Neoadjuvant sintilimab and chemotherapy followed by transoral surgery for HPV-positive resectable oropharyngeal cancer: a single-arm, two-centre, phase 2 trialResearch in context by Shida Yan, Xing Zhang, Fengjiao Li, Ankui Yang, Hui Li, Wanming Hu, Qiaohong Lin, Xiyuan Li, Mingyuan Du, Jingtao Chen, Guodong Man, Jianwei Zhang, Xuemei Fang, Li Ning, Shiting Zhang, Lili Han, Yanmei Ma, Jun Wang, Shuwei Chen, Ming Song

“…Most patients experienced improved symptoms including pain and swallowing at 3 months post-surgery, and remained stable at 6 months and 1 year post-surgery. …”
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MILITARY DARK HUMOR AS A FORM OF ADAPTIVE PROCESSES AND THE INDIVIDUAL’S RESPONSE TO FEAR OF DEATH (PSYCHOLINGUISTIC ASPECT) by Tetyana Ye. Khraban

“…The material for this empirical, inductive study is text fragments, memes and photographs, which are posted on the website of “Military service” Ukrainian group. …”
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MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury by Lei Yuan, Duo Wang, Yale Su, Long Yuan, Mixia Li, Dongdong Zheng, Cuilin Zhu, Hulin Piao, Yong Wang, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu

“…Through systematic validation, we identified the most representative hub gene. Subsequent functional studies, including gene knockdown and overexpression experiments, were conducted to elucidate its role and underlying mechanisms in oxidative stress-induced cardiomyocyte injury.ResultsIntegrated bioinformatics analysis and experimental validation identified MAFF as the most differentially expressed hub gene between pre- and post-CPB conditions. …”
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Noninvasive anatomical assessment for ruling out hemodynamically relevant coronary artery anomalies in adults – A comparison of coronary-CT to invasive coronary angiography: The NA... by Marius R. Bigler, Anselm W. Stark, Isaac Shiri, Joel Illi, Matthias Siepe, Federico Caobelli, Andreas A. Giannopoulos, Ronny R. Buechel, Andreas Haeberlin, Dominik Obrist, Lorenz Räber, Christoph Gräni

“…As the sole presence of AAOCA does not always imply a revascularization, a detailed anatomical and functional analysis is crucial for clinical decision-making. …”
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A Mixed-Methods Evaluation of a Wellbeing Programme Designed for Undergraduate Students: Exploring Participants’ Experiences Using Interpretative Phenomenological Analysis by Maria-Christina Vourda, Jess Collins, Radhika Kandaswamy, Mário Cesar do Nascimento Bevilaqua, Carolina Kralj, Zephyr Percy, Naomi Strauss, Patricia A. Zunszain, Gisele P. Dias

“…Three themes were developed through IPA: the differing functions of TTT, the personal impact of TTT, and placing students who need it the most at the heart of TTT. …”
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Conservative or surgical treatment? Optimizing management strategies in medial hypertensive intracerebral hemorrhages by M.Ye. Polishchuk, A.A. Kaminskyi, A.A. Oblyvach, D.V. Shchehlov, O.M. Honcharuk, A.V. Muravskyi

“…In the conservative group, 50% of patients showed mRS improvement, exceeding the 30% improvement rate in the surgical group. …”
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AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models by Richard Novak, Tiffany Lin, Shruti Kaushal, Megan Sperry, Frederic Vigneault, Erica Gardner, Sahil Loomba, Kostyantyn Shcherbina, Vishal Keshari, Alexandre Dinis, Anish Vasan, Vasanth Chandrasekhar, Takako Takeda, Rahul Nihalani, Sevgi Umur, Jerrold R. Turner, Michael Levin, Donald E. Ingber

“…Abstract Background Many neurodevelopmental genetic disorders, such as Rett syndrome, are caused by a single gene mutation but trigger changes in expression of numerous genes. This impairs functions of multiple organs beyond the central nervous system (CNS), making it difficult to develop broadly effective treatments based on a single drug target. …”
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Promoting the wellbeing of the whole person: a within-subjects mixed-methods study exploring the effects of the flourishing intervention among individuals with depressive symptoms by Camilla Casaletti Braghetta, Juliane Piasseschi de Bernardin Gonçalves, Willyane de Andrade Alvarenga, Richard G. Cowden, Richard G. Cowden, Clarice Gorenstein, Clarice Gorenstein, Giancarlo Lucchetti, Homero Vallada

“…The study also seeks to understand participants’ experiences, acceptability, and satisfaction with the intervention.MethodsA quasi-experimental pre-post mixed-methods design was used, incorporating an embedded approach in which descriptive qualitative data complemented quantitative data. …”
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Chemotherapeutic drug scavenger-based combination therapy toward treating triple-negative breast cancer by Qingqing Yin, Yutong Zhong, Mengchun Chen, Weian Mao, Yuan Yang, Li Li, Dongyan Tian, Shuangshuang Liu, Ying Chen, Jiale Quan, Shiyu Li, Deli Zhuge, Xufei Zhang, Ledan Wang, Fang Wang, Yiming Chen, Xiaosheng Lu, Xiaoji Lin, Yijie Chen, Linzhi Yan

“…Here, we developed a chemotherapeutic drug scavenger (CDS) by encapsulating GC-rich DNA—preferred binding targets of Dox—within an erythrocyte membrane functionalized with a normal tissue-targeting (NTT) peptide. …”
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Craniectomy and Cranioplasty Effects on Balance and Gait in Rehabilitation: A Retrospective Study by Leandra A. Stuckey, PT, DPT, Elizabeth E. Holland, PT, DPT, Miranda G. Gurra, MS, David Aaby, MS, Jennifer H. Kahn, PT, DPT

