Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis by Ziyi Chen, Jiankun Xu, Peijie Hu, Wanting Du, Junjiang Chen, Xiaotian Zhang, Wei Zhou, Jiayang Gao, Yuantao Zhang, Bingyang Dai, Guangshuai Nie, Jun Hu, Liangbin Zhou, Shunxiang Xu, Hisao Chang Chan, Wing‐hoi Cheung, Ye Chun Ruan, Ling Qin

“…In aged (> 15‐month‐old) mice, overexpressing CFTR or VX809 restored the expression of autophagy or myogenic genes, increased mitochondrial LC3‐β level and improved skeletal muscle mass and function. Conclusion Age‐related reduction in skeletal muscle expression of CFTR impairs autophagy and myogenesis, exacerbating skeletal muscle aging. …”
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BRAVA: A randomized controlled trial of a brief group intervention for youth with suicidal ideation and their caregivers by Allison Kennedy, Clare Gray, Nicole Sheridan, Leigh Dunn, Jayme Stewart, Stéphanie Drouin, Hannah Elliott, Ademola Adeponle, Nicholas Barrowman, Ewa Sucha, Mario Cappelli, Mark L. Norris, Mona Jabbour, Paula Cloutier

“…No statistically significant differences were observed for any caregiver outcomes measured except a trend for improved perceived caregiver stress in the BRAVA group post-treatment. …”
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A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry ey... by Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang, Kai Hu

“…Secondary assessments focused on the evaluation of lipid layer, meibomian gland function, and bulbar conjunctival redness. Safety was monitored by recording adverse events (AEs) throughout the study. …”
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How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study by Joshua Dissemond, Tim Havers, Steffen Held, Stephan Geisler, Tihomir Kostov, Patrick Diel, Svea Türschmann, Maria K. Parr, Eduard Isenmann

“…M. vastus lateralis and M. vastus intermedius). Liver and kidney function, along with endocrine parameters, were measured via blood samples pre- and post-intervention. …”
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Impact of distal or pylorus preserving gastrectomy on postoperative quality of life in T1 stage middle third gastric cancer patients by Hao Chen, Siqing Jing, Zhaoping Li, Lianlian Cao, Wenxian Guan, Xin Chen, Meng Wang

“…In this study, we employed questionnaire surveys and follow-up assessments to examine the effects of these surgical procedures on postoperative quality of life and pancreatic exocrine function in patients with stage T1 middle-third gastric cancer. …”
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Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised tr... by Jihoon A Kim, Anjali Sankar, Rebecca Marks, Erin Carrubba, Bernadette Lecza, Susan Quatrano, Linda Spencer, R. Todd Constable, Brian Pittman, Eli R Lebowitz, Wendy K Silverman, Holly A Swartz, Hilary P Blumberg

“…Nineteen BE-SMART-DR and 16 BE-SMART-ER participants completed the intervention, with 11 and 13, respectively, having pre-intervention and post-intervention functional MRI data.Findings In addition to demonstrating feasibility, only BE-SMART-DR showed pre-treatment to post-treatment improvements in DR regularity (Cohen’s d=0.55; 95% CI [0.06, 1.03]), associated with reductions in left amygdala responses to emotional face stimuli (pFWE (family-wise error)-SVC (small volume correction)<0.05), difficulties in emotion regulation (d=0.75; 95% CI [0.23, 1.25]) and suicide risk (d=0.65; 95% CI [0.15, 1.14]). …”
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Managing PVR in the Era of Small Gauge Surgery by Manish Nagpal, Rakesh Juneja, Sham Talati

“…Due to the advancements in wide angle viewing systems, advance vitrectomy machines and fluidics, early identification, use of long-term heavy silicon oil tamponades, high-speed cutters, small-gauge vitrectomies, use of perfluorocarbon liquid (PFCL), and small-gauge forceps and scissors, the success rate in the management of PVR has increased leading to improved anatomical outcomes. However, functional outcomes do not correlate well with improved anatomical outcomes. …”
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THE EFFECT OF TRANSGLUTAMINASE ON THE RHEOLOGICAL PROPERTIES OF YOGURT by Iuliana Aprodu, Gabriela Gurau, Aurelia Ionescu, Iuliana Banu

“…The results indicate that transglutaminase catalyzed cross-linking is an effective tool for improving functional properties of yogurt.…”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…Strategies designed to improve waste prevention through reuse could be limited if they do not consider knowledge improvement of material reserves. …”
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Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats by Zhang Chunhua, Zhang Chunhua, Zhang Chunhua, Fu Le, Fu Le, Fu Le, Li Shengli, Li Shengli, Li Shengli, Wu Sachula, Wu Sachula, Wu Sachula, Hua Bao, Hua Bao, Hua Bao, Mu Lan, Mu Lan, Mu Lan, Marco Antonini, Sun Haizhou, Sun Haizhou, Sun Haizhou

