Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…The study will address three aims: (1) to assess feasibility, acceptability, fidelity and safety of HIIT breaks to improve neurocognitive function in middle-aged and older adults; (2) to quantify the differences between conditions in the change in the amplitude and latency of the P3b component of event-related potentials (a marker for frontoparietal function) and (3) to explore the differences between conditions in attentional control, episodic memory and FC of the FPN and DMN in middle-aged and older adults.Methods and analysis 54 healthy adults, aged 40–75 years, will be recruited from the local community and randomly assigned to a condition sequence (HIIT, LIIT vs LIIT and HIIT). …”
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The Influence of an Eight-Week Home Exercise Program on Spatiotemporal and Kinetic Characteristics of Gait and Knee Function in Women with Severe Knee Osteoarthritis Scheduled for... by Monika Mets, Jelena Sokk, Jaan Ereline, Mati Pääsuke, Tiit Haviko, Helena Gapeyeva

“…<i>Conclusions</i>: An eight-week preoperative HEP improved GRF and KEM during the loading response of gait, muscle strength, knee function, and self-reported knee OA-related health status in women with severe knee OA. …”
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Optimistic effects of dual nano-encapsulated probiotics on breeders laying performance, intestinal barrier functions, immunity and resistance against Salmonella Typhimurium challen... by Mohamed Tharwat Elabbasy, Asmaa T. Y. Kishawy, Walaa S. Abdelaziz, Ahmed Abdelfattah Hassan, Hend S. Nada, Reham A. Elbhnsawy, Amany M. Shosha, Dina Ibrahim, Fatma Eldemery, Shimaa A. E. Atwa, Wafaa R. I. A. Sherief, Eman S. El-Shetry, Ayman A. Saleh, Doaa Ibrahim

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Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary by István Virga, István Virga, Karolina Kósa, Anna Illés, Zsófia Miltényi, Zsófia Miltényi, Tibor Ivánka, Roland Berecz, Anikó Égerházi, Árpád Illés, Árpád Illés, Ferenc Magyari, Ferenc Magyari

“…Long-term improvement in cognitive function was observed post-treatment. …”
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Effect of 8 weeks of high-intensity functional training (HIFT) on previous vascular factors and exercise enjoyment in women suffering from metabolic syndrome by Mina Behari Kia, Bahman Hasanvand

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Effect of Baduanjin on postoperative activity tolerance, lung function and negative emotions in patients with lung cancer: a protocol for systematic review and meta-analysis by Jia Li, Zhening Liu, Daixi Wu, Huijing Dong, Yumin Zheng, Yulei Shen, Huijuan Cui

“…Baduanjin, a traditional Chinese mind-body exercise, has shown benefits in improving exercise tolerance and lung function in populations with chronic diseases. …”
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Functional benefits of a chorioretinal anastomosis at 2 years in eyes with a central retinal vein occlusion treated with ranibizumab compared with ranibizumab monotherapy by David A Mackey, Paul G Sanfilippo, Fred K Chen, Ian L McAllister, Lynne A Smithies

“…Objective To evaluate the functional benefits (best corrected visual acuity (BCVA), central subfield thickness, injection loads, central venous pressure (CVP)) of a laser-induced chorioretinal anastomosis (L-CRA) in patients with central retinal vein occlusion (CRVO) treated with ranibizumab compared with ranibizumab monotherapy.Methods and Analysis This is a post-hoc analysis of the 2-year randomised ranibizumab plus L-CRA for CRVO trial. …”
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Benefits of the Global Integration Method (Método de Integração Global - MIG) in functional priorities of parents of Brazilian children and adolescents with autism spectrum disorde... by Amanda Aparecida Alves Cunha Nascimento, Deisiane Oliveira Souto, Thalita Karla Flores Cruz, Arthur Felipe Barroso de Lima, Gabriela Silva Oliveira, Vitor Geraldi Haase

