Production of <i>Vespa tropica</i> Hyaluronidase by <i>Pichia pastoris</i> by Piyapon Janpan, Bernhard Schmelzer, Anuwatchakij Klamrak, Patthana Tastub, Tewa Upathanpreecha, Shaikh Shahinur Rahman, Jaran Nabnueangsap, Yutthakan Saengkun, Prapenpuksiri Rungsa, Diethard Mattanovich, Sakda Daduang

“…Notably, it exhibits higher hyaluronidase activity than the crude venom and <i>E. coli</i>-expressed protein, likely due to improved folding via endogenous post-translational modifications, such as disulfide bonds and N-glycosylation; this underscores the potential of heterologous systems for producing venomous hyaluronidases from other species. …”
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Coeliac plexus radiosurgery for pain management in patients with advanced cancer : study protocol for a phase II clinical trial by Laura A Dawson, Camilla Zimmermann, Aisling Barry, Galia Jacobson, Ronen Fluss, Amira Dany-BenShushan, Talia Golan, Tikva Meron, Marcin Miszczyk, Michael Buckstein, Dayssy Diaz Pardo, Artur Aguiar, Liat Hammer, Adam P Dicker, Maoz Ben-Ailan, Ofir Morag, David Hausner, Zvi Symon, Yaacov R. Lawrence

“…The protocol requires that 90 evaluable patients be accrued, based upon the assumption that a third of patients are non-evaluable (e.g. due to death prior to 3-weeks post-treatment assessment, or spontaneous improvement of pain pre-treatment), it is estimated that a total of 120 patients will need to be accrued. …”
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Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing by Elena-Emilia Tudoroiu, Mădălina Georgiana Albu Kaya, Cristina Elena Dinu-Pîrvu, Lăcrămioara Popa, Valentina Anuța, Mădălina Ignat, Emilia Visileanu, Durmuș Alpaslan Kaya, Răzvan Mihai Prisada, Mihaela Violeta Ghica

“…<b>Conclusions</b>: New multifunctional films combine diagnostic and therapeutic functions, providing a promising platform for monitoring wound healing, making them suitable for real-time wound assessment.…”
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AVATAR Virtual Reality Social therapy (AVATAR_VRSocial) for distressing voices and their interference in social everyday life in early psychosis: protocol of a single-blind paralle... by Tom K J Craig, Silvia Schneider, Philippa Garety, Thomas Ward, Mar Rus-Calafell, Melina Luker, Maren Marzinzik, Phuong-Mi Nguyen, Tobias Teismann, Nils Ehrbar, Ekincan Tas, Xiao Chi Zhang, Clementine Edwards, Mark Huckvale

“…Introduction Around 70% of people with psychosis experience auditory verbal hallucinations (AVHs), which can cause distress and impair the social functioning of the individual. AVATAR therapy works by facilitating a ‘face-to-face’ dialogue between the person and a digital representation (avatar) of their persecutory voice. …”
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In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

“…Despite advancements in tendon injury repair techniques, outcomes remain suboptimal due to inferior tissue quality and functionality. Tissue engineering offers a promising avenue for tendon regeneration, with biocompatible scaffolds playing a crucial role. …”
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Diagnosis and treatment of synthetic mid-urethral sling complications by Helen E. O’Connell, Christopher K. Harding, Gaurav Khatri, Phyllis Glanc, Eric Bautrant, Sarah Love-Jones, Karen Ward, Henry H. Yao, Ventia Hoe, Charlotte Korte, Nicolle Germano, Sanjeevan Kalavampara, Sherif Mourad, Hashim Hashim

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Fractionated stereotactic radiotherapy in people with drug-resistant focal epilepsy: first-in-human experience with a healthy tissue-preserving dose-fractionation concept by Cas Stefaan Dejonckheere, Attila Rácz, Gustavo Renato Sarria, Julian Philipp Layer, Julian Philipp Layer, Younèss Nour, Lara Caglayan, Molina Grimmer, Victoria Volkenborn, Fabian Kugel, Thomas Müdder, Tobias Baumgartner, Valeri Borger, Alexander Radbruch, Hartmut Vatter, Frank Anton Giordano, Frank Anton Giordano, Frank Anton Giordano, Eleni Gkika, Rainer Surges, Davide Scafa