“…This review highlights recent discoveries in miRNA-mediated regulation of hair follicles, focusing on their dynamic expression patterns and cell-specific functions in keratinocytes, dermal papilla cells, and follicular stem cells. …”
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Is befriending a possible intervention in people living with schizophrenia? by Felicia Iftene, Adriana Farcas, Simon O’Brien

“…Specific psycho-social instruments were used to assess the possible clinical and/or functional changes post-intervention.Results/discussionsNo statistically significant clinical improvement was found at the end of the intervention. …”
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Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement by Duvuru Geetha, Frank B. Cortazar, Annette Bruchfeld, Andreas Kronbichler, Alexandre Karras, Georges N. Nakhoul, Peter A. Merkel, Sarah Bray, Alana M. Bozeman, David R.W. Jayne, C. Au Peh, A. Chakera, B. Cooper, J. Kurtkoti, D. Langguth, V. Levidiotis, G. Luxton, P. Mount, D. Mudge, E. Noble, R. Phoon, D. Ranganathan, A. Ritchie, J. Ryan, M. Suranyi, A. Kronbichler, A. Rosenkranz, K. Lhotta, N. Demoulin, C. Bovy, R. Hellemans, J. Hougardy, B. Sprangers, K. Wissing, C. Pagnoux, S. Barbour, S. Brachemi, S. Cournoyer, L. Girard, L. Laurin, P. Liang, D. Philibert, M. Walsh, C. Rigothier, J. Augusto, A. Belot, D. Chauveau, D. Cornec, N. Jourde-Chiche, M. Ficheux, P. Zaoui. Paris, A. Karras, A. Klein, F. Maurier, R. Mesbah, O. Moranne, A. Neel, T. Quemeneur, D. Saadoun, B. Terrier, P. Zaoui, M. Schaier, U. Benck, R. Bergner, M. Busch, J. Floege, F. Grundmann, H. Haller, M. Haubitz, B. Hellmich, J. Henes, B. Hohenstein, C. Hugo, C. Iking-Konert, F. Arndt, T. Kubacki, I. Kotter, P. Lamprecht, T. Lindner, J. Halbritter, H. Mehling, U. Schönermarck, N. Venhoff, V. Vielhauer, O. Witzke, I. Szombati, G. Szucs, G. Garibotto, F. Alberici, E. Brunetta, L. Dagna, S. De Vita, G. Emmi, A. Gabrielli, L. Manenti, F. Pieruzzi, D. Roccatello, C. Salvarani, H. Dobashi, T. Atsumi, S. Fujimoto, N. Hagino, A. Ihata, S. Kaname, Y. Kaneko, A. Katagiri, M. Katayama, Y. Kirino, K. Kitagawa, A. Komatsuda, H. Kono, T. Kurasawa, R. Matsumura, T. Mimura, A. Morinobu, Y. Murakawa, T. Naniwa, T. Nanki, N. Ogawa, H. Oshima, K. Sada, E. Sugiyama, T. Takeuchi, H. Taki, N. Tamura, T. Tsukamoto, K. Yamagata, M. Yamamura, P. van Daele, J. de Zoysa, A. Rutgers, Y. Teng, R. Walker, I. Chua, M. Collins, K. Rabindranath, J. de Zoysa, M. Svensson, B. Grevbo, S. Kalstad, M. Little, M. Clarkson, E. Molloy, I. Agraz Pamplona, J. Anton, V. Barrio Lucia, S. Ciggaran, M. Cinta Cid, M. Diaz Encarnacion, X. Fulladosa Oliveras, M. Jose Soler, H. Marco Rusinol, M. Praga, L. Quintana Porras, A. Segarra, A. Bruchfeld, M. Segelmark, I. Soveri, E. Thomaidi, K. Westman, T. Neumann, M. Burnier, T. Daikeler, J. Dudler, T. Hauser, H. Seeger, B. Vogt, D. Jayne, J. Burton, R. Al Jayyousi, T. Amin, J. Andrews, L. Baines, P. Brogan, B. Dasgupta, T. Doulton, O. Flossmann, S. Griffin, J. Harper, L. Harper, D. Kidder, R. Klocke, P. Lanyon, R. Luqmani, J. McLaren, D. Makanjuola, L. McCann, A. Nandagudi, S. Selvan, E. O'Riordan, M. Patel, R. Patel, C. Pusey, R. Rajakariar, J. Robson, M. Robson, A. Salama, L. Smyth, J. Sznajd, J. Taylor, P. Merkel, A. Sreih, E. Belilos, A. Bomback, J. Carlin, Y. Chang Chen Lin, V. Derebail, S. Dragoi, A. Dua, L. Forbess, D. Geetha, P. Gipson, R. Gohh, G.T. Greenwood, S. Hugenberg, R. Jimenez, M. Kaskas, T. Kermani, A. Kivitz, C. Koening, C. Langford, G. Marder, A. Mohamed, P. Monach, N. Neyra, G. Niemer, J. Niles, R. Obi, C. Owens, D. Parks, A. Podoll, B. Rovin, R. Sam, W. Shergy, A. Silva, U. Specks, R. Spiera, J. Springer, C. Striebich, A. Swarup, S. Thakar, A. Tiliakos, Y. Tsai, D. Waguespack, M. Chester Wasko

