Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome by Timothy A. Fenton, Stela P. Petkova, Anna Adhikari, Jill L. Silverman

“…In addition, lovastatin’s effects were not assessed in younger subjects, since our study focused exclusively on adult functional outcomes. Metrics of gait, as well as motor coordination and motor learning in rotarod, previously observed to be impaired in AS mice, were not improved by lovastatin treatment. …”
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Acoustic voice assessment in Parkinson's disease patients submitted to posteroventral pallidotomy Parametros acústicos da voz em pacientes com doença de Parkinson submetidos a pali... by Lucia Figueiredo Mourão, Patrícia Maria de Carvalho Aguiar, Fernando Antônio Patriani Ferraz, Mara Suzana Behlau, Henrique Ballalai Ferraz

“…The shimmer and APQ improved. CONCLUSION: This study shows that pallidotomy has little improvement on functional use of communication of PD patients.…”
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Revealing a novel Decorin-expressing tumor stromal subset in hepatocellular carcinoma via integrative analysis single-cell RNA sequencing by Chi Hsiao, Wen-Chieh Liao, Ju-Pi Li, Yu-Cheng Chou, Yu-Lun Chou, Jeng-Rong Lin, Chia-Hua Chen, Chiung-Hui Liu

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Longevity cosmeceuticals as the next frontier in cosmetic innovation: a scientific framework for substantiating product claims by Wannita Klinngam, Athit Chaiwichien, Supawadee Osotprasit, Uracha Ruktanonchai, Mayuree Kanlayavattanakul, Mayuree Kanlayavattanakul, Nattaya Lourith, Nattaya Lourith, Amaraporn Wongrakpanich, Veerawat Teeranachaideekul, Tawin Iempridee

“…To clearly distinguish these scientifically validated products from marketing-driven claims, we define, for the first time, longevity cosmeceutical actives and products based on stringent criteria: (1) they must directly target and modulate established hallmarks of skin aging; (2) they must demonstrably extend “skinspan” over time, reflected by improved skin viability, structure, and functional integrity; and (3) their efficacy must be validated through clinical trials, preferably with post-trial skin biopsies to evaluate aging hallmark biomarkers, along with comprehensive safety assessments. …”
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Loss of appetite in patients with chronic obstructive pulmonary disease - a mixed methods study by Marie Louise Bergmann, Mia Bundgaard Klausen, Lotte Holm, Jens Rikardt Andersen, Jens-Ulrik Stæhr Jensen, Howraman Meteran

“…Among the interviewed patients, the following factors influenced their appetite: Lack of daily routine, insufficient knowledge on nutrition, lack of social contact, bodily limitations, inadequate help and support, limited physical activity and lack of acceptance of life situation.Conclusion Patients with loss of appetite are characterized by a low BMI, impaired lung function, more symptoms and live alone. Improvement in social contact and support, nutritional support, and acceptance of their current life situation will help address these challenges.…”
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METHODOLOGICAL PRINCIPLES OF EDUCATIONAL AND PSYCHOLOGICAL CHATBOT DEVELOPMENT by Vitaliy Panok, Anatoliy Shevchenko, Maksym Nazar, Denys Starkov, Dmytro Meshcheriakov, Andriy Shevtsov

“…This opportunity is particularly relevant for Ukraine in the context of full-scale war and post-war recovery. In-depth scientific research and interdisciplinary support in the issues of revealing and implementing ethical principles of chatbot functioning, such as user safety, privacy protection, and ensuring the certainty and objectivity of the provided information, are of priority importance. …”
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Theory-Driven EEG Indexes for Tracking Motor Recovery and Predicting the Effects of Hybridizing tDCS With Mirror Therapy in Stroke Patients by Chia-Lun Liu, Ken-Hsien Su, Yi-Shiung Horng, Chia-Ling Chen, Shou-Hsien Huang, Ching-Yi Wu

“…Results showed that post-training benefits, measured by Fugl-Meyer Assessment (FMA), were similar across 3 tDCS interventions (premotor, primary motor, sham). …”
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UHVDC Transmission Line Fault Identification Method Based on Generalized Regression Neural Network by XIE Jia, LIU Feng, KE Yanguo, YIN Zhen, RUAN Wei, YAO Jinming

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Comprehensive approaches to design efficient gRNA for SDN1-CRISPR/Cas9 genome editing in wheat by Tushadri Singh, Tushadri Singh, H. M. Mamrutha, Rajender Singh, J. P. Jaiswal, Zeenat Wadhwa, Rakesh Kumar, Omvir Singh, O. P. Ahlawat, Ratan Tiwari

“…By virtue of wheat being a hexaploid crop and having a large genome size with repetitive DNA, a tailor-made strategy for designing the gRNA is crucial.ResultThe manuscript explains the comprehensive strategies and methods for efficient gRNA designing by considering the physical and structural expression of the target gene in the genome and explains the on-target and off-target effects of gRNA for its precise editing through the CRISPR/Cas9-mediated SDN1 method of genome editing in wheat.ConclusionThe present manuscript is first of its kind to address the holistic approach, starting from efficient gene selection, gRNA designing, and post-gRNA designing issues like gRNA stability, binding efficiency, and functionality for SDN1-CRISPR/Cas9 genome editing in wheat. …”
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Reusing of intraoperative exfoliated finger epidermis in the treatment of hand scar contracture in patients with RDEB by Chong Wu, Teng Guo, Yuluo Jian, Xinhe Jiao

