A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis by Kan Li, Michael J. Rudy, Yanmei Hu, Haozhou Tan, George Lambrinidis, Xiangmeng Wu, Kyriakos Georgiou, Bin Tan, Joshua Frost, Courtney Wilson, Penny Clarke, Antonios Kolocouris, Qing-yu Zhang, Kenneth L. Tyler, Jun Wang

“…In a neonatal mouse model of EV-D68 infection, Jun6504 significantly improves paralysis score and weight gain when administered immediately or 24 hours post-infection. …”
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Social media to understand the endometriosis patient journey: Listening to influences driving treatment choices by Vicky Britton, Alexis Sohn, Nicole T Ansani, Brett Hauber, Michele Cole, Martine C Maculaitis, Ruth Kim

“…Dysmenorrhea, described as excruciating and debilitating, was the most discussed symptom (10% of posts) followed by dyspareunia (3% of posts), with emotional and physical impacts detailed. …”
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A 12-Week Strict Low FODMAP Diet Reduces the Severity Levels of Fatigue, Depression, Anxiety, and Inattention in Patients with Irritable Bowel Syndrome by Sol Maja G Bjørkevoll, Eline M Randulff Hillestad, Gülen A Lied, Erica S Teige, Elisabeth K Steinsvik, Birgitte Berentsen, Astri J Lundervold

“…Data were analyzed using Wilcoxon signed-rank tests to evaluate changes from baseline to post intervention. Results: Thirty-six participants completed the intervention. …”
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Spatial optimization of agricultural production from the perspective of “Greater Food Concept” in Yangzhou, China by Xin Li, Xin Xu, Ru Meng Yin

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A plug and play fuzzy mask extraction module for single image deraining by Mingdi Hu, Yao Song, Songxin Zhang, Zejian Xie, Bingyi Jing

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Analysis of value-based healthcare (VBHC) framework by incremental cost-effectiveness of surgical and therapeutic interventions: a retrospective study at tertiary private health gr... by Mona Khamis, Zainab Almoosa, Marie Santos, Engineer Diaa Kamal, Suhail Yaghmor, Muhammad Daniyal, Abbas Al Mutair

“…The study applied median ICER methodology to evaluate value-based healthcare by comparing pre-and post-treatment costs with improvements in mobility, pain management, activity levels, self-care, and Functional Independence Measure (FIM) scores. …”
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Wearable Sensors-Based Intelligent Sensing and Application of Animal Behaviors: A Comprehensive Review by Luyu Ding, Chongxian Zhang, Yuxiao Yue, Chunxia Yao, Zhuo Li, Yating Hu, Baozhu Yang, Weihong Ma, Ligen Yu, Ronghua Gao, Qifeng Li

“…In addition, algorithm development for functional applications post behavior recognition may represent a critical future research direction.…”
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Genome-wide identification, transcriptional profiling, and miRNA-binding site analysis of the LBD gene family in the camphor tree by Jiaqi Zhang, Luyang Shan, Haoran Qi, Haoran Qi, Caihui Chen, Yongda Zhong, Meng Xu

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Optimization of the Solid Fermentation Process of Hordeum vulgare Linn. by Ganoderma lucidum Mycelium and Its Antioxidant and Hypoglycemic Activities by Yuan MENG, Yingxian GUAN, Xiao FANG, Man WU, Xianxian GAO, Donghan ZHANG, Jie GANG

“…The antioxidant activity of highland barley significantly improved post-fermentation, as evidenced by enhanced DPPH radical, hydroxyl radical, and superoxide anion radical scavenging activities (P<0.05). …”
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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial by Sun YY, Wang ML, Zhao RH, Hao MY, Song S, Zhou Y, Zhang N

