Genomic and molecular characterization of a ceftazidime-avibactam resistant Klebsiella pneumoniae strain isolated from a Chinese tertiary hospital by Yanye Tu, Hui Gao, Feng Wang, Rongqing Zhao, Shiyong Chen, Yanzi Chang, Hong Li

“…Plasmid analysis identified three distinct plasmids, among which an IncX3-type plasmid carrying bla NDM−5 was confirmed, while the functional characteristics of the remaining two plasmids require further investigation. …”
Get full text

Optimization of 3D Extrusion Printing Parameters for Raw and Extruded Dehulled Andean Fava Bean Flours Using Response Surface Methodology (RSM) by Grimaldo Wilfredo Quispe Santivañez, Henry Juan Javier Ninahuaman, Joselin Paucarchuco Soto, Maria Teresa Pedrosa Silva Clerici, Rebeca Salvador-Reyes

“…These findings demonstrate the feasibility of using Andean fava bean flour in 3D food printing to create nutrient-dense, functional foods with improved printability. This work offers practical applications for developing personalized foods—such as customized meals for individuals with specific dietary requirements—while contributing to sustainable and secure food production. …”
Get full text

Novel Sonoguided Digital Palpation and Ultrasound-Guided Hydrodissection of the Long Thoracic Nerve for Managing Serratus Anterior Muscle Pain Syndrome: A Case Report with Technica... by Nunung Nugroho, King Hei Stanley Lam, Theodore Tandiono, Teinny Suryadi, Anwar Suhaimi, Wahida Ratnawati, Daniel Chiung-Jui Su, Yonghyun Yoon, Kenneth Dean Reeves

“…The patient reported immediate pain relief post-procedure, with the pain reducing from 9/10 to 1/10 on the Numeric Rating Scale (NRS), and sustained relief and functional improvement at the 12-month follow-up. …”
Get full text

PO27 | B-cell lymphoproliferative disorder and acquired coagulopathy: an insidious link

“…PIVKA-II levels were 41 AU/mL (negative), supporting the lack of a functional vitamin K deficiency. Immunosuppressive steroid therapy with prednisone was started at the time of admission. …”
Get full text

Cognitive behavioral therapy for depression in Japanese Parkinson's disease patients: a pilot study by Shinmei I, Kobayashi K, Oe Y, Takagishi Y, Kanie A, Ito M, Takebayashi Y, Murata M, Horikoshi M, Dobbin RD

“…The patients reported significant improvements in depression (Hedges’ g =-1.02, 95% confidence interval =-1.62 to -0.39). …”
Get full text

Comparison of Per-Operative Outcomes between Simultaneous and Staged Bilateral Total Hip Arthroplasties by S Hiranya Kumar, N Vamshikrishna Chand, B A Pradeep, Thippeswamy Darshan, R V Chandan Kumar, D V Harish

“…Patients who go through the surgery experience better functioning and overall satisfaction with their lives. …”
Get full text

Effect of essential oils as vitamin C preservatives and chia seed (Salvia hispanica) in the fortification of pineapple jam by Tanima Jarin, Md Nazrul Islam, Shormin Choudhury, Md Rabiul Islam, Reana Raen, Redwanul Islam, Sika Mustaki

“…By exploring the combined effects of essential oils and chia seeds in preserving vitamin C and improving the jam's overall nutritional value, this study aims to meet the increasing demand for functional foods that prioritize both health and taste. …”
Get full text

Evaluation of the effect of DRG payment policy based on interrupted time series modeling: evidence from a tertiary hospital in Anhui Province by Guangju Mo, Erchang Zhu, Xinlei Fang, Jingbo Ma, Sijing Kong, Xuan Guo, Zheng Lu

“…Conclusions The findings show that the DRG reform has positively impacted hospital functioning, including quality, safety, efficiency and costs. …”
Get full text

GNNs and ensemble models enhance the prediction of new sRNA-mRNA interactions in unseen conditions by Shani Cohen, Lior Rokach, Isana Veksler-Lublinsky

“…Abstract Bacterial small RNAs (sRNAs) are pivotal in post-transcriptional regulation, affecting functions like virulence, metabolism, and gene expression by binding specific mRNA targets. …”
Get full text

A structured lifestyle intervention to reduce cardiometabolic risk factors in individuals with obsessive–compulsive disorder: feasibility trial by Anna Holmberg, Matthias Lidin, Dante Lenninger, Sofia Asplund, Catharina Lavebratt, Christian Rück, Lina Martinsson, David Mataix-Cols, Lorena Fernández de la Cruz

“…Statistically significant improvements were observed in dietary habits, alcohol consumption, stress, OCD symptom severity and general functioning (within-group effect sizes ranging from 0.27 to 0.56). …”
Get full text

Temporal dynamics of medium and micronutrient requirements in Epimedium pubescens: key elements regulating growth and Icariin-Flavonoids biosynthesis by Xiaojing An, Yanting Wang, Shangnian Liu, Ying Wang, Xianen Li, Baolin Guo, Haiying Wang, Caixia Chen