“…All patients reported improvements in quality of life and regained independence or displayed functional recovery. …”
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Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy by Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

“…Performance of the response criteria in predicting pathologic response was assessed with the area under the receiver operator characteristic curve (AUC).Results: Among all radiologic and pathologic response criteria, MPR was the only independent predictor of post-resection recurrence-free survival (RFS) (adjusted hazard ratio 0.34, 95% CI 0.16– 0.72, p=0.004). …”
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Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with... by K. A. Berdyugin, I. V. Kadyntsev, O. V. Berdyugina, E. A. Taskina, N. G. Kashevarova

“…During treatment, both groups of patients showed improvement (compared to the baseline levels). At the same time, evaluating the intergroup values revealed clear differences: a more pronounced decrease in all WOMAC indicators in Group 1 patients: pain scores, 2 [1; 3] vs. 4 [2; 5] in Group 2 (p&lt;0.001); stiffness, 1 [0; 2] vs. 2 [1; 4] (p&lt;0.001); functional insufficiency, 8 [3; 12] vs. 15.5 [12; 20] (p&lt;0.001); and total WOMAC scores, 12 [7; 13] vs. 21.5 [15; 28] (p&lt;0.001). …”
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Is there an alternative to diclofenac i/m injections for rapid relief of severe pain? Results of randomized controlled and partially blind forsage study by A. E. Karateev, E. Yu. Pogozheva, E. S. Filatova, A. M. Lila, V. N. Amirdjanova, V. A. Nesterenko

“…Final assessment in the morning on day 4 showed significant pain reduction by 4.5±2.6 cm VAS in Group 1 vs baseline, and by 3.6±1.4 cm VAS in Group 2 (p=0.545). Functional improvement in both groups reached 3.7±1.9 and 3.3±1.3 cm VAS, respectively (p=0.837). …”
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Effect of low-intensity resistance training at different levels of blood flow restriction on pain, proprioception and muscle strength in patients with knee osteoarthritis: a random... by Yongjie Li, Shenyu Fu, Dakuan Zhang, Mengling Liu, Hongju Liu

“…Abstract Background Low-intensity resistance training(LIRT) combined with blood flow restriction(BFR) has significant potential for promoting functional recovery in patients with knee osteoarthritis(KOA). …”
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Efectos de seis semanas de entrenamiento isoinercial sobre la capacidad de salto, velocidad de carrera y equilibrio postural dinámico (Effects of six weeks of isoinertial training... by Eric Sáez-Michea, Miguel Alarcón-Rivera, Pablo Valdés-Badilla, Eduardo Guzman Muñoz

“…Keywords: strength training; muscular strength; motor skills; Postural control; functional physical performance. …”
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Protection of CD33-modified hematopoietic stem cell progeny from CD33-directed CAR T cells in rhesus macaques by Nicholas E. Petty, Stefan Radtke, Greta Kanestrom, Emily Fields, Olivier Humbert, Salvatore Fiorenza, Mallory J. Llewellyn, George S. Laszlo, Justin Thomas, Zach Burger, Kyle Swing, Haiying Zhu, Keith R. Jerome, Cameron J. Turtle, Roland B. Walter, Hans-Peter Kiem

“…Both editing strategies showed similar post-transplant recovery kinetics and yielded equivalent levels of engraftment. …”
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The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study by Daniel Uher, Gerhard S. Drenthen, Christianne M. Hoeberigs, Rick H.G.J. van Lanen, Albert J. Colon, Roy A.M. Haast, Vivianne H.J.M. van Kranen-Mastenbroek, Guido Widman, Paul A.M. Hofman, Louis G. Wagner, Jan C. Beckervordersandforth, Jacobus F.A. Jansen, Olaf E.M.G. Schijns, Walter H. Backes