“…The primary efficacy indicator will be the change in NRS score after four weeks of treatment, with secondary outcomes including WOMAC, STAI, and safety assessments. fMRI observations will employ independent component analysis, brain network construction, and functional connectivity, complemented by Pearson correlation analysis to explore the relationship between brain responses and clinical improvements.Conclusion: This study will initially uncover how acupuncture intervention for chronic KOA pain centrally regulates and exerts therapeutic effects through the modulation of abnormal brain network functional connectivity patterns, with a demonstrated long-term effect.Ethics and Dissemination: This study has been approved by the ethics committee of Shandong University of Traditional Chinese Medicine Affiliated Hospital ((2024) Lunshen No. (028) - KY).Clinical Trial Registration: This study has been approved by registered in the Chinese Clinical Trial Registry (ChiCTR2400083695).Keywords: acupuncture, knee osteoarthritis, neuroimaging, RCT, protocol…”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Median maximum flow rate and post-void residual volume were predictors for detrusor underactivity. …”
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Early intensive blood pressure management after endovascular treatment in ischaemic stroke (IDENTIFY): a multicentre, open-label, blinded-endpoint, randomised controlled trialResea... by Xuening Zhang, Le Cao, Simiao Wu, Duolao Wang, Hang Wang, Dingwen Zhang, Jian Wang, Lizhang Chen, Xue Lin, Decai Qian, Qinjun Zhang, Lan Xiong, Weiping Wang, Yufeng Tang, Bo Lei, Tianzhu Liu, Jie He, Li Wang, Fuqiang Guo, Guangzong Li, Kuiyun Wang, Jinglun Li, Jun Luo, Jian Shen, Mangmang Xu, Hongbo Zheng, Dong Zhou, Ming Liu, Fayun Hu, Bo Wu, Bo Wu, Fayun Hu, Hongbo Zheng, Yufeng Tang, Decai Qian, Xiang Luo, Wenjie Zi, Xin Hu, Qingwu Yang, Weihai Xu, Anxin Wang, Duolao Wang, Le Cao, Dingwen Zhang, Xing Zhao, Bo Chen, Fayun Hu, Dong Zhou, Ming Liu, Hongbo Zheng, Xuening Zhang, Hang Wang, Mangmang Xu, Ping Wang, Zilong Hao, Jian Wang, Lizhang Chen, Xue Lin, Yuying Yan, Shuai Jiang, Chen Ye, Ruosu Pan, Tang Yang, Kun Lu, Wenzuo Shang, Jingyu Cui, Xueling Bai, Luyao Zhong, Yajun Cheng, Tianxiang Lan, Yuting Wu, Lanhua Liao, Xinyan Peng, Zengju Wue, Fayun Hu, Shuai Jiang, Chen Ye, Ruosu Pan, Tang Yang, Yuying Yan, Yuting Wu, Hang Wang, Ping Wang, Luyao Zhong, Yajun Cheng, Youjie Wang, Congjun Li, Ruishan Liu, Yuan Yao, Jian Wang, Lizhang Chen, Xue Lin, Decai Qian, Lei Deng, Weiping Wang, Yong Yan, Lan Xiong, Chao Li, Qinjun Zhang, Wei Zhang, Yufeng Tang, Zhaokun Li, Bo Lei, Li Chen, Gaoxian Tianzhu Liu, Jie He, Li Wang, Yu Xie, Guangzong Li, Xiaojing Luo, Fuqiang Guo, Shu Yang, Jian Shen, Lei Zhang, Jun Luo, Zhenxuan Tian, Jinglun Li, Yuan Yang, Kuiyun Wang, Weigang Kong, Jie Shen, Xiangping Cheng, Huan Ren, Youlin Wu, Liu Hua, Hui Zheng, Dong Wei, Hong WangZ, Qingwei Yang, Yufeng Hou, Zhou Yu, Miao Peng, Haizhi Guo, Xiangrong Sun, Wei Fan, Zicheng Hu, Jun Liu, Bo Zhang, Yunbo Chen, Lei Liu, Long Zhou, Bo Li, Jiachuan Liao, Xin Zhou, Li Zhou, Xiaolin Tan, Jian Fan, Daqing Xu, Qin Liu, Jia Duan, Xiaojun Luo, Yuqi Peng, Chao He, Jiajun Huang, Jin Fan, Tiao Qiu, Xuanye Yue, Zhijin Yang, Zhuobo Zhang, Yifei Chen, Pingyun Zeng, Haowen Xu, Shenglin Deng, Xiaoyun She, Chunyu Lei, Yifei Ji

“…Patients were randomised to intensive (systolic BP target <130 mm Hg) or standard (systolic BP target <180 mm Hg) management, maintained until 24 h post-EVT. The primary outcome was unfavourable functional outcome (modified Rankin Scale score of 3–6) at 90 days. …”
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Prevention and treatment of transient dry eye following excimer laser surgery by V. V. Pogorelovа, I. S. Malyutina, R. R. Dolzhich, E. G. Kharchenko, I. A. Efimova, M. I. Danilchenko, I. V. Bubnov