“…In general, the MIG program resulted in significant improvements in performance and satisfaction for the majority of functional priorities (p < 0.05). …”
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Positive Psychology Interventions in Early-Stage Cognitive Decline Related to Dementia: A Systematic Review of Cognitive and Brain Functioning Outcomes of Mindfulness Interventions by Dimitra Vasileiou, Despina Moraitou, Konstantinos Diamantaras, Vasileios Papaliagkas, Christos Pezirkianidis, Magda Tsolaki

“…<b>Methods</b>: A comprehensive search conducted in the databases Scopus, PubMed, ScienceDirect and PsychINFO (December 2024–March 2025) published between 2015 and 2025 to identify records that met inclusion criteria: studies included patients with SCD, MCI and mild AD dementia, implemented PPIs, Randomized controlled trials (RCTs) and pre–post intervention studies with measurable outcomes, assess at least one of the following: cognitive functions and brain functioning. …”
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Baseline characteristics and 2-year functional outcome data of patients undergoing an arthroscopic rotator cuff repair in Switzerland, results of the ARCR_Pred study. by Thomas Stojanov, Laurent Audigé, Soheila Aghlmandi, Claudio Rosso, Philipp Moroder, Thomas Suter, Mai Lan Dao Trong, Emanuel Benninger, Beat Moor, Christophe Spormann, Holger Durchholz, Gregory Cunningham, Alexandre Lädermann, Michael Schär, Matthias Flury, Karim Eid, Markus Scheibel, Christian Candrian, Bernhard Jost, Matthias A Zumstein, Karl Wieser, David Schwappach, Sabina Hunziker, ARCR_Pred Study Group, Andreas M Müller

“…Diff. = 0.56), there were no other major differences in key characteristics between enrolled and non-enrolled patients or in patients lost to follow-up. Functional scores improved over time, with positive changes rates ranging from 83% to 92% at 6-month, reaching 91% to 97% at 12- and 24-month follow-up. …”
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Additive manufacturing of graphene oxide-doped SiOC/Si3N4 photothermal functional bioceramic scaffolds through stereolithography technology by Yange Li, Hongyu Xing, Lei Lai, Hui Li, Hongyu Zhao, Qingguo Lai, Bin Zou

“…This photothermally functional GO/SiOC/Si3N4 scaffold offers a promising dual-functional solution for post-tumor bone regeneration, combining structural adaptability with spatiotemporally controlled therapeutic precision.…”
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Modelling dynamic transitions in neurological functional disability in patients with intracerebral haemorrhage: a prospective cohort study using a multistate Markov model by Ke Ma, Yang Song, Zheng Yan, Dezhi Kang, Shuna Huang, Shaowei Lin, Siying Wu, Minghuan Liu, Shiying Lin, Jialiang Xu, Xiaowan Zhou, Hang Zeng, Huangyuang Li, Xiao-Xu Xie

“…A person with no disability post-ICH can expect to spend 19.42 (12.87~29.30) months in that state, and 9.99 (8.39~11.89) months in state S2 and 8.87 (7.79~10.09) months in state 3 during their lifetime.Conclusions In the year following treatment and discharge, the neurological functional disability of most patients with ICH tends to remain stable. …”
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Effects of inspiratory muscle training on 1RM performance and body composition in professional natural bodybuilders by Baha Engin Çelikel, Coşkun Yılmaz, Alper Demir, Süreyya Yonca Sezer, Levent Ceylan, Tülay Ceylan, Çetin Tan

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NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction by Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

“…Results In our study, wild-type, Nlrp3 knockout and Nlrp3 overexpressed EPC, intracardiac injections effectively improved cardiac function, increased angiogenesis, and reduced infarct size in mice with myocardial infarction. …”
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Caveolin Scaffolding Domain (CSD) Peptide LTI-2355 Modulates the Phagocytic and Synthetic Activity of Lung-Derived Myeloid Cells in Idiopathic Pulmonary Fibrosis (IPF) and Post-Acu... by Brecht Creyns, BreAnne MacKenzie, Yago Amigo Pinho Jannini Sa, Ana Lucia Coelho, Dale Christensen, Tanyalak Parimon, Brian Windsor, Cory M. Hogaboam

