitas, Matheus Manolo Arouca, Guilherme Pereira Ocampos, Olavo Pires de Camargo, Márcia Uchoa de Rezende

“…Conclusions: Genicular nerve ablation in patients with severe OAJ can provide lasting improvements in pain, function, and quality of life. …”
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Efficacy and Safety of Initial Combination Treatment of an Alpha Blocker with an Anticholinergic Medication in Benign Prostatic Hyperplasia Patients with Lower Urinary Tract Sympto... by Hyun Jung Kim, Hwa Yeon Sun, Hoon Choi, Jae Young Park, Jae Hyun Bae, Seung Whan Doo, Won Jae Yang, Yun Seob Song, Young Myoung Ko, Jae Heon Kim

“…<h4>Methods</h4>We conducted a meta-analysis of improvement in LUTS using International Prostate Symptom Score (IPSS), maximal urinary flow rate (Qmax), post-voided residual volume (PVR), and quality of life (QoL).…”
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Statistical modelling of growth curve for longitudinal data on a feeding trial in goat breeds  by Ihab Mostafa Shaat, Alaa Alhamadani, Khafan Al-Shargi, Rashid Al-Habsi, Talal Al-Sedeiri, Asila Al Naabi, Asko Maki-Tanila

“…The higher level of concentrates improved the immediate post-weaning growth in the same way in the breeds while the subsequent growth curve differed with more pronounced weight increments in the Jabbali breed.  …”
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