“…Neither group exhibited contracture recurrence or significant functional improvement. This novel technique repurposes intraoperatively discarded epidermal tissue as biological dressings, effectively minimizing secondary trauma from adherent dressing removal. …”
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Autograft vs Allograft With Bone Marrow Aspirate Concentrate as an Osteotomy Gap Filler in Lateral Column Lengthening for Progressive Collapsing Flatfoot Deformity by Ramesh Radhakrishnan MBBS, MRCS(Eng), Don Thong Siang Koh MBBS, BSc(Hon), MRCS, MMED(Ortho), Eric Wei Liang Cher MD, MRCS, MMed(Ortho), FRCSEd(Ortho), Wenxian Png MBBS, MMed(Ortho), MRCSEd, FRCSEd(Ortho), Inderjeet Rikhraj Singh MBBS, FRCS, FAMS, MHPE (Maastricht)

“…Background: Progressive collapsing flatfoot deformity (PCFD) is a complex condition characterized by hindfoot valgus, midfoot varus, and forefoot abduction, leading to functional impairment and pain. Surgical correction often includes lateral column lengthening (LCL), which addresses structural deformity and restores alignment. …”
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Patient-reported challenges in spinal cord injury rehabilitation and integration within the community of a lower middle-income country: opportunities for changing lives by Rajani Mullerpatan, Aamreen Ryain, Neha Padia, K.R. Salgotra

“…Introduction: Rehabilitation of individuals with spinal cord injury (SCI) is improving in tertiary-healthcare settings of low-middle-income countries (LMICs). …”
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UC-MSCs Secretome Induces Proliferation of CD4+ T Cells, CD8+ T Cells, NK Cells, and Increases sPD-1 Levels in Severe COVID-19’s Whole Blood by Winna Soleha, Heri Wibowo, Murdani Abdullah, Saraswati Pradipta, Lucky Novita Syari, Isabella Kurnia Liem, Arleni Bustami, Anna Rozaliyan

“…Materials and methods: Twelve whole blood samples from healthy individuals and severe COVID-19 patients were analyzed for lymphocyte count and functional activation using flow cytometry, along with sPD-1 level measurement in pre-treatment and post-secretome conditions. …”
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Advancing higher education on sustainable land use: designing socioscientific inquiry-based learning units on oil palm cultivation by Finn Kristen Matthiesen, Jacqueline Dischereit, Raissa Mataniari, Fitta Setiajiati, Fitta Setiajiati, I Nengah Suparta, Susanne Bögeholz, Susanne Bögeholz

“…We systematically analyzed curricular needs, objects of recent scientific research, teaching and learning frameworks, and evaluation approaches to determine design principles. A pre-post-follow-up evaluation (N = 943) showed that the units, when integrated into curricular courses, increased and sustained students’ self-reported knowledge and interest, with improvements from pilot to implementation cycles. …”
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Balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: short- and long-term results from a cohort in Brazil by Fabio Solano de Freitas Souza, Marcelo Gottschald Ferreira, Iury Andrade Melo, Marta Ferreira Leite de Sá, Camila Melo Coelho Loureiro, Rosalvo Abreu, Paulo Henrique Alves de Carvalho, Mateus dos Santos Viana, Valdemar Oliveira Jr, Luiz Eduardo Fonteles Ritt

“…There was an increase in the six-minute walk distance and an improvement in functional class. Acute lung injury with clinical manifestations was observed after 7% of the BPA sessions. …”
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Analysis of Factors Influencing the Development of Community-Based Tourism in Rural Areas, Case Study: Villages Targeted by Tourism in the Markazi Province by Hamid Afshari, Behrouz Mohammadi Yeganeh, Hossein Farahani, Mehdi Cheraghi

“…Out of the total number of interviewees, 6 people (24%) have diplomas and post-diplomas, 11 people (44%) have bachelors, 6 people (24%) have post-graduate degrees, and 2 people (8%) have PhDs. …”
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Perception of facial esthetics and cephalometric correlations in Class II patients: a comparison between two-phase and one-phase treatments by Wener Chen, Chaoning Zhan, Sze Man Chung, Yifan Lin

“…Eighty profile silhouettes (pre- and post-treatment) were assessed by 64 raters, including 23 orthodontists, 21 general dental practitioners, and 20 laypersons. …”
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Impacts of Low-Order Stream Connectivity Restoration Projects on Aquatic Habitat and Fish Diversity by Xinfeng Li, Xuan Che, Xiaolong Chen, Changfeng Tian, Jiahua Zhang

“…Results indicate that (1) the post-restoration aquatic habitat significantly improved with marked increases in fish diversity metrics, where hydrochemical factors and species diversity exhibited the highest sensitivity to connectivity changes; (2) following restoration, the initially barrier-fragmented river segments (upstream, middle, downstream) exhibited significantly decreased differences in aquatic habitat and fish diversity, demonstrating progressive homogenization across reaches; (3) hydrological factors exerted stronger positive effects on fish diversity than hydrochemical factors did, particularly enhancing species diversity, with a significant positive synergistic effect observed between species diversity and functional diversity. …”
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The effects of 12 weeks of high-intensity interval rope skipping training on speed and power indexes in male soccer players by Bo Wei, Bo Wei, Wenhu Cheng, Jiangang Qiu

“…Additionally, HIIRS training significantly improved movement speed (P = 0.0405) and visual reaction speed (P = 0.0441), which were not significantly enhanced by traditional training. …”
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Two-Centre Retrospective Analysis on Selective Sensory Denervation of Shoulder Joint by Means of Cooled Radiofrequency in Chronic Shoulder Pain by Santi C, Haag T, Cooke C, Schatman ME, Tinnirello A

“…Medication intake (non-steroidal anti-inflammatory drugs (NSAIDS) and/or opioids) significantly decreased at all follow ups.Conclusion: Cooled radiofrequency denervation can be an effective procedure to manage chronic shoulder pain, providing sustained pain relief and functional improvement in more than 50% of the patients.Keywords: radiofrequency, neuromodulation, shoulder pain, pain management…”
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