“…Conclusions: Gait and balance outcomes improved during postcraniectomy and postcranioplasty rehabilitation admissions but not immediately post cranioplasty.…”
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Novel Artificial 5′UTR Increase Modified mRNA Translation When Injected into Mouse Heart by Ann Anu Kurian, Matteo Ghiringhelli, Eyal Shalom, Gayatri Mainkar, Magdalena M. Żak, Matthew Adjmi, Jeffrey Downey, Seonghun Yoon, Nicole Dubois, Filip K. Swirski, Lior Zangi

“…<b>Results:</b> This design significantly improves modRNA translation efficiency in cardiomyocytes (CMs) and heart cells both in vitro and in vivo. …”
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Home-use transcranial direct current stimulation (tDCS) as a safe, effective, and feasible application in depression: A randomized, single-blind, placebo-controlled trial by Tuba Aktürk, Mehmet Yücel Ağargün, Sümeyye Özdemir, Esra Dalmızrak, Bahar Güntekin

“…Introduction: Anodal transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (DLPFC) alleviates depression symptoms and enhances cognitive functions in major depressive disorder (MDD) patients. …”
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Comparative Analysis of Ratoon-Competent and Ratoon-Deficient Sugarcane by Hormonal and Transcriptome Profiling by Liping Zhao, Maoyong Ran, Jing Zhang, Peifang Zhao, Fenggang Zan, Jun Zhao, Wei Qin, Qibin Wu, Jiayong Liu, Xinlong Liu

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10 kHz spinal cord stimulation vs. traditional low-frequency spinal cord stimulation for the treatment of diabetes peripheral neuropathic pain: study protocol for a multi-center ra... by Chen Li, Chen Li, Chun-Hua Liu, Chun-Hua Liu, Yi-Fan Li, Hui-Min Hu, Hui-Min Hu, Qing Shi, Qing Shi, An-Xiang Liu, An-Xiang Liu, Wen-Hui Liu, Wen-Hui Liu, Yi Zhang, Peng Mao, Bi-Fa Fan

“…Safety evaluations encompass adverse events, laboratory tests, and imaging findings.DiscussionThis study seeks to provide robust evidence on the superiority of HF-SCS in pain relief, functional improvement, and microcirculatory benefits, potentially establishing it as a preferred neuromodulation strategy for DPNP. …”
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Midterm Outcomes of Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy: A Single‐Center, Observational Study by Xudong Xie, Siyuan Chen, Yawei Cui, Zhenzhen Zhou, Jianhua Lu, Zhi Du, Jie Ding, Kaidi Xing, Yuesheng Zhang, Yijiang Zhou, Jun Li, Xiaogang Guo

“…The primary outcome was the reduction of left ventricular outflow tract gradient after 6 months or more post‐PIMSRA. Secondary outcomes were periprocedural major adverse clinical events. …”
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Single‐Center Evaluation of the Myval Balloon‐Expandable Transcatheter Heart Valve: A Follow‐Up Study: A Retrospective Cohort Study by Mohammadreza Baay, Ata Firouzi, MohammadHossein MozafaryBazargany, Amir Azimi, Armin Elahifar, Mohammad Javad Alemzadeh‐Ansari, Zahra Hosseini, Seifollah Abdi, Amineh Safairad, Peyman Bashghareh, Ehsan Khalilipur

“…The New York Heart Association (NYHA) functional class showed significant improvement from baseline to discharge (p < 0.0001). …”
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In Silico Analysis of miRNA-mRNA Binding Sites in <i>Arabidopsis thaliana</i> as a Model for Drought-Tolerant Plants by Yryszhan Zhakypbek, Aizhan Rakhmetullina, Zhigerbek Kamarkhan, Serik Tursbekov, Qingdong Shi, Fei Xing, Anna Pyrkova, Anatoliy Ivashchenko, Bekzhan D. Kossalbayev, Ayaz M. Belkozhayev

“…While no direct experimental validation was performed, the results from <i>Arabidopsis thaliana</i> provide a useful genomic framework for hypothesis generation and future functional studies in non-model plant species. This work provides a molecular foundation for improving drought and salt stress tolerance through bioinformatics-assisted breeding and genetic research.…”
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Theory-screened Prussian blue analogues-based nanozymes for promoting diabetic wound healing via ferroptosis inhibition by Qingrong Dong, Xiaomei Shen, Ge Fang, Jia Shi, Xiafeng Zhu, Jiangfeng Du, Hui Zhang, Cuicui Ge

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Mitochondria transplanted adipose-derived stem cells/decellularized adipose tissue hydrogel for adipose tissue regeneration by Jiezhang Tang, Yige Han, Pan Ren, Lirong Xu, Zhanjun Lei, Jiaqi Li, Yiwei Cui, Jie Zhang, Jinqing Li, Xueyong Li

“…Nevertheless, the therapeutic potential is constrained by the suboptimal functionality of ADSCs, due to the donor health status, long-term culture, and the post-transplantation environment in vivo. …”
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The influence of altered lower-limb muscle strength on dynamic plantar pressure distribution in participants who underwent anterior cruciate ligament reconstruction by Karolína Matov, Michal Bozděch, Marta Gimunová, Martin Komzák, Marek Dostál, Miloslav Maršálek, Tomáš Vespalec, Milan Mojžíš, Tomáš Vodička

“…Non-parametric Friedman tests with Kendall's W assessed temporal differences, followed by Conover post hoc tests with Bonferroni correction. Spearman's rank correlation examined associations between muscle strength and plantar pressure.ResultsSignificant deficits in extensor strength were found at both postoperative time points compared to preoperative levels (both p &lt; .001), with improvement at six months vs. three (p &lt; .001). …”
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