“…This case study illustrates that advanced image processing of ultra-high field structural and resting-state functional MRI scans may enhance the detection of subtle epileptogenic lesions in presurgical evaluation, potentially improving post-operative seizure outcome and associated quality of life.…”
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A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…Linear mixed-effects models determined significant improvements in PHQ-9 and GAD-7 scores for participants across both conditions (ps < 0.001). …”
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Building Emotional Awareness and Mental Health (BEAM): study protocol for a hybrid implementation-effectiveness trial of the BEAM app-based program for parents with clinical mental... by Kaeley M. Simpson, Robert J. W. McHardy, J. Grace Zhou, Sydney Levasseur-Puhach, Cynthia M. Côté, Millie Braun, Fiona Clement, Anna L. MacKinnon, Nathan Nickel, Tracie O. Afifi, Gerald F. Giesbrecht, Ryan Giuliano, Laurence Y. Katz, Lauren E. Kelly, Terry P. Klassen, Catherine Lebel, Aislin Mushquash, Kristin Reynolds, Elizabeth Decaire, Wajihah Mughal, Frances Chartrand, Olena Kloss, Jennifer M. Hensel, James M. Bolton, Jo Ann M. Unger, Mandy Archibald, Philip Fisher, Ashley Pharazyn, Lianne Tomfohr-Madsen, Leslie E. Roos

“…Assessments of parent and child mental health symptoms will occur at pre-test before BEAM begins (T1), immediately after the last week of the BEAM intervention (post-test, T2), 6-month follow-up (T3), and 12-month follow-up (T4). …”
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H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke by Tingting Sun, Jian-Nan Zhang, Ting Lan, Lei Shi, Liye Hu, Liyan Yan, Chao Wei, Lisha Hei, Weihua Wu, Zhaoli Luo, Meng Liu, Xingmei Ren, Yamei Wang, Yabin Lu, Peipei Wang, Chenguang Zhang, Liheng Bian, Xingquan Zhao, Fei Yang, Qian Li

“…In line with our in vitro findings, inhibiting H3K14la/PMCA2 reduced neuronal degeneration and improved functional outcomes in an ICH mouse model induced by intracranial injection of collagenase into the striatum. …”
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Chemotherapeutic efficacy of curcumin against plasma and cardio-hepatorenal electrolyte disruption in dichlorvos-challenged rats via augmentation of Na⁺/K⁺-ATPase and Ca²⁺/Mg²⁺-ATP... by Adio J. Akamo, Boluwatife A. Olagunju, Iyabode A. Kehinde, Naomi M. Akamo, Adetutu O. Ojelabi, Ofem E. Eteng, Ibiyemi O. Opowoye, Adedayo A. Adebisi, Taiwo S. Oguntona, Mushafau A. Akinsanya, Tobi S. Adekunbi, Olufemi M. Ajagun-Ogunleye, Opeyemi E. Popoola, Jacob K. Akintunde, Oluseyi A. Akinloye

“…Conclusion: These results demonstrated that curcumin chemotherapy improved visceral functions and corrected ionoregulatory disruptions in DDVP-treated rats via modulation of adenosine triphosphatases pump.…”
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Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice by Dilpreet Kour, Dilpreet Kour, Parul Khajuria, Parul Khajuria, Kuhu Sharma, Kuhu Sharma, Alpa Sharma, Alpa Sharma, Ankita Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, P. Ramajayan, P. Ramajayan, Sanghapal D. Sawant, Sanghapal D. Sawant, Sanghapal D. Sawant, Utpal Nandi, Utpal Nandi, Zabeer Ahmed, Zabeer Ahmed, Ajay Kumar, Ajay Kumar

“…Two months of treatment of 5x-FAD mice with IBC at 25 and 50 mg/kg significantly improved cognitive functions, as evidenced by enhanced memory and motor performance in behavioral tests. …”
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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…ABSTRACT Honeybees (Apis mellifera), as social insects, exhibit complex social behaviors and cognitive functions. The short lifespan and stable gut microorganisms of honeybees provide certain availability as a rapid and high-flux animal model for aging research. …”
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