“…Conclusion: In patients with GPA or MPA with kidney involvement, treatment with an avacopan regimen compared with a prednisone taper regimen achieved similar rates of remission, improved recovery of kidney function, led to faster reduction in albuminuria and hematuria, and lowered GC-related toxicity, with an acceptable safety profile.…”
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Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosis: a systematic review and economic evaluation by Steven J Edwards, Benjamin G Farrar, Kate Ennis, Nicole Downes, Victoria Wakefield, Isaac Mackenzie, Archie Walters, Tracey Jhita

“…People treated with lumacaftor/ivacaftor and tezacaftor/ivacaftor also had increases in lung function, but this was not as large an improvement as with elexacaftor/tezacaftor/ivacaftor. …”
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MC21 v.10 – coupled-radiation Monte Carlo transport solver with support for multiphysics simulations by Griesheimer David P., Gill Daniel F., Nease Brian R., Pavlou Andrew, Stedry Mark H., Thompson Jason T., Burke Paul E., Dobreff Peter S.

“…Over the past decade, the development of the MC21 Monte Carlo radiation transport solver has focused on extending the functionality of the code beyond static calculations of reactivity and reaction rate distributions, as well as improving accuracy, performance, and scalability. …”
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Web Resources in a Surgeon’s Everyday Professional Routine by M. V. Shutova, Ya. S. Rocheva

“…The work was based on the principles of pragmatic sociology and revealed structural and functional changes manifested in new ways to improve professional skills through the opportunities provided by digital technologies.Methodology and sources. …”
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Empowering pediatric, adolescent, and young adult patients with cancer utilizing generative AI chatbots to reduce psychological burden and enhance treatment engagement: a pilot stu... by Joe Hasei, Mana Hanzawa, Akihito Nagano, Naoko Maeda, Shinichirou Yoshida, Makoto Endo, Nobuhiko Yokoyama, Motoharu Ochi, Hisashi Ishida, Hideki Katayama, Tomohiro Fujiwara, Eiji Nakata, Ryuichi Nakahara, Toshiyuki Kunisada, Hirokazu Tsukahara, Toshifumi Ozaki

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Novel minimally invasive carpal tunnel release using a specialized surgical kit: a prospective multi-center case series by Hsuan-Fu Chen, Shun-Min Chang, Chih-Ming Kao, Yu-Lin Chen, Li-Ting Kao, Ya-Chuan Hsu, Yin-Chih Fu, Yan-Hsiung Wang, Wen-Chih Liu, Tien-Ching Lee

“…Grip and pinch strengths showed significant improvement from 2 weeks post-surgery. Mean time to return to work was 18.2 days. …”
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The Neural Correlates and Behavioral Impact of Peripheral Noise Electrical Stimulation on Motor Learning by Li-Wei Chou, Man-Wai Kou, Hui-Min Lee, Felipe Fregni, Vincent Chen, Chung-Lan Kao

“…While research has demonstrated that peripheral electrical stimulation with noise waveform improves motor performance and functions, the effects of noise electrical stimulation on motor learning remain unknown. …”
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Valorisation of apple pomace for the development of high-fibre and polyphenol-rich wheat flour cookies by Zahida Naseem, Naseer Ahmad Bhat, Sajad Ahmad Mir

“…Thus, APP shows promise for producing innovative functional cookies, improving consumer health, utilizing industrial by-products, and reducing waste from apple processing plants, thereby mitigating environmental pollution.…”
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Influencing factors related to stroke patients’ rehabilitation motivation: a scoping review by Xiaowen Fan, Yi Xia, Junrong Wu, Shulei Jia, Jiangyu Hu

“…This scoping review synthesizes evidence from 23 studies across domestic and international databases to identify multidimensional factors influencing post-stroke rehabilitation motivation. Key influencing include intrinsic drivers (e.g., self-efficacy, depression), extrinsic supports (familial or social support, economic burden), disease-specific characteristics (severity, functional deficits), and intervention strategies (cognitive-behavioral therapy, gamified rehabilitation). …”
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