“…Results: It was demonstrated that excimer laser surgery provokes transient dry eye in all patients, therefore, artificial tears are required for 2 months and more after the surgery. Post-operative lubricant eye drops use improves tear film stability, tear production, tear osmolarity, and objective signs of dry eye. …”
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Artificial intelligence-guided therapy: Clinic versus home users. Long-term differences in patient-reported outcomes in patients with low back pain by Kenan Alzouhayli, Nathan D. Schilaty, Takashi Nagai, Luca Rigamonti, April L. McPherson, Benjamin Holmes, Nathaniel A. Bates

“…Outcomes of interest were pain, functional status, and kinesiophobia. Results: Group (Home vs. …”
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Gastroepiploic Vascularized Lymph Node Transfer for Extremity Lymphedema: Tips and Insights from Extensive Clinical Experience by Mirco Pozzi, Davide Di Seclì, Alberto Bolletta, Emanuele Cigna, Chiara Camilloni, Beniamino Brunetti, Paolo Persichetti, Michela Schettino, Luigi Losco, Hung-Chi Chen

“…At a mean follow-up of 14.2 months, significant reductions in limb circumference were observed—35.5% ± 24.9% for upper limbs and 32.2% ± 4.5% for lower limbs. Tonicity improved by 6.2%, and no cellulitis episodes were reported post-surgery. …”
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Acute effect of proprioceptive exercises on balance, joint position sense and muscle strength among elder and adult by Mansour Sahebozamani, Abdolhamid Daneshjoo, Saeid Bahiraei, Shima Sheikhbahaie, Sanaz Namazi Zadegan, Faeze Firouzi, Elahe Nasrolahzade, Maliheh Soltanabi

“…Assessments were conducted before, immediately after, and one hour post exercises. Data analysis was performed using a mixed model for repeated measures design. …”
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Correlation of Intraoperative Neuromonitoring (IONM) Signal Changes with Clinical Outcomes in Patients with Compressive Cervical Myelopathy: A Prospective Study by Saumyajit Basu, Aditya Vardhan Guduru, Vikas Hanasoge, Piyush Joshi, Trinanjan Sarangi, Suraj Chakroborthy

“…Paired t-tests were used for the comparison of preoperative and postoperative functional scores. One-way Analysis of variance (ANOVA) tests with Bonferroni post hoc analyses were performed for comparison between the three groups. …”
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Effects of fermented Arctium lappa L. root by Lactobacillus casei on hyperlipidemic mice by MingJu Chen, Yuxiao Wu, Hongxuan Yang, Tianfeng Liu, Tongkun Han, Wangqiang Dai, Junyue Cen, Fan Ouyang, Jingjing Chen, Jianxin Liu, Lin Zhou, Xuguang Hu

“…In vitro antioxidant activity, liver injury, lipid levels, pro-inflammatory cytokine levels, and cholesterol-related mRNA expression were assessed. 16S rRNA sequencing was conducted to evaluate changes in gut microbiota composition.ResultsLC-AR exhibited stronger antioxidant activity and higher metabolite levels than AR. It also improved liver injury as well as better regulation of lipid levels, pro-inflammatory cytokine levels, and cholesterol-related mRNA. 16S rRNA analysis revealed that LC-AR decreased the Firmicutes/Bacteroidetes ratio, which correlated negatively with triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels.DiscussionThese findings suggest that LC-AR may serve as a promising functional food and drug raw material for improving hyperlipidemia, particularly through its beneficial effects on gut microbiota and lipid regulation.…”
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Radiographic and Clinical Results of Minimally Invasive Transverse Distal 1st Metatarsal and Akin Osteotomies for Symptomatic Hallux Valgus by Dino Fanfan BSc, George Todd BS, Christian Guevara BS, Daniel Murray MD, Thomas P. San Giovanni MD, Christopher W. Hodgkins MD, Cary B. Chapman MD

“…Primary radiographic outcomes include pre- and post-operative HV (HVA), inter-metatarsal (IMA), and proximal inter-metatarsal angles (pIMA). …”
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Mandibular advancement devices, irrespective of amount of movement, are effective in treating young patients with obstructive sleep apnea by Wei Min Natalie Tan, Kok Weng Lye, Seyed Ehsan Saffari, Choy Yoke Poon

“…Data were collected from clinical notes, pre- and post-treatment PSG sleep studies. Amount of advancement was determined by the final titrated advancement achieved. …”
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