“…The uptake of pathogen-coated bioparticles was impaired in myeloid cells from both fibrotic patient groups independent of the type of pathogen, highlighting an intrinsic functional cell impairment. LTI-2355 improved the phagocytic activity of both IPF and PASC-F myeloid cells, and this improvement was paired with decreased proinflammatory and pro-fibrotic synthetic activity. …”
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Efficacy and safety of tofacitinib in an open-label, long-term extension study in patients with psoriatic arthritis who received adalimumab or tofacitinib in a Phase 3 randomized c... by Dafna D. Gladman, Peter Nash, Philip J. Mease, Oliver FitzGerald, Stephanie Duench, Mary Jane Cadatal, Karim R. Masri

“…Efficacy was assessed 3 months before the last visit and at the last visit in the Phase 3 study, and at month 3 (or month 6 for select outcomes) in the LTE study and included rates of ≥ 20/50/70% improvement in American College of Rheumatology response criteria, Psoriasis Area and Severity Index ≥ 75% improvement, Health Assessment Questionnaire-Disability Index (HAQ-DI) response (decrease from baseline ≥ 0.35 for patients with baseline HAQ-DI ≥ 0.35), Psoriatic Arthritis Disease Activity Score ≤ 3.2, and minimal disease activity; and change from baseline in Functional Assessment of Chronic Illness Therapy-Fatigue score. …”
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Combining a guided self-help and brief alcohol intervention to improve mental health and reduce substance use among refugee men in Uganda: a cluster-randomized feasibility trial by M. Claire Greene, Lena S. Andersen, Marx R. Leku, Teresa Au, Josephine Akellot, Nawaraj Upadhaya, Raymond Odokonyero, Ross White, Peter Ventevogel, Claudia Garcia-Moreno, Wietse A. Tol

“…Participant outcome measures, including symptoms of psychological distress, functional impairment, self-defined problems, depressive symptoms, post-traumatic stress symptoms, overall substance use risk, substance specific risk (alcohol, cannabis, stimulants and sedatives) and well-being, were sensitive to change. …”
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Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation by An He, An He, Yiren Yang, Katja Kotsch, Arne Sattler

“…Importantly, transplantation of kidneys from ATG pre-treated donors into fully mismatched recipients showed only mild effects on leukocyte re-composition post transplantation. In line with this, serum creatinine and urea levels were similar in animals receiving kidneys from ATG treated donors or controls, demonstrating that donor treatment had no effect on allograft function in the early post-transplantation phase. …”
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Exploration of RNA-binding proteins identified RPS27 as a potential regulator associated with Kaposi’s sarcoma development by Jingzhan Zhang, Peng Wang, Tingting Li, Dong Luo, Yuanyuan Qu, Yuan Ding, Xiaojing Kang

“…Cellular experiments were conducted for dysregulated RPS27 to explore its functions. Additionally, improved RNA immunoprecipitation (iRIP)-seq was performed to investigate potential binding interactions of RPS27 in KS. …”
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‘Time is of the essence’: upper-body aerobic exercise to improve cardiovascular health during inpatient rehabilitation within the first year following spinal cord injury – protocol... by Samuel J E Lucas, Tom E Nightingale, Naveen Kumar, Shin-Yi Chiou, Afroditi Stathi, Manish Kalla, Daniel D Hodgkiss, Shane J T Balthazaar, Aheed E F Osman, Srinivasa C Budithi, Joy Roy Chowdhury

“…While general exercise guidelines are promoted for SCI individuals, when and how to incorporate exercise during the subacute phase post-SCI remains unclear. Consequently, early aerobic exercise to reduce CVD risks is not standard practice in subacute SCI care, potentially missing an opportunity for optimal cardiovascular rehabilitation, especially given observed reductions in cardiac structure and function within the first year post-SCI. …”
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