“…The study proposed a range for key medium and micronutrients with a fertilization scheme: Mg reinforcement (Feb-Apr, Jul); Fe-Zn supplementation (Jul); and Zn prioritization post-Oct. It elucidated medium and micronutrients dynamics in E. pubescens and their relationships with growth and I-Fla synthesis, establishing the nutritional basis for coordinated yield-quality improvement. …”
Get full text

Succession characteristics and assembly process of soil microbiome at reclaimed farmlands in coal mining area by Jianhua Li, Jianhua Li, Zixu Li, Yanwen Sun, Jinjing Lu, Jinjing Lu, Qiang Zhang, Xinhua He, Xinhua He, Xinhua He, Minggang Xu, Minggang Xu

“…We analyzed soil microbial diversity, composition, co-occurrence network structure, and assembly processes using 16S rDNA/ITS sequencing and null models at 0 (R0), 1 (R1), 6 (R6), and 10 (R10) years of post-reclamation. Results showed that (1) Compared to R0, the R10 treatment resulted in significant increases in soil organic matter (SOM), total nitrogen (TN), available phosphorus (AP), and available potassium (AK) by 2.1-fold, 1.3-fold, 1.5-fold, and 0.4-fold, and also in activities of β-glucosidase (BG), N-acetyl-β-glucosaminidase (NAG), and leucine aminopeptidase (LAP), by 17-fold, 8.7-fold, and 1.8-fold, respectively (p < 0.05). (2) Rising bacterial diversity (Shannon, Chao1) over time, contrasting with fungal diversity that declined initially before recovering. (3) As the reclamation progressed, the network complexity was increased for both bacteria and fungi, improving stability. …”
Get full text

Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors by Xiaowei Bian, Minna Piipponen, Zhuang Liu, Lihua Luo, Jennifer Geara, Yongjian Chen, Traimate Sangsuwan, Monica Maselli, Candice Diaz, Connor A. Bain, Evelien Eenjes, Maria Genander, Michael Crichton, Jenna L. Cash, Louis Archambault, Siamak Haghdoost, Julie Fradette, Pehr Sommar, Martin Halle, Ning Xu Landén

“…Notably, fibroblasts in both murine and human post-radiation wound models show heightened and sustained THBS1 expression, impairing fibroblast motility and contractility. …”
Get full text

AAV-shDUX4 provides short-term benefits but limited long-term efficacy in a DUX4 mouse model of FSHD by S. Sohn, S. Reid, M. Bowen, C. Hudon, E. Corbex, B. Morel, C. Hourde, V. Mariot, J. Dumonceaux

“…However, by 10 months post-treatment, the therapeutic effects had substantially diminished, with most pathological markers remaining uncorrected and no sustained improvement in muscle force. …”
Get full text

Effect of different perioperative music interventions on anxiety and blood pressure levels during intravitreal injections by Fuyan Song, Zixun Wang, Xiaoling Zhang, Zhenjie Yu, Zhiqing Li

Get full text

Tuina promotes nerve myelin regeneration in SNI rats through Piezo1/YAP/TAZ pathway by Yue Xu, Na Rentuya, Tianyuan Yu, Jiawang Yan, Hongzheng Zhang, Yingqi Zhang, Hanyu Zhang, Jiawei Sun, Jiayue Liu

“…Abstract Purpose The changes in the mechanical environment of local nerves after peripheral nerve injury (PNI) can cause a series of mechanical electrochemical signal reactions that affect the process of nerve regeneration and functional recovery. Piezo1/YAP/TAZ is an important transduction pathway that affects myelin regeneration. …”
Get full text

Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT) by Beatriz Arce-López, Guadalupe X. Bazan, Susana Molina, Maria Carmen Crespo, María García-Beccaria, Silvia Cruz-Gil, Cristina M. Fernández-Díaz, Ana Ramírez de Molina, Ricardo Ramos-Ruiz, Maria Isabel Espinosa-Salinas

“…These findings suggest its promise as a functional beverage for improving metabolic and gut health in healthy individuals. …”
Get full text

Salidroside alleviates ferroptosis of retinal ganglion cells in db/db mice by Wenqiang Liu, Anqi Liu, Yufei Wang, Shengxue Yu, Chuang Feng, Wanpeng Liu, Yan Fang, Jing Li, Hongdan Yu, Jiayou Liu, Wenjuan Wang, Jiayuan Ding, Pan Lü, Lipan Zhao, Linqin Luo, Xuezheng Liu, Zhongfu Zuo

“…Within the research conducted, Sal was administered via gavage, and observations were made 8 weeks post-treatment. Retinal samples were collected for analysis. …”
Get full text

Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…Traditional ancillary methods like immunohistochemistry (IHC) to assess TP53 functionality face pre- and post-analytical challenges. …”
Get full text

Back pain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: an exploratory study in young male participants by Claire Burny, Mia Potočnjak, Mia Potočnjak, Annika Hestermann, Sophie Gartemann, Michael Hollmann, Frank Schifferdecker-Hoch, Nina Markanovic, Simone Di Sanzo, Simone Di Sanzo, Michael Günsel, Victor Solis-Mezarino, Moritz Voelker-Albert, Moritz Voelker-Albert

“…Monitored exercise therapy is a commonly prescribed treatment to relieve pain and functional limitations. However, the benefits of exercise are often gradual, subtle, and evaluated by subjective self-reported scores. …”
Get full text